Single nucleotide polymorphisms and expression of ERCC1 and ERCC2 vis-à-vis chemotherapy drug cytotoxicity in human glioma.

abstract：:Retaspimycin hydrochloride (IPI-504), an Hsp90 (heat shock protein 90) inhibitor, has shown activity in multiple preclinical cancer models, such as lung, breast and ovarian cancers. However, its biological effects in gliomas and normal brain derived cellular populations remain unknown. In this study, we profiled the e...

journal_title：Journal of neuro-oncology

authors： Di K,Keir ST,Alexandru-Abrams D,Gong X,Nguyen H,Friedman HS,Bota DA

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:The poor results from treatment of high grade glioma prompted us to explore new protocols involving concurrent radio-chemotherapy. Our primary objective was to evaluate the feasibility of very early postoperative chemotherapy with BCNU, concurrent radio-chemotherapy with carboplatin and teniposide, and post-rad...

journal_title：Journal of neuro-oncology

authors： Brandes AA,Rigon A,Zampieri P,Scelzi E,Amistà P,Berti F,Rotilio A,Gardiman M,Fiorentino MV

更新日期：1996-12-01 00:00:00

abstract：:Despite total macroscopic resection of meningiomas relapses do occur in these tumours, possibly because of microscopic clusters of neoplastic cells left in the dura mater or in the arachnoid membrane. The invasiveness of the neoplastic cells of human meningiomas has been related to expression of matrix-metalloproteina...

journal_title：Journal of neuro-oncology

authors： Barresi V,Vitarelli E,Tuccari G,Barresi G

更新日期：2011-04-01 00:00:00

abstract：:We used double-label quantitative autoradiography to measure blood flow (with 131I-iodoantipyrine) and blood-to-tissue transport of 14C-alpha aminoisobutyric acid, AIB) in thirteen 9L gliosarcomas transplanted intracerebrally into Fischer-344 rats. Microscopically, the typical pattern of 9L tumor growth was observed: ...

journal_title：Journal of neuro-oncology

authors： Fross RD,Warnke PC,Groothuis DR

更新日期：1991-12-01 00:00:00

abstract：:The aim of this investigation was to define characteristic properties of cellular energy metabolism in meningiomas in vitro dependent on the histological subtype. We analysed marker enzymes of representative metabolic pathways localized in the mitochondria (respiratory chain, citric acid cycle, beta-oxidation of fatty...

journal_title：Journal of neuro-oncology

authors： Herting B,Meixensberger J,Roggendorf W,Reichmann H

更新日期：2003-11-01 00:00:00

abstract：:Between January 1985 and December 2000, 916 patients with brain metastases were treated with whole brain radiation therapy (WBRT) at the Department of Radiotherapy, University Hospital Freiburg. In 47 patients, a primary tumor could not be identified (cancer of unknown primary (CUP)). Sixteen patients had a solitary b...

journal_title：Journal of neuro-oncology

authors： Bartelt S,Lutterbach J

更新日期：2003-09-01 00:00:00

abstract：:Immune checkpoint inhibitors have demonstrated remarkable benefits in cancer patients. However, concern regarding toxicity in the setting of stereotactic radiosurgery (SRS) is often raised. In this study, we characterize radiation necrosis (RN) following immunotherapy and SRS. Melanoma patients treated with SRS and an...

journal_title：Journal of neuro-oncology

authors： Fang P,Jiang W,Allen P,Glitza I,Guha N,Hwu P,Ghia A,Phan J,Mahajan A,Tawbi H,Li J

更新日期：2017-07-01 00:00:00

abstract：PURPOSE:To analyze patterns of failure according to treatment modalities and evaluate the adequacy of an institution's current volume of postoperative radiotherapy (PORT) for World Health Organization (WHO) grade II or III meningiomas. PATIENTS AND METHODS:Data of 98 patients treated by either surgery and PORT (PORT g...

journal_title：Journal of neuro-oncology

authors： Lee JJB,Lee J,Yoon HI,Kim SH,Cho J,Lee KS,Chang JH,Suh CO

更新日期：2019-09-01 00:00:00

abstract：:Following surgical resection for brain metastases, fractionated stereotactic radiotherapy (FSRT) has been used as an alternative to single dose treatment for large cavities and to reduce risks of late toxicity. The purpose of this study was to evaluate the outcomes of patients treated with FSRT to the post-operative b...

journal_title：Journal of neuro-oncology

authors： Ahmed KA,Freilich JM,Abuodeh Y,Figura N,Patel N,Sarangkasiri S,Chinnaiyan P,Yu HH,Etame AB,Rao NG

更新日期：2014-05-01 00:00:00

abstract：:Papillary meningioma is a rare subtype of meningioma that often behaves aggressively. In order to characterize factors that may influence this behavior, we chose to compare MIB-1 labeling index (LI) and telomerase RNA localization (hTR) in papillary meningiomas, meningiomas, and atypical meningiomas. LI is now often u...

