Expression of HMP/AN2, a melanoma associated antigen, in murine cerebral gliomas: potential for radioimmunotargeting.

Abstract:

:Human melanoma proteoglycan (HMP), a melanoma-associated antigen, is expressed in both human melanomas and gliomas. We used HMP-specific monoclonal antibody (mAb) VT68.2 to investigate whether murine GL261 cerebral gliomas express the HMP homologue AN2 and to determine whether AN2 could be targeted for selective delivery of radiation in vivo. HMP-specific mAb VT68.2 stained murine GL261 glioma cells grown in culture and intracerebrally in syngeneic C57BL/6 mice. Positron emission tomography with radiolabeled mAb VT68.2 showed high-contrast, positive images of gliomas against a negative background. At 96 h after injection, glioma uptake of radiolabeled mAb VT68.2 was 10x greater than that of the isotype control mAb and 20x greater than that detected in normal cerebral tissue. Our results show murine GL261 cerebral gliomas express AN2 and HMP-specific mAb VT68.2 accumulates selectively and specifically at high concentration and is retained within murine cerebral gliomas. Thus, HMP is a potential target for antibody-mediated selective delivery of radiation to cerebral gliomas in vivo.

journal_name

J Neurooncol

authors

Paul AK,Ciesielski MJ,Sajjad M,Wang X,Ferrone S,Abdel-Nabi H,Fenstermaker RA

doi

10.1007/s11060-009-9798-3

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

21-30

issue

1

eissn

0167-594X

issn

1573-7373

journal_volume

94

pub_type

杂志文章
  • Effects of combination chemotherapy with biscoclaurine-derived alkaloid (Cepharanthine) and nimustine hydrochloride on malignant glioma cell lines.

    abstract::In the treatment of malignant glioma, chemotherapy plays a critical role as do surgical resection and irradiation. Cepharanthine (CEP), a biscoclaurine-derived alkaloid, reportedly potentiates the effects of antitumor agents and induces apoptosis in some cancer cells. Here, we examined the effects of CEP, alone and in...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章

    doi:10.1023/a:1014548618440

    authors: Kono K,Takahashi JA,Ueba T,Mori H,Hashimoto N,Fukumoto M

    更新日期:2002-01-01 00:00:00

  • Phase I study of bendamustine with concurrent whole brain radiation therapy in patients with brain metastases from solid tumors.

    abstract::A phase I study was conducted to evaluate the dose-limiting toxicities (DLTs) and to determine the maximum tolerated dose (MTD)/recommended phase II dose of bendamustine with concurrent whole brain radiation (WBR) in patients with brain metastases (BM) from solid tumors. Four doses of intravenous weekly bendamustine w...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章

    doi:10.1007/s11060-014-1510-6

    authors: Pan E,Yu D,Zhao X,Neuger A,Smith P,Chinnaiyan P,Yu HH

    更新日期:2014-09-01 00:00:00

  • Single nucleotide polymorphisms and expression of ERCC1 and ERCC2 vis-à-vis chemotherapy drug cytotoxicity in human glioma.

    abstract::ERCC1 and ERCC2 have been known to belong to the nucleotide excision repair (NER) pathway and are essential to the repair of cisplatin DNA adducts. In the present study, we have examined the potential correlation of ERCC1, ERCC2 mRNA expression and single nucleotide polymorphism (SNP) to chemotherapy drug cytotoxicity...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章

    doi:10.1007/s11060-006-9290-2

    authors: Chen H,Shao C,Shi H,Mu Y,Sai K,Chen Z

    更新日期:2007-05-01 00:00:00

  • Toxicity of IL-2 and Corynebacterium parvum following direct intracranial injection.

    abstract::The toxicity of IL-2 and/or C. Parvum when injected directly into the mouse brain was examined by survival and histopathology using different numbers of injections, different doses of IL-2, different solvents for the IL-2, and different doses and routes of administration of C. Parvum. Two injections was found signific...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章

    doi:10.1007/BF00172920

    authors: Sutton RC 3rd,Kennedy J,Duncan J,Conley FK

    更新日期:1989-09-01 00:00:00

  • Adding DSC PWI and DWI to BT-RADS can help identify postoperative recurrence in patients with high-grade gliomas.

