Abstract：
INTRODUCTION:High hospital case volumes are associated with improved treatment outcomes for numerous diseases. We assessed the association between academic non-profit hospital case volume and survival of adult glioblastoma patients. METHODS:From the nationwide Finnish Cancer Registry, we identified all adult (≥ 18 years) patients with histopathological diagnoses of glioblastoma from 2000 to 2013. Five university hospitals (treating all glioblastoma patients in Finland) were classified as high-volume (one hospital), middle-volume (one hospital), and low-volume (three hospitals) based on their annual numbers of cases. We estimated one-year survival rates, estimated median overall survival times, and compared relative excess risk (RER) of death between high, middle, and low-volume hospitals. RESULTS:A total of 2,045 patients were included. The mean numbers of annually treated patients were 54, 40, and 17 in the high, middle, and low-volume hospitals, respectively. One-year survival rates and median survival times were higher and longer in the high-volume (39%, 9.3 months) and medium-volume (38%, 8.9 months) hospitals than in the low-volume (32%, 7.8 months) hospitals. RER of death was higher in the low-volume hospitals than in the high-volume hospital (RER = 1.19, 95% CI 1.07-1.32, p = 0.002). There was no difference in RER of death between the high-volume and medium-volume hospitals (p = 0.690). CONCLUSION:Higher glioblastoma case volumes were associated with improved survival. Future studies should assess whether this association is due to differences in patient-specific factors or treatment quality.
journal_name
J Neurooncoljournal_title
Journal of neuro-oncologyauthors
Raj R,Seppä K,Luostarinen T,Malila N,Seppälä M,Pitkäniemi J,Korja Mdoi
10.1007/s11060-020-03428-5subject
Has Abstractpub_date
2020-04-01 00:00:00pages
361-370issue
2eissn
0167-594Xissn
1573-7373pii
10.1007/s11060-020-03428-5journal_volume
147pub_type
杂志文章abstract：PURPOSE:Although the survival of most melanoma patients diagnosed with leptomeningeal disease (LMD) is short, some patients can have better outcomes and prolonged survival. A large retrospective cohort of patients was analyzed to identify features associated with survival with LMD from melanoma. METHODS:Clinical chara...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-019-03121-2
更新日期：2019-05-01 00:00:00
abstract：:Glioblastoma is a highly angiogenic tumor with a dismal prognosis. Continuous oral low-dose chemotherapy with methotrexate (MTX) and cyclophosphamide (CPM) has modest activity in heavily pretreated patients with breast cancer. We explored the efficacy of 100 mg CPM daily and 5 mg MTX twice weekly in relapsed glioblast...
journal_title：Journal of neuro-oncology
pub_type： 临床试验,杂志文章
doi：10.1007/s11060-004-1726-y
更新日期：2005-02-01 00:00:00
abstract：:Steroids are beneficial in neurological illness, but have many serious side effects. Having observed several patients with severe steroid psychoses, which greatly prolonged their hospitalizations, the authors sought to improve understanding of this entity. A literature review was conducted. The incidence of severe psy...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章,评审
doi：10.1007/s11060-012-0919-z
更新日期：2012-09-01 00:00:00
abstract：:BCNU is increasingly used in low ethanol (ETOH) concentrations, 5% dextrose-water (D5W), or normal saline (NS) solutions, especially for intra-arterial and prolonged (e.g., 3 day) intravenous (IV) infusions. Little work, however, has been done to evaluate BCNU decomposition rates in concentrations, diluents, and tempe...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/BF00146872
更新日期：1991-04-01 00:00:00
abstract：:We have retrospectively reviewed toxicities and response of a cohort of primary central nervous system lymphoma (PCNSL) patients treated with high dose parenteral methotrexate (MTX) monotherapy without whole brain radiation. From The Massachusetts General Hospital (MGH) Cancer Registry, active since 1946, we selected ...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-009-0090-3
更新日期：2010-07-01 00:00:00
abstract：:In addition to its powerful vasoconstrictive activity, endothelin-1 (ET-1) has been recognized to stimulate DNA synthesis in some cell lines. In this study, we confirmed the existence of ET-1 receptor in YKG-1 human glioma cells, and investigated its effect on DNA synthesis in YKG-1 for 6 consecutive days, comparing i...
