Tissue uptake of BSH in patients with glioblastoma in the EORTC 11961 phase I BNCT trial.

abstract：:Ewing's sarcoma/primitive neuroectodermal tumor (EWS/PNET) has a characteristic chimeric oncogene EWS-FLI1, which results from chromosomal translocation t (11; 22), that is believed to initiate tumorigenesis of EWS/PNET. However, the specific details of EWS/PNET oncogenesis and exact role of EWS-FLI1 remain largely un...

journal_title：Journal of neuro-oncology

authors： Yang Y,Zhang L,Wei Y,Wang H,Fukuma M,Xu H,Xiong W,Zheng J

更新日期：2008-11-01 00:00:00

abstract：:The high incidence of gliomas in Li-Fraumeni families and the high frequency of somatic p53 mutations in sporadic glial tumors have raised the possibility that germline p53 mutations could play an important role in familial aggregation of gliomas. In the present study, 18 families with two or more gliomas were screene...

journal_title：Journal of neuro-oncology

authors： Paunu N,Syrjäkoski K,Sankila R,Simola KO,Helén P,Niemelä M,Matikainen M,Isola J,Haapasalo H

更新日期：2001-12-01 00:00:00

abstract：:Ependymoma is the third most common brain tumor in children, but there is a paucity of large studies with more than 10 years of follow-up examining the long-term survival and recurrence patterns of this disease. We conducted a retrospective chart review of 103 pediatric patients with WHO Grades II/III intracranial epe...

journal_title：Journal of neuro-oncology

authors： Marinoff AE,Ma C,Guo D,Snuderl M,Wright KD,Manley PE,Al-Sayegh H,Sinai CE,Ullrich NJ,Marcus K,Haas-Kogan D,Goumnerova L,London WB,Kieran MW,Chi SN,Fangusaro J,Bandopadhayay P

更新日期：2017-10-01 00:00:00

abstract：:This study investigated a single institution's experience with volumetric modulated arc therapy (VMAT) directed stereotactic ablative body radiotherapy (SABR) for vertebral metastases. From 2010 to 2014, 95 lesions of spinal metastases in 73 patients were treated with SABR using VMAT. Clinical local control, pain leve...

journal_title：Journal of neuro-oncology

authors： Gestaut MM,Thawani N,Kim S,Gutti VR,Jhavar S,Deb N,Morrow A,Ward RA,Huang JH,Patel M

更新日期：2017-05-01 00:00:00

abstract：:Children with pontine glioma usually present classically with ataxia, motor deficits and cranial nerve palsies. The pons has generally not been regarded as a structure that mediates complex affective behaviour. However, we report nine children who either at the time of presentation or progression demonstrated marked b...

journal_title：Journal of neuro-oncology

authors： Hargrave DR,Mabbott DJ,Bouffet E

更新日期：2006-05-01 00:00:00

abstract：:The aim of this study was to assess the effectiveness of adding viral vector-mediated gene therapy with herpes simplex virus thymidine kinase (HSV-tk) to standard treatment, in comparison with standard treatment alone to treat patients with high-grade gliomas (HGGs). A literature search of the databases PubMed, Embase...

journal_title：Journal of neuro-oncology

authors： Zhao F,Tian J,An L,Yang K

更新日期：2014-06-01 00:00:00

abstract：:Diffuse invasion of the brain by tumor cells is a hallmark of human glioblastomas and a major cause for the poor prognosis of these tumors. This phenomenon is only partially reproduced by rodent models of gliomas that display a very high rate of proliferation and limited cell migration. We have analyzed the developmen...

journal_title：Journal of neuro-oncology

authors： Guillamo JS,Lisovoski F,Christov C,Le Guérinel C,Defer GL,Peschanski M,Lefrançois T

更新日期：2001-05-01 00:00:00

abstract：:Six children (ages 2 to 14 years) with recurrent or poor risk primary brain tumors were treated with the '8 drugs in 1 day' chemotherapy regimen. As renal function deteriorated (median after five cycles), carboplatin was substituted in place of cisplatin at a median dose of 300 mg/m2 as a one hour infusion at hour thr...

journal_title：Journal of neuro-oncology

authors： Chan KW,Fryer CJ,Steinbok P

更新日期：1990-10-01 00:00:00

abstract：:This case study describes the long-term course of behavioral alterations and MRI findings in a patient with a combined limbic and cerebellar paraneoplastic syndrome, which was associated with a squamous lung carcinoma. Clinical equivalents were cerebellar ataxia, as well as severe anterograde memory loss, frontal exec...

journal_title：Journal of neuro-oncology

authors： Benke T,Wagner M,Pallua AK,Muigg A,Stockhammer G

更新日期：2004-01-01 00:00:00

abstract：:Ionizing radiation plays a major role in the treatment of brain tumors, but side-effects may restrict the efficacy of therapy. In the present study, our goals were to establish whether the administration of L-alpha-glycerylphosphorylcholine (GPC) can moderate or prevent any of the irradiation-induced functional and mo...

