Single-nucleotide polymorphisms of allergy-related genes and risk of adult glioma.

abstract：:Hot spot mutations in the promoter region of telomerase reverse transcriptase (TERT promoter mutations) occur frequently in tumors of neuroectodermal origin such as melanoma and glioma. Many of these tumors are of neuroectodermal or ectomesenchymal origin which is suggestive of TERT promoter mutations playing a role i...

journal_title：Journal of neuro-oncology

authors： Dubbink HJ,Bakels H,Post E,Zwarthoff EC,Verdijk RM

更新日期：2014-11-01 00:00:00

abstract：:Glioblastomas are aggressive brain tumors that frequently recur in the subventricular zone (SVZ) despite maximal treatment. The purpose of this study was to evaluate imaging patterns of subventricular progression and impact of recurrent subventricular tumor involvement and radiation dose to patient outcome. Retrospect...

journal_title：Journal of neuro-oncology

authors： Weinberg BD,Boreta L,Braunstein S,Cha S

更新日期：2018-07-01 00:00:00

abstract：:Ependymomas are glial neoplasms originating from the wall of the ventricles or from the spinal canal. The significance of histopathological features in accurately predicting biological behavior is still debated. Moreover, key molecular events in the pathogenesis of ependymoma are yet to be defined. The main objective ...

journal_title：Journal of neuro-oncology

authors： Rousseau A,Idbaih A,Ducray F,Crinière E,Fèvre-Montange M,Jouvet A,Delattre JY

更新日期：2010-05-01 00:00:00

abstract：:We proposed to identify the efficacy of an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) using whole brain radiotherapy (WBRT)/stereotactic radiosurgery (SRS)/surgery in brain metastases from patients with non-small cell lung cancer (NSCLC) and clarify the association between treatment outcom...

journal_title：Journal of neuro-oncology

authors： Cai L,Zhu JF,Zhang XW,Lin SX,Su XD,Lin P,Chen K,Zhang LJ

更新日期：2014-11-01 00:00:00

abstract：:The objective of this study was to investigate whether activity and protein expression of ornithine decarboxylase (ODC) the metabolism-rate limiting enzyme of the polyamine biosynthesis, which is involved in the regulation of cellular growth and differentiation, reflects the distinct histopathologic characteristics in...

journal_title：Journal of neuro-oncology

authors： Stenzel W,Röhn G,Miletic H,Radner H,Deckert M,Ernestus RI

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Anaplastic lymphoma kinase (ALK) is expressed in ~ 60% of glioblastomas and conveys tumorigenic functions. Therefore, ALK inhibitory strategies with alectinib are conceivable for patients with glioblastoma. The aims of this preclinical study were to investigate efficacy as well as to understand and potential...

journal_title：Journal of neuro-oncology

authors： Berberich A,Schmitt LM,Pusch S,Hielscher T,Rübmann P,Hucke N,Latzer P,Heßling B,Lemke D,Kessler T,Platten M,Wick W

更新日期：2020-01-01 00:00:00

abstract：:The soft agar technique for culturing human clonogenic tumor cells has been usefully applied for predicting individual clinical responses to chemotherapy, for screening of new antineoplastic drugs, and in basic biological research. The counting of colonies formed by clonogenic cells is, however, a rather time consumin...

journal_title：Journal of neuro-oncology

authors： Unsgaard G,Larsen B,Dalen A,Vik R,Ringkjøb R

更新日期：1985-01-01 00:00:00

abstract：:The aim of the present study was to investigate the localization and distribution of the putative brain tumour stem cell marker CD133 in formalin fixed paraffin embedded astrocytomas. A retrospective analysis of 114 grade II, III and IV astrocytomas was undertaken. The immunohistochemical expression of CD133 in paraff...

journal_title：Journal of neuro-oncology

authors： Christensen K,Schrøder HD,Kristensen BW

更新日期：2008-11-01 00:00:00

abstract：:p53 mutations are the most frequently detected genetic alterations of gliomas, appearing in a similar proportion of low and high grade astrocytomas, while the amplification of epidermal growth factor receptor (EGFR) gene appears mainly in glioblastomas. Thus, these changes seem to delineate two subgroups of high grade...

journal_title：Journal of neuro-oncology

authors： Kordek R,Biernat W,Alwasiak J,Maculewicz R,Yanagihara R,Liberski PP

更新日期：1995-10-01 00:00:00

abstract：OBJECTIVES:To study the inhibitory effects of plasmid-based siRNA targeting human epidermal growth factor receptor (EGFR) on tumor proliferation and invasion of TJ905 glioblastoma cells. METHODS:Two siRNA expression constructs targeting human EGFR extracellular domain (516-536) and catalytic domain (2400-2420) were tr...

