The cost-effectiveness of surgical resection and cesium-131 intraoperative brachytherapy versus surgical resection and stereotactic radiosurgery in the treatment of metastatic brain tumors.

abstract：:Our previous investigations correlated the degree of cytogenetic and immunophenotypic heterogeneity of cultured normal glia, astrocytomas and malignant gliomas. The possible significance was suggested by the statistical correlation of individual antigens with diagnosis and patient survival. The present study has estab...

journal_title：Journal of neuro-oncology

authors： Jennings MT,Asadourian LL,Jennings VD,Shapiro JR,Thaler HT

更新日期：1990-12-01 00:00:00

abstract：:A 44 year-old man with subcutaneous meningioma and rare combination of spinal lesions, consisting of dermal sinus and lipoma of the filum terminale. The literature concerning the subcutaneous meningioma is reviewed and the embryogenesis of these lesions is discussed. ...

journal_title：Journal of neuro-oncology

authors： Qasho R,Lunardi P,Lo Bianco FM,di Stefano M

更新日期：1998-05-01 00:00:00

abstract：:The basic mechanism of cell death induced by 5-aminolevulinic acid (5-ALA)-mediated photodynamic therapy (PDT) (ALA-PDT) in glioma cells has not been fully elucidated. In this study, the details of the cell death mechanism induced by ALA-PDT were investigated in three human glioma cell lines (U251MG, U87MG, and U118MG...

journal_title：Journal of neuro-oncology

authors： Inoue H,Kajimoto Y,Shibata MA,Miyoshi N,Ogawa N,Miyatake S,Otsuki Y,Kuroiwa T

更新日期：2007-07-01 00:00:00

abstract：:Fractionated external beam radiotherapy is an important component of standard treatment for high grade glioma. Due to resource constraints, patients may experience delays in receiving treatment. The purpose of this study was to evaluate the effect of radiotherapy waiting time on survival in patients with high grade gl...

journal_title：Journal of neuro-oncology

authors： Irwin C,Hunn M,Purdie G,Hamilton D

更新日期：2007-12-01 00:00:00

abstract：:Cell differentiation agent-2 (CDA-2) is an extraction from healthy human urine consisting of primary organic acids and peptides, and it has been demonstrated to inhibit growth and induce differentiation in glioma and other cell lines. But the mechanism of CDA-2 remains unclear. In this study, we demonstrated that CDA-...

journal_title：Journal of neuro-oncology

authors： Xie YK,Huo SF,Zhang G,Zhang F,Lian ZP,Tang XL,Jin C

更新日期：2012-11-01 00:00:00

abstract：:Central nervous system (CNS) involvement is a rare complication of chronic lymphocytic leukemia (CLL) with varied outcomes. We contribute two additional cases of CLL with CNS involvement. The clinical course and response to treatment are described. All 78 previously reported cases of CLL with CNS involvement are prese...

journal_title：Journal of neuro-oncology

authors： Moazzam AA,Drappatz J,Kim RY,Kesari S

更新日期：2012-01-01 00:00:00

abstract：:The Coronavirus pandemic has created unprecedented strain on medical resources at health care institutions around the world. At many institutions, this has resulted in efforts to prioritize cases with an attempt to balance the acuity of medical needs with available resources. Here, we provide a framework for instituti...

journal_title：Journal of neuro-oncology

authors： Ramakrishna R,Zadeh G,Sheehan JP,Aghi MK

更新日期：2020-05-01 00:00:00

abstract：:Meningiomas in identical twins are extremely rare. To our knowledge, only one previous report of meningiomas in identical twins has been published. We present identical twin sisters with meningiomas. The tumors were located at a similar, but not a common, position (the cerebellopontine angle) in both twins. Histologic...

journal_title：Journal of neuro-oncology

authors： Ohba S,Yoshida K,Hirose Y,Ikeda E,Kawase T

更新日期：2010-07-01 00:00:00

abstract：:Treatment of infant hypothalamic chiasmatic glioma (iCHG) is challenging, about 30% of the children progress during chemotherapy. Despite subsequent treatments the 5 year overall-survival rate is only 70%. This study investigates treatment strategies currently applied for progressive iCHG. A web-based questionnaire wa...

journal_title：Journal of neuro-oncology

authors： Azizi AA,Schouten-van Meeteren AYN

更新日期：2018-01-01 00:00:00

abstract：:We retrospectively evaluated the relationship between the response of lung lesions and distant progression-free survival (DPFS) after radiosurgery in patients with brain metastases. A total of 47 consecutive patients were treated with radiosurgery for brain metastases. Distant progression was defined as a new enhancin...

journal_title：Journal of neuro-oncology

authors： Han JH,Kim DG,Oh CW,Kim CY,Kim YH,Park JH,Kim EK,Jung HW

更新日期：2012-01-01 00:00:00

abstract：:Developing and conducting gene therapy clinical trials poses unique challenges which must be addressed to satisfy regulatory requirements and, most importantly, to protect human subjects. Experimental products used for gene transfer studies, such as viral vectors, are often complex and cannot be sterilized or complete...