journal_title：Journal of neuro-oncology
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更新日期：1994-01-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-012-1011-4
更新日期：2013-02-01 00:00:00
abstract：BACKGROUND:Macroautophagy/autophagy is considered to play key roles in tumor cell evasion of therapy and establishment of metastases in breast cancer. High expression of LC3, a residual autophagy marker, in primary breast tumors has been associated with metastatic disease and poor outcome. FIP200/Atg17, a multi-functio...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-018-2959-5
更新日期：2018-11-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-010-0421-4
更新日期：2011-07-01 00:00:00
abstract：:The utility of current response criteria has not been established in anaplastic astrocytoma (AA). We retrospectively reviewed MR images for 20 patients with AA and compared RANO-based approaches to clinician impression described as follow: (1) standard RANO-based criteria met by growth of or development of new enhanci...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-014-1703-z
更新日期：2015-03-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-012-0820-9
更新日期：2012-06-01 00:00:00
abstract：BACKGROUND:Our primary objective was to report the current neuroimaging classification systems of spatial patterns of progression in glioblastoma. In addition, we aimed to report the terminology used to describe 'progression' and to assess the compliance with the Response Assessment in Neuro-Oncology (RANO) Criteria. ...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-018-2843-3
更新日期：2018-08-01 00:00:00
abstract：:Neural cell adhesion molecule (NCAM) is a cell surface glycoprotein whose expression may be important in metastatic or local growth of neoplasms. Expression of NCAM in human pituitary adenomas was assessed on snap-frozen and Bouin's and/or formalin-fixed, paraffin-embedded archival tissue using a sensitive alkaline ph...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/BF01053153
更新日期：1995-01-01 00:00:00
abstract：:The cell-penetrating trans-activator of transcription (TAT) is a cationic peptide derived from human immunodeficiency virus-1. It has been used to facilitate macromolecule delivery to various cell types. This cationic peptide is capable of crossing the blood-brain barrier and therefore might be useful for enhancing th...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-017-2429-5
更新日期：2017-05-01 00:00:00
abstract：:Transfection of primary cultures of human cells with origin of replication deficient SV40 DNA has been carried out by others to generate in vitro models of malignant transformation in vivo. The present work describes progressive alterations in karyotype and phenotype in one such transfected (neuroglial) cell line (SVG...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/BF00182082
更新日期：1990-02-01 00:00:00
abstract：:The name of author Do Hoon Lim was incorrect in the initial online publication. The original article has been corrected. ...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章,已发布勘误
doi：10.1007/s11060-020-03532-6
更新日期：2020-05-01 00:00:00
abstract：BACKGROUND:Lymphomatoid granulomatosis (LYG) is an angiocentric and angiodestructive lymphoreticular proliferation, which usually involves the lungs, but may also involve the central nervous system (CNS). Unique involvement of the CNS has been reported rarely. We report our experience with LYG confined to the brain and...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章,评审
doi：10.1007/s11060-009-9834-3
更新日期：2009-09-01 00:00:00
abstract：:Autologous brain tumor specific CTLs were induced from the patient's PBL by a mixed lymphocyte-tumor culture, and were maintained for more than 2 months in a medium containing exogenous IL-2. The autologous T cell line containing specific CTL was administered into the tumor-bed for the treatment of malignant glioma. I...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/BF00195603
更新日期：1987-01-01 00:00:00
abstract：:Aberrant expression of microRNAs (miRNAs), a class of small non-coding regulatory RNAs, has been implicated in the development and progression of high-grade gliomas. However, the precise mechanistic role of many miRNAs in this disease remains unclear. Here, we investigate the functional role of miR-331-3p in glioblast...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-013-1271-7
更新日期：2014-01-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-017-2742-z
更新日期：2018-05-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/BF01059959
更新日期：1995-01-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-008-9583-8
更新日期：2008-08-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-004-4276-4
更新日期：2005-06-01 00:00:00
abstract：PURPOSE:White matter changes (WMCs) can develop following systemic chemotherapy in patients with primary central nervous system lymphomas (PCNSLs), but the frequency and extent of these changes is not well characterized. This single center retrospective semi-quantitative study was performed to determine the rate, timin...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-019-03279-9
更新日期：2019-12-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/BF02427837
更新日期：1990-10-01 00:00:00
abstract：:Bevacizumab, an anti-angiogenic agent, is FDA-approved for use in patients with recurrent glioblastoma multiforme (rGBM). The radiologic evaluation of tumor response to bevacizumab is complex and there is no validated method of monitoring tumor vascularity during therapy. We evaluated perfusion-weighted MR imaging (PW...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-016-2300-0
更新日期：2017-01-01 00:00:00
abstract：:Ependymomas (EPN) show site specific genetic alterations and a recent DNA methylation profiling study identified nine molecular subgroups. C11orf95-RELA and YAP1 fusions characterise the RELA and YAP1 molecular subgroups, respectively, of supratentorial (ST)-EPNs. Current guidelines recommend molecular subgrouping ove...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-018-2767-y
更新日期：2018-05-01 00:00:00
abstract：:Pediatric glial tumors differ from adult gliomas in several ways that are of major therapeutic importance. First, the value of extensive tumor resection, which is controversial for malignant intrinsic brain tumors in adults, has been confirmed for a variety of childhood brain tumors, such as supratentorial high-grade ...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章,评审
doi：10.1023/a:1006107227856
更新日期：1999-05-01 00:00:00
abstract：:Topotecan was studied as a 72 h infusion given every 3 weeks. Treatment began at a dose of 1.0 mg/m2/day and was increased to 1.25 mg/m2/day after the first 6 patients tolerated this higher dose without excessive toxicities. Eighty-eight evaluable children were accrued in 6 strata. There were no complete nor partial r...
journal_title：Journal of neuro-oncology
pub_type： 临床试验,杂志文章
doi：10.1023/a:1006294102611
更新日期：1999-05-01 00:00:00
abstract：:We have investigated the anti-tumor activity of ex vivo activated and expanded T cells which had been sensitized in vivo to one of two different syngeneic rat glioma cell lines; D74 or RT-2. Rats were sensitized by inoculation of irradiated tumor cells into each hind foot pad. After 10 days, the tumor-draining lymph n...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1023/a:1005771717409
更新日期：1997-03-01 00:00:00
