Ceramide increases Fas-mediated apoptosis in glioblastoma cells through FLIP down-regulation.

abstract：:We describe the case of a young man presenting with an extra-nodal, intramedullary non-Hodgkin's lymphoma of the cervical spinal cord. This is a very uncommon presentation of this neoplasm. The patient was treated with craniospinal radiotherapy, with survival for two and a half years before death from recurrent diseas...

journal_title：Journal of neuro-oncology

authors： McDonald AC,Nicoll JA,Rampling R

更新日期：1995-01-01 00:00:00

abstract：:The effect of methionine enkephalin on the growth of human brain tumor cells was investigated. The results show that this endogenous opioid has dual effects on tumor cell growth. This peptide exerted an inhibitory effect in SK-N-MC human neuroblastoma cell line; in contrast, in U-373 MG human astrocytoma cell line, th...

journal_title：Journal of neuro-oncology

authors： Lee YS,Wurster RD

更新日期：1994-01-01 00:00:00

abstract：:Chordoid is a rare variant of meningioma that displays a high recurrence rate. In this study we evaluated the immunohistochemical expression of factors that regulate the neo-angiogenesis process in a case of chordoid meningioma with an adverse clinical course. A high microvessel density (MVD), as well as high VEGF and...

journal_title：Journal of neuro-oncology

authors： Barresi V,Tuccari G

更新日期：2009-12-01 00:00:00

abstract：OBJECT:Subependymomas are rare ependymal neoplasms. To date, a large clinicopathologic study of these benign neoplasms treated with modern neurosurgical techniques has not been reported. METHODS:Eighty-three cases of subependymoma were retrieved from the files of the Armed Forces Institute of Pathology. Clinicopatholo...

journal_title：Journal of neuro-oncology

authors： Rushing EJ,Cooper PB,Quezado M,Begnami M,Crespo A,Smirniotopoulos JG,Ecklund J,Olsen C,Santi M

更新日期：2007-12-01 00:00:00

abstract：:Leptomeningeal dissemination of low-grade gliomas is an uncommon event. A 43-year old male presented with dizziness, gait ataxia, and diplopia. A nonenhancing lesion in the right cerebellar peduncle was identified, subtotally resected, and diagnosed as a grade II astrocytoma. After one year a nodular spread in the bra...

journal_title：Journal of neuro-oncology

authors： Passarin MG,Moretto G,Musso AM,Ottaviani S,Masotto B,Ghimenton C,Iuzzolino P,Buffone E,Rudà R,Soffietti R,Vattemi E,Pedersini R

更新日期：2010-05-01 00:00:00

abstract：:Malignant gliomas (MG) are very aggressive tumors. In an effort to improve the outcome, the patients receive multi-modal therapies such as surgery, radiation and chemotherapy (temozolomide followed in many cases by bevacizumab). The survivors are affected by multiple learning and memory deficits. Greater deterioration...

journal_title：Journal of neuro-oncology

authors： Nolen SC,Lee B,Shantharam S,Yu HJ,Su L,Billimek J,Bota DA

更新日期：2016-09-01 00:00:00

abstract：:Proliferative activities were determined in 72 human brain tumors, including 20 metastatic carcinomas, 41 gliomas, 8 meningiomas and 3 hematological tumors. Immunocytochemical techniques included labeling with monoclonal antibody (mAb) to bromodeoxyuridine (BrdU) which identifies S phase cells after previous in vitro ...

journal_title：Journal of neuro-oncology

authors： Morimura T,Kitz K,Stein H,Budka H

更新日期：1991-02-01 00:00:00

abstract：INTRODUCTION:Glioblastoma (GBM) is the most common primary brain cancer. The average survival time for the majority of patients is approximately 15 months after diagnosis. A major feature of GBM that contributes to its poor prognosis is its high invasiveness. Caveolae are plasma membrane subdomains that participate in ...