journal_title：Journal of neuro-oncology

authors： Kang CS,Pu PY,Li YH,Zhang ZY,Qiu MZ,Huang Q,Wang GX

更新日期：2005-09-01 00:00:00

abstract：PURPOSE:A prospective study of patients with glioma was carried out. Special attention was paid to the first seizure, to the histology, and to the efficacy and prophylactic role of antiepileptic drugs (AEDs). Prognostic factors were analyzed. METHODS:Between February 1st 2004 and April 1st 2006 patients who underwent ...

journal_title：Journal of neuro-oncology

authors： Rosati A,Tomassini A,Pollo B,Ambrosi C,Schwarz A,Padovani A,Bonetti B

更新日期：2009-07-01 00:00:00

abstract：:ERCC1 and ERCC2 have been known to belong to the nucleotide excision repair (NER) pathway and are essential to the repair of cisplatin DNA adducts. In the present study, we have examined the potential correlation of ERCC1, ERCC2 mRNA expression and single nucleotide polymorphism (SNP) to chemotherapy drug cytotoxicity...

journal_title：Journal of neuro-oncology

authors： Chen H,Shao C,Shi H,Mu Y,Sai K,Chen Z

更新日期：2007-05-01 00:00:00

abstract：:Malignant gliomas (MG) are very aggressive tumors. In an effort to improve the outcome, the patients receive multi-modal therapies such as surgery, radiation and chemotherapy (temozolomide followed in many cases by bevacizumab). The survivors are affected by multiple learning and memory deficits. Greater deterioration...

journal_title：Journal of neuro-oncology

authors： Nolen SC,Lee B,Shantharam S,Yu HJ,Su L,Billimek J,Bota DA

更新日期：2016-09-01 00:00:00

abstract：:The function of proteases in brain tumor invasion is currently not well established. For tumors of epithelial and fibromatous origin collagenase production can enhance the invasive capacity of cells to penetrate basement membranes. We showed previously that a c-Ha-ras transformed glial cell line (CxT24neo3) invaded ha...

journal_title：Journal of neuro-oncology

authors： Boghaert ER,Chan SK,Zimmer C,Grobelny D,Galardy RE,Vanaman TC,Zimmer SG

更新日期：1994-01-01 00:00:00

abstract：:To evaluate diagnostic accuracy of perfusion weighted imaging (PWI) and positron emission tomography (PET) using an integrated PET/MR system in tumor grading as well as in differentiating recurrent tumor from treatment-induced effects (TIE) in brain tumor patients. Twenty patients (Group A: treatment naïve, 9 patients...

journal_title：Journal of neuro-oncology

authors： Sacconi B,Raad RA,Lee J,Fine H,Kondziolka D,Golfinos JG,Babb JS,Jain R

更新日期：2016-04-01 00:00:00

abstract：:Chordomas constitute about 1% of intracranial tumors. They are generally extradural destroying the bone. Intradural chordomas are very rare. We present one such case of a clival intradural chordoma who presented with a left trigeminal nerve sensory neuropathy. The lesion was totally excised uneventfully via a retromas...

journal_title：Journal of neuro-oncology

authors： Bhat DI,Yasha M,Rojin A,Sampath S,Shankar SK

更新日期：2010-01-01 00:00:00

abstract：:Approximately 200,000 men will be diagnosed with prostate cancer in 1994. While localized disease is potentially curable with surgery or radiation therapy, metastatic disease is incurable. The most frequent site of metastasis is bone. Spinal cord compression occurs in approximately 7% of men with prostate cancer. Back...

journal_title：Journal of neuro-oncology

authors： Osborn JL,Getzenberg RH,Trump DL

更新日期：1995-01-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) and its receptors (VEGFR) are central components in the development and progression of glioblastoma. To investigate if genetic variation in VEGF and VEGFR2 is associated with glioblastoma prognosis, we examined blood samples from 154 glioblastoma cases collected in Sweden and ...

journal_title：Journal of neuro-oncology

authors： Sjöström S,Wibom C,Andersson U,Brännström T,Broholm H,Johansen C,Collatz-Laier H,Liu Y,Bondy M,Henriksson R,Melin B

更新日期：2011-09-01 00:00:00

abstract：:We have developed an in vitro assay for Natural Killer (NK) cell cytolysis of and binding to substrate attached human glioma and fetal brain cells. The monolayer cells were labeled with [51Cr] and the effectors were directly sedimented onto these substrate attached target cells. Using this method we screened several g...

journal_title：Journal of neuro-oncology

authors： Kazimer RM,Whisler RL,Stephens RE,Pearl DK,Yates AJ

更新日期：1989-07-01 00:00:00

abstract：:Intracranial Hodgkin's lymphoma (ICHL) in the HIV positive population is a rarely reported event with only three prior cases reported in the literature. In these prior reports, the outcome of the patients was uncertain or very poor. We report here the case of an HIV seropositive patient with an isolated intracranial r...

