Successful high-dose chemotherapy for widespread neuroaxis dissemination of an optico-hypothalamic juvenile pilocytic astrocytoma in an infant: a case report.

abstract：:Glioblastomas are aggressive brain tumors that frequently recur in the subventricular zone (SVZ) despite maximal treatment. The purpose of this study was to evaluate imaging patterns of subventricular progression and impact of recurrent subventricular tumor involvement and radiation dose to patient outcome. Retrospect...

journal_title：Journal of neuro-oncology

authors： Weinberg BD,Boreta L,Braunstein S,Cha S

更新日期：2018-07-01 00:00:00

abstract：:Radiotherapy (RT) and concomitant/adjuvant therapy with temozolomide (Temodar) is a common treatment regimen for children and adults with glioma. Although temozolomide is generally well tolerated with temporary myelosuppression as the primary dose-limiting toxicity, irreversible bone-marrow aplasia after treatment wit...

journal_title：Journal of neuro-oncology

authors： Morris EB,Kasow K,Reiss U,Ellison D,Broniscer A

更新日期：2009-01-01 00:00:00

abstract：:The purpose of this study is to characterize the time course of N-isopropyl-p-[123I]-iodoamphetamine (123I-IMP) uptake of primary central nervous system lymphomas (PCNSL) comparing with those of other common brain tumors such as malignant gliomas and meningioma. Ten patients with PCNSL, 14 with malignant gliomas and 7...

journal_title：Journal of neuro-oncology

authors： Shinoda J,Yano H,Murase S,Yoshimura S,Sakai N,Asano T

更新日期：2003-02-01 00:00:00

abstract：:Some unresectable and symptomatic meningiomas recur after conventional radiation therapy or stereotactic radiosurgery and are a therapeutic challenge. Evidence-based data from medical therapy for patients with recurrent meningioma can be deemed insufficient. Because of the prevalent expression of PDGF receptors in men...

journal_title：Journal of neuro-oncology

authors： Horak P,Wöhrer A,Hassler M,Hainfellner J,Preusser M,Marosi C

更新日期：2012-09-01 00:00:00

abstract：:The use of radiation therapy in the management of intramedullary spinal cord tumors remains controversial. Several studies indicate that the use of postoperative radiation therapy modestly improves both local control and survival in spinal cord ependymomas and astrocytomas. Modern treatment planning and imaging allow ...

journal_title：Journal of neuro-oncology

authors： Isaacson SR

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:Macroautophagy/autophagy is considered to play key roles in tumor cell evasion of therapy and establishment of metastases in breast cancer. High expression of LC3, a residual autophagy marker, in primary breast tumors has been associated with metastatic disease and poor outcome. FIP200/Atg17, a multi-functio...

journal_title：Journal of neuro-oncology

authors： Hashemi-Sadraei N,Müller-Greven GM,Abdul-Karim FW,Ulasov I,Downs-Kelly E,Burgett ME,Lauko A,Qadan MA,Weil RJ,Ahluwalia MS,Du L,Prayson RA,Chao ST,Budd TG,Barnholtz-Sloan J,Nowacki AS,Keri RA,Gladson CL

更新日期：2018-11-01 00:00:00

abstract：:The classification of cartilaginous tumors of the skull base, including chondroid chordoma and chondrosarcoma remains the subject of controversy. Critical review of the literature and our own experience of chordomas and cartilaginous tumors of the skull base led to the following conclusions: 1) Chondrosarcoma of the s...

journal_title：Journal of neuro-oncology

authors： Ishida T,Dorfman HD

更新日期：1994-01-01 00:00:00

abstract：:To identify molecular therapeutic targets for glioma, we performed gene expression profiling by using a complementary DNA (cDNA) microarray method and identified the urokinase plasminogen activator receptor-associated protein (uPARAP/Endo180) as a gene expressed highly in glioma tissue compared with the normal brain t...

journal_title：Journal of neuro-oncology

authors： Takahashi S,Yamada-Okabe H,Hamada K,Ohta S,Kawase T,Yoshida K,Toda M

更新日期：2011-06-01 00:00:00

abstract：:Glioblastoma is the most common and most aggressive primary brain tumor. Despite maximum treatment, patients only have a median survival time of 15 months, because of the tumor's resistance to current therapeutic approaches. Thus far, methylation of the O (6)-methylguanine-DNA methyltransferase (MGMT) promoter has bee...

journal_title：Journal of neuro-oncology

authors： Bleeker FE,Molenaar RJ,Leenstra S

更新日期：2012-05-01 00:00:00

abstract：:Previous study revealed that higher expression of transforming growth factor beta induced (TGFBI) is correlated to poorer cancer-specific survival and higher proportion of tumor necrosis and Fuhrman grades III and IV in clear cell renal cell carcinomas. However, the relationships between TGFBI expression and malignant...

