Evaluation of RANO response criteria compared to clinician evaluation in WHO grade III anaplastic astrocytoma: implications for clinical trial reporting and patterns of failure.

abstract：:Convection-enhanced delivery (CED) of highly stable PEGylated liposomes encapsulating chemotherapeutic drugs has previously been effective against malignant glioma xenografts. We have developed a novel, convectable non-PEGylated liposomal formulation that can be used to encapsulate both the topoisomerase I inhibitor t...

journal_title：Journal of neuro-oncology

authors： Grahn AY,Bankiewicz KS,Dugich-Djordjevic M,Bringas JR,Hadaczek P,Johnson GA,Eastman S,Luz M

更新日期：2009-11-01 00:00:00

abstract：:The p21WAF1/Cip1 (p21) protein, a negative regulator of G1 checkpoint control, was overexpressed in the majority of human gliomas. To investigate whether p21 expression in brain metastases from various systemic origins is similar to that in gliomas and whether p21 expression is regulated differently in brain metastase...

journal_title：Journal of neuro-oncology

authors： Ruan S,Fuller G,Levin V,Bruner JM,Zhang W

更新日期：1998-05-01 00:00:00

abstract：:While the 5-year overall survival is better in pediatric than in adult patients diagnosed with glioblastoma (GBM), outcomes in children remain very poor. Understanding the mechanisms of tumorigenesis and tumor propagation can identify therapeutic targets to improve these outcomes. Human cytomegalovirus (CMV) proteins ...

journal_title：Journal of neuro-oncology

authors： Wakefield A,Pignata A,Ghazi A,Ashoori A,Hegde M,Landi D,Gray T,Scheurer ME,Chintagumpala M,Adesina A,Gottschalk S,Hicks J,Powell SZ,Ahmed N

更新日期：2015-11-01 00:00:00

abstract：:One hundred-twenty seven human brain tumors were examined by an immunoperoxidase technique for the expression of collagen Type IV, a major constituent of basement membrane. The parenchymal components were negative for the marker protein in all tumors except for neurilemmomas which were positively stained. In every cas...

journal_title：Journal of neuro-oncology

authors： Ogawa K,Oguchi M,Nakashima Y,Yamabe H

更新日期：1989-11-01 00:00:00

abstract：:We proposed to identify the efficacy of an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) using whole brain radiotherapy (WBRT)/stereotactic radiosurgery (SRS)/surgery in brain metastases from patients with non-small cell lung cancer (NSCLC) and clarify the association between treatment outcom...

journal_title：Journal of neuro-oncology

authors： Cai L,Zhu JF,Zhang XW,Lin SX,Su XD,Lin P,Chen K,Zhang LJ

更新日期：2014-11-01 00:00:00

abstract：INTRODUCTION:It is useful to know the molecular subtype of lower-grade gliomas (LGG) when deciding on a treatment strategy. This study aims to diagnose this preoperatively. METHODS:A deep learning model was developed to predict the 3-group molecular subtype using multimodal data including magnetic resonance imaging (M...

journal_title：Journal of neuro-oncology

authors： Matsui Y,Maruyama T,Nitta M,Saito T,Tsuzuki S,Tamura M,Kusuda K,Fukuya Y,Asano H,Kawamata T,Masamune K,Muragaki Y

更新日期：2020-01-01 00:00:00

abstract：:Gliomas, the most common malignant primary brain tumors, are universally fatal once they progress from low-grade into high-grade neoplasms. In recent years, we have accumulated unprecedented data about the genetic and epigenetic abnormalities in gliomas; yet, our appreciation of how these deadly tumors arise is still ...

journal_title：Journal of neuro-oncology

authors： Tsankova NM,Canoll P

更新日期：2014-09-01 00:00:00

abstract：:Since the introduction of CT and MRI as diagnostic aids, it has been possible to obtain direct images of neoplastic meningiosis. After more than ten years experience, the combination of MRI with the administration of a paramagnetic contrast medium is now accepted as the method of choice for the sensitive detection of ...

journal_title：Journal of neuro-oncology

authors： Schumacher M,Orszagh M

更新日期：1998-06-01 00:00:00

abstract：:Magnetic resonance imaging (MRI) or computerized tomography (CT) is routinely performed after resection of brain metastases (BrM), regardless of whether there are specific clinical concerns about residual tumor or potential complications. Routine imaging studies contribute a significant amount to the cost of medical c...

journal_title：Journal of neuro-oncology

authors： Benveniste RJ,Ferraro N,Tsimpas A

更新日期：2014-06-01 00:00:00

abstract：:We have investigated the anti-tumor activity of ex vivo activated and expanded T cells which had been sensitized in vivo to one of two different syngeneic rat glioma cell lines; D74 or RT-2. Rats were sensitized by inoculation of irradiated tumor cells into each hind foot pad. After 10 days, the tumor-draining lymph n...

