Topotecan for the treatment of recurrent or progressive central nervous system tumors - a pediatric oncology group phase II study.

abstract：:To evaluate the safety and efficacy of hypofractionated radiotherapy (RT) with a standard temozolomide (TMZ) regimen for adults with newly diagnosed glioblastoma multiforme (GBM), twenty-six consecutive adults (range 39-79 years) who met our enrollment criteria received short courses of hypofractionated RT (45 Gy in 1...

journal_title：Journal of neuro-oncology

authors： Terasaki M,Eto T,Nakashima S,Okada Y,Ogo E,Sugita Y,Tokutomi T,Shigemori M

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Anaplastic lymphoma kinase (ALK) is expressed in ~ 60% of glioblastomas and conveys tumorigenic functions. Therefore, ALK inhibitory strategies with alectinib are conceivable for patients with glioblastoma. The aims of this preclinical study were to investigate efficacy as well as to understand and potential...

journal_title：Journal of neuro-oncology

authors： Berberich A,Schmitt LM,Pusch S,Hielscher T,Rübmann P,Hucke N,Latzer P,Heßling B,Lemke D,Kessler T,Platten M,Wick W

更新日期：2020-01-01 00:00:00

abstract：:p53 mutations are the most frequently detected genetic alterations of gliomas, appearing in a similar proportion of low and high grade astrocytomas, while the amplification of epidermal growth factor receptor (EGFR) gene appears mainly in glioblastomas. Thus, these changes seem to delineate two subgroups of high grade...

journal_title：Journal of neuro-oncology

authors： Kordek R,Biernat W,Alwasiak J,Maculewicz R,Yanagihara R,Liberski PP

更新日期：1995-10-01 00:00:00

abstract：OBJECTIVE AND IMPORTANCE:Epithelioid hemangioendothelioma (EHE) is a rare vascular tumor that presents histological features and biological behavior of low-grade malignancy. The authors report a case of malignant intracranial EHE, in which surgical excisions and additional immuno-chemotherapy were ineffective. Emphasis...

journal_title：Journal of neuro-oncology

authors： Endo T,Su CC,Numagami Y,Shirane R

更新日期：2004-05-01 00:00:00

abstract：:Subcutaneous vaccination using granulocyte-macrophage colony-stimulating factor (GM-CSF)-transduced glioma cells substantially prolongs survival in the mouse GL261 glioma model. To potentiate the efficacy of GM-CSF-based vaccination, syngeneic C57BL/6 mice bearing pre-implanted intracerebral GL261 gliomas were vaccina...

journal_title：Journal of neuro-oncology

authors： Herrlinger U,Aulwurm S,Strik H,Weit S,Naumann U,Weller M

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Macroautophagy/autophagy is considered to play key roles in tumor cell evasion of therapy and establishment of metastases in breast cancer. High expression of LC3, a residual autophagy marker, in primary breast tumors has been associated with metastatic disease and poor outcome. FIP200/Atg17, a multi-functio...

journal_title：Journal of neuro-oncology

authors： Hashemi-Sadraei N,Müller-Greven GM,Abdul-Karim FW,Ulasov I,Downs-Kelly E,Burgett ME,Lauko A,Qadan MA,Weil RJ,Ahluwalia MS,Du L,Prayson RA,Chao ST,Budd TG,Barnholtz-Sloan J,Nowacki AS,Keri RA,Gladson CL

更新日期：2018-11-01 00:00:00

abstract：:The outcome of children less than 3 years of age with medulloblastoma has been poor in comparison to older children. The cure rates were below 30%, and the quality of life for cured children was frequently reduced by a complex syndrome of long-term sequelae including intellectual retardation and growth hormone deficie...

journal_title：Journal of neuro-oncology

authors： Schmandt S,Kühl J

更新日期：1998-06-01 00:00:00

abstract：INTRODUCTION:It is useful to know the molecular subtype of lower-grade gliomas (LGG) when deciding on a treatment strategy. This study aims to diagnose this preoperatively. METHODS:A deep learning model was developed to predict the 3-group molecular subtype using multimodal data including magnetic resonance imaging (M...

