Abstract：
:Six children (ages 2 to 14 years) with recurrent or poor risk primary brain tumors were treated with the '8 drugs in 1 day' chemotherapy regimen. As renal function deteriorated (median after five cycles), carboplatin was substituted in place of cisplatin at a median dose of 300 mg/m2 as a one hour infusion at hour three. Four patients also had their lomustine deleted and replaced by etoposide 100 mg/m2 at hour four. Compared to earlier cycles of chemotherapy, there was a moderate increase in transfusion requirement (especially platelets) but the incidences of fever and neutropenia were unchanged. Glomerular function as measured by nuclear glomerular filtration rate (GFR) remained unchanged or improved at the end of therapy. The severity of nausea and vomiting after substitution was markedly improved. Four of the six patients are still in complete remission 19 to 41 months after diagnosis or recurrence. It is feasible to substitute carboplatin and etoposide into the '8 drugs in 1 day' regimen when extramedullary toxicity is found.
journal_name
J Neurooncoljournal_title
Journal of neuro-oncologyauthors
Chan KW,Fryer CJ,Steinbok Pdoi
10.1007/BF02427836subject
Has Abstractpub_date
1990-10-01 00:00:00pages
153-7issue
2eissn
0167-594Xissn
1573-7373journal_volume
9pub_type
杂志文章abstract：BACKGROUND:Oligodendroglial tumors are rare and chemosensitive diseases; but the overall results with current chemotherapy regimens cannot be considered satisfactory and other active treatments are necessary. We decided to determine the efficacy and toxicity profile of the carboplatin and etoposide (CE) regimen in this...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-006-9144-y
更新日期：2006-09-01 00:00:00
abstract：:In a cohort of 25 patients with supratentorial low grade glioma, the timing of radiotherapy made no significance difference for 10 year survival. Patients who received early radiotherapy had a 55% 10 year survival and those receiving delayed radiotherapy had a 53% 10 year survival. Radiotherapy was delayed a median of...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1023/a:1005703102687
更新日期：1997-08-01 00:00:00
abstract：:Hepatoma-derived growth factor (HDGF) is a neurotrophic factor found in mouse spinal cord and hippocampal neurons. In various malignant tumors, the role of HDGF in tumor progression and its use as a diagnostic biomarker or therapeutic target have been extensively explored. However, the prognostic function and mitogeni...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-011-0733-z
更新日期：2012-03-01 00:00:00
abstract：PURPOSE:The purpose of this study was to determine outcomes in recurrent pediatric ependymoma. METHODS:We performed a systematic review of PubMed, Embase, Web of Science and the Cochrane Library for studies reporting on survival outcomes for pediatric patients with recurrent ependymoma. We then performed a meta-analys...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章,meta分析
doi：10.1007/s11060-019-03255-3
更新日期：2019-09-01 00:00:00
abstract：:The outcome of children less than 3 years of age with medulloblastoma has been poor in comparison to older children. The cure rates were below 30%, and the quality of life for cured children was frequently reduced by a complex syndrome of long-term sequelae including intellectual retardation and growth hormone deficie...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章,评审
doi：10.1023/a:1005924017460
更新日期：1998-06-01 00:00:00
abstract：:Various subtypes of intracerebral hamartomas, associated with seizure disorders, have long been described. We describe a cerebral hamartoma placed in the left frontal lobe, associated with drug-resistant epilepsy, composed exclusively of mature oligodendroglial cells. The patient was a 27-year-old right-handed male pr...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-010-0253-2
更新日期：2011-01-01 00:00:00
abstract：INTRODUCTION:While hypofractionated stereotactic radiotherapy (HFSRT) is being increasingly used for treating brain metastases, clinical data concerning the incidence and risk factors of its main side-effect, namely radiation necrosis (RN), remain limited. In this context, we assessed risk factors of RN in a single cen...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-020-03628-z
更新日期：2020-09-01 00:00:00
abstract：:This review identifies the current literature on the use of bevacizumab for cerebral radiation necrosis in patients with high-grade gliomas, summarizes the clinical course and complications following bevacizumab, and discusses the relative costs and benefits of this therapeutic option. A Medline search was conducted o...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章,评审
doi：10.1007/s11060-013-1233-0
更新日期：2013-12-01 00:00:00
abstract：:The classification of cartilaginous tumors of the skull base, including chondroid chordoma and chondrosarcoma remains the subject of controversy. Critical review of the literature and our own experience of chordomas and cartilaginous tumors of the skull base led to the following conclusions: 1) Chondrosarcoma of the s...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章,评审
doi：10.1007/BF01328954
更新日期：1994-01-01 00:00:00
abstract：:Primary brain tumor patients experience high levels of distress. The purpose of this cross-sectional, retrospective study is to evaluate the level and different sources of psychosocial distress and how these pertain to health-related quality of life (HRQoL). The Primary and Recurrent Glioma registry at Duke's The Pres...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-017-2535-4
更新日期：2017-09-01 00:00:00
abstract：:Glioblastoma is a highly angiogenic tumor with a dismal prognosis. Continuous oral low-dose chemotherapy with methotrexate (MTX) and cyclophosphamide (CPM) has modest activity in heavily pretreated patients with breast cancer. We explored the efficacy of 100 mg CPM daily and 5 mg MTX twice weekly in relapsed glioblast...
