Primary anaplastic pleomorphic xanthoastrocytoma with widespread neuroaxis dissemination at diagnosis--a pediatric case report and review of the literature.

abstract：:Anti-Hu paraneoplastic syndromes are usually associated with an underlying neoplasia, although a few patients who are anti-Hu-positive never develop cancer after long-term follow-up. Tumour therapy remains the mainstay of therapeutic options, and early immune therapy in parallel is advisable. When no tumour is found, ...

journal_title：Journal of neuro-oncology

authors： Coret F,Bosca I,Fratalia L,Perez-Griera J,Pascual A,Casanova B

更新日期：2009-07-01 00:00:00

abstract：:The Notch signal regulates both cell viability and apoptosis, and maintains stemness of various cancers including glioblastoma (GBM). Although Notch signal inhibition may be an effective strategy in treating GBM initiating cells (GICs), its applicability to the different subtypes of GBM remains unclear. Here, we analy...

journal_title：Journal of neuro-oncology

authors： Tanaka S,Nakada M,Yamada D,Nakano I,Todo T,Ino Y,Hoshii T,Tadokoro Y,Ohta K,Ali MA,Hayashi Y,Hamada J,Hirao A

更新日期：2015-01-01 00:00:00

abstract：:To cast light on the mechanisms of drug-resistance, experimental brain tumors were immunohistochemically evaluated for expression of glutathione S-transferase (GST)-alpha, mu, pi, p-glycoprotein and apoptosis-related factors, such as bcl-2 and p53, as well as by the terminal deoxynucleotidyl transferase-mediated dUTP-...

journal_title：Journal of neuro-oncology

authors： Yabuno T,Konishi N,Nakamura M,Tsuzuki T,Tsunoda S,Sakaki T,Hiasa Y

更新日期：1998-01-01 00:00:00

abstract：:The cell-penetrating trans-activator of transcription (TAT) is a cationic peptide derived from human immunodeficiency virus-1. It has been used to facilitate macromolecule delivery to various cell types. This cationic peptide is capable of crossing the blood-brain barrier and therefore might be useful for enhancing th...

journal_title：Journal of neuro-oncology

authors： Nguyen J,Hossain SS,Cooke JRN,Ellis JA,Deci MB,Emala CW,Bruce JN,Bigio IJ,Straubinger RM,Joshi S

更新日期：2017-05-01 00:00:00

abstract：:Antiangiogenic therapies for malignant gliomas often result in transient response, and recurrent disease is characterized by adoption of invasive and hypoxic phenotype. The notch signaling pathway is activated in gliomas, and augments cell migration and hypoxic response. Here we report a clinical study of the combinat...

journal_title：Journal of neuro-oncology

authors： Pan E,Supko JG,Kaley TJ,Butowski NA,Cloughesy T,Jung J,Desideri S,Grossman S,Ye X,Park DM

更新日期：2016-12-01 00:00:00

abstract：:It is unknown whether the addition of temozolomide (TMZ) to radiotherapy (RT) is associated with improved overall survival (OS) among older glioblastoma patients. We performed a retrospective cohort SEER-Medicare analysis of 1652 patients aged ≥65 years with glioblastoma who received ≥10 fractions of RT from 2005 to 2...

journal_title：Journal of neuro-oncology

authors： Arvold ND,Cefalu M,Wang Y,Zigler C,Schrag D,Dominici F

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:Atypical and malignant meningiomas are at high risk for local failure. The role of radiation therapy (RT) and dose levels required to improve tumor control are poorly defined. This study reviews our experience with RT. MATERIAL AND METHODS:Thirty-one patients underwent fractionated RT for atypical (AM, 15 pa...

journal_title：Journal of neuro-oncology

authors： Hug EB,Devries A,Thornton AF,Munzenride JE,Pardo FS,Hedley-Whyte ET,Bussiere MR,Ojemann R

更新日期：2000-06-01 00:00:00

abstract：:Successful management of a heavily pretreated 58-year-old woman with metastatic esthesioneuoblastoma using temozolomide is reported. There is no standard treatment of this tumors with extra- and intracranial manifestations. The response, long term stability and high quality of life using temozolomide for this tumor en...

journal_title：Journal of neuro-oncology

authors： Wick W,Wick A,Küker W,Dichgans J,Weller M

更新日期：2004-10-01 00:00:00

abstract：:Epigenetic silencing of the O(6)-methylguanine-DNA-methyltransferase (MGMT) gene by promoter methylation is correlated with improved progression-free survival (PFS) and overall survival (OS) in adult patients with newly diagnosed glioblastoma multiforme (GBM) who receive alkylating agents. The aim of this study is to ...

journal_title：Journal of neuro-oncology

authors： Minniti G,Salvati M,Arcella A,Buttarelli F,D'Elia A,Lanzetta G,Esposito V,Scarpino S,Maurizi Enrici R,Giangaspero F

更新日期：2011-04-01 00:00:00

abstract：:This study retrospectively reviewed our single institute experience to clarify the optimal indication and timing of salvage surgery. Retrospective analysis of 159 consecutive cases with germ cell tumors identified 20 cases with salvage surgery. These cases were classified based on the radiological response to neoadjuv...