journal_title：Journal of neuro-oncology

authors： Rice CD,Baldwin NG,Biron RT,Bear HD,Merchant RE

更新日期：1997-03-01 00:00:00

abstract：:Fibroblast growth factor-2 (FGF-2) is involved as an autocrine growth factor in the autonomous proliferation of glioma cells. To develop a new strategy for treating patients with glioma, we studied the effect on human glioma cells of a 16-mer oligopeptide with conformational similarity to the putative receptor-binding...

journal_title：Journal of neuro-oncology

authors： Kono K,Ueba T,Takahashi JA,Murai N,Hashimoto N,Myoumoto A,Itoh N,Fukumoto M

更新日期：2003-06-01 00:00:00

abstract：:We describe two patients with fatal vascular malformations of the thalamus whom we thought had gliomas. They had progressive neurological impairment with subacute onset as adults. Computed tomography showed lesions of increased density with slight post-contrast enhancement; cerebral angiography was normal. Without bio...

journal_title：Journal of neuro-oncology

authors： Norcross K,Ciric IS,Mikhael MA,Vick NA

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Prior studies have highlighted infratentorial tumor location as a prognostic factor for solitary fibrous tumor (SFT) and hemangiopericytoma (HPC) of the central nervous system (CNS), and spinal location is considered a positive prognostic factor for other tumors of the CNS. While SFT/HPC of the CNS is known ...

journal_title：Journal of neuro-oncology

authors： Boyett D,Kinslow CJ,Bruce SS,Sonabend AM,Rae AI,McKhann GM,Sisti MB,Bruce JN,Cheng SK,Wang TJC

更新日期：2019-07-01 00:00:00

abstract：:In earlier studies, we demonstrated that intratumoral infusions of alloreactive cytotoxic T lymphocytes (aCTL), sensitized to the major histocompatibility complex (MHC) antigens of the host, effectively retarded the intracranial growth of Fischer 9L gliosarcoma. We further demonstrated that continuous in vitro exposur...

journal_title：Journal of neuro-oncology

authors： Paul DB,Read SB,Kulprathipanja NV,Gomez GG,Kleinschmidt-DeMasters BK,Schiltz PM,Kruse CA

更新日期：2003-08-01 00:00:00

abstract：TARGET POPULATION:These recommendations apply to adults with a newly diagnosed lesion with a suspected or histopathologically proven glioblastoma (GBM). QUESTION:What are the optimal imaging techniques to be used in the management of a suspected glioblastoma (GBM), specifically: which imaging sequences are critical fo...

journal_title：Journal of neuro-oncology

authors： Lundy P,Domino J,Ryken T,Fouke S,McCracken DJ,Ormond DR,Olson JJ

更新日期：2020-11-01 00:00:00

abstract：:Glioblastomas (GBM) may originate de novo (primary), or following transformation from a lower grade glioma (secondary), and it has been postulated that these tumors may have different biological behaviors. We performed a correlative analysis involving 204 patients with glioma treated prospectively on NCCTG clinical tr...

journal_title：Journal of neuro-oncology

authors： Jaeckle KA,Decker PA,Ballman KV,Flynn PJ,Giannini C,Scheithauer BW,Jenkins RB,Buckner JC

更新日期：2011-08-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most malignant glioma. In the current study, 149 astrocytoma gene expression datasets were classified by prediction analysis of microarray. Strikingly, disks large homolog 3 (DLG3), a membrane-associated guanylate kinase-family gene, had the highest score in the GBM subset. DLG3 mR...

journal_title：Journal of neuro-oncology

authors： Liu Z,Niu Y,Xie M,Bu Y,Yao Z,Gao C

更新日期：2014-02-01 00:00:00

abstract：:Meningiomas of the anterior skull base account for 40% of all intracranial meningiomas. Of these, almost half are sphenoid wing meningiomas; the other half are tuberculum sella tumors or olfactory groove tumors. Anterior clinoidal (medial sphenoid wing) meningiomas are a subcategory of the sphenoid wing meningiomas; t...

journal_title：Journal of neuro-oncology

authors： DeMonte F

更新日期：1996-09-01 00:00:00

abstract：:We studied the effect of intracarotid infusion of various calcium antagonists on regional CBF (rCBF) in the C6 rat glioma by a hydrogen clearance method. Nimodipine at doses of 0.1, 0.5 and 1 microgram/kg/min was found to produce tumor-specific increases in the rCBF (40.2 +/- 18.4%, p < 0.01, 67.8 +/- 32.6%, p < 0.001...

journal_title：Journal of neuro-oncology

authors： Matsukado K,Ikezaki K,Nomura T,Fukui M

更新日期：1996-01-01 00:00:00

abstract：:A better understanding of the relationship between glioblastomas molecular subtypes and radio-chemotherapy is needed for the development of individualized strategies. In this study, we aimed to assess whether non-homologous end-joining (NHEJ) protein expression is associated and could predict responses to treatment of...

journal_title：Journal of neuro-oncology

authors： Pinel B,Duchesne M,Godet J,Milin S,Berger A,Wager M,Karayan-Tapon L

更新日期：2017-04-01 00:00:00

abstract：:The labeling index (LI) of 216 cases of human brain tumors was determined by the immunohistochemical technique with monoclonal antibody to bromodeoxyuridine (BrdU). The proliferative potential of 110 cases was estimated using the intra-operative intravenous infusion of BrdU at a dose of 200 mg/sq m. In another 106 cas...