journal_title：Journal of neuro-oncology

authors： Ramchandar K,Verhey LH,Jha NK,Murty NK,McMillan W

更新日期：2008-08-01 00:00:00

abstract：:The main problem in the treatment of malignant astrocytomas is their invasive behaviour. Successful resection of the main tumour mass cannot prevent recurrence due to single cells invading the surrounding brain parenchyma at the time of diagnosis. The classical combination therapy, PCV (Procarbazine, CCNU and Vincrist...

journal_title：Journal of neuro-oncology

authors： Kinsella P,Clynes M,Amberger-Murphy V

更新日期：2011-01-01 00:00:00

abstract：:Glioblastoma (GBM) is the most common and deadly form of primary brain tumor with a median survival of eleven months, despite use of extensive chemotherapy, radiotherapy and surgery. We have previously shown that nuclear factor-kappa B (NF-κB) is aberrantly expressed in GBM tumors and primary cell lines derived from t...

journal_title：Journal of neuro-oncology

authors： Raychaudhuri B,Vogelbaum MA

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:A previous study confirmed that a novel splicing variant of large vascular endothelial growth factor (L-VEGF) termed L-VEGF144, a nucleolus protein, is found in glioblastoma cells and specimens, but the actual biological function and clinical significance of L-VEGF144 remain unclear. METHODS:In this study...

journal_title：Journal of neuro-oncology

authors： Cheng WY,Shen CC,Chiao MT,Liang YJ,Mao TF,Liu BS,Chen JP

更新日期：2018-10-01 00:00:00

abstract：:We observed three neoplasms with completely different histologies: malignant fibrous histiocytoma (MFH), atypical meningioma (AM), and glioblastoma (GB), developing in a patient with Li-Fraumeni syndrome. By using a combined molecular approach we performed molecular characterization of all three tumours. Data obtained...

journal_title：Journal of neuro-oncology

authors： Rieske P,Zakrzewska M,Biernat W,Bartkowiak J,Zimmermann A,Liberski PP

更新日期：2005-01-01 00:00:00

abstract：:Once considered a "no man's land" especially when invaded by a diffuse low grade glioma (DLGG), the insula remains to this day a surgical challenge. Surgery for insular DLGG involves consideration of its hidden location under the potentially eloquent operculae, the proximity to vascular tree and high density of functi...

journal_title：Journal of neuro-oncology

authors： Michaud K,Duffau H

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The postoperative cerebellar mutism syndrome (CMS) is an unique acute postoperative complication characterized by transient decrease in speech output (often mutism), apathy, irritability as well as global cerebellar dysfunction. As much as 25% of patients undergoing a resection of a cerebellar...

journal_title：Journal of neuro-oncology

authors： Siffert J,Poussaint TY,Goumnerova LC,Scott RM,LaValley B,Tarbell NJ,Pomeroy SL

更新日期：2000-05-01 00:00:00

abstract：:Signal transducers and activators of transcription 3 (STAT3) are activated by various cytokines and oncogenes; however, the activity and pathogenesis of STAT3 in diffuse large B cell lymphoma of the central nervous system have not been thoroughly elucidated. We investigated the phosphorylation levels of STAT3 in 40 sp...

journal_title：Journal of neuro-oncology

authors： Mizowaki T,Sasayama T,Tanaka K,Mizukawa K,Takata K,Nakamizo S,Tanaka H,Nagashima H,Nishihara M,Hirose T,Itoh T,Kohmura E

更新日期：2015-09-01 00:00:00

abstract：:The utility of current response criteria has not been established in anaplastic astrocytoma (AA). We retrospectively reviewed MR images for 20 patients with AA and compared RANO-based approaches to clinician impression described as follow: (1) standard RANO-based criteria met by growth of or development of new enhanci...

journal_title：Journal of neuro-oncology

authors： Kazda T,Hardie JG,Pafundi DH,Kaufmann TJ,Brinkmann DH,Laack NN

更新日期：2015-03-01 00:00:00

abstract：:Despite advances in surgery, chemotherapy and radiotherapy, the outcomes of patients with GBM have not significantly improved. Tumor recurrence in the resection margins occurs in more than 80% of cases indicating aggressive treatment modalities, such as gene therapy are warranted. We have examined photochemical intern...

journal_title：Journal of neuro-oncology

authors： Wang F,Zamora G,Sun CH,Trinidad A,Chun C,Kwon YJ,Berg K,Madsen SJ,Hirschberg H

更新日期：2014-05-01 00:00:00

abstract：:A list of active investigative brain tumor protocols in North America is presented. The fact that there are 138 protocols (and certainly some have been missed) indicates the diversity and intensity of research into this difficult problem. The geographic diversity of institutions involved in brain tumor clinical trials...

journal_title：Journal of neuro-oncology

authors： Bernstein M,Rutka J

更新日期：1993-09-01 00:00:00