Spinal cord compression in prostate cancer.

abstract：INTRODUCTION:To evaluate the prognostic value of the Glasgow Prognostic Score (GPS), the combination of C-reactive protein (CRP) and albumin, in glioblastoma multiforme (GBM) patients treated with radiotherapy (RT) and concurrent plus adjuvant temozolomide (GPS). METHODS:Data of newly diagnosed GBM patients treated wi...

journal_title：Journal of neuro-oncology

authors： Topkan E,Selek U,Ozdemir Y,Yildirim BA,Guler OC,Ciner F,Mertsoylu H,Tufan K

更新日期：2018-09-01 00:00:00

abstract：PURPOSE:Elongation of telomeres is necessary for tumor cell immortalization and senescence escape; neoplastic cells use to alternative pathways to elongate telomeres: telomerase reactivation or a telomerase-independent mechanism termed alternative lengthening of telomeres (ALT). Telomerase and ALT pathway has been expl...

journal_title：Journal of neuro-oncology

authors： Minasi S,Baldi C,Pietsch T,Donofrio V,Pollo B,Antonelli M,Massimino M,Giangaspero F,Buttarelli FR

更新日期：2019-05-01 00:00:00

abstract：PURPOSE:To analyze patterns of failure according to treatment modalities and evaluate the adequacy of an institution's current volume of postoperative radiotherapy (PORT) for World Health Organization (WHO) grade II or III meningiomas. PATIENTS AND METHODS:Data of 98 patients treated by either surgery and PORT (PORT g...

journal_title：Journal of neuro-oncology

authors： Lee JJB,Lee J,Yoon HI,Kim SH,Cho J,Lee KS,Chang JH,Suh CO

更新日期：2019-09-01 00:00:00

abstract：:Neural cell adhesion molecule (NCAM) is a cell surface glycoprotein whose expression may be important in metastatic or local growth of neoplasms. Expression of NCAM in human pituitary adenomas was assessed on snap-frozen and Bouin's and/or formalin-fixed, paraffin-embedded archival tissue using a sensitive alkaline ph...

journal_title：Journal of neuro-oncology

authors： Kleinschmidt-DeMasters BK,Conway DR,Franklin WA,Lillehei KO,Kruse CA

更新日期：1995-01-01 00:00:00

abstract：:Computational modeling shows that intra-arterial delivery is most efficient when the delivered drugs rapidly and avidly bind to the target site. The cell-penetrating peptide trans-activator of transcription (TAT) is a candidate carrier molecule that could mediate such specificity for brain tumor chemotherapeutics. To ...

journal_title：Journal of neuro-oncology

authors： Joshi S,Cooke JRN,Ellis JA,Emala CW,Bruce JN

更新日期：2017-12-01 00:00:00

abstract：:Cell differentiation agent-2 (CDA-2) is an extraction from healthy human urine consisting of primary organic acids and peptides, and it has been demonstrated to inhibit growth and induce differentiation in glioma and other cell lines. But the mechanism of CDA-2 remains unclear. In this study, we demonstrated that CDA-...

journal_title：Journal of neuro-oncology

authors： Xie YK,Huo SF,Zhang G,Zhang F,Lian ZP,Tang XL,Jin C

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Tumor treating fields (TTFields) are anti-mitotic, non-invasive loco-regional cancer therapy comprising low intensity, intermediate frequency alternating electric fields. TTFields plus Temozolomide (TTFields/TMZ) extended survival versus TMZ alone in newly diagnosed glioblastoma (GBM) patients in the EF-14 t...

journal_title：Journal of neuro-oncology

authors： Kim CY,Paek SH,Nam DH,Chang JH,Hong YK,Kim JH,Kim OL,Kim SH

更新日期：2020-02-01 00:00:00

abstract：:High-dose (1-3.5 g/m2) methotrexate (MTX) followed by whole-brain radiation therapy (WBRT) has consistently improved length of survival in primary central nervous system lymphoma (PCNSL), but the prognosis remains dismal. To optimize and enhance the dose intensity of MTX, we applied MTX at 8 g/m2 to 20 patients with P...

