Abstract：
:Ionizing radiation plays a major role in the treatment of brain tumors, but side-effects may restrict the efficacy of therapy. In the present study, our goals were to establish whether the administration of L-alpha-glycerylphosphorylcholine (GPC) can moderate or prevent any of the irradiation-induced functional and morphological changes in a rodent model of hippocampus irradiation. Anesthetized adult (6-weeks-old) male Sprague-Dawley rats were subjected to 40 Gy irradiation of one hemisphere of the brain, without or with GPC treatment (50 mg/kg bw by gavage), the GPC treatment continuing for 4 months. The effects of this partial rat brain irradiation on the spatial orientation and learning ability of the rats were assessed with the repeated Morris water maze (MWM) test. Histopathologic (HP) evaluation based on hematoxylin-eosin and Luxol blue staining was performed 4 months after irradiation. The 40 Gy irradiation resulted in a moderate neurological deficit at the levels of both cognitive function and morphology 4 months after the irradiation. The MWM test proved to be a highly sensitive tool for the detection of neurofunctional impairment. The site navigation of the rats was impaired by the irradiation, but the GPC treatment markedly decreased the cognitive impairment. HP examination revealed lesser amounts of macrophage density, reactive gliosis, calcification and extent of demyelination in the GPC-treated group. GPC treatment led to significant protection against the cognitive decline and cellular damage, evoked by focal brain irradiation at 40 Gy dose level. Our study warrants further research on the protective or mitigating effects of GPC on radiation injuries.
journal_name
J Neurooncoljournal_title
Journal of neuro-oncologyauthors
Plangár I,Szabó ER,Tőkés T,Mán I,Brinyiczki K,Fekete G,Németh I,Ghyczy M,Boros M,Hideghéty Kdoi
10.1007/s11060-014-1489-zsubject
Has Abstractpub_date
2014-09-01 00:00:00pages
253-61issue
2eissn
0167-594Xissn
1573-7373journal_volume
119pub_type
杂志文章abstract：:A case of multiple brain metastases from breast carcinoma treated with tamoxifen is described. She remained in remission for 58 months and is still alive after 82+ months of hormone therapy. The case indicates that hormonal treatment may be very effective in the management of brain metastases from breast carcinoma. ...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/BF00146879
更新日期：1991-04-01 00:00:00
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journal_title：Journal of neuro-oncology
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journal_title：Journal of neuro-oncology
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doi：10.1007/BF00177896
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journal_title：Journal of neuro-oncology
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doi：10.1007/s11060-015-1732-2
更新日期：2015-05-01 00:00:00
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journal_title：Journal of neuro-oncology
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journal_title：Journal of neuro-oncology
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更新日期：2011-09-01 00:00:00
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更新日期：2020-05-01 00:00:00
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journal_title：Journal of neuro-oncology
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doi：10.1007/BF00253270
更新日期：1984-01-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
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更新日期：2011-01-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章,随机对照试验
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更新日期：2020-02-01 00:00:00
abstract：:In this review on current concepts in radiation therapy in the treatment of incompletely resected supratentorial low-grade glioma, a number of important issues are discussed. They include indication for radiation therapy, timing (early vs delayed), dose response issue, impact of modern neuroimaging, 'optimal' treatmen...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章,评审
doi：10.1023/a:1013333905202
更新日期：2001-11-01 00:00:00
abstract：:Thirty-five adult recurrent GBM patients, divided randomly in two groups of 19 and 16 cases, had been treated with two regimens of chemotherapy: a) 'eight-drugs-in-one-day'; b) procarbazine + CCNU + vincristine (PCV) respectively. Chemotherapy was planned at the tumour relapse and delivered as long as tolerated withou...
journal_title：Journal of neuro-oncology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00172666
更新日期：1992-02-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-009-9805-8
更新日期：2009-08-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-012-0961-x
更新日期：2012-11-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-008-9665-7
更新日期：2008-12-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章,评审
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journal_title：Journal of neuro-oncology
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journal_title：Journal of neuro-oncology
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journal_title：Journal of neuro-oncology
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journal_title：Journal of neuro-oncology
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doi：10.1007/s11060-020-03549-x
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
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更新日期：2014-05-01 00:00:00
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journal_title：Journal of neuro-oncology
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journal_title：Journal of neuro-oncology
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doi：10.1007/BF01057957
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章,评审
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journal_title：Journal of neuro-oncology
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更新日期：1984-01-01 00:00:00
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journal_title：Journal of neuro-oncology
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更新日期：2020-01-01 00:00:00
abstract：:Various histological types of tumors arise in the pineal region. The most common tumors are pineal parenchymal tumors and germ cell tumors. Pineal parenchymal tumors are divided into pineocytoma, pineal parenchymal tumor with intermediate differentiation and pineoblastoma. Pineocytomas are well-differentiated tumors a...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章,评审
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abstract：:Glioma is the most common primary brain tumor in adults. Six3 is a human homologue of the highly conserved sine oculis gene family and essential transcription regulatory factor in process of eye and fetal forebrain development. However, little is known about the role of Six3 in human tumorigenesis. The aim of this stu...
journal_title：Journal of neuro-oncology
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更新日期：2017-07-01 00:00:00
