Cyclin D1 is overexpressed in atypical teratoid/rhabdoid tumor with hSNF5/INI1 gene inactivation.

abstract：:Intracranial atypical teratoid/rhabdoid tumors (AT/RT) are rare with a poor prognosis. We report one case of a 7-year old girl living over 17 months after the diagnosis of AT/RT in the left frontal lobe. Treatment was partial surgical resection and post-operative radiation therapy. Radiation therapy resulted in comple...

journal_title：Journal of neuro-oncology

authors： Howes TL,Buatti JM,O'Dorisio MS,Kirby PA,Ryken TC

更新日期：2005-03-01 00:00:00

abstract：:O(6)-methylguanine-DNA-methyltransferase (MGMT) is mainly regulated by cytosine-guanine island promoter methylation that is believed to occur only in neoplastic tissue. The present study was undertaken to investigate whether methylation occurs also in non-neoplastic brains by collecting 45 non-neoplastic brains from a...

journal_title：Journal of neuro-oncology

authors： Hsu CY,Ho HL,Chang-Chien YC,Chang YW,Ho DM

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Non-viral manufacturing of CAR T cells via the Sleeping Beauty transposon is cost effective and reduces the risk of insertional mutagenesis from viral transduction. However, the current gold standard methodology requires ex vivo numerical expansion of these cells on artificial antigen-presenting cells (AaPCs...

journal_title：Journal of neuro-oncology

authors： Caruso HG,Tanaka R,Liang J,Ling X,Sabbagh A,Henry VK,Collier TL,Heimberger AB

更新日期：2019-12-01 00:00:00

abstract：:The new anticancer agent Taxol appears to potentiate the effects of radiation on brain tumor cell lines in vitro and was recently evaluated by our group as a radiosensitizer in a phase I study for primary brain tumors. In that study, we administered Taxol as a three-hour IV infusion repeated every week for six weeks a...

journal_title：Journal of neuro-oncology

authors： Wehbe T,Glantz M,Choy H,Glantz L,Cortez S,Akerley W 3rd,Mills P,Cole B

更新日期：1998-09-01 00:00:00

abstract：:Epigenetic silencing of the O(6)-methylguanine-DNA-methyltransferase (MGMT) gene by promoter methylation is correlated with improved progression-free survival (PFS) and overall survival (OS) in adult patients with newly diagnosed glioblastoma multiforme (GBM) who receive alkylating agents. The aim of this study is to ...

journal_title：Journal of neuro-oncology

authors： Minniti G,Salvati M,Arcella A,Buttarelli F,D'Elia A,Lanzetta G,Esposito V,Scarpino S,Maurizi Enrici R,Giangaspero F

更新日期：2011-04-01 00:00:00

abstract：:A thirty-year-old male with an intracranial malignant meningioma, first diagnosed 9 years ago, with three recurrences was admitted with a hypoglycemic shock. The blood glucose level was 17 mg/dl, requiring treatment with high doses of intravenous and oral dextrose for improvement. A large metastatic tumor in the liver...

journal_title：Journal of neuro-oncology

authors： Yoshida D,Sugisaki Y,Tamaki T,Saitoh N,Node Y,Shimura T,Teramoto A

更新日期：2000-03-01 00:00:00

abstract：:Mitochondrial dysfunction is putatively central to glioblastoma (GBM) pathophysiology but there has been no systematic analysis in GBM of the proteins which are integral to mitochondrial function. Alterations in proteins in mitochondrial enriched fractions from patients with GBM were defined with label-free liquid chr...

journal_title：Journal of neuro-oncology

authors： Deighton RF,Le Bihan T,Martin SF,Gerth AMJ,McCulloch M,Edgar JM,Kerr LE,Whittle IR,McCulloch J

更新日期：2014-06-01 00:00:00

abstract：:Anaplastic mixed gliomas are rare tumors that occur mostly in the cerebral hemispheres. They have a distinctive histological appearance characterized by the presence of two or more glial cellular constituents. The incidence of malignant mixed glioma of the brainstem and posterior fossa is extremely low. The authors re...