journal_title：Journal of neuro-oncology

authors： Matsui Y,Maruyama T,Nitta M,Saito T,Tsuzuki S,Tamura M,Kusuda K,Fukuya Y,Asano H,Kawamata T,Masamune K,Muragaki Y

更新日期：2020-01-01 00:00:00

abstract：INTRODUCTION:The standard treatment for primary central nervous system lymphoma (PCNSL) involves induction methotrexate-based chemotherapy with or without consolidation whole brain radiotherapy (WBRT). As WBRT carries a substantial risk for cognitive impairment, alternative consolidation treatments have been used to re...

journal_title：Journal of neuro-oncology

authors： Correa DD,Braun E,Kryza-Lacombe M,Ho KW,Reiner AS,Panageas KS,Yahalom J,Sauter CS,Abrey LE,DeAngelis LM,Omuro A

更新日期：2019-09-01 00:00:00

abstract：:The effect of methionine enkephalin on the growth of human brain tumor cells was investigated. The results show that this endogenous opioid has dual effects on tumor cell growth. This peptide exerted an inhibitory effect in SK-N-MC human neuroblastoma cell line; in contrast, in U-373 MG human astrocytoma cell line, th...

journal_title：Journal of neuro-oncology

authors： Lee YS,Wurster RD

更新日期：1994-01-01 00:00:00

abstract：:The aim of this study was to test by means of a voxel-based approach the hypothesis that there is a different spatial distribution of brain metastases (BM) and white matter hyperintensities (WMH) and that the presence of WMH affects the location of BM in lung and non-lung cancer patients. Two-hundred consecutive cance...

journal_title：Journal of neuro-oncology

authors： Quattrocchi CC,Errante Y,Mallio CA,Carideo L,Scarciolla L,Santini D,Tonini G,Zobel BB

更新日期：2014-11-01 00:00:00

abstract：:Cavernous sinus is an uncommon site of metastasis for the head and neck tumors, and especially for the tumors of parotid gland. The case reported here is the second reported case of parotid carcinoma metastatic to the cavernous sinus, proven by histopathology. Also it is the first reported parotid gland acinic cell ca...

journal_title：Journal of neuro-oncology

authors： Yildirim N,Oksüzoğlu B,Vural M,Han O,Zengin N

更新日期：2005-06-01 00:00:00

abstract：INTRODUCTION:Carmustine (BCNU)-impregnated biodegradable polymer wafers have been shown to prolong survival in patients with recurrent malignant glioma. Interferon alfa-2b (IFNalpha(2b)) has demonstrated antitumor activity against a number of cancers, but its use in glioma has been limited. The use of these agents in c...

journal_title：Journal of neuro-oncology

authors： Olson JJ,McKenzie E,Skurski-Martin M,Zhang Z,Brat D,Phuphanich S

更新日期：2008-12-01 00:00:00

abstract：PURPOSE:Intracranial glioblastomas with simultaneous spinal lesions prior to chemoradiation therapy or craniotomy, defined as initial spinal metastasis, are not well understood. Herein, we investigated intracranial glioblastoma and demonstrated the importance of spinal screening using gadolinium enhanced spinal magneti...

journal_title：Journal of neuro-oncology

authors： Shibahara I,Saito R,Osada Y,Kanamori M,Sonoda Y,Kumabe T,Mugikura S,Watanabe M,Tominaga T

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Despite aspirations to achieve equality in healthcare we know that socioeconomic differences exist and may affect treatment and patient outcome, also in serious diseases such as cancer. We investigated disparities in neurosurgical care and outcome for patients with low-grade glioma (LGG). METHODS:In this na...

journal_title：Journal of neuro-oncology

authors： Carstam L,Rydén I,Gulati S,Rydenhag B,Henriksson R,Salvesen Ø,Smits A,Jakola AS