journal_title：Journal of neuro-oncology

authors： Aguilar LK,Aguilar-Cordova E

更新日期：2003-12-01 00:00:00

abstract：:Five quantitative histologic factors, differing linear combinations of 26 reliably recognized histologic features, account for much of the histologic variance in 1068 children with infratentorial neuroglial tumors in the Childhood Brain Tumor Consortium (CBTC) database. In this study, we used the scores on the Spongy,...

journal_title：Journal of neuro-oncology

authors： Gilles FH,Sobel EL,Leviton A,Tavaré CJ

更新日期：1998-08-01 00:00:00

abstract：:Glioblastoma is the most common and most aggressive primary brain tumor. Despite maximum treatment, patients only have a median survival time of 15 months, because of the tumor's resistance to current therapeutic approaches. Thus far, methylation of the O (6)-methylguanine-DNA methyltransferase (MGMT) promoter has bee...

journal_title：Journal of neuro-oncology

authors： Bleeker FE,Molenaar RJ,Leenstra S

更新日期：2012-05-01 00:00:00

abstract：:Malignant glioma (MG), the most common primary brain tumor in adults, is extremely aggressive and uniformly fatal. Several treatment strategies have shown significant preclinical promise in murine models of glioma; however, none have produced meaningful clinical responses in human patients. We hypothesize that introdu...

journal_title：Journal of neuro-oncology

authors： Filley A,Henriquez M,Bhowmik T,Tewari BN,Rao X,Wan J,Miller MA,Liu Y,Bentley RT,Dey M

更新日期：2018-05-01 00:00:00

abstract：:Overexpression of the EGFR, IGFBP-2 and HIF-2A genes has been observed in high-grade astrocytomas and these genes seem to be functionally related to one another. This study aimed to define the profile of their expressions, interactions and correlation with clinical features and prognostic significance in microdissecte...

journal_title：Journal of neuro-oncology

authors： Scrideli CA,Carlotti CG Jr,Mata JF,Neder L,Machado HR,Oba-Sinjo SM,Rosemberg S,Marie SK,Tone LG

更新日期：2007-07-01 00:00:00

abstract：:Central neurocytomas are uncommon intraventricular neoplasms whose optimal management remains controversial due to their rarity. We assessed outcomes for a historical cohort of neurocytoma patients and evaluated effects of tumor atypia, size, resection extent, and adjuvant radiotherapy. Progression-free survival (PFS)...

journal_title：Journal of neuro-oncology

authors： Imber BS,Braunstein SE,Wu FY,Nabavizadeh N,Boehling N,Weinberg VK,Tihan T,Barnes M,Mueller S,Butowski NA,Clarke JL,Chang SM,McDermott MM,Prados MD,Berger MS,Haas-Kogan DA

更新日期：2016-01-01 00:00:00

abstract：:Radiation therapy (RT) for brain tumors is associated with neurocognitive toxicity which may be a result of damage to neural progenitor cells (NPCs). We present a novel technique to limit the radiation dose to NPC without compromising tumor coverage. A study was performed in mice to examine the rationale and another w...

journal_title：Journal of neuro-oncology

authors： Redmond KJ,Achanta P,Grossman SA,Armour M,Reyes J,Kleinberg L,Tryggestad E,Quinones-Hinojosa A,Ford EC

更新日期：2011-09-01 00:00:00

abstract：:Glioblastoma (GBM) is the most common adult CNS malignancy but its impact on quality of life (QOL) is poorly understood. In other patient populations, illness intrusiveness (the extent to which disease and treatment disrupts valued activities and interests) is associated with low subjective well-being, after controlli...

journal_title：Journal of neuro-oncology

authors： Edelstein K,Coate L,Massey C,Jewitt NC,Mason WP,Devins GM

更新日期：2016-01-01 00:00:00

abstract：:To characterize a population of pediatric high-grade astrocytoma (HGA) patients by confirming the proportion with a correct diagnosis, and determine prognostic factors for survival in a subset diagnosed with uniform pathologic criteria. Sixty-three children diagnosed with HGA were treated at the Johns Hopkins Hospital...

journal_title：Journal of neuro-oncology

authors： Hales RK,Shokek O,Burger PC,Paynter NP,Chaichana KL,Quiñones-Hinojosa A,Jallo GI,Cohen KJ,Song DY,Carson BS,Wharam MD

更新日期：2010-08-01 00:00:00

abstract：:Patients with brain metastasis (BM) from renal cell carcinoma (RCC) are associated with poor prognosis. Between 1990 and 2015, data of consecutive RCC patients with BM were retrospectively analyzed from a urologic oncologic database. The treatment outcome was evaluated by overall survival (OS), which was defined as in...

journal_title：Journal of neuro-oncology

authors： Du Y,Pahernik S,Hadaschik B,Teber D,Duensing S,Jäger D,Hohenfellner M,Grüllich C