journal_title：Journal of neuro-oncology

authors： Lee TT,Galarza M,Petito CK,Heros RC

更新日期：1998-04-01 00:00:00

abstract：:Developing and conducting gene therapy clinical trials poses unique challenges which must be addressed to satisfy regulatory requirements and, most importantly, to protect human subjects. Experimental products used for gene transfer studies, such as viral vectors, are often complex and cannot be sterilized or complete...

journal_title：Journal of neuro-oncology

authors： Aguilar LK,Aguilar-Cordova E

更新日期：2003-12-01 00:00:00

abstract：SUBJECT:To date there is no established tumor marker for the clinical follow-up of glioblastoma, WHO grade IV, (GBM) which constitutes the most frequent and malignant primary brain tumor. However, since there is promising data that the serum glial fibrillary acidic protein (sGFAP) may serve as a biomarker for glial bra...

journal_title：Journal of neuro-oncology

authors： Baumgarten P,Quick-Weller J,Gessler F,Wagner M,Tichy J,Forster MT,Foerch C,Seifert V,Mittelbronn M,Senft C

更新日期：2018-09-01 00:00:00

abstract：:In the following study, we present our experience in the treatment of PCNSL patients using a multi-step schedule combining chemotherapy and deferred radiotherapy. Patients were treated with two modified M-BACOD cycles and then differently according to radiological response For PR, SD and PD patients, chemotherapy was ...

journal_title：Journal of neuro-oncology

authors： Silvani A,Salmaggi A,Eoli M,Lamperti E,Broggi G,Marras CE,Fariselli L,Milanesi I,Fiumani A,Gaviani P,Erbetta A,Giovagnoli AR,Pollo B,Botturi A,Boiardi A

更新日期：2007-05-01 00:00:00

abstract：:The utility of current response criteria has not been established in anaplastic astrocytoma (AA). We retrospectively reviewed MR images for 20 patients with AA and compared RANO-based approaches to clinician impression described as follow: (1) standard RANO-based criteria met by growth of or development of new enhanci...

journal_title：Journal of neuro-oncology

authors： Kazda T,Hardie JG,Pafundi DH,Kaufmann TJ,Brinkmann DH,Laack NN

更新日期：2015-03-01 00:00:00

abstract：:Unexpected early epidural spinal metastasis in a case of osteosarcoma occurred in a patient receiving treatment with cis-diamminedichloroplatinum-II (cisplatin). The initial neurologic symptomatology manifested as paresthesias in the feet which developed 2 months after initiation of treatment (cumulative dose of cispl...

journal_title：Journal of neuro-oncology

authors： Shimizu H,Jaffe N,Kleinerman E

更新日期：1986-01-01 00:00:00

abstract：:Aberrant expression of microRNAs (miRNAs), a class of small non-coding regulatory RNAs, has been implicated in the development and progression of high-grade gliomas. However, the precise mechanistic role of many miRNAs in this disease remains unclear. Here, we investigate the functional role of miR-331-3p in glioblast...

journal_title：Journal of neuro-oncology

authors： Epis MR,Giles KM,Candy PA,Webster RJ,Leedman PJ

更新日期：2014-01-01 00:00:00

abstract：:Disparities in American health care based on socially-defined patient characteristics such as race, ethnicity, and socioeconomic position are well-documented. We review differences and disparities in incidence, pathobiology, processes and outcomes of care, and survival based on social factors for brain tumors of all h...

journal_title：Journal of neuro-oncology

authors： Curry WT Jr,Barker FG 2nd

更新日期：2009-05-01 00:00:00

abstract：:To assess the clinical outcome and late side effect profile of pencil beam scanning proton therapy (PT) delivered to children with intracranial ependymoma. Between July-2004 and March-2013, 50 patients with intracranial ependymoma (n = 46, grade 3) received involved-field PT at Paul Scherrer Institute (PSI). Median ag...