journal_title：Journal of neuro-oncology

authors： Watanabe T,Katayama Y,Yoshino A,Komine C,Yokoyama T,Fukushima T

更新日期：2003-05-01 00:00:00

abstract：:The aim of the study was to examine associations between occupational exposure to metals and meningioma risk in the international INTEROCC study. INTEROCC is a seven-country population-based case-control study including 1906 adult meningioma cases and 5565 population controls. Incident cases were recruited between 200...

journal_title：Journal of neuro-oncology

authors： Sadetzki S,Chetrit A,Turner MC,van Tongeren M,Benke G,Figuerola J,Fleming S,Hours M,Kincl L,Krewski D,McLean D,Parent ME,Richardson L,Schlehofer B,Schlaefer K,Blettner M,Schüz J,Siemiatycki J,Cardis E

更新日期：2016-12-01 00:00:00

abstract：:In the present study we investigated the feasibility and effectiveness of a new biweekly schedule of fotemustine (FTM) in patients with recurrent glioblastoma, after at least one previous treatment. The primary endpoint was progression-free survival at 6 months; secondary objectives were clinical response, overall sur...

journal_title：Journal of neuro-oncology

authors： Addeo R,Caraglia M,De Santi MS,Montella L,Abbruzzese A,Parlato C,Vincenzi B,Carraturo M,Faiola V,Genovese M,Cennamo G,Del Prete S

更新日期：2011-05-01 00:00:00

abstract：:This review identifies the current literature on the use of bevacizumab for cerebral radiation necrosis in patients with high-grade gliomas, summarizes the clinical course and complications following bevacizumab, and discusses the relative costs and benefits of this therapeutic option. A Medline search was conducted o...

journal_title：Journal of neuro-oncology

authors： Lubelski D,Abdullah KG,Weil RJ,Marko NF

更新日期：2013-12-01 00:00:00

abstract：:Anti-Hu paraneoplastic syndromes are usually associated with an underlying neoplasia, although a few patients who are anti-Hu-positive never develop cancer after long-term follow-up. Tumour therapy remains the mainstay of therapeutic options, and early immune therapy in parallel is advisable. When no tumour is found, ...

journal_title：Journal of neuro-oncology

authors： Coret F,Bosca I,Fratalia L,Perez-Griera J,Pascual A,Casanova B

更新日期：2009-07-01 00:00:00

abstract：:Chemotherapy is often omitted in elderly patients with glioblastoma multiforme due to a fear of side effects. We applied metronomic chemotherapy with low-dose temozolomide and celecoxib (LD-TEM/CEL) during and after external beam radiotherapy (EBRT) and here report on how this regimen compares to standard temozolomide...

journal_title：Journal of neuro-oncology

authors： Welzel G,Gehweiler J,Brehmer S,Appelt JU,von Deimling A,Seiz-Rosenhagen M,Schmiedek P,Wenz F,Giordano FA

更新日期：2015-09-01 00:00:00

abstract：PURPOSE:Current medulloblastoma therapy, surgery, radiation, and chemotherapy, is unacceptably toxic. However, 13-cis retinoic acid (RA) and SAHA, a histone deacetylase inhibitor, have each been shown to induce apoptosis in medulloblastoma cultures and mouse models. Both drugs cross the blood brain barrier, have been g...

journal_title：Journal of neuro-oncology

authors： Spiller SE,Ditzler SH,Pullar BJ,Olson JM

更新日期：2008-04-01 00:00:00

abstract：:Ionizing radiation plays a major role in the treatment of brain tumors, but side-effects may restrict the efficacy of therapy. In the present study, our goals were to establish whether the administration of L-alpha-glycerylphosphorylcholine (GPC) can moderate or prevent any of the irradiation-induced functional and mo...