    abstract:BACKGROUND:The Brain Tumor Reporting and Data System (BT-RADS) category 3 is suitable for identifying cases with intermediate probability of tumor recurrence that do not meet the Response Assessment in Neuro-Oncology (RANO) criteria for progression. The aim of this study was to evaluate the added value of dynamic susce...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章

    doi:10.1007/s11060-019-03387-6

    authors: Yang Y,Yang Y,Wu X,Pan Y,Zhou D,Zhang H,Chen Y,Zhao J,Mo Z,Huang B

    更新日期:2020-01-01 00:00:00

  • Vertebral collapse with quadraparesis due to metastatic gliobla multiforme: case report and review of the literature.

    abstract::A case is reported of a patient rendered quadraparetic following collapse of a cervical vertebra due to neoplastic invasion by metastatic glioblastoma multiforme. The case is discussed in light of a review of the world literature regarding the clinical incidence and significance of metastasis of glial tumors. It is re...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章,评审

    doi:10.1007/BF01324700

    authors: Chesnut RM,Abitbol JJ,Chamberlain M,Marshall LF

    更新日期:1993-05-01 00:00:00

  • Phase II study of weekly dose-intensified cisplatin chemotherapy with oral etoposide in recurrent glioma.

    abstract:BACKGROUND:In most patients with recurrent glioma chemotherapy is the only remaining treatment option. In general results of chemotherapy in these patients are poor, and trials on new regimens are indicated. Because relatively good results have been achieved with combinations of platin compounds and etoposide, we inves...

    journal_title:Journal of neuro-oncology

    pub_type: 临床试验,杂志文章

    doi:10.1023/a:1006201909435

    authors: van den Bent MJ,Pronk L,Sillevis Smitt PA,Vecht CJ,Eskens FA,Verweij J

    更新日期:1999-08-01 00:00:00

  • Radical surgery after chemotherapy: a new therapeutic strategy to envision in grade II glioma.

    abstract::While surgery is proned in low-grade glioma (LGG), the invasion of functional areas frequently prevents a complete resection. We report the first case of a patient operated on for a left frontal LGG, diagnosed because of seizures, with partial resection due to an invasion of the controlateral hemisphere. Chemotherapy ...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章

    doi:10.1007/s11060-006-9168-3

    authors: Duffau H,Taillandier L,Capelle L

    更新日期:2006-11-01 00:00:00

  • Descriptive epidemiology of primary spinal cord tumors.

    abstract:OBJECT:There is little population-based data available on primary spinal cord tumors. Many of the existing statistics are not current or were obtained from surgical series. Historically, population-based data were collected only for malignant tumors, and only recently have data begun to be collected on non-malignant tu...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章

    doi:10.1007/s11060-007-9507-z

    authors: Schellinger KA,Propp JM,Villano JL,McCarthy BJ

    更新日期:2008-04-01 00:00:00

  • Cyclin D1 is overexpressed in atypical teratoid/rhabdoid tumor with hSNF5/INI1 gene inactivation.

    abstract:OBJECT:Although atypical teratoid/rhabdoid tumor (AT/RT) is known to generate through inactivation of the hSNF5/INI1 gene on chromosome 22q, the downstream molecular mechanism remains unclear. We histologically and molecularly reviewed our pediatric brain tumors for unrecognized AT/RTs and evaluated the role of cyclin ...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章

    doi:10.1007/s11060-004-4276-4

    authors: Fujisawa H,Misaki K,Takabatake Y,Hasegawa M,Yamashita J

    更新日期:2005-06-01 00:00:00

  • Acromegaly: historical perspectives and current therapy.

    abstract::Soon after the initial description of acromegaly in the late 19th century, neurosurgeons performed the first operative procedures for the disease. Transcranial procedures eventually yielded to the transsphenoidal approach. Reasonably effective medical therapy was introduced in the 1970s and pharmacological progress co...

    journal_title:Journal of neuro-oncology

    pub_type: 历史文章,杂志文章,评审

    doi:10.1023/a:1012949214960

    authors: Jane JA Jr,Thapar K,Laws ER Jr

    更新日期:2001-09-01 00:00:00

  • Factor analysis of the immunophenotypes of astrocytomas and malignant gliomas: correlations with tumor grade and patient survival.

