当前位置： SCI文献检索 > JOURNAL OF NEURO-ONCOLOGY期刊下所有文献 > Prospective evaluation of serum glial fibrillary acidic protein (GFAP) as a diagnostic marker for glioblastoma.

Prospective evaluation of serum glial fibrillary acidic protein (GFAP) as a diagnostic marker for glioblastoma.

Abstract：

:Glioblastoma (GBM) is the most common malignant primary brain tumor. Although clinical presentation and brain imaging might be suggestive, histopathological evaluation by means of a brain biopsy is routinely performed to establish the diagnosis. A serum marker indicative of GBM may simplify the diagnostic work-up of patients suspected to having a brain tumor. We prospectively examined 113 patients with newly diagnosed single supratentorial or infratentorial space-occupying brain lesions. Glial fibrillary acidic protein (GFAP) levels were determined from venous blood samples via a prototype ELISA assay prior to any invasive procedures. Serum levels of GFAP were correlated with histopathological findings and MRI parameters. GFAP values were significantly higher in GBM patients (n = 33) compared to all other tumors (p < 0.001). A GFAP serum concentration of ≥0.01 µg/L revealed a sensitivity of 85 % and a specificity of 70 % for differentiating GBM from other entities. By applying a GFAP cut-off point of 0.20 µg/L, specificity was maximized (99 %), but sensitivity dropped to 27 %. In GBM patients, serum GFAP values were significantly correlated with tumor volume. GBM patients with high GFAP levels showed more in vivo GFAP expression as well as more necrosis and perilesional edema compared to GBM patients having low or non-detectable GFAP levels. GFAP serum concentrations differentiated between patients with GBM and patients with cerebral mass lesions of other entities with a moderate diagnostic accuracy. Serum GFAP levels in GBM patients were positively correlated with tumor volume and histopathological tumor characteristics.

journal_name

J Neurooncol

journal_title

Journal of neuro-oncology

authors

Tichy J,Spechtmeyer S,Mittelbronn M,Hattingen E,Rieger J,Senft C,Foerch C

doi

10.1007/s11060-015-1978-8

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

361-9

issue

2

eissn

0167-594X

issn

1573-7373

pii

10.1007/s11060-015-1978-8

journal_volume

126

pub_type

杂志文章

相关文献

JOURNAL OF NEURO-ONCOLOGY文献大全
  • Gliomatosis cerebri: clinical characteristics, management, and outcomes.

    abstract：:Gliomatosis cerebri is a rare diffusely infiltrating primary neoplastic glial process of the brain. Our objective is to review clinical presentation, management, and outcome in a large single institution series of gliomatosis cerebri patients. 54 consecutive gliomatosis cerebri cases presenting to Mayo Clinic Rocheste...

    journal_title：Journal of neuro-oncology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s11060-013-1058-x

    authors： Chen S,Tanaka S,Giannini C,Morris J,Yan ES,Buckner J,Lachance DH,Parney IF

    更新日期：2013-04-01 00:00:00

  • Rethinking childhood ependymoma: a retrospective, multi-center analysis reveals poor long-term overall survival.

    abstract：:Ependymoma is the third most common brain tumor in children, but there is a paucity of large studies with more than 10 years of follow-up examining the long-term survival and recurrence patterns of this disease. We conducted a retrospective chart review of 103 pediatric patients with WHO Grades II/III intracranial epe...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s11060-017-2568-8

    authors： Marinoff AE,Ma C,Guo D,Snuderl M,Wright KD,Manley PE,Al-Sayegh H,Sinai CE,Ullrich NJ,Marcus K,Haas-Kogan D,Goumnerova L,London WB,Kieran MW,Chi SN,Fangusaro J,Bandopadhayay P

    更新日期：2017-10-01 00:00:00

  • Gamma interferon transduced 9L gliosarcoma. Cytokine gene therapy and its relevance to cellular therapy with alloreactive cytotoxic T lymphocytes.

    abstract：:In earlier studies, we demonstrated that intratumoral infusions of alloreactive cytotoxic T lymphocytes (aCTL), sensitized to the major histocompatibility complex (MHC) antigens of the host, effectively retarded the intracranial growth of Fischer 9L gliosarcoma. We further demonstrated that continuous in vitro exposur...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/BF02700024

    authors： Paul DB,Read SB,Kulprathipanja NV,Gomez GG,Kleinschmidt-DeMasters BK,Schiltz PM,Kruse CA