更新日期：2020-01-01 00:00:00

abstract：:Death ligand-mediated apoptosis is a promising strategy of gene therapy for human malignant glioma. We here report that the infection of human malignant glioma cell lines with an adenoviral vector encoding full length human Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand (Ad-Apo2L/TRAIL) results in...

journal_title：Journal of neuro-oncology

authors： Naumann U,Waltereit R,Schulz JB,Weller M

更新日期：2003-01-01 00:00:00

abstract：:Patients with unresectable glioblastoma or anaplastic astrocytoma have a dismal prognosis. The role of neoadjuvant chemotherapy prior to irradiation in these patients has been studied primarily in non-randomized studies. We have compared the effect of neoadjuvant chemotherapy plus radiotherapy versus concomitant radio...

journal_title：Journal of neuro-oncology

authors： Capdevila L,Cros S,Ramirez JL,Sanz C,Carrato C,Romeo M,Etxaniz O,Hostalot C,Massuet A,Cuadra JL,Villà S,Balañà C

更新日期：2014-03-01 00:00:00

abstract：PURPOSE:Ferumoxtran-10 belongs to the Ultra Small Particles of Iron Oxide (USPIO) class of contrast agents and induces delayed tumor enhancement in brain tumors, reflecting the trapping of iron oxide particles by the macrophages and activated microglia. The aim of the study was to compare Ferumoxtran-10 contrast enhanc...

journal_title：Journal of neuro-oncology

authors： Kremer S,Pinel S,Védrine PO,Bressenot A,Robert P,Bracard S,Plénat F

更新日期：2007-06-01 00:00:00

abstract：:The aim of the present study was to investigate the localization and distribution of the putative brain tumour stem cell marker CD133 in formalin fixed paraffin embedded astrocytomas. A retrospective analysis of 114 grade II, III and IV astrocytomas was undertaken. The immunohistochemical expression of CD133 in paraff...

journal_title：Journal of neuro-oncology

authors： Christensen K,Schrøder HD,Kristensen BW

更新日期：2008-11-01 00:00:00

abstract：:Leptomeningeal dissemination of low-grade gliomas is an uncommon event. A 43-year old male presented with dizziness, gait ataxia, and diplopia. A nonenhancing lesion in the right cerebellar peduncle was identified, subtotally resected, and diagnosed as a grade II astrocytoma. After one year a nodular spread in the bra...

journal_title：Journal of neuro-oncology

authors： Passarin MG,Moretto G,Musso AM,Ottaviani S,Masotto B,Ghimenton C,Iuzzolino P,Buffone E,Rudà R,Soffietti R,Vattemi E,Pedersini R

更新日期：2010-05-01 00:00:00

abstract：:Neuroblastoma (NB) is a tumor of pediatric age that is associated with high mortality in metastatic stages, although stage IVS patients undergo frequent spontaneous regression. Since apoptosis has been proposed as a possible cause of remission among cancer patients, we tested this hypothesis among both localized and m...

journal_title：Journal of neuro-oncology

authors： Tonini GP,Mazzocco K,di Vinci A,Geido E,de Bernardi B,Giaretti W

更新日期：1997-01-01 00:00:00

abstract：:The records of thirty-four patients with meningeal carcinomatosis treated at our hospital between 1984 and 1990 were reviewed. The sources, histologies, metastatic lesions outside the central nervous system, the history of the treatment of primary lesions and intraparenchymal of metastatic brain tumors and the period ...

journal_title：Journal of neuro-oncology

authors： Nakagawa H,Murasawa A,Kubo S,Nakajima S,Nakajima Y,Izumoto S,Hayakawa T

更新日期：1992-05-01 00:00:00

abstract：:Six children (ages 2 to 14 years) with recurrent or poor risk primary brain tumors were treated with the '8 drugs in 1 day' chemotherapy regimen. As renal function deteriorated (median after five cycles), carboplatin was substituted in place of cisplatin at a median dose of 300 mg/m2 as a one hour infusion at hour thr...

