Intrathecal liposomal cytarabine in combination with temozolomide in low-grade oligoastrocytoma with leptomeningeal dissemination.

abstract：INTRODUCTION:Central nervous system (CNS) involvement, especially involvement of the cerebrospinal fluid (CSF), is common in several haematological malignancies. Intrathecal (IT) chemotherapy can be used to manage CSF involvement. METHODS:Here we evaluated the effectiveness of IT chemotherapy among 80 patients with ha...

journal_title：Journal of neuro-oncology

authors： Dara A,Mook BB,Doorduijn JK,van den Bent MJ,Dinmohamed AG,Bromberg JEC

更新日期：2018-08-01 00:00:00

abstract：INTRODUCTION:The standard treatment for primary central nervous system lymphoma (PCNSL) involves induction methotrexate-based chemotherapy with or without consolidation whole brain radiotherapy (WBRT). As WBRT carries a substantial risk for cognitive impairment, alternative consolidation treatments have been used to re...

journal_title：Journal of neuro-oncology

authors： Correa DD,Braun E,Kryza-Lacombe M,Ho KW,Reiner AS,Panageas KS,Yahalom J,Sauter CS,Abrey LE,DeAngelis LM,Omuro A

更新日期：2019-09-01 00:00:00

abstract：:Adrenomedullin is a vasoactive peptide that is upregulated in higher-grade gliomas and promotes tumor cell proliferation. Since reduced activity of the anti-oncogene PTEN seems to also correlate with higher tumor grade, this suggests an inverse association between PTEN activity and adrenomedullin expression. PC12 pheo...

journal_title：Journal of neuro-oncology

authors： Betchen SA,Musatov S,Roberts J,Pena J,Kaplitt MG

更新日期：2006-09-01 00:00:00

abstract：:Targeting tumor angiogenesis is a potential therapeutic strategy for glioblastoma because of its high vascularization. Tivozanib is an oral pan-VEGF receptor tyrosine kinase inhibitor that hits a central pathway in glioblastoma angiogenesis. We conducted a phase II study to test the effectiveness of tivozanib in patie...

journal_title：Journal of neuro-oncology

authors： Kalpathy-Cramer J,Chandra V,Da X,Ou Y,Emblem KE,Muzikansky A,Cai X,Douw L,Evans JG,Dietrich J,Chi AS,Wen PY,Stufflebeam S,Rosen B,Duda DG,Jain RK,Batchelor TT,Gerstner ER

更新日期：2017-02-01 00:00:00

abstract：:A phase I study was conducted to evaluate the dose-limiting toxicities (DLTs) and to determine the maximum tolerated dose (MTD)/recommended phase II dose of bendamustine with concurrent whole brain radiation (WBR) in patients with brain metastases (BM) from solid tumors. Four doses of intravenous weekly bendamustine w...

journal_title：Journal of neuro-oncology

authors： Pan E,Yu D,Zhao X,Neuger A,Smith P,Chinnaiyan P,Yu HH

更新日期：2014-09-01 00:00:00

abstract：:In earlier studies, we demonstrated that intratumoral infusions of alloreactive cytotoxic T lymphocytes (aCTL), sensitized to the major histocompatibility complex (MHC) antigens of the host, effectively retarded the intracranial growth of Fischer 9L gliosarcoma. We further demonstrated that continuous in vitro exposur...

journal_title：Journal of neuro-oncology

authors： Paul DB,Read SB,Kulprathipanja NV,Gomez GG,Kleinschmidt-DeMasters BK,Schiltz PM,Kruse CA

更新日期：2003-08-01 00:00:00

abstract：:A 44 year-old man with subcutaneous meningioma and rare combination of spinal lesions, consisting of dermal sinus and lipoma of the filum terminale. The literature concerning the subcutaneous meningioma is reviewed and the embryogenesis of these lesions is discussed. ...

journal_title：Journal of neuro-oncology

authors： Qasho R,Lunardi P,Lo Bianco FM,di Stefano M

更新日期：1998-05-01 00:00:00

abstract：:Ewing's sarcoma/primitive neuroectodermal tumor (EWS/PNET) has a characteristic chimeric oncogene EWS-FLI1, which results from chromosomal translocation t (11; 22), that is believed to initiate tumorigenesis of EWS/PNET. However, the specific details of EWS/PNET oncogenesis and exact role of EWS-FLI1 remain largely un...

journal_title：Journal of neuro-oncology

authors： Yang Y,Zhang L,Wei Y,Wang H,Fukuma M,Xu H,Xiong W,Zheng J

更新日期：2008-11-01 00:00:00

abstract：:In a cohort of 25 patients with supratentorial low grade glioma, the timing of radiotherapy made no significance difference for 10 year survival. Patients who received early radiotherapy had a 55% 10 year survival and those receiving delayed radiotherapy had a 53% 10 year survival. Radiotherapy was delayed a median of...