    更新日期：2003-08-01 00:00:00

  • The value of tandem CSF/MRI evaluation for predicting disseminated disease in childhood central nervous system neoplasms.

    abstract：:Leptomeningeal spread of childhood primary central nervous system (CNS) neoplasms, also known as leptomeningeal disease (LMD), significantly affects prognosis and treatment. Lumbar cerebrospinal fluid (CSF) cytology and spinal magnetic resonance imaging (MRI) are considered critical for diagnosis of LMD. It has been s...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-007-9493-1

    authors： Pang J,Banerjee A,Tihan T

    更新日期：2008-03-01 00:00:00

  • The risk of radiation necrosis following stereotactic radiosurgery with concurrent systemic therapies.

    abstract：:To investigate late toxicity among patients with newly-diagnosed brain metastases undergoing stereotactic radiosurgery (SRS) with concurrent systemic therapies with or without whole-brain radiation therapy (WBRT). Patients with newly-diagnosed brain metastasis who underwent SRS at a single tertiary-care institution fr...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-017-2442-8

    authors： Kim JM,Miller JA,Kotecha R,Xiao R,Juloori A,Ward MC,Ahluwalia MS,Mohammadi AM,Peereboom DM,Murphy ES,Suh JH,Barnett GH,Vogelbaum MA,Angelov L,Stevens GH,Chao ST

    更新日期：2017-06-01 00:00:00

  • Disparities in glioblastoma survival by case volume: a nationwide observational study.

    abstract：INTRODUCTION:High hospital case volumes are associated with improved treatment outcomes for numerous diseases. We assessed the association between academic non-profit hospital case volume and survival of adult glioblastoma patients. METHODS:From the nationwide Finnish Cancer Registry, we identified all adult (≥ 18 yea...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-020-03428-5

    authors： Raj R,Seppä K,Luostarinen T,Malila N,Seppälä M,Pitkäniemi J,Korja M

    更新日期：2020-04-01 00:00:00

  • Cyclin D1 is overexpressed in atypical teratoid/rhabdoid tumor with hSNF5/INI1 gene inactivation.

    abstract：OBJECT:Although atypical teratoid/rhabdoid tumor (AT/RT) is known to generate through inactivation of the hSNF5/INI1 gene on chromosome 22q, the downstream molecular mechanism remains unclear. We histologically and molecularly reviewed our pediatric brain tumors for unrecognized AT/RTs and evaluated the role of cyclin ...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-004-4276-4

    authors： Fujisawa H,Misaki K,Takabatake Y,Hasegawa M,Yamashita J

    更新日期：2005-06-01 00:00:00

  • Low-grade pure and mixed cerebral astrocytomas treated in the CT scan era.

    abstract：:From 1974 to 1992, 63 patients diagnosed with low-grade pure or mixed oligo-astrocytoma were seen and treated at our institution. All patients underwent CT scan pre-operatively. There were 20 female and 43 males ranging in age from 12 to 73 years (median age of 33 years). 15 patients had a stereotactic biopsy as the o...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/BF00177481

    authors： Bahary JP,Villemure JG,Choi S,Leblanc R,Olivier A,Bertrand G,Souhami L,Tampieri D,Hazel J

    更新日期：1996-02-01 00:00:00

  • Outcomes after discontinuation of antiepileptic drugs after surgery in patients with low grade brain tumors and meningiomas.

    abstract：:Low grade tumors are associated with a high risk of seizures. Prolonged use of antiepileptic drugs (AEDs) is associated with morbidity. Determining which patients can safely discontinue AEDs perioperatively is difficult. We examined patients with low grade supratentorial brain tumors to determine characteristics of pa...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-011-0779-y

    authors： Das RR,Artsy E,Hurwitz S,Wen PY,Black P,Golby A,Dworetzky B,Lee JW

    更新日期：2012-05-01 00:00:00

  • Expression of TrkA, TrkB and TrkC in human neuroblastomas.