journal_title：Journal of neuro-oncology

authors： Rushing EJ,Colvin SM,Gazdar A,Miura N,White CL 3rd,Coimbra C,Burns DK

更新日期：1999-01-01 00:00:00

abstract：:Twenty-eight consecutive patients were given high-dose dexamethasone (96 mg i.v. loading dose, decreasing doses to zero in 14 days) and radiotherapy for epidural spinal cord compression due to malignant disease. There were eight events classified as side effects of the dexamethasone treatment. Four of these were consi...

journal_title：Journal of neuro-oncology

authors： Heimdal K,Hirschberg H,Slettebø H,Watne K,Nome O

更新日期：1992-02-01 00:00:00

abstract：:This adjunct to a prospective phase II blinded study of 48 patients with recurrent malignant glioma evaluated the predictive reliability of an extreme drug resistance (EDR) to identify clinical resistance to irinotecan (CPT-11), using fresh tumor biopsies obtained from recurrent patients immediately prior to their fir...

journal_title：Journal of neuro-oncology

authors： Parker RJ,Fruehauf JP,Mehta R,Filka E,Cloughesy T

更新日期：2004-02-01 00:00:00

abstract：:Hepatoma-derived growth factor (HDGF) is a neurotrophic factor found in mouse spinal cord and hippocampal neurons. In various malignant tumors, the role of HDGF in tumor progression and its use as a diagnostic biomarker or therapeutic target have been extensively explored. However, the prognostic function and mitogeni...

journal_title：Journal of neuro-oncology

authors： Hsu SS,Chen CH,Liu GS,Tai MH,Wang JS,Wu JC,Kung ML,Chan EC,Liu LF

更新日期：2012-03-01 00:00:00

abstract：QUESTION:Should patients with newly-diagnosed metastatic brain tumors undergo open surgical resection versus whole brain radiation therapy (WBRT) and/or other treatment modalities such as radiosurgery, and in what clinical settings? Target population These recommendations apply to adults with a newly diagnosed single b...

journal_title：Journal of neuro-oncology

authors： Kalkanis SN,Kondziolka D,Gaspar LE,Burri SH,Asher AL,Cobbs CS,Ammirati M,Robinson PD,Andrews DW,Loeffler JS,McDermott M,Mehta MP,Mikkelsen T,Olson JJ,Paleologos NA,Patchell RA,Ryken TC,Linskey ME

更新日期：2010-01-01 00:00:00

abstract：:ATP-binding cassette transporters (ABC transporters) regulate traffic of multiple compounds, including chemotherapeutic agents, through biological membranes. They are expressed by multiple cell types and have been implicated in the drug resistance of some cancer cells. Despite significant research in ABC transporters ...

journal_title：Journal of neuro-oncology

authors： Dréan A,Rosenberg S,Lejeune FX,Goli L,Nadaradjane AA,Guehennec J,Schmitt C,Verreault M,Bielle F,Mokhtari K,Sanson M,Carpentier A,Delattre JY,Idbaih A

更新日期：2018-07-01 00:00:00

abstract：:Medulloblastomas are the most common malignant brain tumors in childhood. Emerging evidence suggests that medulloblastoma comprises at least four distinct diseases (WNT, SHH, Group 3 and 4) with different biology, clinical presentation, and outcome, with especially poor prognosis in Group 3. The tight connection of bi...

journal_title：Journal of neuro-oncology

authors： Milde T,Lodrini M,Savelyeva L,Korshunov A,Kool M,Brueckner LM,Antunes AS,Oehme I,Pekrun A,Pfister SM,Kulozik AE,Witt O,Deubzer HE

更新日期：2012-12-01 00:00:00

abstract：:Pediatric glial tumors differ from adult gliomas in several ways that are of major therapeutic importance. First, the value of extensive tumor resection, which is controversial for malignant intrinsic brain tumors in adults, has been confirmed for a variety of childhood brain tumors, such as supratentorial high-grade ...

journal_title：Journal of neuro-oncology

authors： Pollack IF

更新日期：1999-05-01 00:00:00

abstract：:Various subtypes of intracerebral hamartomas, associated with seizure disorders, have long been described. We describe a cerebral hamartoma placed in the left frontal lobe, associated with drug-resistant epilepsy, composed exclusively of mature oligodendroglial cells. The patient was a 27-year-old right-handed male pr...

journal_title：Journal of neuro-oncology

authors： Marucci G,Giulioni M,Martinoni M,Volpi L,Michelucci R

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVES:To study the inhibitory effects of plasmid-based siRNA targeting human epidermal growth factor receptor (EGFR) on tumor proliferation and invasion of TJ905 glioblastoma cells. METHODS:Two siRNA expression constructs targeting human EGFR extracellular domain (516-536) and catalytic domain (2400-2420) were tr...

journal_title：Journal of neuro-oncology

authors： Kang CS,Pu PY,Li YH,Zhang ZY,Qiu MZ,Huang Q,Wang GX

更新日期：2005-09-01 00:00:00

abstract：:Cranial radiation can impact the cerebral vasculature in many ways, with a wide range of clinical manifestations. The incidence of these late effects including cerebrovascular accidents (CVAs), lacunar lesions, vascular occlusive disease including moyamoya syndrome, vascular malformations, and hemorrhage is not well k...