更新日期：2016-10-01 00:00:00

abstract：PURPOSE:Children with recurrent medulloblastoma have a poor prognosis. Re-irradiation is an option for some patients, but has not been well-studied in the era of molecular characterization for pediatric medulloblastoma. METHODS:This was a retrospective cohort study of 14 children age 18 years and younger at initial di...

journal_title：Journal of neuro-oncology

authors： Tsang DS,Sarhan N,Ramaswamy V,Nobre L,Yee R,Taylor MD,Hawkins C,Bartels U,Huang A,Tabori U,Hodgson DC,Bouffet E,Laperriere N

更新日期：2019-10-01 00:00:00

abstract：:Subcutaneous vaccination using granulocyte-macrophage colony-stimulating factor (GM-CSF)-transduced glioma cells substantially prolongs survival in the mouse GL261 glioma model. To potentiate the efficacy of GM-CSF-based vaccination, syngeneic C57BL/6 mice bearing pre-implanted intracerebral GL261 gliomas were vaccina...

journal_title：Journal of neuro-oncology

authors： Herrlinger U,Aulwurm S,Strik H,Weit S,Naumann U,Weller M

更新日期：2004-01-01 00:00:00

abstract：:This study investigated the effects of the intracarotid infusion of etoposide in combination with angiotensin II (AT II)-induced hypertension on the blood-brain barrier (BBB) and brain tissue in rats. Eighty rats were divided into five groups: Group 1, intravenous infusion of AT II to increase arterial blood pressure;...

journal_title：Journal of neuro-oncology

authors： Ogasawara H,Kiya K,Kurisu K,Hotta T,Mikami T,Sugiyama K,Nakahara T,Uozumi T

更新日期：1992-06-01 00:00:00

abstract：:Identification of cytotoxic T lymphocyte (CTL) epitopes from additional tumor antigens is essential for the development of specific immunotherapy of malignant tumors. Neuritin, a recently discovered antigen overexpressed in astrocytoma, is considered to be a promising target for biological therapy. In the present stud...

journal_title：Journal of neuro-oncology

authors： Yang Z,Zhao T,Liu Y,Gong Z,Cheng S,Yang Q

更新日期：2013-08-01 00:00:00

abstract：:The aim of the present study was to investigate the localization and distribution of the putative brain tumour stem cell marker CD133 in formalin fixed paraffin embedded astrocytomas. A retrospective analysis of 114 grade II, III and IV astrocytomas was undertaken. The immunohistochemical expression of CD133 in paraff...

journal_title：Journal of neuro-oncology

authors： Christensen K,Schrøder HD,Kristensen BW

更新日期：2008-11-01 00:00:00

abstract：:Thymidine analogs (TAs) are synthetic nucleosides that incorporate into newly synthesized DNA. Halogenated pyrimidines (HPs), such as bromodeoxyuridine (BrdU), are a class of TAs that can be detected with antibodies and are commonly used for birthdating individual cells and for assessing the proliferative index of cel...

journal_title：Journal of neuro-oncology

authors： Ross HH,Rahman M,Levkoff LH,Millette S,Martin-Carreras T,Dunbar EM,Reynolds BA,Laywell ED

更新日期：2011-12-01 00:00:00

abstract：:The mainstays of primary treatment of ependymoma are aggressive surgery followed by radiotherapy. Although spreading occasionally occurs in the cerebrospinal pathways, chemotherapy is still not established and no ultimate drug has so far been found. Estramustine-phosphate (EMP), with a demonstrated effect on astrocyto...

journal_title：Journal of neuro-oncology

authors： Bergenheim AT,Hartman M,Bergh J,Ridderheim PA,Henriksson R

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:Intracranial glioblastomas with simultaneous spinal lesions prior to chemoradiation therapy or craniotomy, defined as initial spinal metastasis, are not well understood. Herein, we investigated intracranial glioblastoma and demonstrated the importance of spinal screening using gadolinium enhanced spinal magneti...

journal_title：Journal of neuro-oncology

authors： Shibahara I,Saito R,Osada Y,Kanamori M,Sonoda Y,Kumabe T,Mugikura S,Watanabe M,Tominaga T

更新日期：2019-01-01 00:00:00

abstract：:Two distinct mechanisms, vasculogenesis and angiogenesis implement the formation of the vascular network in the embryo. Vasculogenesis gives rise to the heart and the first primitive vascular plexus inside the embryo and in its surrounding membranes, as the yolk sac circulation. Angiogenesis is responsible for the rem...

journal_title：Journal of neuro-oncology

authors： Patan S

更新日期：2000-10-01 00:00:00

abstract：:Calcification is a rare phenomenon in high grade glioma (HGG). CT scans are sensitive to mineralization but used infrequently for tumor assessment in the MRI era. The presence of calcification can be overlooked on routine MRI. Calcification may reflect chronicity and natural changes in the tumor or its milieu over tim...

journal_title：Journal of neuro-oncology

authors： Blumenthal DT,Aisenstein O,Ben-Horin I,Ben Bashat D,Artzi M,Corn BW,Kanner AA,Ram Z,Bokstein F

更新日期：2015-06-01 00:00:00