    abstract：:There is considerable interest in the role of the TRK family of neurotrophin receptors in regulating the survival, growth and differentiation of normal and neoplastic nerve cells. Indeed, there is increasing evidence that TRK genes play an important role in the biology and clinical behavior of neuroblastomas, tumors o...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1023/a:1005729329526

    authors： Brodeur GM,Nakagawara A,Yamashiro DJ,Ikegaki N,Liu XG,Azar CG,Lee CP,Evans AE

    更新日期：1997-01-01 00:00:00

  • Cerebellar anaplastic astrocytoma in a teenager with Ollier Disease.

    abstract：INTRODUCTION:Ollier Disease is a sporadic skeletal disorder with a predisposition to oncogenesis. It is estimated at around 1/100,000. We are presenting a young patient with Ollier Disease and high-grade astrocytoma. CASE REPORT:A 14-year-old, Caucasian male with Ollier Disease presented with a history of headaches, v...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-008-9583-8

    authors： Walid MS,Troup EC

    更新日期：2008-08-01 00:00:00

  • Primary intracranial myxoma of the parietal region. Illustrated case report.

    abstract：:An extremely rare case of primary intracranial myxoma mimicking an intraaxial parenchymal tumour is reported. A 25 year old male presented with complaints of headache and right sided hemiparesis. A gross total resection of the tumour was achieved. Histology confirmed that the tumour was a myxoma. Investigations did no...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-008-9555-z

    authors： Menon RK,Goel A,Shah A,Goel N,Rajashekharan P

    更新日期：2008-06-01 00:00:00

  • Surgery of insular and paralimbic diffuse low-grade gliomas: technical considerations.

    abstract：:Once considered a "no man's land" especially when invaded by a diffuse low grade glioma (DLGG), the insula remains to this day a surgical challenge. Surgery for insular DLGG involves consideration of its hidden location under the potentially eloquent operculae, the proximity to vascular tree and high density of functi...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,评审

    doi：10.1007/s11060-016-2120-2

    authors： Michaud K,Duffau H

    更新日期：2016-11-01 00:00:00

  • Shortened ex vivo manufacturing time of EGFRvIII-specific chimeric antigen receptor (CAR) T cells reduces immune exhaustion and enhances antiglioma therapeutic function.

    abstract：BACKGROUND:Non-viral manufacturing of CAR T cells via the Sleeping Beauty transposon is cost effective and reduces the risk of insertional mutagenesis from viral transduction. However, the current gold standard methodology requires ex vivo numerical expansion of these cells on artificial antigen-presenting cells (AaPCs...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-019-03311-y

    authors： Caruso HG,Tanaka R,Liang J,Ling X,Sabbagh A,Henry VK,Collier TL,Heimberger AB

    更新日期：2019-12-01 00:00:00

  • HD-MB03 is a novel Group 3 medulloblastoma model demonstrating sensitivity to histone deacetylase inhibitor treatment.

    abstract：:Medulloblastomas are the most common malignant brain tumors in childhood. Emerging evidence suggests that medulloblastoma comprises at least four distinct diseases (WNT, SHH, Group 3 and 4) with different biology, clinical presentation, and outcome, with especially poor prognosis in Group 3. The tight connection of bi...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-012-0978-1

    authors： Milde T,Lodrini M,Savelyeva L,Korshunov A,Kool M,Brueckner LM,Antunes AS,Oehme I,Pekrun A,Pfister SM,Kulozik AE,Witt O,Deubzer HE

    更新日期：2012-12-01 00:00:00

  • Long-lasting remission after rituximab treatment in a case of anti-Hu-associated sensory neuronopathy and gastric pseudoobstruction.

    abstract：:Anti-Hu paraneoplastic syndromes are usually associated with an underlying neoplasia, although a few patients who are anti-Hu-positive never develop cancer after long-term follow-up. Tumour therapy remains the mainstay of therapeutic options, and early immune therapy in parallel is advisable. When no tumour is found, ...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-008-9787-y

    authors： Coret F,Bosca I,Fratalia L,Perez-Griera J,Pascual A,Casanova B

    更新日期：2009-07-01 00:00:00

  • A pilot study of cis-diamminedichloroplatinum and radiation therapy in patients with high grade astrocytomas.