journal_title：Journal of neuro-oncology

authors： Kanamori M,Kumabe T,Watanabe M,Chonan M,Saito R,Yamashita Y,Ogawa Y,Sonoda Y,Tominaga T

更新日期：2018-07-01 00:00:00

abstract：:Chordoid is a rare variant of meningioma that displays a high recurrence rate. In this study we evaluated the immunohistochemical expression of factors that regulate the neo-angiogenesis process in a case of chordoid meningioma with an adverse clinical course. A high microvessel density (MVD), as well as high VEGF and...

journal_title：Journal of neuro-oncology

authors： Barresi V,Tuccari G

更新日期：2009-12-01 00:00:00

abstract：:Comparison between myelography (MY) and magnetic resonance imaging (MRI) was carried out in 36 patients with clinical suspicion of spinal cord or root compression due to metastatic disease in the spinal canal. In 3 patients metastatic lesions were visualized on MY but not on MRI, while there were no cases with a negat...

journal_title：Journal of neuro-oncology

authors： Helweg-Larsen S,Wagner A,Kjaer L,Johnsen A,Boesen J,Palner T,Sørensen PS

更新日期：1992-07-01 00:00:00

abstract：:Embryonal tumors are an aggressive subtype of high-grade, pediatric central nervous system (CNS) tumors often with dismal survival rates. The 5-year survival for highest-risk embryonal tumors may be as low as 10 %. We report feasibility and efficacy from our experience using intravenous (IV) cyclophosphamide concurren...

journal_title：Journal of neuro-oncology

authors： Campen CJ,Dearlove J,Partap S,Murphy P,Gibbs IC,Dahl GV,Fisher PG

更新日期：2012-11-01 00:00:00

abstract：:The labeling index (LI) of 216 cases of human brain tumors was determined by the immunohistochemical technique with monoclonal antibody to bromodeoxyuridine (BrdU). The proliferative potential of 110 cases was estimated using the intra-operative intravenous infusion of BrdU at a dose of 200 mg/sq m. In another 106 cas...

journal_title：Journal of neuro-oncology

authors： Kharbanda K,Dinda AK,Sarkar C,Karak AK,Dhir R,Mathur M,Roy S

更新日期：1995-01-01 00:00:00

abstract：:Central neurocytoma was originally described as a rare benign neuronal tumor. However, progression and local recurrences after surgery are well recognized. Stereotactic radiosurgery is another option for treatment of CN. In order to evaluate the efficacy of SRS, we performed a quantitative systematic review of the ava...

journal_title：Journal of neuro-oncology

authors： Park HK,Steven D C

更新日期：2012-05-01 00:00:00

abstract：:A prospective pilot study was performed in order to assess the safety of treating recurrent malignant gliomas (MGs) with locally infused autologous tumor infiltrating lymphocytes (TILs) and recombinant interleukin-2 (rIL-2). Six patients were entered between June 27, 1994 and June 2, 1995 and followed until July 1, 19...

journal_title：Journal of neuro-oncology

authors： Quattrocchi KB,Miller CH,Cush S,Bernard SA,Dull ST,Smith M,Gudeman S,Varia MA

更新日期：1999-01-01 00:00:00

abstract：:Magnetic resonance imaging (MRI) or computerized tomography (CT) is routinely performed after resection of brain metastases (BrM), regardless of whether there are specific clinical concerns about residual tumor or potential complications. Routine imaging studies contribute a significant amount to the cost of medical c...

journal_title：Journal of neuro-oncology

authors： Benveniste RJ,Ferraro N,Tsimpas A

更新日期：2014-06-01 00:00:00

abstract：:Glioblastomas are aggressive brain tumors that frequently recur in the subventricular zone (SVZ) despite maximal treatment. The purpose of this study was to evaluate imaging patterns of subventricular progression and impact of recurrent subventricular tumor involvement and radiation dose to patient outcome. Retrospect...

journal_title：Journal of neuro-oncology

authors： Weinberg BD,Boreta L,Braunstein S,Cha S

更新日期：2018-07-01 00:00:00

abstract：OBJECT:Prophylactic cranial irradiation (PCI) is commonly offered to patients with limited stage primary small cell lung cancer following a complete response. METHODS:We present the unique case of a 76-year-old woman treated with PCI with a dose of 30 Gy in 15 fractions, at 200 cGy per fraction who developed progressi...

journal_title：Journal of neuro-oncology

authors： D'Ambrosio DJ,Cohen RB,Glass J,Konski A,Buyyounouski MK,Feigenberg SJ

更新日期：2007-10-01 00:00:00

abstract：:In a retrospective analysis based on a malignant glioma databank, we describe effects of age, sex and diagnosis upon survival in patients with malignant cerebral glioma with a pre-treatment Karnofsky-index of 60 or more. All patients had been treated with 55-60Gy radiotherapy and nitrosurea-based adjuvant chemotherapy...