journal_title：Journal of neuro-oncology

authors： Plangár I,Szabó ER,Tőkés T,Mán I,Brinyiczki K,Fekete G,Németh I,Ghyczy M,Boros M,Hideghéty K

更新日期：2014-09-01 00:00:00

abstract：:Visual field defect is a major indication for surgery of pituitary adenoma, but visual outcome after surgery is difficult to predict. We developed a nomogram that predicts postoperative restoration of visual field defects in patients with pituitary adenoma. This study was a retrospective cohort investigation of patien...

journal_title：Journal of neuro-oncology

authors： Lee J,Kim SW,Kim DW,Shin JY,Choi M,Oh MC,Kim SM,Kim EH,Kim SH,Byeon SH

更新日期：2016-10-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most common and devastating form of primary central nervous system malignancy. The prognosis for patients diagnosed with GBM is poor, having a median survival rate of 12-15 months. Despite modern advances in the development of antineoplastic agents, the efficacy of newer anti-cance...

journal_title：Journal of neuro-oncology

authors： Gurley SN,Abidi AH,Allison P,Guan P,Duntsch C,Robertson JH,Kosanke SD,Keir ST,Bigner DD,Elberger AJ,Moore BM 2nd

更新日期：2012-11-01 00:00:00

abstract：:The effectiveness of radiotherapy and chemotherapy in high grade gliomas (HGG) depends on tumor micro-environment. We summarize our experience of the influence of spinal cord stimulation (SCS) on this micro-environment. Patients with HGG (n = 26) were assessed pre- and post-SCS, using: (1) Doppler in middle cerebral a...

journal_title：Journal of neuro-oncology

authors： Clavo B,Robaina F,Valcarcel B,Catala L,Perez JL,Cabezon A,Jorge IJ,Fiuza D,Hernandez MA,Jover R,Carreras JL

更新日期：2012-01-01 00:00:00

abstract：:Medulloblastoma is a rare malignancy in adults, accounting for approximately 1% of all primary brain tumors. Extraneural metastases have been reported in 10-30% of cases and most commonly involve bone; rarely lymph nodes, visceral organs and bone marrow may be involved with disease. We report here our experience with ...

journal_title：Journal of neuro-oncology

authors： Wendland MM,Shrieve DC,Watson GA,Chin SS,Blumenthal DT

更新日期：2006-06-01 00:00:00

abstract：:Carcinomatous meningitis (CM) occurs in less than 10% of cancer patients. Although patients frequently present with a focal complaint, multifocal signs are often found following careful neurological examination. The gold standard for diagnosis remains the demonstration of neoplastic cells in the cerebrospinal fluid. D...

journal_title：Journal of neuro-oncology

authors： McClelland S 3rd,Garcia RE,Monaco SE,Goldman JE,Olson TJ,Kim GH,Petrylak DP,Goodman RR

更新日期：2006-01-01 00:00:00

abstract：:We evaluated the results of stereotactic radiosurgery (SRS) alone using gamma knife (GK) for selected patients with 1-10 brain metastases without prophylactic whole-brain radiation therapy (WBRT) among JLGK0901-eligible cases. Seven hundred seventy-eight consecutive cases meeting the following JLGK0901 study inclusion...

journal_title：Journal of neuro-oncology

authors： Serizawa T,Hirai T,Nagano O,Higuchi Y,Matsuda S,Ono J,Saeki N

更新日期：2010-06-01 00:00:00

abstract：:Between January 1985 and December 2000, 916 patients with brain metastases were treated with whole brain radiation therapy (WBRT) at the Department of Radiotherapy, University Hospital Freiburg. In 47 patients, a primary tumor could not be identified (cancer of unknown primary (CUP)). Sixteen patients had a solitary b...

journal_title：Journal of neuro-oncology

authors： Bartelt S,Lutterbach J

更新日期：2003-09-01 00:00:00

abstract：:The aim of the present study is to evaluate the impact of extent of resection at initial and repeat craniotomy on overall survival of patients with recurrent glioblastoma. The authors retrospectively reviewed the records of all adults patients who underwent repeat resection of recurrent glioblastoma following radiatio...