journal_title：Journal of neuro-oncology

authors： Plangár I,Szabó ER,Tőkés T,Mán I,Brinyiczki K,Fekete G,Németh I,Ghyczy M,Boros M,Hideghéty K

更新日期：2014-09-01 00:00:00

abstract：INTRODUCTION:To evaluate the prognostic value of the Glasgow Prognostic Score (GPS), the combination of C-reactive protein (CRP) and albumin, in glioblastoma multiforme (GBM) patients treated with radiotherapy (RT) and concurrent plus adjuvant temozolomide (GPS). METHODS:Data of newly diagnosed GBM patients treated wi...

journal_title：Journal of neuro-oncology

authors： Topkan E,Selek U,Ozdemir Y,Yildirim BA,Guler OC,Ciner F,Mertsoylu H,Tufan K

更新日期：2018-09-01 00:00:00

abstract：:Latino Americans are a rapidly growing ethnic group in the United States but studies of glioblastoma in this population are limited. We have evaluated characteristics of 21,184 glioblastoma patients from the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute. This SEER data fro...

journal_title：Journal of neuro-oncology

authors： Shabihkhani M,Telesca D,Movassaghi M,Naeini YB,Naeini KM,Hojat SA,Gupta D,Lucey GM,Ontiveros M,Wang MW,Hanna LS,Sanchez DE,Mareninov S,Khanlou N,Vinters HV,Bergsneider M,Nghiemphu PL,Lai A,Liau LM,Cloughesy TF,Yon

更新日期：2017-04-01 00:00:00

abstract：:The soft agar technique for culturing human clonogenic tumor cells has been usefully applied for predicting individual clinical responses to chemotherapy, for screening of new antineoplastic drugs, and in basic biological research. The counting of colonies formed by clonogenic cells is, however, a rather time consumin...

journal_title：Journal of neuro-oncology

authors： Unsgaard G,Larsen B,Dalen A,Vik R,Ringkjøb R

更新日期：1985-01-01 00:00:00

abstract：:When SK-N-BE(2) human neuroblastoma cells were exposed for 1h to growth medium supplemented with [14C]arachidonic acid (AA) at final concentrations ranging from 1 microM to 100 microM, an amount of this fatty acid was uptaken ranging form a 2% to a 120% of that present in cells at steady state. As more [14C]AA was upt...

journal_title：Journal of neuro-oncology

authors： Spinedi A

更新日期：1997-01-01 00:00:00

abstract：:Pituitary metastases are uncommon, ranging from 1 to 5 % of all metastases. Between 10 and 30 % of pituitary lesions are symptomatic responsible for diabetes insipidus, visual field defect or cranial nerve palsy. Primary sites are lung or breast in two-thirds of cases. There is no current reference concerning treatmen...

journal_title：Journal of neuro-oncology

authors： Gilard V,Alexandru C,Proust F,Derrey S,Hannequin P,Langlois O

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Erlotinib and Gefitinib (EGFRi) are small molecules specifically inhibiting epidermal growth factor receptor (EGFR). We present here data of an exploratory study evaluating EGFRi monotherapy in patients with recurrent or progressive malignant glioma. PATIENTS:21 patients with recurrent or progressive mali...

journal_title：Journal of neuro-oncology

authors： Preusser M,Gelpi E,Rottenfusser A,Dieckmann K,Widhalm G,Dietrich W,Bertalanffy A,Prayer D,Hainfellner JA,Marosi C

更新日期：2008-09-01 00:00:00

abstract：:The main problem in the treatment of malignant astrocytomas is their invasive behaviour. Successful resection of the main tumour mass cannot prevent recurrence due to single cells invading the surrounding brain parenchyma at the time of diagnosis. The classical combination therapy, PCV (Procarbazine, CCNU and Vincrist...

journal_title：Journal of neuro-oncology

authors： Kinsella P,Clynes M,Amberger-Murphy V

更新日期：2011-01-01 00:00:00

abstract：:A better understanding of the relationship between glioblastomas molecular subtypes and radio-chemotherapy is needed for the development of individualized strategies. In this study, we aimed to assess whether non-homologous end-joining (NHEJ) protein expression is associated and could predict responses to treatment of...

journal_title：Journal of neuro-oncology

authors： Pinel B,Duchesne M,Godet J,Milin S,Berger A,Wager M,Karayan-Tapon L

更新日期：2017-04-01 00:00:00

abstract：:Neural cell adhesion molecule (NCAM) is down-regulated during periods of embryological cell migration and may be important in local tumor migration or metastases. Conflicting information exists in the literature about NCAM expression in human glial tumors and little is known about its expression in human brain metasta...

journal_title：Journal of neuro-oncology

authors： Kleinschmidt-DeMasters BK,Orr EA,Savelieva E,Owens GC,Kruse CA

更新日期：1999-01-01 00:00:00

abstract：:A retrospective evaluation of single agent bevacizumab in adults with recurrent glioblastoma (GBM) with an objective of determining progression free survival (PFS). There is no standard therapy for recurrent GBM after failure of alkylator-based chemotherapy. A total of 50 adults, ages 36-70 years (median 64), with rec...