journal_title：Journal of neuro-oncology

authors： Ares C,Albertini F,Frei-Welte M,Bolsi A,Grotzer MA,Goitein G,Weber DC

更新日期：2016-05-01 00:00:00

abstract：PURPOSE:To evaluate the effectiveness of complete resection and postoperative radiotherapy in spinal cord ependymomas. METHODS AND MATERIALS:We conducted a retrospective study over 20 patients (13 males and 7 females) with histologically confirmed spinal cord ependymomas between July 1985 and April 2001. Among them, 1...

journal_title：Journal of neuro-oncology

authors： Lin YH,Huang CI,Wong TT,Chen MH,Shiau CY,Wang LW,Ming-Tak Ho D,Yen SH

更新日期：2005-01-01 00:00:00

abstract：:When SK-N-BE(2) human neuroblastoma cells were exposed for 1h to growth medium supplemented with [14C]arachidonic acid (AA) at final concentrations ranging from 1 microM to 100 microM, an amount of this fatty acid was uptaken ranging form a 2% to a 120% of that present in cells at steady state. As more [14C]AA was upt...

journal_title：Journal of neuro-oncology

authors： Spinedi A

更新日期：1997-01-01 00:00:00

abstract：:Since its description in 1982, central neurocytoma (CN) has been a relatively innocuous rare tumor of the central nervous system. Comprising of less than 0.5% of all intracranial tumors, most are reported to be slow growing, with low recurrence rates, and a favorable prognosis. Because of its rarity, its cellular biol...

journal_title：Journal of neuro-oncology

authors： Tran H,Medina-Flores R,Cerilli LA,Phelps J,Lee FC,Wong G,Turner P

更新日期：2010-11-01 00:00:00

abstract：:High-grade gliomas release excitotoxic concentrations of glutamate which contributes to their malignant phenotype. To improve our understanding of the mechanisms by which glutamate enhances tumor growth and invasion, we examined alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-mediated signaling in glio...

journal_title：Journal of neuro-oncology

authors： de Groot JF,Piao Y,Lu L,Fuller GN,Yung WK

更新日期：2008-06-01 00:00:00

abstract：:Aneurysmal bone cysts (ABCs) are benign bone lesions with annual incidences ranging from 1.4 to 3.2 cases per million people. Approximately, 10-30% of ABCs are found in the spine. Such lesions are traditionally treated with curettage or other intralesional techniques. Because ABCs can be locally aggressive, intralesio...

journal_title：Journal of neuro-oncology

authors： Boriani S,Lo SF,Puvanesarajah V,Fisher CG,Varga PP,Rhines LD,Germscheid NM,Luzzati A,Chou D,Reynolds JJ,Williams RP,Zadnik P,Groves M,Sciubba DM,Bettegowda C,Gokaslan ZL,AOSpine Knowledge Forum Tumor.

更新日期：2014-10-01 00:00:00

abstract：:We prospectively evaluated the efficacy and safety of imatinib plus hydroxyurea in patients with progressive/recurrent meningioma. A total of 21 patients with progressive/recurrent meningioma were enrolled in this dual center, single-arm, phase II trial. All patients received 500 mg of hydroxyurea twice a day. Imatini...

journal_title：Journal of neuro-oncology

authors： Reardon DA,Norden AD,Desjardins A,Vredenburgh JJ,Herndon JE 2nd,Coan A,Sampson JH,Gururangan S,Peters KB,McLendon RE,Norfleet JA,Lipp ES,Drappatz J,Wen PY,Friedman HS

更新日期：2012-01-01 00:00:00

abstract：PURPOSE:Most recent literature has confirmed the efficacy of single-session radiosurgery (sRS) in the treatment of intracranial meningioma. Unfortunately, sRS is not always applicable due to large tumor volume and the proximity of the tumor to critical structures. When sRS is not recommended, multi-session radiosurgery...

