Effect of intracarotid infusion of etoposide with angiotensin II-induced hypertension on the blood-brain barrier and the brain tissue.

abstract：:The basement membrane collagen IV-degrading matrix metalloproteinases -2 and -9 (MMPs) are most often linked to the malignant phenotype of tumor cells by playing a critical role in invasion, metastasis, angiogenesis, and vasculogenesis. We verified the activity of these two MMPs in the sera of patients affected by bra...

journal_title：Journal of neuro-oncology

authors： Ricci S,Guadagno E,Bruzzese D,Del Basso De Caro M,Peca C,Sgulò FG,Maiuri F,Di Carlo A

更新日期：2017-01-01 00:00:00

abstract：:Central nervous system (brain or leptomeningeal) metastases (BLm) are considered rare in castration-resistant prostate cancer (CRPC) patients. Now that docetaxel has become the reference drug for first-line treatment of CRPC, patients whose disease is not controlled by hormonal manipulations may live much longer than ...

journal_title：Journal of neuro-oncology

authors： Caffo O,Gernone A,Ortega C,Sava T,Cartenì G,Facchini G,Re GL,Amadio P,Bortolus R,Pagliarulo V,Prati V,Veccia A,Galligioni E

更新日期：2012-03-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) remains refractory to conventional therapy. CD133+ GBM cells have been recently isolated and characterized as chemo-/radio-resistant tumor-initiating cells and are hypothesized to be responsible for post-treatment recurrence. In order to explore the molecular properties of tumorigenic CD1...

journal_title：Journal of neuro-oncology

authors： Liu Q,Nguyen DH,Dong Q,Shitaku P,Chung K,Liu OY,Tso JL,Liu JY,Konkankit V,Cloughesy TF,Mischel PS,Lane TF,Liau LM,Nelson SF,Tso CL

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:Because raised matrix metalloprotease (MMP) levels are associated with glioma invasion and angiogenesis, we tested the efficacy of marimastat (MT) an orally active drug that can reduce MMP levels, in patients with gliomas. PATIENTS AND METHODS:A total of 162 patients with intracranial glioblastoma multiforme o...

journal_title：Journal of neuro-oncology

authors： Levin VA,Phuphanich S,Yung WK,Forsyth PA,Maestro RD,Perry JR,Fuller GN,Baillet M

更新日期：2006-07-01 00:00:00

abstract：:Neurological complications may occur in the course of Waldenström's macroglobulinemia (Wm). These complications affect both the central and peripheral nervous system. Pathogenesis is debated and several mechanisms have been suggested. Direct malignant lymphoid infiltration (MLI) is very rare and has only been reported...

journal_title：Journal of neuro-oncology

authors： Massengo S,Riffaud L,Morandi X,Bernard M,Verin M

更新日期：2003-05-01 00:00:00

abstract：:The members of the PERNO Study Group were not individually captured in the metadata of the original publication. They are included in the metadata of this publication. ...

journal_title：Journal of neuro-oncology

authors： Franceschi E,Depenni R,Paccapelo A,Ermani M,Faedi M,Sturiale C,Michiara M,Servadei F,Pavesi G,Urbini B,Pisanello A,Crisi G,Cavallo MA,Dazzi C,Biasini C,Bertolini F,Mucciarini C,Pasini G,Baruzzi A,Brandes AA,PERNO

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:Under-enrollment in clinical trials significantly limits valid analyses of clinical interventions and generalizability of findings. Often it results in premature study termination, with estimates of 22% to 50% of clinical trials terminated due to poor accrual. Currently, there are limited reports addressing the...

journal_title：Journal of neuro-oncology

authors： Morshed RA,Reihl SJ,Molinaro AM,Kakaizada S,Young JS,Schulte JD,Butowski N,Taylor J,Bush NA,Aghi MK,Berger MS,Chang S,Clarke J,Hervey-Jumper SL

更新日期：2020-05-01 00:00:00

abstract：PURPOSE:Post-operative radiation therapy for brain metastases (BM) has become standard treatment. Concerns regarding the deleterious cognitive effects of Whole Brain Radiation Therapy spurred a trend to use focal therapies such as stereotactic radiosurgery (SRS). The purpose of this study was to prospectively evaluate ...