journal_title：Journal of neuro-oncology

authors： Chamberlain MC,Johnston SK

更新日期：2010-01-01 00:00:00

abstract：:Glioblastoma multiforme is the most frequent and aggressive primary brain tumor. A strong rationale to identify innovative approaches to treat these tumors is required since treatment failures result in local recurrences and median survivals range from 9 to 12 months. Glioma cells are reported to have less mitochondri...

journal_title：Journal of neuro-oncology

authors： Huang Z,Jiang J,Belikova NA,Stoyanovsky DA,Kagan VE,Mintz AH

更新日期：2010-10-01 00:00:00

abstract：:Previous studies have shown an inverse association between allergies and glioma risk; however, results for associations between single nucleotide polymorphisms (SNPs) of allergy-related genes and glioma risk have been inconsistent and restricted to a small number of SNPs. The objective of this study was to examine the...

journal_title：Journal of neuro-oncology

authors： Backes DM,Siddiq A,Cox DG,Calboli FC,Gaziano JM,Ma J,Stampfer M,Hunter DJ,Camargo CA,Michaud DS

更新日期：2013-06-01 00:00:00

abstract：:This study aims to evaluate the cost-effectiveness of surgical resection (S) and Cesium-131 (Cs-131) [S + Cs-131] intraoperative brachytherapy versus S and stereotactic radiosurgery (SRS) [S + SRS] for the treatment of brain metastases. Treatment records as well as hospital and outpatient charts of 49 patients with br...

journal_title：Journal of neuro-oncology

authors： Wernicke AG,Yondorf MZ,Parashar B,Nori D,Clifford Chao KS,Boockvar JA,Pannullo S,Stieg P,Schwartz TH

更新日期：2016-03-01 00:00:00

abstract：INTRODUCTION:Low-grade glioma (LGG) represent the most common pediatric central nervous system tumor. When total surgical resection is not feasible, chemotherapy is first-line therapy in children. Multiple pediatric LGG chemotherapy regimens have been investigated with variable 2-year event free survival (EFS) rates of...

journal_title：Journal of neuro-oncology

authors： Nellan A,Wright E,Campbell K,Davies KD,Donson AM,Amani V,Judd A,Hemenway MS,Raybin J,Foreman NK,Rush S,Dorris K

更新日期：2020-07-01 00:00:00

abstract：:One objection to using cell cultures for studying the proliferation of tumors is the potential for phenotypic changes that may occur in vitro. Here, we compared the antigen pattern expression of cultured meningioma cells with that of the primary tumor. Cell cultures established from 9 intracranial meningiomas and depa...

journal_title：Journal of neuro-oncology

authors： Pallini R,Casalbore P,Mercanti D,Maggiano N,Larocca LM

更新日期：2000-08-01 00:00:00

abstract：:A prospective study was performed in patients treated with cisplatin to evaluate the occurrence and degree of central, peripheral and autonomic neuropathy and to determine the most accurate method to study this neuropathy. Twelve patients were examined before, during and after treatment. Evaluation included neurologic...

journal_title：Journal of neuro-oncology

authors： Boogerd W,ten Bokkel Huinink WW,Dalesio O,Hoppenbrouwers WJ,van der Sande JJ

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND:A prospective Phase II study of CPT-11 in adult patients with recurrent supratentorial glioblastoma multiforme (GBM). METHODS:Forty patients (25 men, 15 women) ages 32-71 years (median 59), with recurrent GBM were treated. All patients had previously been treated with surgery and involved field radiotherapy...

journal_title：Journal of neuro-oncology

authors： Chamberlain MC

更新日期：2002-01-01 00:00:00

abstract：:Choroid plexus carcinoma (CPC) arising in the infant poses several treatment dilemmas. The tumor is often not totally resectable at presentation given its large size and tendency to invade adjacent brain. Because of its predisposition to regrow and metastasize, some form of postoperative cytotoxic therapy is required....

journal_title：Journal of neuro-oncology

authors： Allen J,Wisoff J,Helson L,Pearce J,Arenson E

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:Gliomas are the most common cancer of the brain, with a poor prognosis in particular for glioblastoma. In 2014, a study suggested reduced survival in relation to latency of mobile phone use among glioblastoma patients. A joint epidemiological/experimental project to study effects of RF-EMF on tumor development ...

journal_title：Journal of neuro-oncology

authors： Olsson A,Bouaoun L,Auvinen A,Feychting M,Johansen C,Mathiesen T,Melin B,Lahkola A,Larjavaara S,Villegier AS,Byrnes G,Deltour I,Schüz J

更新日期：2019-01-01 00:00:00

abstract：PURPOSE:To evaluate the effectiveness of complete resection and postoperative radiotherapy in spinal cord ependymomas. METHODS AND MATERIALS:We conducted a retrospective study over 20 patients (13 males and 7 females) with histologically confirmed spinal cord ependymomas between July 1985 and April 2001. Among them, 1...

journal_title：Journal of neuro-oncology

authors： Lin YH,Huang CI,Wong TT,Chen MH,Shiau CY,Wang LW,Ming-Tak Ho D,Yen SH

更新日期：2005-01-01 00:00:00