journal_title：Journal of neuro-oncology

authors： Kharbanda K,Dinda AK,Sarkar C,Karak AK,Dhir R,Mathur M,Roy S

更新日期：1995-01-01 00:00:00

abstract：:Cranial radiation can impact the cerebral vasculature in many ways, with a wide range of clinical manifestations. The incidence of these late effects including cerebrovascular accidents (CVAs), lacunar lesions, vascular occlusive disease including moyamoya syndrome, vascular malformations, and hemorrhage is not well k...

journal_title：Journal of neuro-oncology

authors： Murphy ES,Xie H,Merchant TE,Yu JS,Chao ST,Suh JH

更新日期：2015-05-01 00:00:00

abstract：PURPOSE:Glioblastoma multiforme (GBM) is a common and aggressive malignancy associated with poor prognosis. Characteristics and treatment of long-term survivors are of particular interest in efforts to improve outcomes. Therefore, the objective of this study was to examine trends and prognostic factors for 3-year survi...

journal_title：Journal of neuro-oncology

authors： Zreik J,Moinuddin FM,Yolcu YU,Alvi MA,Chaichana KL,Quinones-Hinojosa A,Bydon M

更新日期：2020-05-01 00:00:00

abstract：INTRODUCTION:There is growing evidence that the subventricular zone (SVZ) plays a key role in glioblastoma (GBM) tumorigenesis. However, little is known regarding how the SVZ, which is a harbor for adult neural stem cells, may be influenced by chemoradiation. The current diffusion-weighted imaging (DWI) study explored ...

journal_title：Journal of neuro-oncology

authors： Cho N,Wang C,Raymond C,Kaprealian T,Ji M,Salamon N,Pope WB,Nghiemphu PL,Lai A,Cloughesy TF,Ellingson BM

更新日期：2020-05-01 00:00:00

abstract：:Thirty-six infants and children with brain stem glioma diagnosed between 1967 and 1980 were reviewed. Posterior fossa craniotomy was performed in 25, with biopsy or partial resection in 18, cyst aspiration in 2, and exploration alone in 5. The 19 surgical specimens obtained revealed neoplastic cells in 15 but only gli...

journal_title：Journal of neuro-oncology

authors： Tomita T,McLone DG,Naidich TP

更新日期：1984-01-01 00:00:00

abstract：:Assessing central nervous system (CNS) involvement in patients with lymphoma or carcinoma is important in determining therapy and prognosis. Progranulin (PGRN) is a secreted glycosylated protein with roles in cancer growth and survival; it is highly expressed in aggressive cancer cell lines and specimens from many can...

journal_title：Journal of neuro-oncology

authors： Kimura A,Takemura M,Serrero G,Yoshikura N,Hayashi Y,Saito K,Inuzuka T

更新日期：2018-05-01 00:00:00

abstract：:Gemistocytic astrocytoma still continues to be enigmatic; both in terms of definition and prognostic implications. The major issue of contention has been the clinical relevance of this pathological entity. The currently accepted definition of gemistocytic astrocytoma requires 20% or more gemistocytes, and considers th...

journal_title：Journal of neuro-oncology

authors： Tihan T,Vohra P,Berger MS,Keles GE

更新日期：2006-01-01 00:00:00

abstract：:Glioblastoma stands out as the most frequent central nervous system neoplasia, presenting a poor prognosis. The aim of this study was to verify the frequency and clinical significance of the aneuploidy of chromosomes 7 and 10, EGFR amplification, PTEN and TP53 deletions and 1p/19q deficiency in adult patients diagnose...

journal_title：Journal of neuro-oncology

authors： Koshiyama DB,Trevisan P,Graziadio C,Rosa RFM,Cunegatto B,Scholl J,Provenzi VO,de Sá AP,Soares FP,Velho MC,de A P Filho N,Oliveira CA,Zen PRG

更新日期：2017-12-01 00:00:00

abstract：:Neuroblastoma (NB) is a tumor of pediatric age that is associated with high mortality in metastatic stages, although stage IVS patients undergo frequent spontaneous regression. Since apoptosis has been proposed as a possible cause of remission among cancer patients, we tested this hypothesis among both localized and m...

journal_title：Journal of neuro-oncology

authors： Tonini GP,Mazzocco K,di Vinci A,Geido E,de Bernardi B,Giaretti W

更新日期：1997-01-01 00:00:00

abstract：:Radiotherapy (RT) and concomitant/adjuvant therapy with temozolomide (Temodar) is a common treatment regimen for children and adults with glioma. Although temozolomide is generally well tolerated with temporary myelosuppression as the primary dose-limiting toxicity, irreversible bone-marrow aplasia after treatment wit...

journal_title：Journal of neuro-oncology

authors： Morris EB,Kasow K,Reiss U,Ellison D,Broniscer A

更新日期：2009-01-01 00:00:00