Abstract:
:Gliomatosis cerebri (GC) are extensively infiltrative glial tumors classified as astrocytic tumors in the current World Health Organization (WHO) classification scheme. In investigating the tumorigenesis of GC, we reviewed 28 cases of GC immunohistochemically and carried out array-based comparative genomic hybridization (CGH) in ten of those cases. In histological and immunohistochemical review, 18 cases (64%) were of astrocytic lineage, three (11%) were of oligodendroglial lineage, and seven (25%) were of uncommitted lineage. In the array-based CGH, 52 clones were frequently lost on 6p, 9p, and 9q in more than six cases, and six clones were frequently gained on 1p, 6q, 10q, and 21q in more than three cases. Some gained or lost genetic loci differed significantly between the histologically high-grade and low-grade GC (P < 0.05), but unsupervised hierarchical clustering failed to produce evidence of any clinical significance. These altered genetic foci are not known to be involved in the development of conventional glial tumors, including astrocytic tumors. In conclusion, despite the dominant astrocytic differentiation of GC histologically, novel genomic aberrations found in our GC cases were different from those of astrocytic tumors.
journal_name
J Neurooncoljournal_title
Journal of neuro-oncologyauthors
Min HS,Kim B,Park SHdoi
10.1007/s11060-008-9665-7subject
Has Abstractpub_date
2008-12-01 00:00:00pages
259-66issue
3eissn
0167-594Xissn
1573-7373journal_volume
90pub_type
杂志文章abstract::The aim of this article is to evaluate and assess the impact of various factors on quality of life (QOL) in adult patients with primary brain tumors seen consecutively in routine neurooncology practice. Two hundred and fifty-seven adult patients, after undergoing surgical intervention and histologically proven primary...
journal_title:Journal of neuro-oncology
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更新日期:2009-12-01 00:00:00
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更新日期:2015-09-01 00:00:00
abstract::Thirty-five adult recurrent GBM patients, divided randomly in two groups of 19 and 16 cases, had been treated with two regimens of chemotherapy: a) 'eight-drugs-in-one-day'; b) procarbazine + CCNU + vincristine (PCV) respectively. Chemotherapy was planned at the tumour relapse and delivered as long as tolerated withou...
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更新日期:2019-05-01 00:00:00
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更新日期:2017-12-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
doi:10.1007/s11060-015-2026-4
更新日期:2016-03-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1991-12-01 00:00:00
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journal_title:Journal of neuro-oncology
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更新日期:2014-08-01 00:00:00
abstract:PURPOSE:To evaluate the effectiveness of complete resection and postoperative radiotherapy in spinal cord ependymomas. METHODS AND MATERIALS:We conducted a retrospective study over 20 patients (13 males and 7 females) with histologically confirmed spinal cord ependymomas between July 1985 and April 2001. Among them, 1...
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doi:10.1007/s11060-012-0883-7
更新日期:2012-08-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
doi:10.1023/a:1006399804896
更新日期:1999-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s11060-011-0660-z
更新日期:2012-01-01 00:00:00
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pub_type: 杂志文章,已发布勘误
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更新日期:2020-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/BF00165174
更新日期:1985-01-01 00:00:00
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更新日期:2006-09-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
doi:10.1023/a:1015832726054
更新日期:2002-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-09-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
doi:10.1007/s11060-008-9683-5
更新日期:2009-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-04-01 00:00:00