journal_title：Journal of neuro-oncology
pub_type： 临床试验,杂志文章
doi：10.1007/s11060-004-1726-y
更新日期：2005-02-01 00:00:00
abstract：:Mutations in the gene encoding isocitrate dehydrogenase 1 (IDH1) have been identified in approximately 70-80 % of astrocytomas and oligodendrogliomas of WHO grades II and III, and in secondary glioblastomas. In addition, a low incidence of IDH2 mutations has been detected in these tumors, and the occurence of IDH1 and...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-012-0863-y
更新日期：2012-08-01 00:00:00
abstract：:The Hedgehog (Hh) signaling pathway has been implicated in the most common childhood brain tumor, medulloblastoma (MB). Given the toxicity of post-surgical treatments for MB, continued need exists for new, targeted therapies. Based upon our finding that Neuropilin (Nrp) transmembrane proteins are required for Hh signa...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-013-1216-1
更新日期：2013-11-01 00:00:00
abstract：PURPOSE:The uptake of the boron compound Na2B12H10-SH (BSH) in tumor and normal tissues was investigated in the frame of the EORTC phase I trial 'Postoperative treatment of glioblastoma with BNCT at the Petten Irradiation Facility' (protocol 11961). METHODS AND MATERIALS:The boron concentration in blood, tumor, normal...
journal_title：Journal of neuro-oncology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/BF02699941
更新日期：2003-03-01 00:00:00
abstract：:A case is reported of a patient rendered quadraparetic following collapse of a cervical vertebra due to neoplastic invasion by metastatic glioblastoma multiforme. The case is discussed in light of a review of the world literature regarding the clinical incidence and significance of metastasis of glial tumors. It is re...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章,评审
doi：10.1007/BF01324700
更新日期：1993-05-01 00:00:00
abstract：OBJECT:There is little population-based data available on primary spinal cord tumors. Many of the existing statistics are not current or were obtained from surgical series. Historically, population-based data were collected only for malignant tumors, and only recently have data begun to be collected on non-malignant tu...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-007-9507-z
更新日期：2008-04-01 00:00:00
abstract：:The purpose of this study is to characterize the time course of N-isopropyl-p-[123I]-iodoamphetamine (123I-IMP) uptake of primary central nervous system lymphomas (PCNSL) comparing with those of other common brain tumors such as malignant gliomas and meningioma. Ten patients with PCNSL, 14 with malignant gliomas and 7...
