Vertebral collapse with quadraparesis due to metastatic gliobla multiforme: case report and review of the literature.

abstract：:The objective of this study was to investigate racial/ethnic differences in survival for pediatric high-grade glioma (HGG) and medulloblastoma in the state of California. We obtained data from the California Cancer Registry on 552 high-grade glioma patients (110 brainstem, 442 non-brainstem) and 648 medulloblastoma pa...

journal_title：Journal of neuro-oncology

authors： Cooney T,Fisher PG,Tao L,Clarke CA,Partap S

更新日期：2018-05-01 00:00:00

abstract：:The determination of optimal therapy for ependymoma (EP) in infants is ongoing. We describe the incidence, management and outcomes of Canadian infants with EP to discern potential future research questions. Of 579 cases registered in a national database of children <36 months of age diagnosed with a brain tumor from 1...

journal_title：Journal of neuro-oncology

authors： Purdy E,Johnston DL,Bartels U,Fryer C,Carret AS,Crooks B,Eisenstat DD,Lafay-Cousin L,Larouche V,Wilson B,Zelcer S,Silva M,Bouffet E,Keene D,Strother DR

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Recent studies suggest a relatively high prevalence of autoimmune disorders (AD) among primary CNS lymphoma (PCNSL) patients, however, the literature is limited to case reports. To gain a better understanding of AD-PCNSL we reviewed and analyzed all cases described in the literature. METHODS:We searched the...

journal_title：Journal of neuro-oncology

authors： Kaulen LD,Karschnia P,Dietrich J,Baehring JM

更新日期：2020-08-01 00:00:00

abstract：:The new anticancer agent Taxol appears to potentiate the effects of radiation on brain tumor cell lines in vitro and was recently evaluated by our group as a radiosensitizer in a phase I study for primary brain tumors. In that study, we administered Taxol as a three-hour IV infusion repeated every week for six weeks a...

journal_title：Journal of neuro-oncology

authors： Wehbe T,Glantz M,Choy H,Glantz L,Cortez S,Akerley W 3rd,Mills P,Cole B

更新日期：1998-09-01 00:00:00

abstract：:Hot spot mutations in the promoter region of telomerase reverse transcriptase (TERT promoter mutations) occur frequently in tumors of neuroectodermal origin such as melanoma and glioma. Many of these tumors are of neuroectodermal or ectomesenchymal origin which is suggestive of TERT promoter mutations playing a role i...

journal_title：Journal of neuro-oncology

authors： Dubbink HJ,Bakels H,Post E,Zwarthoff EC,Verdijk RM

更新日期：2014-11-01 00:00:00

abstract：:Treatment of recurrent primary CNS lymphoma (PCNSL) though not standardized most often utilizes whole brain radiotherapy, re-challenge with high-dose methotrexate, or administration of an alkylating chemotherapy. High-dose cytarabine (HD-araC) has been advocated as an active agent in PCNSL but limited information exis...

journal_title：Journal of neuro-oncology

authors： Chamberlain MC

更新日期：2016-02-01 00:00:00

abstract：:High expression of ERBB2 has been reported in medulloblastoma and ependymoma; EGFR is amplified and over-expressed in brainstem glioma suggesting these proteins as potential therapeutic targets. We conducted a molecular biology (MB) and phase II study to estimate inhibition of tumor ERBB signaling and sustained respon...

journal_title：Journal of neuro-oncology

authors： Fouladi M,Stewart CF,Blaney SM,Onar-Thomas A,Schaiquevich P,Packer RJ,Goldman S,Geyer JR,Gajjar A,Kun LE,Boyett JM,Gilbertson RJ

更新日期：2013-09-01 00:00:00

abstract：:We prospectively addressed whether EGFR and KRAS mutations, EML4-ALK, ROS1 and RET rearrangements, or wild-type (WT), affects radiosurgery outcomes and overall survival (OS) in non-small cell lung cancer (NSCLC) patients with brain metastases (BM). Of 326 patients with BM treated in 2012-2014 with Gamma Knife radiosur...