journal_title：Journal of neuro-oncology

authors： Pan YB,Zhang CH,Wang SQ,Ai PH,Chen K,Zhu L,Sun ZL,Feng DF

更新日期：2018-04-01 00:00:00

abstract：:Brain metastasis often has a poor prognosis in patients with advanced non-small cell lung cancer (NSCLC). Therefore, it is urgent to identify factors associated with lung cancer brain metastasis. Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) also known as noncoding nuclear-enriched abundant transcrip...

journal_title：Journal of neuro-oncology

authors： Shen L,Chen L,Wang Y,Jiang X,Xia H,Zhuang Z

更新日期：2015-01-01 00:00:00

abstract：:Supratentorial primitive neuroectodermal tumors (sPNET) occurring in adults are rare. Only 56 such cases have been previously reported. This report documents a 56-year-old male who presented with the chief complaint of right facial palsy. Magnetic resonance imaging (MRI) revealed left frontal and bilateral periventric...

journal_title：Journal of neuro-oncology

authors： Ohba S,Yoshida K,Hirose Y,Ikeda E,Kawase T

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Despite aspirations to achieve equality in healthcare we know that socioeconomic differences exist and may affect treatment and patient outcome, also in serious diseases such as cancer. We investigated disparities in neurosurgical care and outcome for patients with low-grade glioma (LGG). METHODS:In this na...

journal_title：Journal of neuro-oncology

authors： Carstam L,Rydén I,Gulati S,Rydenhag B,Henriksson R,Salvesen Ø,Smits A,Jakola AS

更新日期：2020-01-01 00:00:00

abstract：:Tripartite motif (TRIM) proteins are involved in tumorigenesis. Here, we examined the expression, biological function, and clinical significance of tripartite motif containing 28 (TRIM28) in glioma, a locally aggressive brain tumor. First, TRIM28 expression was significantly higher in glioma (n = 138) than in non-glio...

journal_title：Journal of neuro-oncology

authors： Qi ZX,Cai JJ,Chen LC,Yue Q,Gong Y,Yao Y,Mao Y

更新日期：2016-01-01 00:00:00

abstract：:Pituitary tumors were experimentally induced in female Wistar rats by repeated injections of estradiol dipropionate. The hypothalamus and pituitary tumors were studied simultaneously by fluorescence histochemistry and immunohistochemistry. The pituitary gland became larger with a concomitant increase of serum prolacti...

journal_title：Journal of neuro-oncology

authors： Fujimoto M,Yoshino E,Hirakawa K,Chihara K,Ibata Y

更新日期：1987-01-01 00:00:00

abstract：:Neural stem cells (NSC) have unique differentiation-, proliferation-, and motility properties. To investigate whether they secrete factors that interfere with the proliferation of glioma cells, we grew glioma cells in conditioned medium (CM) obtained from cultures of neurospheres including neural stem / progenitor cel...

journal_title：Journal of neuro-oncology

authors： Suzuki T,Izumoto S,Wada K,Fujimoto Y,Maruno M,Yamasaki M,Kanemura Y,Shimazaki T,Okano H,Yoshimine T

更新日期：2005-09-01 00:00:00

abstract：PURPOSE:To interrogate grade II, III, and IV gliomas and characterize the critical effectors within the PI3-kinase pathway upstream and downstream of mTOR. Experimental design Tissues from 87 patients who were treated at UCSF between 1990 and 2004 were analyzed. Twenty-eight grade II, 17 grade III glioma, 26 grade IV g...

journal_title：Journal of neuro-oncology

authors： Ermoian RP,Kaprealian T,Lamborn KR,Yang X,Jelluma N,Arvold ND,Zeidman R,Berger MS,Stokoe D,Haas-Kogan DA

更新日期：2009-01-01 00:00:00

abstract：:Successful management of a heavily pretreated 58-year-old woman with metastatic esthesioneuoblastoma using temozolomide is reported. There is no standard treatment of this tumors with extra- and intracranial manifestations. The response, long term stability and high quality of life using temozolomide for this tumor en...

journal_title：Journal of neuro-oncology

authors： Wick W,Wick A,Küker W,Dichgans J,Weller M

更新日期：2004-10-01 00:00:00

abstract：:We report a case of a 2 year-old boy who initially presented with macrocephaly and severe global developmental delay. Imaging revealed a large left temporo-parietal mass that was lobulated, calcified, focally enhancing and partially cystic. A second surgery was required for tumor recurrence approximately one year late...

journal_title：Journal of neuro-oncology

authors： Dunham C,Sugo E,Tobias V,Wills E,Perry A

更新日期：2007-08-01 00:00:00

abstract：INTRODUCTION:To improve the standard treatment paradigm for glioblastoma (GBM), efforts have been made to explore the efficacy of epigenetic agents as chemosensitizers. Recent data suggest possible synergy between decitabine (DAC), a DNA hypomethylating agent, and temozolomide (TMZ) in GBM, but the mechanism remains un...

