Abstract:
:Low grade tumors are associated with a high risk of seizures. Prolonged use of antiepileptic drugs (AEDs) is associated with morbidity. Determining which patients can safely discontinue AEDs perioperatively is difficult. We examined patients with low grade supratentorial brain tumors to determine characteristics of patients who underwent AED withdrawal. A retrospective chart review was performed in patients who underwent resection between 1/1/2004 and 12/31/2005 at a single center. Data were collected regarding the use of postoperative AEDs, occurrence of postoperative seizures, and patient/tumor characteristics. We examined 169 patients with a median follow-up of 3.1 years. AEDs were withdrawn or never started in 111 patients; post-withdrawal seizures occurred in 11 (9.9%). The rate was similar between meningiomas and primary brain tumors. No independent risk factors for post-withdrawal seizures were found. Of 58 patients whose AEDs were not withdrawn, postoperative seizures occurred in 28 (48%). Predictors of AED continuation included existence of preoperative seizures, temporal tumor location, tumor recurrence, incomplete resection, and male sex. The decision to continue AEDs was predictive for postoperative seizures even after controlling for known risk factors. Although clinicians are able to identify patients at high risk for postoperative seizures, treatment with AEDs is ineffective in many patients.
journal_name
J Neurooncoljournal_title
Journal of neuro-oncologyauthors
Das RR,Artsy E,Hurwitz S,Wen PY,Black P,Golby A,Dworetzky B,Lee JWdoi
10.1007/s11060-011-0779-ysubject
Has Abstractpub_date
2012-05-01 00:00:00pages
565-70issue
3eissn
0167-594Xissn
1573-7373journal_volume
107pub_type
杂志文章abstract:PURPOSE:Glioblastoma (GBM) is the most aggressive adult brain cancer, with a 15 month median survivorship attributed to the existence of treatment-refractory brain tumor initiating cells (BTICs). In order to better understand the mechanisms regulating the tumorigenic properties of this population, we studied the role o...
journal_title:Journal of neuro-oncology
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journal_title:Journal of neuro-oncology
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更新日期:1995-10-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
doi:10.1007/s11060-016-2244-4
更新日期:2016-12-01 00:00:00
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journal_title:Journal of neuro-oncology
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更新日期:1992-05-01 00:00:00
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journal_title:Journal of neuro-oncology
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pub_type: 杂志文章
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更新日期:1998-01-01 00:00:00
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更新日期:2016-01-01 00:00:00
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更新日期:2011-12-01 00:00:00
abstract::Ependymomas (EPN) show site specific genetic alterations and a recent DNA methylation profiling study identified nine molecular subgroups. C11orf95-RELA and YAP1 fusions characterise the RELA and YAP1 molecular subgroups, respectively, of supratentorial (ST)-EPNs. Current guidelines recommend molecular subgrouping ove...
journal_title:Journal of neuro-oncology
pub_type: 杂志文章
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更新日期:2018-05-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
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更新日期:2018-08-01 00:00:00
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更新日期:2006-01-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章,meta分析,评审
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更新日期:2014-06-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
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更新日期:2017-09-01 00:00:00