journal_title：Journal of neuro-oncology

authors： Pu W,Nassar ZD,Khabbazi S,Xie N,McMahon KA,Parton RG,Riggins GJ,Harris JM,Parat MO

更新日期：2019-06-01 00:00:00

abstract：INTRODUCTION:It is useful to know the molecular subtype of lower-grade gliomas (LGG) when deciding on a treatment strategy. This study aims to diagnose this preoperatively. METHODS:A deep learning model was developed to predict the 3-group molecular subtype using multimodal data including magnetic resonance imaging (M...

journal_title：Journal of neuro-oncology

authors： Matsui Y,Maruyama T,Nitta M,Saito T,Tsuzuki S,Tamura M,Kusuda K,Fukuya Y,Asano H,Kawamata T,Masamune K,Muragaki Y

更新日期：2020-01-01 00:00:00

abstract：:The outcome of children less than 3 years of age with medulloblastoma has been poor in comparison to older children. The cure rates were below 30%, and the quality of life for cured children was frequently reduced by a complex syndrome of long-term sequelae including intellectual retardation and growth hormone deficie...

journal_title：Journal of neuro-oncology

authors： Schmandt S,Kühl J

更新日期：1998-06-01 00:00:00

abstract：:A prospective pilot study was performed in order to assess the safety of treating recurrent malignant gliomas (MGs) with locally infused autologous tumor infiltrating lymphocytes (TILs) and recombinant interleukin-2 (rIL-2). Six patients were entered between June 27, 1994 and June 2, 1995 and followed until July 1, 19...

journal_title：Journal of neuro-oncology

authors： Quattrocchi KB,Miller CH,Cush S,Bernard SA,Dull ST,Smith M,Gudeman S,Varia MA

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE AND IMPORTANCE:Epithelioid hemangioendothelioma (EHE) is a rare vascular tumor that presents histological features and biological behavior of low-grade malignancy. The authors report a case of malignant intracranial EHE, in which surgical excisions and additional immuno-chemotherapy were ineffective. Emphasis...

journal_title：Journal of neuro-oncology

authors： Endo T,Su CC,Numagami Y,Shirane R

更新日期：2004-05-01 00:00:00

abstract：:Conventional Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) are the cornerstone in the initial evaluation of brain tumours. The purpose of this study is to evaluate the contribution of Magnetic Resonance Spectroscopy (MRS) and Perfusion-weighted MRI to distinguish malignant from benign tumours. We inclu...

journal_title：Journal of neuro-oncology

authors： Fayed N,Modrego PJ

更新日期：2005-05-01 00:00:00

abstract：:We prospectively addressed whether EGFR and KRAS mutations, EML4-ALK, ROS1 and RET rearrangements, or wild-type (WT), affects radiosurgery outcomes and overall survival (OS) in non-small cell lung cancer (NSCLC) patients with brain metastases (BM). Of 326 patients with BM treated in 2012-2014 with Gamma Knife radiosur...

journal_title：Journal of neuro-oncology

authors： Shin SM,Cooper BT,Chachoua A,Butler J,Donahue B,Silverman JS,Kondziolka D

更新日期：2016-02-01 00:00:00

abstract：:While surgery is proned in low-grade glioma (LGG), the invasion of functional areas frequently prevents a complete resection. We report the first case of a patient operated on for a left frontal LGG, diagnosed because of seizures, with partial resection due to an invasion of the controlateral hemisphere. Chemotherapy ...

journal_title：Journal of neuro-oncology

authors： Duffau H,Taillandier L,Capelle L

更新日期：2006-11-01 00:00:00

abstract：:Intracranial pseudolymphoma is a rare tumor of the central nervous system. A 35-year-old woman presented with a frontal subcutaneous tumor. Magnetic resonance imaging revealed a left frontal meningeal tumor involving subcutaneous tissue without bone involvement. The mass was completely removed and the histological asp...