journal_title：Journal of neuro-oncology

authors： Berger A,Strauss I,Ben Moshe S,Corn BW,Limon D,Shtraus N,Shahar T,Kanner AA

更新日期：2018-11-01 00:00:00

abstract：:Aberrant activation of Akt is a common finding in adult malignant gliomas, resulting in most cases from mutations or deletions involving PTEN, which allows constitutive Akt phosphorylation. In contrast, we have previously reported that pediatric malignant gliomas, which are morphologically similar to lesions arising i...

journal_title：Journal of neuro-oncology

authors： Pollack IF,Hamilton RL,Burger PC,Brat DJ,Rosenblum MK,Murdoch GH,Nikiforova MN,Holmes EJ,Zhou T,Cohen KJ,Jakacki RI,Children's Oncology Group.

更新日期：2010-09-01 00:00:00

abstract：:Cavernous angiomas of the spinal cord exhibit imaging characteristics that may overlap with those of hemorrhagic ependymoma. In the present study, we aimed to identify specific magnetic resonance imaging (MRI) findings that could be used to differentiate cavernous angioma from hemorrhagic ependymoma, and to evaluate s...

journal_title：Journal of neuro-oncology

authors： Jeon I,Jung WS,Suh SH,Chung TS,Cho YE,Ahn SJ

更新日期：2016-10-01 00:00:00

abstract：:A case of multiple brain metastases from breast carcinoma treated with tamoxifen is described. She remained in remission for 58 months and is still alive after 82+ months of hormone therapy. The case indicates that hormonal treatment may be very effective in the management of brain metastases from breast carcinoma. ...

journal_title：Journal of neuro-oncology

authors： Pors H,von Eyben FE,Sørensen OS,Larsen M

更新日期：1991-04-01 00:00:00

abstract：:Although bevacizumab has not proven effective in adults with newly diagnosed high-grade gliomas (HGG), feasibility in newly diagnosed children with diffuse intrinsic pontine gliomas (DIPG) or HGG has not been reported in a prospective study. In a safety and feasibility study, children and young adults with newly diagn...

journal_title：Journal of neuro-oncology

authors： Hummel TR,Salloum R,Drissi R,Kumar S,Sobo M,Goldman S,Pai A,Leach J,Lane A,Pruitt D,Sutton M,Chow LM,Grimme L,Doughman R,Backus L,Miles L,Stevenson C,Fouladi M,DeWire M

更新日期：2016-03-01 00:00:00

abstract：:The antiproliferative effect of IFNalpha was tested on the human glioblastoma cell lines, U-373MG and T98G. IFNalpha significantly inhibited the growth of both cell lines, but was more effective in retarding the growth of U-373MG cells. Flow cytometry analysis indicated that synchronized IFNalpha-treated U-373MG cells...

journal_title：Journal of neuro-oncology

authors： Tanabe T,Kominsky SL,Subramaniam PS,Johnson HM,Torres BA

更新日期：2000-07-01 00:00:00

abstract：:Ependymomas are glial neoplasms originating from the wall of the ventricles or from the spinal canal. The significance of histopathological features in accurately predicting biological behavior is still debated. Moreover, key molecular events in the pathogenesis of ependymoma are yet to be defined. The main objective ...

journal_title：Journal of neuro-oncology

authors： Rousseau A,Idbaih A,Ducray F,Crinière E,Fèvre-Montange M,Jouvet A,Delattre JY

更新日期：2010-05-01 00:00:00

abstract：:Intraspinal location of central PNET (cPNET) is very rare. We present a case, critically review all publications of primary intraspinal cPNET occurrence and discuss tendencies in clinical presentation. In several previous attempts to summarise, authors often confused cPNET with peripheral PNET (pPNET). cPNET and pPNET...

journal_title：Journal of neuro-oncology

authors： Kampman WA,Kros JM,De Jong TH,Lequin MH

更新日期：2006-03-01 00:00:00

abstract：:The objective of this study was to investigate whether activity and protein expression of ornithine decarboxylase (ODC) the metabolism-rate limiting enzyme of the polyamine biosynthesis, which is involved in the regulation of cellular growth and differentiation, reflects the distinct histopathologic characteristics in...