    abstract：:A pilot study was performed combining cis-diamminedichloroplatinum (CDDP) and radiation therapy to treat patients with high-grade astrocytomas. CDDP at a dose of 40 mg/m2/week intravenously was given during the course of cranial irradiation. Following irradiation, CDDP was given every three weeks on a schedule of 35-4...

    journal_title：Journal of neuro-oncology

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF00182955

    authors： Feun LG,Stewart DJ,Maor M,Leavens M,Savaraj N,Burgess MA,Yung WK,Benjamin RS

    更新日期：1983-01-01 00:00:00

  • Occupational exposure to metals and risk of meningioma: a multinational case-control study.

    abstract：:The aim of the study was to examine associations between occupational exposure to metals and meningioma risk in the international INTEROCC study. INTEROCC is a seven-country population-based case-control study including 1906 adult meningioma cases and 5565 population controls. Incident cases were recruited between 200...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-016-2244-4

    authors： Sadetzki S,Chetrit A,Turner MC,van Tongeren M,Benke G,Figuerola J,Fleming S,Hours M,Kincl L,Krewski D,McLean D,Parent ME,Richardson L,Schlehofer B,Schlaefer K,Blettner M,Schüz J,Siemiatycki J,Cardis E

    更新日期：2016-12-01 00:00:00

  • The cost-effectiveness of surgical resection and cesium-131 intraoperative brachytherapy versus surgical resection and stereotactic radiosurgery in the treatment of metastatic brain tumors.

    abstract：:This study aims to evaluate the cost-effectiveness of surgical resection (S) and Cesium-131 (Cs-131) [S + Cs-131] intraoperative brachytherapy versus S and stereotactic radiosurgery (SRS) [S + SRS] for the treatment of brain metastases. Treatment records as well as hospital and outpatient charts of 49 patients with br...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-015-2026-4

    authors： Wernicke AG,Yondorf MZ,Parashar B,Nori D,Clifford Chao KS,Boockvar JA,Pannullo S,Stieg P,Schwartz TH

    更新日期：2016-03-01 00:00:00

  • Central nervous system atypical teratoid tumor/rhabdoid tumor: response to intensive therapy and review of the literature.

    abstract：:Central nervous system atypical teratoid/rhabdoid tumor (ATT/RT) of infancy and childhood is a unique histologic entity with an extremely aggressive natural history. Standard therapy for infant and childhood medulloblastoma, for which this entity is often mistaken, has been ineffective; most children survive less than...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,评审

    doi：10.1023/a:1006125120866

    authors： Hilden JM,Watterson J,Longee DC,Moertel CL,Dunn ME,Kurtzberg J,Scheithauer BW

    更新日期：1998-12-01 00:00:00

  • Diffusion MRI changes in the anterior subventricular zone following chemoradiation in glioblastoma with posterior ventricular involvement.

    abstract：INTRODUCTION:There is growing evidence that the subventricular zone (SVZ) plays a key role in glioblastoma (GBM) tumorigenesis. However, little is known regarding how the SVZ, which is a harbor for adult neural stem cells, may be influenced by chemoradiation. The current diffusion-weighted imaging (DWI) study explored ...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-020-03460-5

    authors： Cho N,Wang C,Raymond C,Kaprealian T,Ji M,Salamon N,Pope WB,Nghiemphu PL,Lai A,Cloughesy TF,Ellingson BM

    更新日期：2020-05-01 00:00:00

  • Detection of p21WAF1/Cip1 in brain metastases.

    abstract：:The p21WAF1/Cip1 (p21) protein, a negative regulator of G1 checkpoint control, was overexpressed in the majority of human gliomas. To investigate whether p21 expression in brain metastases from various systemic origins is similar to that in gliomas and whether p21 expression is regulated differently in brain metastase...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1023/a:1005972808311

    authors： Ruan S,Fuller G,Levin V,Bruner JM,Zhang W

    更新日期：1998-05-01 00:00:00

  • Efficacy of stereotactic radiosurgery for radiation-induced meningiomas.

    abstract：PURPOSE:Stereotactic radiosurgery is an established treatment option for sporadic meningiomas, though limited data exists for radiation-induced lesions. METHODS:Patients treated with cobalt-60 radiosurgery between October 2005 and December 2018 in an institutional registry were reviewed. Single fraction treatments wer...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-020-03515-7

    authors： Huo M,Laperriere N,van Prooijen M,Shultz D,Coolens C,Hodaie M,Cusimano M,Gentili F,Zadeh G,Payne D,Schwartz M,Tsang DS