journal_title：Journal of neuro-oncology

authors： Knisely JP,Haffty BG,Christopher SR

更新日期：1997-08-01 00:00:00

abstract：:SF188/V+ is a highly vascular human glioma model that is based on transfection of vascular endothelial growth factor (VEGF) cDNA into SF188/V- cells. This study aims to assess its growth and vascularity properties in vivo in a rat model. Thirty-two adult rats were inoculated with SF188/V+ tumor cells, and, for compari...

journal_title：Journal of neuro-oncology

authors： Grossman R,Tyler B,Brem H,Eberhart CG,Wang S,Fu DX,Wen Z,Zhou J

更新日期：2012-12-01 00:00:00

abstract：:Leptomeningeal disease (LMD) is a highly aggressive and usually rapidly fatal condition. The purpose of this study is to identify clinical factors that can serve to predict for LMD at the time of stereotactic radiosurgery (SRS) for brain metastases from breast carcinoma. We conducted a retrospective review of patients...

journal_title：Journal of neuro-oncology

authors： Trifiletti DM,Romano KD,Xu Z,Reardon KA,Sheehan J

更新日期：2015-09-01 00:00:00

abstract：:Malignancy involving the skull base remains a formidable management challenge. Advances and refinements in diagnostic imaging, instrumentation, microvascular reconstruction, and an improved overall appreciation of the anatomy of the skullbase have extended the boundaries of tumor resectability and in some cases, obvia...

journal_title：Journal of neuro-oncology

authors： DeMonte F

更新日期：2004-08-01 00:00:00

abstract：:Intramedullary spinal cord metastases of solid neoplasms are associated with poor long-term survival. As the characteristics of secondary intramedullary spinal cord non-Hodgkin's lymphoma (NHL) are not well understood, we sought to describe its clinical features and outcome. We retrospectively reviewed the Mayo Clinic...

journal_title：Journal of neuro-oncology

authors： Flanagan EP,O'Neill BP,Habermann TM,Porter AB,Keegan BM

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:The role of immunotherapy for metastatic melanoma has expanded over the past decade triggering questions regarding the combination and timing of immunotherapy and radiation for brain metastases. We used the National Cancer Database (NCDB) to see if the time from radiation to immunotherapy in patients with me...

journal_title：Journal of neuro-oncology

authors： Wegner RE,Abel S,D'Amico RS,Mehta GU,Sheehan J

更新日期：2021-01-11 00:00:00

abstract：:Among diffuse gliomas, oligodendrogliomas may account for 25% of cases. They have a better prognosis and chemosensitivity as compared to astrocytomas. Genetic studies have shown a correlation between oligodendrocyte phenotype and presence of 1p/19q deletions. In addition, these deletions are of prognostic value. The a...

journal_title：Journal of neuro-oncology

authors： Bouvier C,Roll P,Quilichini B,Metellus P,Calisti A,Gilles S,Chinot O,Fina F,Martin PM,Figarella-Branger D

更新日期：2004-06-01 00:00:00

abstract：:Neural cell adhesion molecule (NCAM) is a cell surface glycoprotein whose expression may be important in metastatic or local growth of neoplasms. Expression of NCAM in human pituitary adenomas was assessed on snap-frozen and Bouin's and/or formalin-fixed, paraffin-embedded archival tissue using a sensitive alkaline ph...

journal_title：Journal of neuro-oncology

authors： Kleinschmidt-DeMasters BK,Conway DR,Franklin WA,Lillehei KO,Kruse CA

更新日期：1995-01-01 00:00:00

abstract：:Two patients with metastasis from lung carcinoma of the midbrain are presented. The computerized tomographic (CT) findings mimicked a primary pineal tumor, but autopsy confirmed a metastatic nodule in the midbrain in both cases. The rational approach to posterior third ventricular tumors seen on CT in adulthood is dis...

journal_title：Journal of neuro-oncology

authors： Tomita T,Wetzel N

更新日期：1984-01-01 00:00:00

abstract：:Children with recurrent high grade gliomas (HGG) have a dismal outcome with a median progression free survival (PFS) of 12 weeks. Adults with recurrent HGG treated with irinotecan and bevacizumab reportedly have a 63% response rate and a median PFS of 23 weeks. There is a paucity of corresponding published pediatric d...

journal_title：Journal of neuro-oncology

authors： Parekh C,Jubran R,Erdreich-Epstein A,Panigrahy A,Bluml S,Finlay J,Dhall G

更新日期：2011-07-01 00:00:00

abstract：:The labeling index (LI) of 216 cases of human brain tumors was determined by the immunohistochemical technique with monoclonal antibody to bromodeoxyuridine (BrdU). The proliferative potential of 110 cases was estimated using the intra-operative intravenous infusion of BrdU at a dose of 200 mg/sq m. In another 106 cas...

journal_title：Journal of neuro-oncology

authors： Kharbanda K,Dinda AK,Sarkar C,Karak AK,Dhir R,Mathur M,Roy S

更新日期：1995-01-01 00:00:00

abstract：:Twenty-eight patients who were previously treated by aggressive surgery and radiation and were diagnosed with supratentorial malignant gliomas received a combination of nimustine hydrochloride; 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU), cisplatin and etoposide (ACE ...

