Abstract:
:We present a computer aided diagnostic workflow focusing on two diagnostic branch points in neuropathology (intraoperative consultation and p53 status in tumor biopsy specimens) by means of texture analysis via discrete wavelet frames decomposition. For intraoperative consultation, our methodology is capable of classifying glioblastoma versus metastatic cancer by extracting textural features from the non-nuclei region of cytologic preparations based on the imaging characteristics of glial processes, which appear as anisotropic thin linear structures. For metastasis, these are homogeneous in appearance, thus suitable and extractable texture features distinguish the two tissue types. Experiments on 53 images (29 glioblastomas and 24 metastases) resulted in average accuracy as high as 89.7 % for glioblastoma, 87.5 % for metastasis and 88.7 % overall. For p53 interpretation, we detect and classify p53 status by classifying staining intensity into strong, moderate, weak and negative sub-classes. We achieved this by developing a novel adaptive thresholding for detection, a two-step rule based on weighted color and intensity for the classification of positively and negatively stained nuclei, followed by texture classification to classify the positively stained nuclei into the strong, moderate and weak intensity sub-classes. Our detection method is able to correctly locate and distinguish the four types of cells, at 85 % average precision and 88 % average sensitivity rate. These classification methods on the other hand recorded 81 % accuracy in classifying the positive and negative cells, and 60 % accuracy in further classifying the positive cells into the three intensity groups, which is comparable with neuropathologists' markings.
journal_name
J Neurooncoljournal_title
Journal of neuro-oncologyauthors
Fauzi MFA,Gokozan HN,Elder B,Puduvalli VK,Pierson CR,Otero JJ,Gurcan MNdoi
10.1007/s11060-015-1872-4subject
Has Abstractpub_date
2015-09-01 00:00:00pages
393-402issue
3eissn
0167-594Xissn
1573-7373journal_volume
124pub_type
杂志文章abstract::Gender-specific incidence patterns and the presence of hormonal receptors on tumor cells suggest that sex hormones may play a role in the onset of primary brain tumors. However, epidemiological studies on the relation of hormonal risk factors to the risk of brain tumors have been inconsistent. We examined the role of ...
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journal_title:Journal of neuro-oncology
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更新日期:2006-01-01 00:00:00
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journal_title:Journal of neuro-oncology
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更新日期:2008-12-01 00:00:00
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更新日期:2003-05-01 00:00:00
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更新日期:2017-02-01 00:00:00
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journal_title:Journal of neuro-oncology
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abstract:INTRODUCTION:Intramedullary spinal cord metastases (ISCMs) are rare lesions affecting the spinal cord in patients with disseminated malignancy. Today, due to increased survival, these lesions are more frequently diagnosed. Literature on survival and neurologic outcomes is sparse. Herein, we describe a single institutio...
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更新日期:2019-04-01 00:00:00
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journal_title:Journal of neuro-oncology
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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