Recent advances in the molecular understanding of glioblastoma.

abstract：:Lonidamine (LND) has been shown to inhibit tumor aerobic glycolysis. Its effect was evaluated on several human astrocytomas at different degrees of malignancy; a correlation was found between LDN effect on lactate production and tumor malignancy: in grade I and II astrocytomas LND stimulates lactate production, while ...

journal_title：Journal of neuro-oncology

authors： Paggi MG,Carapella CM,Fanciulli M,Del Carlo C,Giorno S,Zupi G,Silvestrini B,Caputo A,Floridi A

更新日期：1988-11-01 00:00:00

abstract：PURPOSE:Children with recurrent medulloblastoma have a poor prognosis. Re-irradiation is an option for some patients, but has not been well-studied in the era of molecular characterization for pediatric medulloblastoma. METHODS:This was a retrospective cohort study of 14 children age 18 years and younger at initial di...

journal_title：Journal of neuro-oncology

authors： Tsang DS,Sarhan N,Ramaswamy V,Nobre L,Yee R,Taylor MD,Hawkins C,Bartels U,Huang A,Tabori U,Hodgson DC,Bouffet E,Laperriere N

更新日期：2019-10-01 00:00:00

abstract：INTRODUCTION:Recurrent intracranial epidermoid cysts may be difficult to address surgically given their proximity to critical neurovascular structures of the skull base. There are emerging reports of using radiotherapy (RT) for the treatment of recurrent epidermoid cysts. Here, we report a case series of adjuvant fract...

journal_title：Journal of neuro-oncology

authors： Morshed RA,Wu SY,Sneed PK,McDermott MW

更新日期：2019-08-01 00:00:00

abstract：:Comparison between myelography (MY) and magnetic resonance imaging (MRI) was carried out in 36 patients with clinical suspicion of spinal cord or root compression due to metastatic disease in the spinal canal. In 3 patients metastatic lesions were visualized on MY but not on MRI, while there were no cases with a negat...

journal_title：Journal of neuro-oncology

authors： Helweg-Larsen S,Wagner A,Kjaer L,Johnsen A,Boesen J,Palner T,Sørensen PS

更新日期：1992-07-01 00:00:00

abstract：:To identify molecular therapeutic targets for glioma, we performed gene expression profiling by using a complementary DNA (cDNA) microarray method and identified the urokinase plasminogen activator receptor-associated protein (uPARAP/Endo180) as a gene expressed highly in glioma tissue compared with the normal brain t...

journal_title：Journal of neuro-oncology

authors： Takahashi S,Yamada-Okabe H,Hamada K,Ohta S,Kawase T,Yoshida K,Toda M

更新日期：2011-06-01 00:00:00

abstract：:The classification of cartilaginous tumors of the skull base, including chondroid chordoma and chondrosarcoma remains the subject of controversy. Critical review of the literature and our own experience of chordomas and cartilaginous tumors of the skull base led to the following conclusions: 1) Chondrosarcoma of the s...

journal_title：Journal of neuro-oncology

authors： Ishida T,Dorfman HD

更新日期：1994-01-01 00:00:00

abstract：:A major toxic effect of the chemotherapeutic agents paclitaxel and cisplatin is peripheral neuropathy. We report the use of a rat model of cytotoxic neuropathy to evaluate the role of glutamate as a possible neuroprotectant for these two drugs. Neuropathy was manifest as gait disturbance in 100% of paclitaxel treated ...

journal_title：Journal of neuro-oncology

authors： Boyle FM,Wheeler HR,Shenfield GM

更新日期：1999-01-01 00:00:00

abstract：PURPOSE:Intracranial glioblastomas with simultaneous spinal lesions prior to chemoradiation therapy or craniotomy, defined as initial spinal metastasis, are not well understood. Herein, we investigated intracranial glioblastoma and demonstrated the importance of spinal screening using gadolinium enhanced spinal magneti...

journal_title：Journal of neuro-oncology

authors： Shibahara I,Saito R,Osada Y,Kanamori M,Sonoda Y,Kumabe T,Mugikura S,Watanabe M,Tominaga T

更新日期：2019-01-01 00:00:00

abstract：PURPOSE:Gliomas are the most common cancer of the brain, with a poor prognosis in particular for glioblastoma. In 2014, a study suggested reduced survival in relation to latency of mobile phone use among glioblastoma patients. A joint epidemiological/experimental project to study effects of RF-EMF on tumor development ...

journal_title：Journal of neuro-oncology

authors： Olsson A,Bouaoun L,Auvinen A,Feychting M,Johansen C,Mathiesen T,Melin B,Lahkola A,Larjavaara S,Villegier AS,Byrnes G,Deltour I,Schüz J

更新日期：2019-01-01 00:00:00

abstract：:This study concerns the use of the MTT [3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H tetrazolium bromide] colorimetric assay to evaluate the chemosensitivity of the C6 rat glioma cell line to a panel of twelve chemotherapeutic agents. In a previous study of in vitro chemosensitivity of human glioma cell lines, the pre...