journal_title：Journal of neuro-oncology

authors： Perrini P,Gambacciani C,Weiss A,Pasqualetti F,Delishaj D,Paiar F,Morganti R,Vannozzi R,Lutzemberger L

更新日期：2017-02-01 00:00:00

abstract：:Dysembryoplastic neuroepithelial tumors (DNET) are usually benign lesions that arise in cortical regions and are discovered after new onset of seizure. These lesions have many different imaging characteristics. We report a patient with a presumed low-grade medial temporal lobe lesion that was followed for many years w...

journal_title：Journal of neuro-oncology

authors： Jensen RL,Caamano E,Jensen EM,Couldwell WT

更新日期：2006-05-01 00:00:00

abstract：:It is unknown whether the addition of temozolomide (TMZ) to radiotherapy (RT) is associated with improved overall survival (OS) among older glioblastoma patients. We performed a retrospective cohort SEER-Medicare analysis of 1652 patients aged ≥65 years with glioblastoma who received ≥10 fractions of RT from 2005 to 2...

journal_title：Journal of neuro-oncology

authors： Arvold ND,Cefalu M,Wang Y,Zigler C,Schrag D,Dominici F

更新日期：2017-01-01 00:00:00

abstract：:Ependymomas (EPN) show site specific genetic alterations and a recent DNA methylation profiling study identified nine molecular subgroups. C11orf95-RELA and YAP1 fusions characterise the RELA and YAP1 molecular subgroups, respectively, of supratentorial (ST)-EPNs. Current guidelines recommend molecular subgrouping ove...

journal_title：Journal of neuro-oncology

authors： Malgulwar PB,Nambirajan A,Pathak P,Faruq M,Rajeshwari M,Singh M,Suri V,Sarkar C,Sharma MC

更新日期：2018-05-01 00:00:00

abstract：:Antisense bcl-2 therapy combined with chemotherapy has been proved to be effective in various tumors. However, the role played by antisense bcl-2 therapy alone is not clear. In this study, we compared the apoptosis and the protein profiles of antisense bcl-2 transfected human neuroblastoma SK-N-MC cells to the control...

journal_title：Journal of neuro-oncology

authors： Li Y,Lu Z,Chen F,Guan J,Hu L,Xu Y,Chen J

更新日期：2005-03-01 00:00:00

abstract：:We report a 13-month-old boy with diencephalic syndrome (DS) due to an optico-hypothalamic juvenile pilocytic astrocytoma (JPA). Massive neuroaxis dissemination was identified at diagnosis. He received 6 courses of combined conventional-dose chemotherapy consisting of carboplatin (CBDCA), etoposide (VP-16), and cyclop...

journal_title：Journal of neuro-oncology

authors： Kageji T,Nagahiro S,Horiguchi H,Watanabe T,Suzuya H,Okamoto Y,Kuroda Y

更新日期：2003-05-01 00:00:00

abstract：:Intraspinal location of central PNET (cPNET) is very rare. We present a case, critically review all publications of primary intraspinal cPNET occurrence and discuss tendencies in clinical presentation. In several previous attempts to summarise, authors often confused cPNET with peripheral PNET (pPNET). cPNET and pPNET...

journal_title：Journal of neuro-oncology

authors： Kampman WA,Kros JM,De Jong TH,Lequin MH

更新日期：2006-03-01 00:00:00

abstract：:Both cell proliferation and cell death occur simultaneously in tumor tissue, and extent of tumor growth reflects the net balance of these events. We correlated cell proliferation, spontaneous cell death, and alterations in tumor suppressor proteins with one another and with survival of patients with primary astrocytic...

journal_title：Journal of neuro-oncology

authors： Nakamizo A,Inamura T,Ikezaki K,Yoshimoto K,Inoha S,Mizoguchi M,Amano T,Fukui M

更新日期：2002-04-01 00:00:00