Abstract:
:The embolization of cancer cells to cerebral vessels occurs early in the multi-step metastatic process. We aimed to determine whether the presence of leukoaraiosis (LA) before treatment would predict the development of brain metastases (BM) in patients with lung cancer. Between January 2014 and June 2015, 1007 patients underwent initial (i.e., prior to any chemotherapy) or routine magnetic resonance (MR) imaging of the brain and exhibited no evidence of BM. Of these, 189 underwent repeat MR imaging; 34 of 189 patients (18%) developed new BM, whereas 155 patients did not. LA was retrospectively evaluated according to Fazekas scale on the initial screening MR images of these 189 patients. The frequency of grade 0 periventricular hyperintensity (PVH) was greater among patients with BM, compared to those without BM (p = 0.001). In a multivariate analysis, patients with adenocarcinoma (95% confidence interval [CI] 1.8-171.8) and small cell carcinoma (95% CI 1.4-172.4) respectively developed BM at 9.3- and 8.8-fold higher rates than those with squamous cell carcinoma. Patients with grade 0 PVH developed BM at a rate 3.5-, 8.6-, and 3.6-fold higher rates than those with grade 1 (95% CI 1.4-9.0), 2 (95% CI 2.4-41.9), and 3 (95% CI 1.02-15.0), respectively. Lung cancer patients with grade 0 PVH on initial MR images have a high subsequent incidence of BM. PVH is a useful method for evaluating risk of BM.
journal_name
J Neurooncoljournal_title
Journal of neuro-oncologyauthors
Hayashi N,Mitsuya K,Nakasu Y,Naito T,Ohka F,Takahashi Tdoi
10.1007/s11060-017-2574-xsubject
Has Abstractpub_date
2017-11-01 00:00:00pages
299-306issue
2eissn
0167-594Xissn
1573-7373pii
10.1007/s11060-017-2574-xjournal_volume
135pub_type
杂志文章abstract::Topotecan was studied as a 72 h infusion given every 3 weeks. Treatment began at a dose of 1.0 mg/m2/day and was increased to 1.25 mg/m2/day after the first 6 patients tolerated this higher dose without excessive toxicities. Eighty-eight evaluable children were accrued in 6 strata. There were no complete nor partial r...
journal_title:Journal of neuro-oncology
pub_type: 临床试验,杂志文章
doi:10.1023/a:1006294102611
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abstract::Unexpected early epidural spinal metastasis in a case of osteosarcoma occurred in a patient receiving treatment with cis-diamminedichloroplatinum-II (cisplatin). The initial neurologic symptomatology manifested as paresthesias in the feet which developed 2 months after initiation of treatment (cumulative dose of cispl...
journal_title:Journal of neuro-oncology
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abstract::Aneurysmal bone cysts (ABCs) are benign bone lesions with annual incidences ranging from 1.4 to 3.2 cases per million people. Approximately, 10-30% of ABCs are found in the spine. Such lesions are traditionally treated with curettage or other intralesional techniques. Because ABCs can be locally aggressive, intralesio...
journal_title:Journal of neuro-oncology
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doi:10.1007/s11060-014-1540-0
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journal_title:Journal of neuro-oncology
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journal_title:Journal of neuro-oncology
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更新日期:1990-10-01 00:00:00
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journal_title:Journal of neuro-oncology
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doi:10.1007/s11060-010-0216-7
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更新日期:2012-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s11060-016-2344-1
更新日期:2017-03-01 00:00:00
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doi:10.1007/s11060-010-0306-6
更新日期:2011-04-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 临床试验,杂志文章
doi:10.1007/s11060-010-0329-z
更新日期:2011-05-01 00:00:00
abstract::A 65 year old woman presented with a recurrent locally advanced esthesioneuroblastoma. She had earlier been treated with radiation followed by surgery. The recurrence was located in earlier radiated tissues with intracranial infiltration. She underwent treatment with combined intra-arterial chemotherapy (BCNU) i.a., v...
journal_title:Journal of neuro-oncology
pub_type: 杂志文章
doi:10.1007/BF00162764
更新日期:1987-01-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
doi:10.1007/s11060-015-1796-z
更新日期:2015-06-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 临床试验,杂志文章
doi:10.1007/s11060-019-03129-8
更新日期:2019-05-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s11060-019-03361-2
更新日期:2020-02-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
doi:10.1007/s11060-014-1520-4
更新日期:2014-10-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
doi:10.1007/s11060-008-9643-0
更新日期:2008-11-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
doi:10.1007/s11060-016-2330-7
更新日期:2017-02-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章,评审
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章,评审
doi:10.1023/a:1006446020377
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
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更新日期:2009-08-01 00:00:00
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更新日期:2007-08-01 00:00:00
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更新日期:2009-08-01 00:00:00
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pub_type: 杂志文章,meta分析
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更新日期:2007-05-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
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更新日期:1986-01-01 00:00:00
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