journal_title：Journal of neuro-oncology

authors： Hand CM,Vender JR,Black P

更新日期：1998-01-01 00:00:00

abstract：INTRODUCTION:While hypofractionated stereotactic radiotherapy (HFSRT) is being increasingly used for treating brain metastases, clinical data concerning the incidence and risk factors of its main side-effect, namely radiation necrosis (RN), remain limited. In this context, we assessed risk factors of RN in a single cen...

journal_title：Journal of neuro-oncology

authors： Di Perri D,Tanguy R,Malet C,Robert A,Sunyach MP

更新日期：2020-09-01 00:00:00

abstract：:To investigate local control and radiation-induced brain necrosis in patients with melanoma brain metastases who received complete resection plus fractionated stereotactic radiosurgery (fSRS, 3 × 9 Gy) or fSRS alone. Factors associated with the clinical outcomes and the development of brain necrosis have been assessed...

journal_title：Journal of neuro-oncology

authors： Minniti G,Paolini S,D'Andrea G,Lanzetta G,Cicone F,Confaloni V,Bozzao A,Esposito V,Osti M

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:To interrogate grade II, III, and IV gliomas and characterize the critical effectors within the PI3-kinase pathway upstream and downstream of mTOR. Experimental design Tissues from 87 patients who were treated at UCSF between 1990 and 2004 were analyzed. Twenty-eight grade II, 17 grade III glioma, 26 grade IV g...

journal_title：Journal of neuro-oncology

authors： Ermoian RP,Kaprealian T,Lamborn KR,Yang X,Jelluma N,Arvold ND,Zeidman R,Berger MS,Stokoe D,Haas-Kogan DA

更新日期：2009-01-01 00:00:00

abstract：PURPOSE:To report outcomes of salvage re-irradiation (re-RT) in recurrent/progressive medulloblastoma (MB). METHODS:Medical records of patients treated with curative-intent re-RT as multi-modality management for recurrent/progressive MB between 2008 and 2018 were analyzed retrospectively. RESULTS:A total of 28 patien...

journal_title：Journal of neuro-oncology

authors： Gupta T,Maitre M,Sastri GJ,Krishnatry R,Shirsat N,Epari S,Sahay A,Chinnaswamy G,Patil V,Shetty P,Moiyadi A

更新日期：2019-09-01 00:00:00

abstract：:The embolization of cancer cells to cerebral vessels occurs early in the multi-step metastatic process. We aimed to determine whether the presence of leukoaraiosis (LA) before treatment would predict the development of brain metastases (BM) in patients with lung cancer. Between January 2014 and June 2015, 1007 patient...

journal_title：Journal of neuro-oncology

authors： Hayashi N,Mitsuya K,Nakasu Y,Naito T,Ohka F,Takahashi T

更新日期：2017-11-01 00:00:00

abstract：:Medulloblastoma with melanotic differentiation, a rare variant of medulloblastoma, often carries a poor prognosis. We present such a case of a 4 year male with this rare, aggressive tumor. Additionally, we have reviewed the literature and report on the features important in the pathologic and radiologic diagnosis in t...

journal_title：Journal of neuro-oncology

authors： Phillips CL,Miles L,Jones BV,Sutton M,Crone K,Fouladi M

更新日期：2011-07-01 00:00:00

abstract：:Resveratrol (Res) has been reported to inhibit tumor initiation, promotion, and progression in a variety of cell culture systems depending on the specific cell type and cellular environment. In the present study, we determined the effect of Res on the cell growth and apoptosis of rat glioma C6 cell line as well as mou...

journal_title：Journal of neuro-oncology

authors： Zhang W,Fei Z,Zhen HN,Zhang JN,Zhang X

更新日期：2007-02-01 00:00:00

abstract：:Although 1p19q codeleted gliomas are the most favorable molecular subgroup of lower-grade gliomas, there are cases with early recurrence or short survival. The objective of this study was to elucidate molecular-genetic and clinicopathological prognostic factors in patients with gliomas showing total 1p19q loss. The st...

journal_title：Journal of neuro-oncology

authors： Hayashi S,Kitamura Y,Hirose Y,Yoshida K,Sasaki H

更新日期：2017-03-01 00:00:00

abstract：:Primary intramedullary spinal cord tumors are a rare entity, comprising 4–10 %of all spinal cord tumors. The current report presents data on intramedullary spinal cord anaplastic astrocytomas and glioblastomas in adults using the national surveillance, epidemiology, and end results database (1973–2008), and evaluates ...

journal_title：Journal of neuro-oncology

authors： Wong AP,Dahdaleh NS,Fessler RG,Melkonian SC,Lin Y,Smith ZA,Lam SK

更新日期：2013-12-01 00:00:00

abstract：:The outcome of children less than 3 years of age with medulloblastoma has been poor in comparison to older children. The cure rates were below 30%, and the quality of life for cured children was frequently reduced by a complex syndrome of long-term sequelae including intellectual retardation and growth hormone deficie...