journal_title：Journal of neuro-oncology

authors： Beppu T,Yoshida Y,Arai H,Wada T,Suzuki M,Ogawa A,Hakozaki S,Kubo N

更新日期：2000-09-01 00:00:00

abstract：:Optimal treatment of recurrent glioblastoma multiforme (rGBM) in elderly and/or frail patients remains virtually unexplored, the best supportive care (BSC) only is routinely administered due to the fatal prognosis. We evaluated the impact of different treatment methods on post-progression survival (PPS) and overall su...

journal_title：Journal of neuro-oncology

authors： Socha J,Kepka L,Ghosh S,Roa W,Kumar N,Sinaika V,Matiello J,Lomidze D,de Castro DG,Hentati D,Fidarova E

更新日期：2016-02-01 00:00:00

abstract：:Cranial radiation can impact the cerebral vasculature in many ways, with a wide range of clinical manifestations. The incidence of these late effects including cerebrovascular accidents (CVAs), lacunar lesions, vascular occlusive disease including moyamoya syndrome, vascular malformations, and hemorrhage is not well k...

journal_title：Journal of neuro-oncology

authors： Murphy ES,Xie H,Merchant TE,Yu JS,Chao ST,Suh JH

更新日期：2015-05-01 00:00:00

abstract：PURPOSE:Current medulloblastoma therapy, surgery, radiation, and chemotherapy, is unacceptably toxic. However, 13-cis retinoic acid (RA) and SAHA, a histone deacetylase inhibitor, have each been shown to induce apoptosis in medulloblastoma cultures and mouse models. Both drugs cross the blood brain barrier, have been g...

journal_title：Journal of neuro-oncology

authors： Spiller SE,Ditzler SH,Pullar BJ,Olson JM

更新日期：2008-04-01 00:00:00

abstract：:The Coronavirus pandemic has created unprecedented strain on medical resources at health care institutions around the world. At many institutions, this has resulted in efforts to prioritize cases with an attempt to balance the acuity of medical needs with available resources. Here, we provide a framework for instituti...

journal_title：Journal of neuro-oncology

authors： Ramakrishna R,Zadeh G,Sheehan JP,Aghi MK

更新日期：2020-05-01 00:00:00

abstract：:Assessing central nervous system (CNS) involvement in patients with lymphoma or carcinoma is important in determining therapy and prognosis. Progranulin (PGRN) is a secreted glycosylated protein with roles in cancer growth and survival; it is highly expressed in aggressive cancer cell lines and specimens from many can...

journal_title：Journal of neuro-oncology

authors： Kimura A,Takemura M,Serrero G,Yoshikura N,Hayashi Y,Saito K,Inuzuka T

更新日期：2018-05-01 00:00:00

abstract：:Six children (ages 2 to 14 years) with recurrent or poor risk primary brain tumors were treated with the '8 drugs in 1 day' chemotherapy regimen. As renal function deteriorated (median after five cycles), carboplatin was substituted in place of cisplatin at a median dose of 300 mg/m2 as a one hour infusion at hour thr...

journal_title：Journal of neuro-oncology

authors： Chan KW,Fryer CJ,Steinbok P

更新日期：1990-10-01 00:00:00

abstract：:Signal transducers and activators of transcription 3 (STAT3) are activated by various cytokines and oncogenes; however, the activity and pathogenesis of STAT3 in diffuse large B cell lymphoma of the central nervous system have not been thoroughly elucidated. We investigated the phosphorylation levels of STAT3 in 40 sp...

journal_title：Journal of neuro-oncology

authors： Mizowaki T,Sasayama T,Tanaka K,Mizukawa K,Takata K,Nakamizo S,Tanaka H,Nagashima H,Nishihara M,Hirose T,Itoh T,Kohmura E

更新日期：2015-09-01 00:00:00

abstract：:We present a computer aided diagnostic workflow focusing on two diagnostic branch points in neuropathology (intraoperative consultation and p53 status in tumor biopsy specimens) by means of texture analysis via discrete wavelet frames decomposition. For intraoperative consultation, our methodology is capable of classi...

journal_title：Journal of neuro-oncology

authors： Fauzi MFA,Gokozan HN,Elder B,Puduvalli VK,Pierson CR,Otero JJ,Gurcan MN

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:A prospective Phase II study of CPT-11 in adult patients with recurrent supratentorial glioblastoma multiforme (GBM). METHODS:Forty patients (25 men, 15 women) ages 32-71 years (median 59), with recurrent GBM were treated. All patients had previously been treated with surgery and involved field radiotherapy...

journal_title：Journal of neuro-oncology

authors： Chamberlain MC

更新日期：2002-01-01 00:00:00

abstract：INTRODUCTION:While hypofractionated stereotactic radiotherapy (HFSRT) is being increasingly used for treating brain metastases, clinical data concerning the incidence and risk factors of its main side-effect, namely radiation necrosis (RN), remain limited. In this context, we assessed risk factors of RN in a single cen...

journal_title：Journal of neuro-oncology

authors： Di Perri D,Tanguy R,Malet C,Robert A,Sunyach MP

更新日期：2020-09-01 00:00:00