    更新日期：2020-06-01 00:00:00

  • Multivariate analysis of clinical prognostic factors in children with intracranial ependymomas.

    abstract：:The optimal postoperative management of pediatric intracranial ependymomas is controversial. We analyzed clinical prognostic factors for their influence on outcome in such children. Our retrospective series included 15 with supratentorial and 28 with infratentorial tumors. Twenty ependymomas were grade II, and 23 were...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1023/b:neon.0000033383.84900.c1

    authors： Jaing TH,Wang HS,Tsay PK,Tseng CK,Jung SM,Lin KL,Lui TN

    更新日期：2004-07-01 00:00:00

  • Long-term survivors of glioblastoma multiforme: clinical and molecular characteristics.

    abstract：:Long term survival is rare in patients with glioblastoma multiforme (GBM). To determine if the tumors of patients with long survivals constitute a subgroup of patients with identifiable molecular genetic characteristics, we studied the p53 gene and Epidermal Growth Factor Receptor (EGF-R) expression in long-term survi...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/BF00165483

    authors： Morita M,Rosenblum MK,Bilsky MH,Fraser RA,Rosenfeld MR

    更新日期：1996-03-01 00:00:00

  • Cationic surface charge enhances early regional deposition of liposomes after intracarotid injection.

    abstract：:Rapid first pass uptake of drugs is necessary to increase tissue deposition after intraarterial (IA) injection. Here we tested whether brain tissue deposition of a nanoparticulate liposomal carrier could be enhanced by coordinated manipulation of liposome surface charge and physiological parameters, such as IA injecti...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-014-1584-1

    authors： Joshi S,Singh-Moon R,Wang M,Chaudhuri DB,Ellis JA,Bruce JN,Bigio IJ,Straubinger RM

    更新日期：2014-12-01 00:00:00

  • Phenotypic change of human cultured meningioma cells.

    abstract：:One objection to using cell cultures for studying the proliferation of tumors is the potential for phenotypic changes that may occur in vitro. Here, we compared the antigen pattern expression of cultured meningioma cells with that of the primary tumor. Cell cultures established from 9 intracranial meningiomas and depa...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1023/a:1006436903976

    authors： Pallini R,Casalbore P,Mercanti D,Maggiano N,Larocca LM

    更新日期：2000-08-01 00:00:00

  • Interactions among mitochondrial proteins altered in glioblastoma.

    abstract：:Mitochondrial dysfunction is putatively central to glioblastoma (GBM) pathophysiology but there has been no systematic analysis in GBM of the proteins which are integral to mitochondrial function. Alterations in proteins in mitochondrial enriched fractions from patients with GBM were defined with label-free liquid chr...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-014-1430-5

    authors： Deighton RF,Le Bihan T,Martin SF,Gerth AMJ,McCulloch M,Edgar JM,Kerr LE,Whittle IR,McCulloch J

    更新日期：2014-06-01 00:00:00

  • Effects of slice thickness and head rotation when measuring glioma sizes on MRI: in support of volume segmentation versus two largest diameters methods.

    abstract：:This paper presents a study of the effects of scanning parameters variability when assessing glioma sizes on MRI. A database of lesions of various shapes and sizes, segmented on 3D-SPGR MRI images, was acquired on 65 patients with low-grade glioma. Simulations of large slice thickness and patient's head rotation were ...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-013-1051-4

    authors： Schmitt P,Mandonnet E,Perdreau A,Angelini ED

    更新日期：2013-04-01 00:00:00

  • Multisession gamma knife surgery for large brain metastases.

    abstract：:This study aimed to explore the safety and efficacy of multisession gamma knife surgery (GKS) for large brain metastases with a volume of 10 cm3 or larger. Fifty-six patients who had 65 brain metastases with a volume of at least 10 cm3 were treated with multisession GKS. Three-session GKS at a prescription dose of 10 ...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-016-2317-4

    authors： Hasegawa T,Kato T,Yamamoto T,Iizuka H,Nishikawa T,Ito H,Kato N

    更新日期：2017-02-01 00:00:00