journal_title：Journal of neuro-oncology

authors： Schmandt S,Kühl J

更新日期：1998-06-01 00:00:00

abstract：:The effectiveness of temozolomide (TMZ) dosing schemes and the "rechallenge" of recurrent glioblastoma (GBM) with TMZ are controversial. We therefore compared the efficacy of different TMZ dosing schemes against GBM cancer stem cell (CSC) lines in vitro. In O(6)-methyl-guanidine-methyl-transferase (MGMT)-negative CSC ...

journal_title：Journal of neuro-oncology

authors： Beier D,Schriefer B,Brawanski K,Hau P,Weis J,Schulz JB,Beier CP

更新日期：2012-08-01 00:00:00

abstract：:Sacral chordoma is a vessel-rich and infiltrative tumor, but the fundamental knowledge of its biological behavior remains unknown. This study was designed to investigate the expression levels and contributions of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) in the angiogenesis and r...

journal_title：Journal of neuro-oncology

authors： Chen KW,Yang HL,Lu J,Wang GL,Ji YM,Wu GZ,Zhu LF,Liu JY,Chen XQ,Gu YP

更新日期：2011-02-01 00:00:00

abstract：:Recently, many studies have found that the miR-106b ~25 cluster plays an oncogenic role in tumor progression. However, the precise role of each microRNAs (miRNAs) in the cluster is not yet clear. In the present study, we examined the expression of miR-106b in glioma samples and a tissue microarray by real-time PCR and...

journal_title：Journal of neuro-oncology

authors： Zhang A,Hao J,Wang K,Huang Q,Yu K,Kang C,Wang G,Jia Z,Han L,Pu P

更新日期：2013-04-01 00:00:00

abstract：:We report one year follow up of a case of extramedullary hematopoiesis within the clivus. The imaging findings, brief clinical course, and endoscopic transphenoidal approach are described. A 29-year-old female with thalassemia developed worsening cranial nerve signs. After imaging studies discovered a large clival mas...

journal_title：Journal of neuro-oncology

authors： Reames DL,Lindstrom K,Raghavan P,Jane J Jr

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:Molecular data has become an essential part of the updated World Health Organization (WHO) grading of central nervous system tumors. However, stereotactic needle biopsies provide only small volume specimens and limit the extent of histologic and molecular testing that can be performed. We assessed the use of a ...

journal_title：Journal of neuro-oncology

authors： Bander ED,Jones SH,Pisapia D,Magge R,Fine H,Schwartz TH,Ramakrishna R

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:In most patients with recurrent glioma chemotherapy is the only remaining treatment option. In general results of chemotherapy in these patients are poor, and trials on new regimens are indicated. Because relatively good results have been achieved with combinations of platin compounds and etoposide, we inves...

journal_title：Journal of neuro-oncology

authors： van den Bent MJ,Pronk L,Sillevis Smitt PA,Vecht CJ,Eskens FA,Verweij J

更新日期：1999-08-01 00:00:00

abstract：:The aim of the present study is to evaluate the impact of extent of resection at initial and repeat craniotomy on overall survival of patients with recurrent glioblastoma. The authors retrospectively reviewed the records of all adults patients who underwent repeat resection of recurrent glioblastoma following radiatio...

journal_title：Journal of neuro-oncology

authors： Perrini P,Gambacciani C,Weiss A,Pasqualetti F,Delishaj D,Paiar F,Morganti R,Vannozzi R,Lutzemberger L

更新日期：2017-02-01 00:00:00

abstract：:Central nervous system (CNS) involvement is a rare complication of chronic lymphocytic leukemia (CLL) with varied outcomes. We contribute two additional cases of CLL with CNS involvement. The clinical course and response to treatment are described. All 78 previously reported cases of CLL with CNS involvement are prese...

journal_title：Journal of neuro-oncology

authors： Moazzam AA,Drappatz J,Kim RY,Kesari S

更新日期：2012-01-01 00:00:00

abstract：:To investigate the underlying intratumoral diversity of molecular profiles in glioblastomas, a proteomic approach was introduced to compare samples from regions of different histological grade. Using two-dimensional gel electrophoresis (2DE) with matrix-assisted laser-desorption/ionization time-of-flight mass spectrom...

journal_title：Journal of neuro-oncology

authors： Park CK,Jung JH,Park SH,Jung HW,Cho BK

更新日期：2009-08-01 00:00:00

abstract：:Improvements in imaging are increasing the detection of multiple lesions in the setting of glioblastoma. Occasionally distant non-enhancing lesions may be identified which have the appearances of a multicentric low-grade glioma. We aimed to determine the incidence, prognostic significance and diagnostic value of this ...

journal_title：Journal of neuro-oncology

authors： Lasocki A,Gaillard F,Tacey MA,Drummond KJ,Stuckey SL

更新日期：2016-09-01 00:00:00