journal_title：Journal of neuro-oncology

authors： Donnet A,Horschowski N,Dufour H,Figarella-Branger D,Bryon PA,Berger F,Harle JR,Grisoli F

更新日期：2000-04-01 00:00:00

abstract：QUESTION:Should patients with newly-diagnosed metastatic brain tumors undergo open surgical resection versus whole brain radiation therapy (WBRT) and/or other treatment modalities such as radiosurgery, and in what clinical settings? Target population These recommendations apply to adults with a newly diagnosed single b...

journal_title：Journal of neuro-oncology

authors： Kalkanis SN,Kondziolka D,Gaspar LE,Burri SH,Asher AL,Cobbs CS,Ammirati M,Robinson PD,Andrews DW,Loeffler JS,McDermott M,Mehta MP,Mikkelsen T,Olson JJ,Paleologos NA,Patchell RA,Ryken TC,Linskey ME

更新日期：2010-01-01 00:00:00

abstract：:Elevated neutrophil-lymphocyte ratio (NLR) may predict worse outcomes in cancer, including glioblastoma (GBM). This study assessed whether change in NLR during focal radiotherapy and concomitant temozolomide (RT-TMZ) provides further prognostic information. This was a retrospective review of patients treated with RT-T...

journal_title：Journal of neuro-oncology

authors： Mason M,Maurice C,McNamara MG,Tieu MT,Lwin Z,Millar BA,Menard C,Laperriere N,Milosevic M,Atenafu EG,Mason W,Chung C

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:To assess the neurocognitive function and neurological toxicity of frameless linear accelerator (LINAC)-based stereotactic radiosurgery (SRS) in patients with 10 or more brain metastases (BM). PATIENTS AND METHODS:Forty consecutive adult patients who received SRS for ten or more 10 BM < 3 cm in maximum size we...

journal_title：Journal of neuro-oncology

authors： Minniti G,Capone L,Nardiello B,El Gawhary R,Raza G,Scaringi C,Bianciardi F,Gentile P,Paolini S

更新日期：2020-05-01 00:00:00

abstract：:Intracranial atypical teratoid/rhabdoid tumors (AT/RT) are rare with a poor prognosis. We report one case of a 7-year old girl living over 17 months after the diagnosis of AT/RT in the left frontal lobe. Treatment was partial surgical resection and post-operative radiation therapy. Radiation therapy resulted in comple...

journal_title：Journal of neuro-oncology

authors： Howes TL,Buatti JM,O'Dorisio MS,Kirby PA,Ryken TC

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Lymphomatoid granulomatosis (LYG) is an angiocentric and angiodestructive lymphoreticular proliferation, which usually involves the lungs, but may also involve the central nervous system (CNS). Unique involvement of the CNS has been reported rarely. We report our experience with LYG confined to the brain and...

journal_title：Journal of neuro-oncology

authors： Lucantoni C,De Bonis P,Doglietto F,Esposito G,Larocca LM,Mangiola A,Martini M,Papacci F,Teofili L,Pompucci A

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:Intracranial glioblastomas with simultaneous spinal lesions prior to chemoradiation therapy or craniotomy, defined as initial spinal metastasis, are not well understood. Herein, we investigated intracranial glioblastoma and demonstrated the importance of spinal screening using gadolinium enhanced spinal magneti...

journal_title：Journal of neuro-oncology

authors： Shibahara I,Saito R,Osada Y,Kanamori M,Sonoda Y,Kumabe T,Mugikura S,Watanabe M,Tominaga T

更新日期：2019-01-01 00:00:00

abstract：:Thirty-five adult recurrent GBM patients, divided randomly in two groups of 19 and 16 cases, had been treated with two regimens of chemotherapy: a) 'eight-drugs-in-one-day'; b) procarbazine + CCNU + vincristine (PCV) respectively. Chemotherapy was planned at the tumour relapse and delivered as long as tolerated withou...