journal_title：Journal of neuro-oncology

authors： Shin SM,Cooper BT,Chachoua A,Butler J,Donahue B,Silverman JS,Kondziolka D

更新日期：2016-02-01 00:00:00

abstract：PURPOSE:To evaluate the hypothesis that adults with partially resected (PR<50% resection) supratentorial low-grade glioma (LGG) benefit from higher doses of radiation. METHODS:Patients receiving post-operative radiation for WHO grade I-II LGG at the University of Western Ontario between 1979 and 2001 were studied. Pat...

journal_title：Journal of neuro-oncology

authors： Leighton C,Fisher B,Macdonald D,Stitt L,Bauman G,Cairncross J

更新日期：2007-04-01 00:00:00

abstract：:Lonidamine (LND) has been shown to inhibit tumor aerobic glycolysis. Its effect was evaluated on several human astrocytomas at different degrees of malignancy; a correlation was found between LDN effect on lactate production and tumor malignancy: in grade I and II astrocytomas LND stimulates lactate production, while ...

journal_title：Journal of neuro-oncology

authors： Paggi MG,Carapella CM,Fanciulli M,Del Carlo C,Giorno S,Zupi G,Silvestrini B,Caputo A,Floridi A

更新日期：1988-11-01 00:00:00

abstract：:Targeting tumor angiogenesis is a potential therapeutic strategy for glioblastoma because of its high vascularization. Tivozanib is an oral pan-VEGF receptor tyrosine kinase inhibitor that hits a central pathway in glioblastoma angiogenesis. We conducted a phase II study to test the effectiveness of tivozanib in patie...

journal_title：Journal of neuro-oncology

authors： Kalpathy-Cramer J,Chandra V,Da X,Ou Y,Emblem KE,Muzikansky A,Cai X,Douw L,Evans JG,Dietrich J,Chi AS,Wen PY,Stufflebeam S,Rosen B,Duda DG,Jain RK,Batchelor TT,Gerstner ER

更新日期：2017-02-01 00:00:00

abstract：:Cancer is a leading cause of death in the United States. Despite the development of advanced treatment for many malignancies, a large number of patients will require evaluation and possible surgical intervention for lesions which have metastasized to or directly invaded the spinal column. The recommendations for opera...

journal_title：Journal of neuro-oncology

authors： Welch WC,Jacobs GB

更新日期：1995-01-01 00:00:00

abstract：:Extensive surgical resection of centrally localized, newly diagnosed glioblastoma can lead to opening ventricles and therefore carries a potential risk of spreading tumor cells into the cebrospinal fluid. However, whether ventricle opening consequently implies a greater frequency of distant tumor recurrence after radi...

journal_title：Journal of neuro-oncology

authors： Adeberg S,Diehl C,Jung CS,Rieken S,Combs SE,Unterberg A,Debus J

更新日期：2016-05-01 00:00:00

abstract：TARGET POPULATION:These recommendations apply to adults with a newly diagnosed lesion with a suspected or histopathologically proven glioblastoma (GBM). QUESTION:What are the optimal imaging techniques to be used in the management of a suspected glioblastoma (GBM), specifically: which imaging sequences are critical fo...

journal_title：Journal of neuro-oncology

authors： Lundy P,Domino J,Ryken T,Fouke S,McCracken DJ,Ormond DR,Olson JJ

更新日期：2020-11-01 00:00:00

abstract：UNLABELLED:Cranio-spinal irradiation is the gold standard treatment used in non metastatic medulloblastoma as prophylaxis against central nervous system (CNS) metastases. However, given the severe late effects caused by this procedure in children under 3 years of age, most pediatric oncologists are currently treating t...