journal_title：Journal of neuro-oncology

authors： Diete S,Treuheit T,Dietzmann K,Schmidt U,Wallesch CW

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:The diagnosis of sarcomatous transformation of plexiform neurofibromas in Neurofibromatosis-1 (NF 1) is a clinical and radiological challenge. Considerable overlap exists in the clinical and the radiological characteristics between the benign enlarging neurofibromas and their counterparts undergoing malignan...

journal_title：Journal of neuro-oncology

authors： Basu S,Nair N

更新日期：2006-10-01 00:00:00

abstract：:The aim of this study is to investigate the anti-cancer effect of the bispecific diphtheria toxin (DT) based immunotoxin DTATEGF, which targets both the epidermal growth factor (EGF) receptor (EGFR) and the urokinase-type plasminogen activator (uPA) receptor (uPAR) in vitro and in vivo when delivered by convection-enh...

journal_title：Journal of neuro-oncology

authors： Huang J,Li YM,Massague J,Sicheneder A,Vallera DA,Hall WA

更新日期：2012-09-01 00:00:00

abstract：:The function of proteases in brain tumor invasion is currently not well established. For tumors of epithelial and fibromatous origin collagenase production can enhance the invasive capacity of cells to penetrate basement membranes. We showed previously that a c-Ha-ras transformed glial cell line (CxT24neo3) invaded ha...

journal_title：Journal of neuro-oncology

authors： Boghaert ER,Chan SK,Zimmer C,Grobelny D,Galardy RE,Vanaman TC,Zimmer SG

更新日期：1994-01-01 00:00:00

abstract：:Intracranial Hodgkin's lymphoma (ICHL) in the HIV positive population is a rarely reported event with only three prior cases reported in the literature. In these prior reports, the outcome of the patients was uncertain or very poor. We report here the case of an HIV seropositive patient with an isolated intracranial r...

journal_title：Journal of neuro-oncology

authors： Ramchandar K,Verhey LH,Jha NK,Murty NK,McMillan W

更新日期：2008-08-01 00:00:00

abstract：:We have retrospectively reviewed toxicities and response of a cohort of primary central nervous system lymphoma (PCNSL) patients treated with high dose parenteral methotrexate (MTX) monotherapy without whole brain radiation. From The Massachusetts General Hospital (MGH) Cancer Registry, active since 1946, we selected ...

journal_title：Journal of neuro-oncology

authors： Cobert J,Hochberg E,Woldenberg N,Hochberg F

更新日期：2010-07-01 00:00:00

abstract：:In January 2003 a symposium was held to discuss the current state of progress and future challenges for the recently described technique of convection enhanced delivery (CED). The focus of the CED symposium was on the potential use of this novel drug delivery technology to enhance the delivery of chemotherapy to malig...

journal_title：Journal of neuro-oncology

authors： Vogelbaum MA

更新日期：2005-05-01 00:00:00

abstract：:To evaluate diagnostic accuracy of perfusion weighted imaging (PWI) and positron emission tomography (PET) using an integrated PET/MR system in tumor grading as well as in differentiating recurrent tumor from treatment-induced effects (TIE) in brain tumor patients. Twenty patients (Group A: treatment naïve, 9 patients...

journal_title：Journal of neuro-oncology

authors： Sacconi B,Raad RA,Lee J,Fine H,Kondziolka D,Golfinos JG,Babb JS,Jain R

更新日期：2016-04-01 00:00:00

abstract：:Surgical resection is not the standard of care for primary central nervous system lymphoma (PCNSL), as historical studies have demonstrated unfavorable complication rates and limited benefits. Some recent studies suggest that resection may provide a therapeutic benefit, yet the safety of these procedures has not been ...

journal_title：Journal of neuro-oncology

authors： Cloney MB,Sonabend AM,Yun J,Yang J,Iwamoto F,Singh S,Bhagat G,Canoll P,Zanazzi G,Bruce JN,Sisti M,Sheth S,Connolly ES,McKhann G

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Prior studies have highlighted infratentorial tumor location as a prognostic factor for solitary fibrous tumor (SFT) and hemangiopericytoma (HPC) of the central nervous system (CNS), and spinal location is considered a positive prognostic factor for other tumors of the CNS. While SFT/HPC of the CNS is known ...

journal_title：Journal of neuro-oncology

authors： Boyett D,Kinslow CJ,Bruce SS,Sonabend AM,Rae AI,McKhann GM,Sisti MB,Bruce JN,Cheng SK,Wang TJC

更新日期：2019-07-01 00:00:00

abstract：:To characterize a population of pediatric high-grade astrocytoma (HGA) patients by confirming the proportion with a correct diagnosis, and determine prognostic factors for survival in a subset diagnosed with uniform pathologic criteria. Sixty-three children diagnosed with HGA were treated at the Johns Hopkins Hospital...

journal_title：Journal of neuro-oncology

authors： Hales RK,Shokek O,Burger PC,Paynter NP,Chaichana KL,Quiñones-Hinojosa A,Jallo GI,Cohen KJ,Song DY,Carson BS,Wharam MD

更新日期：2010-08-01 00:00:00