journal_title：Journal of neuro-oncology

authors： Chan KW,Fryer CJ,Steinbok P

更新日期：1990-10-01 00:00:00

abstract：:We report a 5 year-old boy with primary anaplastic pleomorphic xanthoastrocytoma (PXA) with whole neuroaxis dissemination at diagnosis who experienced the sudden onset of generalized convulsion. Head- and spinal magnetic resonance imaging (MRI) showed widespread gadolinium (Gd)-enhanced lesions extending to the bilate...

journal_title：Journal of neuro-oncology

authors： Okazaki T,Kageji T,Matsuzaki K,Horiguchi H,Hirose T,Watanabe H,Ohnishi T,Nagahiro S

更新日期：2009-09-01 00:00:00

abstract：:Twenty-eight consecutive patients were given high-dose dexamethasone (96 mg i.v. loading dose, decreasing doses to zero in 14 days) and radiotherapy for epidural spinal cord compression due to malignant disease. There were eight events classified as side effects of the dexamethasone treatment. Four of these were consi...

journal_title：Journal of neuro-oncology

authors： Heimdal K,Hirschberg H,Slettebø H,Watne K,Nome O

更新日期：1992-02-01 00:00:00

abstract：:We studied the effect of intracarotid infusion of various calcium antagonists on regional CBF (rCBF) in the C6 rat glioma by a hydrogen clearance method. Nimodipine at doses of 0.1, 0.5 and 1 microgram/kg/min was found to produce tumor-specific increases in the rCBF (40.2 +/- 18.4%, p < 0.01, 67.8 +/- 32.6%, p < 0.001...

journal_title：Journal of neuro-oncology

authors： Matsukado K,Ikezaki K,Nomura T,Fukui M

更新日期：1996-01-01 00:00:00

abstract：:Ceramide is a physiologic regulator of growth and differentiation in mammalian cells. In this study, the relationship between ceramide and FLICE inhibitory protein (FLIP) in the induction of apoptosis in glioblastoma cell lines was investigated. We found that LN215 cells were slightly more sensitive to Fas-mediated ap...

journal_title：Journal of neuro-oncology

authors： Yoon G,Kim KO,Lee J,Kwon D,Shin JS,Kim SJ,Choi IH

更新日期：2002-11-01 00:00:00

abstract：:To investigate late toxicity among patients with newly-diagnosed brain metastases undergoing stereotactic radiosurgery (SRS) with concurrent systemic therapies with or without whole-brain radiation therapy (WBRT). Patients with newly-diagnosed brain metastasis who underwent SRS at a single tertiary-care institution fr...

journal_title：Journal of neuro-oncology

authors： Kim JM,Miller JA,Kotecha R,Xiao R,Juloori A,Ward MC,Ahluwalia MS,Mohammadi AM,Peereboom DM,Murphy ES,Suh JH,Barnett GH,Vogelbaum MA,Angelov L,Stevens GH,Chao ST

更新日期：2017-06-01 00:00:00

abstract：:Aberrant expression of microRNAs (miRNAs), a class of small non-coding regulatory RNAs, has been implicated in the development and progression of high-grade gliomas. However, the precise mechanistic role of many miRNAs in this disease remains unclear. Here, we investigate the functional role of miR-331-3p in glioblast...

journal_title：Journal of neuro-oncology

authors： Epis MR,Giles KM,Candy PA,Webster RJ,Leedman PJ

更新日期：2014-01-01 00:00:00

abstract：:Central nervous system (brain or leptomeningeal) metastases (BLm) are considered rare in castration-resistant prostate cancer (CRPC) patients. Now that docetaxel has become the reference drug for first-line treatment of CRPC, patients whose disease is not controlled by hormonal manipulations may live much longer than ...

journal_title：Journal of neuro-oncology

authors： Caffo O,Gernone A,Ortega C,Sava T,Cartenì G,Facchini G,Re GL,Amadio P,Bortolus R,Pagliarulo V,Prati V,Veccia A,Galligioni E

更新日期：2012-03-01 00:00:00