journal_title：Journal of neuro-oncology

authors： Dupuis-Girod S,Hartmann O,Benhamou E,Doz F,Mechinaud F,Bouffet E,Coze C,Kalifa C

更新日期：1996-01-01 00:00:00

abstract：:Approximately 200,000 men will be diagnosed with prostate cancer in 1994. While localized disease is potentially curable with surgery or radiation therapy, metastatic disease is incurable. The most frequent site of metastasis is bone. Spinal cord compression occurs in approximately 7% of men with prostate cancer. Back...

journal_title：Journal of neuro-oncology

authors： Osborn JL,Getzenberg RH,Trump DL

更新日期：1995-01-01 00:00:00

abstract：:Glioblastomas are malignant brain tumors with poor prognosis. Lately, data from clinical studies assessing the role of co-medications in different cancer types suggested reduced mortality and potential anti-tumor activity for statins, angiotensin-I converting enzyme inhibitors (ACEI) and angiotensin II receptor blocke...

journal_title：Journal of neuro-oncology

authors： Happold C,Gorlia T,Nabors LB,Erridge SC,Reardon DA,Hicking C,Picard M,Stupp R,Weller M,EORTC Brain Tumor Group and on behalf of the CENTRIC and CORE Clinical Trial Groups.

更新日期：2018-05-01 00:00:00

abstract：PURPOSE:Because raised matrix metalloprotease (MMP) levels are associated with glioma invasion and angiogenesis, we tested the efficacy of marimastat (MT) an orally active drug that can reduce MMP levels, in patients with gliomas. PATIENTS AND METHODS:A total of 162 patients with intracranial glioblastoma multiforme o...

journal_title：Journal of neuro-oncology

authors： Levin VA,Phuphanich S,Yung WK,Forsyth PA,Maestro RD,Perry JR,Fuller GN,Baillet M

更新日期：2006-07-01 00:00:00

abstract：:The optimal postoperative management of pediatric intracranial ependymomas is controversial. We analyzed clinical prognostic factors for their influence on outcome in such children. Our retrospective series included 15 with supratentorial and 28 with infratentorial tumors. Twenty ependymomas were grade II, and 23 were...

journal_title：Journal of neuro-oncology

authors： Jaing TH,Wang HS,Tsay PK,Tseng CK,Jung SM,Lin KL,Lui TN

更新日期：2004-07-01 00:00:00

abstract：:This study concerns the use of the MTT [3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H tetrazolium bromide] colorimetric assay to evaluate the chemosensitivity of the C6 rat glioma cell line to a panel of twelve chemotherapeutic agents. In a previous study of in vitro chemosensitivity of human glioma cell lines, the pre...

journal_title：Journal of neuro-oncology

authors： Hand CM,Vender JR,Black P

更新日期：1998-01-01 00:00:00

abstract：:A pilot study was performed combining cis-diamminedichloroplatinum (CDDP) and radiation therapy to treat patients with high-grade astrocytomas. CDDP at a dose of 40 mg/m2/week intravenously was given during the course of cranial irradiation. Following irradiation, CDDP was given every three weeks on a schedule of 35-4...

journal_title：Journal of neuro-oncology

authors： Feun LG,Stewart DJ,Maor M,Leavens M,Savaraj N,Burgess MA,Yung WK,Benjamin RS

更新日期：1983-01-01 00:00:00

abstract：INTRODUCTION:Informal family caregivers (FCG) are an integral and crucial human component in the cancer care continuum. However, research and interventions to help alleviate documented anxiety and burden on this group is lacking. To address the absence of effective interventions, we developed the electronic Support Net...

journal_title：Journal of neuro-oncology

authors： Reblin M,Ketcher D,Forsyth P,Mendivil E,Kane L,Pok J,Meyer M,Wu YP,Agutter J