    abstract::Our previous investigations correlated the degree of cytogenetic and immunophenotypic heterogeneity of cultured normal glia, astrocytomas and malignant gliomas. The possible significance was suggested by the statistical correlation of individual antigens with diagnosis and patient survival. The present study has estab...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章

    doi:10.1007/BF02341157

    authors: Jennings MT,Asadourian LL,Jennings VD,Shapiro JR,Thaler HT

    更新日期:1990-12-01 00:00:00

  • Pathology of pineal region tumors.

    abstract::Various histological types of tumors arise in the pineal region. The most common tumors are pineal parenchymal tumors and germ cell tumors. Pineal parenchymal tumors are divided into pineocytoma, pineal parenchymal tumor with intermediate differentiation and pineoblastoma. Pineocytomas are well-differentiated tumors a...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章,评审

    doi:10.1023/a:1012721723387

    authors: Hirato J,Nakazato Y

    更新日期:2001-09-01 00:00:00

  • Late sequela after treatment of childhood low-grade gliomas: a retrospective analysis of 69 long-term survivors treated between 1983 and 2003.

    abstract::The aim of the present study was to evaluate the spectrum of late effects in a large cohort of pediatric patients with low-grade gliomas (WHO grade I and II) during an observation period of 20 years. Eighty-seven patients with low-grade gliomas grouped according to tumor location (cerebellum: n=28; cerebral hemisphere...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章

    doi:10.1007/s11060-005-9091-z

    authors: Benesch M,Lackner H,Sovinz P,Suppan E,Schwinger W,Eder HG,Dornbusch HJ,Moser A,Triebl-Roth K,Urban C

    更新日期:2006-06-01 00:00:00

  • The dose-volume interaction in adult supratentorial low-grade glioma: higher radiation dose is beneficial among patients with partial resection.

    abstract:PURPOSE:To evaluate the hypothesis that adults with partially resected (PR<50% resection) supratentorial low-grade glioma (LGG) benefit from higher doses of radiation. METHODS:Patients receiving post-operative radiation for WHO grade I-II LGG at the University of Western Ontario between 1979 and 2001 were studied. Pat...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章

    doi:10.1007/s11060-006-9141-1

    authors: Leighton C,Fisher B,Macdonald D,Stitt L,Bauman G,Cairncross J

    更新日期:2007-04-01 00:00:00

  • Prognostic value of proliferation index and expression of the RNA component of human telomerase (hTR) in papillary meningiomas.

    abstract::Papillary meningioma is a rare subtype of meningioma that often behaves aggressively. In order to characterize factors that may influence this behavior, we chose to compare MIB-1 labeling index (LI) and telomerase RNA localization (hTR) in papillary meningiomas, meningiomas, and atypical meningiomas. LI is now often u...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章

    doi:10.1023/a:1006353322307

    authors: Rushing EJ,Colvin SM,Gazdar A,Miura N,White CL 3rd,Coimbra C,Burns DK

    更新日期:1999-01-01 00:00:00

  • Concomitant differentiation and partial proteasome inhibition trigger apoptosis in neuroblastoma cells.

    abstract::Proteasome activity is essential during cAMP-induced terminal differentiation of a murine neuroblastoma cell line (NBP2). However, the mechanisms through which proteasome affects NBP2 differentiation have not been characterized. We hypothesized that proteasome is required to implement the differentiation-mediated effe...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章

    doi:10.1023/a:1023713008809

    authors: Nahreini P,Andreatta C,Hanson A,Prasad KN

    更新日期:2003-05-01 00:00:00

  • Identification of new HLA-A*0201-restricted cytotoxic T lymphocyte epitopes from neuritin.

    abstract::Identification of cytotoxic T lymphocyte (CTL) epitopes from additional tumor antigens is essential for the development of specific immunotherapy of malignant tumors. Neuritin, a recently discovered antigen overexpressed in astrocytoma, is considered to be a promising target for biological therapy. In the present stud...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章

    doi:10.1007/s11060-013-1167-6

    authors: Yang Z,Zhao T,Liu Y,Gong Z,Cheng S,Yang Q

    更新日期:2013-08-01 00:00:00

  • High 123I-IMP retention on SPECT image in primary central nervous system lymphoma.