journal_title：Journal of neuro-oncology

authors： Marchetti M,Conti A,Beltramo G,Pinzi V,Pontoriero A,Tramacere I,Senger C,Pergolizzi S,Fariselli L

更新日期：2019-07-01 00:00:00

abstract：:Some unresectable and symptomatic meningiomas recur after conventional radiation therapy or stereotactic radiosurgery and are a therapeutic challenge. Evidence-based data from medical therapy for patients with recurrent meningioma can be deemed insufficient. Because of the prevalent expression of PDGF receptors in men...

journal_title：Journal of neuro-oncology

authors： Horak P,Wöhrer A,Hassler M,Hainfellner J,Preusser M,Marosi C

更新日期：2012-09-01 00:00:00

abstract：INTRODUCTION:Intramedullary spinal cord metastases (ISCMs) are rare lesions affecting the spinal cord in patients with disseminated malignancy. Today, due to increased survival, these lesions are more frequently diagnosed. Literature on survival and neurologic outcomes is sparse. Herein, we describe a single institutio...

journal_title：Journal of neuro-oncology

authors： Goyal A,Yolcu Y,Kerezoudis P,Alvi MA,Krauss WE,Bydon M

更新日期：2019-04-01 00:00:00

abstract：:Although several studies have quantified costs of cancer care; none to date have examined how cancer costs impact family caregivers' emotional health. This study was designed to evaluate how perceptions of economic hardship influence burden, depressive symptoms, and anxiety in family caregivers of persons with a prima...

journal_title：Journal of neuro-oncology

authors： Bradley SE,Sherwood PR,Kuo J,Kammerer CM,Gettig EA,Ren D,Rohrer WM,Donovan HS,Hricik A,Newberry A,Given B

更新日期：2009-07-01 00:00:00

abstract：:Intracranial Hodgkin's lymphoma (ICHL) in the HIV positive population is a rarely reported event with only three prior cases reported in the literature. In these prior reports, the outcome of the patients was uncertain or very poor. We report here the case of an HIV seropositive patient with an isolated intracranial r...

journal_title：Journal of neuro-oncology

authors： Ramchandar K,Verhey LH,Jha NK,Murty NK,McMillan W

更新日期：2008-08-01 00:00:00

abstract：:Ependymomas are rare neuroepithelial tumors which may arise anywhere along the ventricular system. Tumors arising in the fourth ventricle present unique challenges. Complete tumor resection favors prolonged survival, but may result in inadvertent injury of surrounding neural structures-such as cranial nerve (CN) nucle...

journal_title：Journal of neuro-oncology

authors： Winkler EA,Birk H,Safaee M,Yue JK,Burke JF,Viner JA,Pekmezci M,Perry A,Aghi MK,Berger MS,McDermott MW

更新日期：2016-11-01 00:00:00

abstract：:Gliomatosis cerebri is a rare diffusely infiltrating primary neoplastic glial process of the brain. Our objective is to review clinical presentation, management, and outcome in a large single institution series of gliomatosis cerebri patients. 54 consecutive gliomatosis cerebri cases presenting to Mayo Clinic Rocheste...

journal_title：Journal of neuro-oncology

authors： Chen S,Tanaka S,Giannini C,Morris J,Yan ES,Buckner J,Lachance DH,Parney IF

更新日期：2013-04-01 00:00:00

abstract：:Global and gene-specific changes to the epigenome are hallmarks of most tumours including those of pituitary origin, and this fact might offer important clues about diagnostic and therapeutic applications. We performed global DNA methylation screening with 6 invasive and 6 noninvasive nonfunctioning pituitary adenomas...

journal_title：Journal of neuro-oncology

authors： Gu Y,Zhou X,Hu F,Yu Y,Xie T,Huang Y,Zhao X,Zhang X

更新日期：2016-08-01 00:00:00