更新日期：2018-09-01 00:00:00

abstract：:Hepatoma-derived growth factor (HDGF) is a neurotrophic factor found in mouse spinal cord and hippocampal neurons. In various malignant tumors, the role of HDGF in tumor progression and its use as a diagnostic biomarker or therapeutic target have been extensively explored. However, the prognostic function and mitogeni...

journal_title：Journal of neuro-oncology

authors： Hsu SS,Chen CH,Liu GS,Tai MH,Wang JS,Wu JC,Kung ML,Chan EC,Liu LF

更新日期：2012-03-01 00:00:00

abstract：:We report a case of radiation necrosis occurring 47 years after resection and radiotherapy for a juvenile pilocystic cerebellar astrocytoma, the longest yet reported. The patient presented with progressive lower cranial nerve dysfunction, and eventually died from cardiopulmonary arrest secondary to aspiration. The pre...

journal_title：Journal of neuro-oncology

authors： Babu R,Huang PP,Epstein F,Budzilovich GN

更新日期：1993-07-01 00:00:00

abstract：:Platelet-derived growth factor receptor (PDGFR) signaling plays an important role in the biology of malignant gliomas. To investigate mechanisms modulating PDGFR signaling in gliomagenesis, we employed a Drosophila glioma model and genetic screen to identify genes interacting with Pvr, the fly homolog of PDGFRs. Glial...

journal_title：Journal of neuro-oncology

authors： Jeibmann A,Halama K,Witte HT,Kim SN,Eikmeier K,Koos B,Klämbt C,Paulus W

更新日期：2015-09-01 00:00:00

abstract：:Glioblastoma is the most common and most aggressive primary brain tumor. Despite maximum treatment, patients only have a median survival time of 15 months, because of the tumor's resistance to current therapeutic approaches. Thus far, methylation of the O (6)-methylguanine-DNA methyltransferase (MGMT) promoter has bee...

journal_title：Journal of neuro-oncology

authors： Bleeker FE,Molenaar RJ,Leenstra S

更新日期：2012-05-01 00:00:00

abstract：:Ewing's sarcoma/primitive neuroectodermal tumor (EWS/PNET) has a characteristic chimeric oncogene EWS-FLI1, which results from chromosomal translocation t (11; 22), that is believed to initiate tumorigenesis of EWS/PNET. However, the specific details of EWS/PNET oncogenesis and exact role of EWS-FLI1 remain largely un...

journal_title：Journal of neuro-oncology

authors： Yang Y,Zhang L,Wei Y,Wang H,Fukuma M,Xu H,Xiong W,Zheng J

更新日期：2008-11-01 00:00:00

abstract：:Our objective was to explore the impact of the histopathological tumor type on affective symptoms before surgery among male and female patients with supratentorial primary brain tumors. A total of 44 adult patients were included in the study. Depression and anxiety were measured using the Beck Depression Inventory (BD...

journal_title：Journal of neuro-oncology

authors： Richter A,Jenewein J,Krayenbühl N,Woernle C,Bellut D

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Oligodendroglial tumors are rare and chemosensitive diseases; but the overall results with current chemotherapy regimens cannot be considered satisfactory and other active treatments are necessary. We decided to determine the efficacy and toxicity profile of the carboplatin and etoposide (CE) regimen in this...

journal_title：Journal of neuro-oncology

authors： Scopece L,Franceschi E,Cavallo G,Paioli A,Paioli G,Conforti R,Palmerini E,Berzioli C,Spagnolli F,Esposti RD,Crinò L

更新日期：2006-09-01 00:00:00

abstract：:The objective of this study was to investigate whether activity and protein expression of ornithine decarboxylase (ODC) the metabolism-rate limiting enzyme of the polyamine biosynthesis, which is involved in the regulation of cellular growth and differentiation, reflects the distinct histopathologic characteristics in...

journal_title：Journal of neuro-oncology

authors： Stenzel W,Röhn G,Miletic H,Radner H,Deckert M,Ernestus RI

更新日期：2004-01-01 00:00:00