    abstract::The purpose of this study is to characterize the time course of N-isopropyl-p-[123I]-iodoamphetamine (123I-IMP) uptake of primary central nervous system lymphomas (PCNSL) comparing with those of other common brain tumors such as malignant gliomas and meningioma. Ten patients with PCNSL, 14 with malignant gliomas and 7...

    journal_title:Journal of neuro-oncology

    pub_type: 临床试验,杂志文章

    doi:10.1023/a:1022583610812

    authors: Shinoda J,Yano H,Murase S,Yoshimura S,Sakai N,Asano T

    更新日期:2003-02-01 00:00:00

  • Considerations on the role of chemotherapy and modern radiotherapy in the treatment of childhood low grade glioma.

    abstract::The treatment of childhood low grade glioma (LGG), if not amenable to complete resection, quite often is a relevant clinical challenge. LGG in many instances are indeed slow growing tumors, which, if not controlled, can cause severe morbidity and ultimately jeopardize life. Most of the time children bearing an unresec...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章,评审

    doi:10.1007/s11060-005-6754-8

    authors: Perilongo G

    更新日期:2005-12-01 00:00:00

  • Evaluation of the microenvironmental heterogeneity in high-grade gliomas with IDH1/2 gene mutation using histogram analysis of diffusion-weighted imaging and dynamic-susceptibility contrast perfusion imaging.

    abstract::The purpose of our study was to explore the difference between isocitrate dehydrogenase (IDH)-1/2 gene mutation-positive and -negative high-grade gliomas (HGGs) using histogram analysis of apparent diffusion coefficient (ADC) and normalized cerebral blood volume (nCBV) maps. We enrolled 52 patients with histopathologi...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章

    doi:10.1007/s11060-014-1614-z

    authors: Lee S,Choi SH,Ryoo I,Yoon TJ,Kim TM,Lee SH,Park CK,Kim JH,Sohn CH,Park SH,Kim IH

    更新日期:2015-01-01 00:00:00

  • A phase II study of nimustine hydrochloride, cisplatin, and etoposide combination chemotherapy for supratentorial malignant gliomas.

    abstract::Twenty-eight patients who were previously treated by aggressive surgery and radiation and were diagnosed with supratentorial malignant gliomas received a combination of nimustine hydrochloride; 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU), cisplatin and etoposide (ACE ...

    journal_title:Journal of neuro-oncology

    pub_type: 临床试验,杂志文章

    doi:10.1023/a:1006486528418

    authors: Beppu T,Yoshida Y,Arai H,Wada T,Suzuki M,Ogawa A,Hakozaki S,Kubo N

    更新日期:2000-09-01 00:00:00

  • Telomere elongation via alternative lengthening of telomeres (ALT) and telomerase activation in primary metastatic medulloblastoma of childhood.

    abstract:PURPOSE:Elongation of telomeres is necessary for tumor cell immortalization and senescence escape; neoplastic cells use to alternative pathways to elongate telomeres: telomerase reactivation or a telomerase-independent mechanism termed alternative lengthening of telomeres (ALT). Telomerase and ALT pathway has been expl...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章

    doi:10.1007/s11060-019-03127-w

    authors: Minasi S,Baldi C,Pietsch T,Donofrio V,Pollo B,Antonelli M,Massimino M,Giangaspero F,Buttarelli FR

    更新日期:2019-05-01 00:00:00

  • Inhibition of matrix degrading enzymes and invasion in human glioblastoma (U87MG) cells by isoflavones.

    abstract::Glioblastoma multiforme is a primary brain tumor associated with extensive invasion into surrounding brain tissue. Matrix metalloproteinases (MMPs) and urokinase plasminogen activation (uPA) system are shown to be involved in tumor invasion as they help in degradation of extracellular matrix (ECM) proteins and thus as...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章

    doi:10.1007/s11060-006-9126-0

    authors: Puli S,Lai JC,Bhushan A

    更新日期:2006-09-01 00:00:00

  • Efficacy and safety of bevacizumab in active brain metastases from non-small cell lung cancer.