journal_title：Journal of neuro-oncology

authors： Boiardi A,Silvani A,Milanesi I,Broggi G,Fariselli L

更新日期：1992-02-01 00:00:00

abstract：INTRODUCTION:Low-grade glioma (LGG) represent the most common pediatric central nervous system tumor. When total surgical resection is not feasible, chemotherapy is first-line therapy in children. Multiple pediatric LGG chemotherapy regimens have been investigated with variable 2-year event free survival (EFS) rates of...

journal_title：Journal of neuro-oncology

authors： Nellan A,Wright E,Campbell K,Davies KD,Donson AM,Amani V,Judd A,Hemenway MS,Raybin J,Foreman NK,Rush S,Dorris K

更新日期：2020-07-01 00:00:00

abstract：:Ionizing radiation plays a major role in the treatment of brain tumors, but side-effects may restrict the efficacy of therapy. In the present study, our goals were to establish whether the administration of L-alpha-glycerylphosphorylcholine (GPC) can moderate or prevent any of the irradiation-induced functional and mo...

journal_title：Journal of neuro-oncology

authors： Plangár I,Szabó ER,Tőkés T,Mán I,Brinyiczki K,Fekete G,Németh I,Ghyczy M,Boros M,Hideghéty K

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:In most patients with recurrent glioma chemotherapy is the only remaining treatment option. In general results of chemotherapy in these patients are poor, and trials on new regimens are indicated. Because relatively good results have been achieved with combinations of platin compounds and etoposide, we inves...

journal_title：Journal of neuro-oncology

authors： van den Bent MJ,Pronk L,Sillevis Smitt PA,Vecht CJ,Eskens FA,Verweij J

更新日期：1999-08-01 00:00:00

abstract：SUBJECT:To date there is no established tumor marker for the clinical follow-up of glioblastoma, WHO grade IV, (GBM) which constitutes the most frequent and malignant primary brain tumor. However, since there is promising data that the serum glial fibrillary acidic protein (sGFAP) may serve as a biomarker for glial bra...

journal_title：Journal of neuro-oncology

authors： Baumgarten P,Quick-Weller J,Gessler F,Wagner M,Tichy J,Forster MT,Foerch C,Seifert V,Mittelbronn M,Senft C

更新日期：2018-09-01 00:00:00

abstract：:Treatment of infant hypothalamic chiasmatic glioma (iCHG) is challenging, about 30% of the children progress during chemotherapy. Despite subsequent treatments the 5 year overall-survival rate is only 70%. This study investigates treatment strategies currently applied for progressive iCHG. A web-based questionnaire wa...

journal_title：Journal of neuro-oncology

authors： Azizi AA,Schouten-van Meeteren AYN

更新日期：2018-01-01 00:00:00

abstract：:Most tumors, including gliomas, are resistant to tumor necrosis factor (TNF) cytotoxicity unless protein or RNA synthesis is inhibited. We investigated the effects of the combined use of TNF-alpha and cisplatin (CDDP) on cultured malignant glioma cells, T98G, U373MG, A172, and U87MG. All glioma cell lines were sensiti...

journal_title：Journal of neuro-oncology

authors： Duan L,Aoyagi M,Tamaki M,Nakagawa K,Nagashima G,Nagasaka Y,Ohno K,Yamamoto K,Hirakawa K

更新日期：2001-03-01 00:00:00

abstract：:The aim of this study was to test by means of a voxel-based approach the hypothesis that there is a different spatial distribution of brain metastases (BM) and white matter hyperintensities (WMH) and that the presence of WMH affects the location of BM in lung and non-lung cancer patients. Two-hundred consecutive cance...

journal_title：Journal of neuro-oncology

authors： Quattrocchi CC,Errante Y,Mallio CA,Carideo L,Scarciolla L,Santini D,Tonini G,Zobel BB

更新日期：2014-11-01 00:00:00