journal_title：Journal of neuro-oncology

authors： Murphy ES,Xie H,Merchant TE,Yu JS,Chao ST,Suh JH

更新日期：2015-05-01 00:00:00

abstract：:Five quantitative histologic factors, differing linear combinations of 26 reliably recognized histologic features, account for much of the histologic variance in 1068 children with infratentorial neuroglial tumors in the Childhood Brain Tumor Consortium (CBTC) database. In this study, we used the scores on the Spongy,...

journal_title：Journal of neuro-oncology

authors： Gilles FH,Sobel EL,Leviton A,Tavaré CJ

更新日期：1998-08-01 00:00:00

abstract：:There is general agreement that most chemotherapy agents achieve only relatively low concentrations in the normal central nervous system, that the blood-brain barrier is variably disrupted in malignant brain tumors, and that the concentration of chemotherapy drugs in the brain adjacent to tumor is intermediate between...

journal_title：Journal of neuro-oncology

authors： Stewart DJ

更新日期：1994-01-01 00:00:00

abstract：:Cancer related stroke may have different phenotypes from non-cancer stroke, especially in terms of stroke progression and recurrence. We performed a case-control study to identify their incidences and risk factors in cancer related stroke. Between January 2001 and December 2009, we conducted a retrospective review of ...

journal_title：Journal of neuro-oncology

authors： Kim JM,Jung KH,Park KH,Lee ST,Chu K,Roh JK

更新日期：2013-02-01 00:00:00

abstract：:Transfection of primary cultures of human cells with origin of replication deficient SV40 DNA has been carried out by others to generate in vitro models of malignant transformation in vivo. The present work describes progressive alterations in karyotype and phenotype in one such transfected (neuroglial) cell line (SVG...

journal_title：Journal of neuro-oncology

authors： Davey P,Rauth AM,Mason L,Addy L

更新日期：1990-02-01 00:00:00

abstract：:Aberrant activation of Akt is a common finding in adult malignant gliomas, resulting in most cases from mutations or deletions involving PTEN, which allows constitutive Akt phosphorylation. In contrast, we have previously reported that pediatric malignant gliomas, which are morphologically similar to lesions arising i...

journal_title：Journal of neuro-oncology

authors： Pollack IF,Hamilton RL,Burger PC,Brat DJ,Rosenblum MK,Murdoch GH,Nikiforova MN,Holmes EJ,Zhou T,Cohen KJ,Jakacki RI,Children's Oncology Group.

更新日期：2010-09-01 00:00:00

abstract：:Primary germinomas in the spinal cord are very rare with only 15 cases published previously. In this case a 22-year-old woman with urinary incontinence, lumbago, and bilateral leg pain and weakness was found to have a solid tumor in the conus medullaris between the L1 and L2 vertebral bodies. Serum HCG was elevated wi...

journal_title：Journal of neuro-oncology

authors： Takahashi M,Koyama H,Matsubara T,Murata H,Miura K,Nagano A

更新日期：2006-01-01 00:00:00

abstract：:We describe the case of a young man presenting with an extra-nodal, intramedullary non-Hodgkin's lymphoma of the cervical spinal cord. This is a very uncommon presentation of this neoplasm. The patient was treated with craniospinal radiotherapy, with survival for two and a half years before death from recurrent diseas...

journal_title：Journal of neuro-oncology

authors： McDonald AC,Nicoll JA,Rampling R

更新日期：1995-01-01 00:00:00

abstract：:Both cell proliferation and cell death occur simultaneously in tumor tissue, and extent of tumor growth reflects the net balance of these events. We correlated cell proliferation, spontaneous cell death, and alterations in tumor suppressor proteins with one another and with survival of patients with primary astrocytic...

journal_title：Journal of neuro-oncology

authors： Nakamizo A,Inamura T,Ikezaki K,Yoshimoto K,Inoha S,Mizoguchi M,Amano T,Fukui M

更新日期：2002-04-01 00:00:00

abstract：:Carcinomatous meningitis (CM) occurs in less than 10% of cancer patients. Although patients frequently present with a focal complaint, multifocal signs are often found following careful neurological examination. The gold standard for diagnosis remains the demonstration of neoplastic cells in the cerebrospinal fluid. D...

journal_title：Journal of neuro-oncology

authors： McClelland S 3rd,Garcia RE,Monaco SE,Goldman JE,Olson TJ,Kim GH,Petrylak DP,Goodman RR

更新日期：2006-01-01 00:00:00

abstract：:The name of author Do Hoon Lim was incorrect in the initial online publication. The original article has been corrected. ...

journal_title：Journal of neuro-oncology

authors： Wee CW,Kim IH,Park CK,Kim N,Suh CO,Chang JH,Lim DH,Nam DH,Kim IA,Kim CY,Oh YT,Chung WK,Kim SH

更新日期：2020-05-01 00:00:00