journal_title：Journal of neuro-oncology

authors： Gallitto M,Cheng He R,Inocencio JF,Wang H,Zhang Y,Deikus G,Wasserman I,Strahl M,Smith M,Sebra R,Yong RL

更新日期：2020-05-01 00:00:00

abstract：:Intracranial atypical teratoid/rhabdoid tumors (AT/RT) are rare with a poor prognosis. We report one case of a 7-year old girl living over 17 months after the diagnosis of AT/RT in the left frontal lobe. Treatment was partial surgical resection and post-operative radiation therapy. Radiation therapy resulted in comple...

journal_title：Journal of neuro-oncology

authors： Howes TL,Buatti JM,O'Dorisio MS,Kirby PA,Ryken TC

更新日期：2005-03-01 00:00:00

abstract：:Future success using chemotherapy against human gliomas may result from exploiting unique molecular vulnerabilities of these tumors. Chemotherapy frequently results in DNA damage. When such damage is sensed by the cell, programmed cell death, or apoptosis, may be initiated. However, chemotherapy-induced DNA damage may...

journal_title：Journal of neuro-oncology

authors： Weaver KD,Yeyeodu S,Cusack JC Jr,Baldwin AS Jr,Ewend MG

更新日期：2003-02-01 00:00:00

abstract：:The human glioma cell line, NP-1, expresses IL-8 mRNA and constitutively secretes IL-8 protein. Administration of recombinant IL-8 increased the proliferation of NP-1 cells in a dose-dependent manner. In the presence of anti-IL-8 antiserum, the IL-8 mediated proliferation of NP-1 cell growth was inhibited. Further, NP...

journal_title：Journal of neuro-oncology

authors： Yamanaka R,Tanaka R,Yoshida S,Saitoh T,Fujita K

更新日期：1995-01-01 00:00:00

abstract：:In the context of bevacizumab therapy for the treatment of progressive malignant gliomas, it is currently unclear how different magnetic resonance imaging (MRI) sequences correlate with each other over time. The objective of this study was to determine if a reliable and predictable relationship over time exists betwee...

journal_title：Journal of neuro-oncology

authors： Thompson EM,Dosa E,Kraemer DF,Neuwelt EA

更新日期：2011-06-01 00:00:00

abstract：:One hundred-twenty seven human brain tumors were examined by an immunoperoxidase technique for the expression of collagen Type IV, a major constituent of basement membrane. The parenchymal components were negative for the marker protein in all tumors except for neurilemmomas which were positively stained. In every cas...

journal_title：Journal of neuro-oncology

authors： Ogawa K,Oguchi M,Nakashima Y,Yamabe H

更新日期：1989-11-01 00:00:00

abstract：:The growth pattern of pilocytic astrocytoma (PAs) is unpredictable. Gene expression profiling has recently demonstrated an inverse relationship between myelin basic protein (MBP) expression and progression free survival (PFS) in PAs. We present here the pattern of expression of oligodendroglial differentiation markers...

journal_title：Journal of neuro-oncology

authors： Takei H,Yogeswaren ST,Wong KK,Mehta V,Chintagumpala M,Dauser RC,Lau CC,Adesina AM

更新日期：2008-01-01 00:00:00

abstract：:Chordomas constitute about 1% of intracranial tumors. They are generally extradural destroying the bone. Intradural chordomas are very rare. We present one such case of a clival intradural chordoma who presented with a left trigeminal nerve sensory neuropathy. The lesion was totally excised uneventfully via a retromas...

journal_title：Journal of neuro-oncology

authors： Bhat DI,Yasha M,Rojin A,Sampath S,Shankar SK

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:The purpose of this study is to describe the long-term toxicities of intracranial germ cell tumor (IGCT) in the adolescent and young adult (AYA) population. METHODS:We report late toxicities of a multi-center cohort of AYA patients treated for IGCT between 1975 and 2015. Charts were retrospectively reviewed fo...

journal_title：Journal of neuro-oncology

authors： Wong J,Goddard K,Laperriere N,Dang J,Bouffet E,Bartels U,Hodgson D,Tyldesley S,Hukin J,Cheng S,Bedard PL,Lo AC

更新日期：2020-09-01 00:00:00

abstract：:There is a need for better predictors for short survival in patients with brain metastases undergoing open surgery. The graded prognostic assessment (GPA) has recently been developed to predict survival in patients with brain metastases. We explored the prognostic capabilities of GPA in a consecutive neurosurgical pop...

journal_title：Journal of neuro-oncology

authors： Jakola AS,Gulati S,Nerland US,Solheim O

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Based on limited literature, an at risk group of patients for development of neoplastic meningitis (NM) are those with resected cerebellar parenchymal metastases. OBJECTIVE:Characterize the incidence of NM in patients with cerebellar metastases treated with either surgical resection or radiotherapy. PATIEN...

journal_title：Journal of neuro-oncology

authors： Chamberlain MC

更新日期：2008-08-01 00:00:00