    abstract::Bevacizumab is effective for the treatment of non-small cell lung cancer (NSCLC). Ongoing trials are exploring the safety of bevacizumab in patients with inactive, previously treated brain metastases. However, bevacizumab safety and efficacy in the treatment of active brain metastases is unknown. Bevacizumab received ...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章

    doi:10.1007/s11060-010-0200-2

    authors: De Braganca KC,Janjigian YY,Azzoli CG,Kris MG,Pietanza MC,Nolan CP,Omuro AM,Holodny AI,Lassman AB

    更新日期:2010-12-01 00:00:00

  • Alterations of cell cycle regulators in gliomatosis cerebri.

    abstract::Gliomatosis cerebri (GC) is regarded as a rare glial neoplasm of unknown origin, and a detailed analysis of molecular alterations underlying this disease has started only recently. However, because GC characteristically affects large parts of the brain and spinal cord, the distribution of genetic alterations may be hi...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章

    doi:10.1007/s11060-004-2061-z

    authors: Mawrin C,Kirches E,Schneider-Stock R,Boltze C,Vorwerk CK,von Mawrin A,Kirches E,Schneider-Stock R,Boltze C,Vorwerk CK,von Mawrin A,Kirches E,Schneider-Stock R,Boltze C,Vorwerk CK,von Mawrin A,Kirches E,Schneider-Stock R

    更新日期:2005-04-01 00:00:00

  • A cure is possible: a study of 10-year survivors of brain metastases.

    abstract::Little is known on the natural history, recurrence patterns, neurocognitive outcomes and prognostic factors associated with survival in long-term survivors (≥10 years) from brain metastasis (BM). In this study, the records of 1953 patients who underwent treatment for BM with a potential for ≥10 years of follow-up were...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章

    doi:10.1007/s11060-016-2208-8

    authors: Kotecha R,Vogel S,Suh JH,Barnett GH,Murphy ES,Reddy CA,Parsons M,Vogelbaum MA,Angelov L,Mohammadi AM,Stevens GHJ,Peereboom DM,Ahluwalia MS,Chao ST

    更新日期:2016-09-01 00:00:00

  • Up-front temozolomide in elderly patients with anaplastic oligodendroglioma and oligoastrocytoma.

    abstract::Optimal treatment of anaplastic oligodendroglial tumors (AOT) in elderly patients is debatable. We report a retrospective study of 44 consecutive patients aged 70 years or older [median age: 74 years; median Karnofsky performance status (KPS): 70] treated with up-front chemotherapy using temozolomide (TMZ) at conventi...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章

    doi:10.1007/s11060-010-0264-z

    authors: Ducray F,del Rio MS,Carpentier C,Psimaras D,Idbaih A,Dehais C,Kaloshi G,Mokhtari K,Taillibert S,Laigle-Donadey F,Omuro A,Sanson M,Delattre JY,Hoang-Xuan K

    更新日期:2011-02-01 00:00:00

  • Phenotypic change of human cultured meningioma cells.

    abstract::One objection to using cell cultures for studying the proliferation of tumors is the potential for phenotypic changes that may occur in vitro. Here, we compared the antigen pattern expression of cultured meningioma cells with that of the primary tumor. Cell cultures established from 9 intracranial meningiomas and depa...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章

    doi:10.1023/a:1006436903976

    authors: Pallini R,Casalbore P,Mercanti D,Maggiano N,Larocca LM

    更新日期:2000-08-01 00:00:00

  • Diffusion MRI changes in the anterior subventricular zone following chemoradiation in glioblastoma with posterior ventricular involvement.

    abstract:INTRODUCTION:There is growing evidence that the subventricular zone (SVZ) plays a key role in glioblastoma (GBM) tumorigenesis. However, little is known regarding how the SVZ, which is a harbor for adult neural stem cells, may be influenced by chemoradiation. The current diffusion-weighted imaging (DWI) study explored ...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章

    doi:10.1007/s11060-020-03460-5

    authors: Cho N,Wang C,Raymond C,Kaprealian T,Ji M,Salamon N,Pope WB,Nghiemphu PL,Lai A,Cloughesy TF,Ellingson BM

    更新日期:2020-05-01 00:00:00