journal_title：Journal of neuro-oncology
pub_type： 临床试验,杂志文章
doi：10.1023/a:1022583610812
更新日期：2003-02-01 00:00:00
abstract：PURPOSE:We evaluated the outcomes after stereotactic radiosurgery (SRS) for patients who developed new or progressive brain disease regardless of whether they had no prior radiation, PCI, or WBRT. METHODS:We retrospectively identified 90 SCLC patients who had SRS between 1991 and 2018. Thirty-one patients had no evide...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-019-03224-w
更新日期：2019-08-01 00:00:00
abstract：:NF1, NF2, and Schwannomatosis are incurable tumor suppressor syndromes associated with poor quality of life. The aim of this study was to determine the feasibility, acceptability, and preliminary efficacy of an NF adapted, 8-week group mind body skills based intervention, the relaxation response resiliency program (3R...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-014-1522-2
更新日期：2014-10-01 00:00:00
abstract：:Bevacizumab is effective for the treatment of non-small cell lung cancer (NSCLC). Ongoing trials are exploring the safety of bevacizumab in patients with inactive, previously treated brain metastases. However, bevacizumab safety and efficacy in the treatment of active brain metastases is unknown. Bevacizumab received ...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-010-0200-2
更新日期：2010-12-01 00:00:00
abstract：:This study retrospectively reviewed our single institute experience to clarify the optimal indication and timing of salvage surgery. Retrospective analysis of 159 consecutive cases with germ cell tumors identified 20 cases with salvage surgery. These cases were classified based on the radiological response to neoadjuv...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-018-2827-3
更新日期：2018-07-01 00:00:00
abstract：:Aberrant expression of stem cell-related genes in tumors may confer more primitive and aggressive traits affecting clinical outcome. Here, we investigated expression and prognostic value of the neural stem cell marker CD133, as well as of the pluripotency genes LIN28 and OCT4 in 37 samples of pediatric medulloblastoma...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-011-0647-9
更新日期：2012-01-01 00:00:00
abstract：:Treatment options and prognosis remains poor for patients with recurrent glioblastoma multiforme. These tumors are highly vascularised and over express angiogenic factors such as vascular endothelial growth factor and may potentially be responsive to antiangiogenic therapies. We present the results of a phase II trial...
journal_title：Journal of neuro-oncology
pub_type： 临床试验,杂志文章
doi：10.1023/a:1012554328801
更新日期：2001-08-01 00:00:00
abstract：:The completion of the Human Genome Project resulted in discovery of many unknown novel genes. This feat paved the way for the future development of novel therapeutics for the treatment of human disease based on novel biological functions and pathways. Towards this aim, we undertook a bioinformatics analysis of in-hous...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-010-0314-6
更新日期：2011-04-01 00:00:00
abstract：:Low grade tumors are associated with a high risk of seizures. Prolonged use of antiepileptic drugs (AEDs) is associated with morbidity. Determining which patients can safely discontinue AEDs perioperatively is difficult. We examined patients with low grade supratentorial brain tumors to determine characteristics of pa...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-011-0779-y
更新日期：2012-05-01 00:00:00
abstract：:Recurrent gliomas are most often treated by chemotherapy. However, these tumors typically acquire resistance to most drugs administered, and patients will usually die of recurrent tumor. Factors which may play a role include overexpression of putative multidrug resistance genes, such as the multidrug resistance gene 1...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/BF00182138
更新日期：1996-08-01 00:00:00
abstract：:The effectiveness of radiotherapy and chemotherapy in high grade gliomas (HGG) depends on tumor micro-environment. We summarize our experience of the influence of spinal cord stimulation (SCS) on this micro-environment. Patients with HGG (n = 26) were assessed pre- and post-SCS, using: (1) Doppler in middle cerebral a...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-011-0660-z
更新日期：2012-01-01 00:00:00
abstract：:Nineteen patients with nervous system metastasis of hepatocellular carcinoma (HCC) were evaluated retrospectively. Nervous system metastasis was frequently initial presentation of HCC (seven out of 19 patients). Seven patients had metastases of the brain, of whom four had a stroke-like presentation. CT or MRI in these...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1023/a:1005716408970
更新日期：1998-01-01 00:00:00
abstract：:Human melanoma proteoglycan (HMP), a melanoma-associated antigen, is expressed in both human melanomas and gliomas. We used HMP-specific monoclonal antibody (mAb) VT68.2 to investigate whether murine GL261 cerebral gliomas express the HMP homologue AN2 and to determine whether AN2 could be targeted for selective deliv...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-009-9798-3
更新日期：2009-08-01 00:00:00
abstract：:In this retrospective, IRB-exempt study, we analyzed data from 68 patients diagnosed with glioblastoma (GBM) in two institutions and investigated the relationship between tumor shape, quantified using algorithmic analysis of magnetic resonance images, and survival. Each patient's Fluid Attenuated Inversion Recovery (F...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章,多中心研究
doi：10.1007/s11060-016-2359-7
更新日期：2017-03-01 00:00:00
