Abstract:
:This study assesses the controversial role of temozolomide (TMZ) concurrent with adjuvant radiation (RT) in patients with anaplastic astrocytoma (AA). The impact of isocitrate dehydrogenase (IDH) status on therapy and outcomes is also examined. All adult patients diagnosed with AA from 2001 to 2011 and treated with standard doses of adjuvant RT were identified retrospectively for clinical data extraction. IDH status was determined by IDH1-R132H immunostain and sequencing for other mutations in IDH1/IDH2. Cumulative survival probabilities were estimated using the Kaplan-Meier method. Cox proportional hazards regression models were fit for univariable/multivariable analyses. 136 patients had received concurrent TMZ while 29 had not. Of these, IDH status was determined on 114 and 27 patients, respectively. On univariable analysis, improved five-year survival was independently associated with concurrent TMZ (46.2 vs. 29.3%, p = 0.02) and IDH mutation (78.9 vs. 22.0%, p < 0.001). IDH mutation was additionally associated with a greater likelihood of extensive resection possibly secondary to a more favorable tumor location. Gross total/subtotal resections also led to improved survival when compared to biopsy alone on univariable analysis. On multivariable analysis, the association with five-year survival persisted for both concurrent TMZ and IDH mutation, but not with extent of surgery. Both IDH mutation and concurrent TMZ are associated with improved five-year survival in patients with AA who are receiving adjuvant RT. Secondarily, the association between five-year survival and extent of resection is lost on multivariable analysis. This suggests a possible association between IDH mutation, tumor location and consequent resectability.
journal_name
J Neurooncoljournal_title
Journal of neuro-oncologyauthors
Kizilbash SH,Giannini C,Voss JS,Decker PA,Jenkins RB,Hardie J,Laack NN,Parney IF,Uhm JH,Buckner JCdoi
10.1007/s11060-014-1520-4subject
Has Abstractpub_date
2014-10-01 00:00:00pages
85-93issue
1eissn
0167-594Xissn
1573-7373journal_volume
120pub_type
杂志文章abstract::Magnetic resonance imaging (MRI) or computerized tomography (CT) is routinely performed after resection of brain metastases (BrM), regardless of whether there are specific clinical concerns about residual tumor or potential complications. Routine imaging studies contribute a significant amount to the cost of medical c...
journal_title:Journal of neuro-oncology
pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
doi:10.1007/s11060-010-0175-z
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journal_title:Journal of neuro-oncology
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journal_title:Journal of neuro-oncology
pub_type: 临床试验,杂志文章
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journal_title:Journal of neuro-oncology
pub_type: 临床试验,杂志文章
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更新日期:2002-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-11-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
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更新日期:2017-02-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
doi:10.1023/a:1005771717409
更新日期:1997-03-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s11060-018-2909-2
更新日期:2018-09-01 00:00:00
abstract:INTRODUCTION:Glioblastoma (GBM) is the most common primary brain cancer. The average survival time for the majority of patients is approximately 15 months after diagnosis. A major feature of GBM that contributes to its poor prognosis is its high invasiveness. Caveolae are plasma membrane subdomains that participate in ...
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更新日期:2019-06-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 临床试验,杂志文章
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pub_type: 临床试验,杂志文章
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更新日期:2004-02-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:1999-05-01 00:00:00
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journal_title:Journal of neuro-oncology
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更新日期:2010-02-01 00:00:00
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journal_title:Journal of neuro-oncology
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abstract::In the context of bevacizumab therapy for the treatment of progressive malignant gliomas, it is currently unclear how different magnetic resonance imaging (MRI) sequences correlate with each other over time. The objective of this study was to determine if a reliable and predictable relationship over time exists betwee...
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pub_type: 杂志文章,多中心研究
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