journal_title：Journal of neuro-oncology

authors： Stenzel W,Röhn G,Miletic H,Radner H,Deckert M,Ernestus RI

更新日期：2004-01-01 00:00:00

abstract：:Brain tumor patients undergo various combinations therapies, leading to very complex and confusing imaging appearances on follow up MR imaging and hence, differentiating recurrent or progressing tumors from treatment induced necrosis or effects has always been a challenge in neuro-oncologic imaging. This particular to...

journal_title：Journal of neuro-oncology

authors： Jain R,Narang J,Sundgren PM,Hearshen D,Saksena S,Rock JP,Gutierrez J,Mikkelsen T

更新日期：2010-10-01 00:00:00

abstract：:Central neurocytomas are uncommon intraventricular neoplasms whose optimal management remains controversial due to their rarity. We assessed outcomes for a historical cohort of neurocytoma patients and evaluated effects of tumor atypia, size, resection extent, and adjuvant radiotherapy. Progression-free survival (PFS)...

journal_title：Journal of neuro-oncology

authors： Imber BS,Braunstein SE,Wu FY,Nabavizadeh N,Boehling N,Weinberg VK,Tihan T,Barnes M,Mueller S,Butowski NA,Clarke JL,Chang SM,McDermott MM,Prados MD,Berger MS,Haas-Kogan DA

更新日期：2016-01-01 00:00:00

abstract：:Various histological types of tumors arise in the pineal region. The most common tumors are pineal parenchymal tumors and germ cell tumors. Pineal parenchymal tumors are divided into pineocytoma, pineal parenchymal tumor with intermediate differentiation and pineoblastoma. Pineocytomas are well-differentiated tumors a...

journal_title：Journal of neuro-oncology

authors： Hirato J,Nakazato Y

更新日期：2001-09-01 00:00:00

abstract：:A high affinity folate receptor is expressed in some human cancers, including choroid plexus tumors and ependymomas, and has been suggested as a target for therapeutics. In this report, the expression of folate receptors in an SV40 large T antigen transgenic mouse (SV11) was investigated. SV11 mice develop choroid ple...

journal_title：Journal of neuro-oncology

authors： Patrick TA,Kranz DM,van Dyke TA,Roy EJ

更新日期：1997-04-01 00:00:00

abstract：:To study the clinical characteristics, treatment approach and outcome of pleomorphic xanthoastrocytoma (PXA), patients were identified using the National Cancer Intitute's Surveillance, Epidemiology, and End Results (SEER) database. A total of 214 patients were identified with PXA using the November 2010 submission. P...

journal_title：Journal of neuro-oncology

authors： Perkins SM,Mitra N,Fei W,Shinohara ET

更新日期：2012-10-01 00:00:00

abstract：:This study aims to evaluate the cost-effectiveness of surgical resection (S) and Cesium-131 (Cs-131) [S + Cs-131] intraoperative brachytherapy versus S and stereotactic radiosurgery (SRS) [S + SRS] for the treatment of brain metastases. Treatment records as well as hospital and outpatient charts of 49 patients with br...

journal_title：Journal of neuro-oncology

authors： Wernicke AG,Yondorf MZ,Parashar B,Nori D,Clifford Chao KS,Boockvar JA,Pannullo S,Stieg P,Schwartz TH

更新日期：2016-03-01 00:00:00

abstract：:Intramedullary spinal cord metastases of solid neoplasms are associated with poor long-term survival. As the characteristics of secondary intramedullary spinal cord non-Hodgkin's lymphoma (NHL) are not well understood, we sought to describe its clinical features and outcome. We retrospectively reviewed the Mayo Clinic...

journal_title：Journal of neuro-oncology

authors： Flanagan EP,O'Neill BP,Habermann TM,Porter AB,Keegan BM

更新日期：2012-05-01 00:00:00

abstract：:The authors studied 24 patients affected by anaplastic gliomas in regard to the killer (Antibody-Dependent Cellular Cytotoxicity) and natural killer (Spontaneous Lymphocyte-Mediated Cytotoxicity) immunological functions, by counting the Cr51 release in Change liver and K 562 cell cultures, respectively. These paramete...

journal_title：Journal of neuro-oncology

authors： Servadei F,Parente R,Bucci M,Beltrandi E,Tognetti F,Gaist G

更新日期：1983-01-01 00:00:00

abstract：:We previously showed that inhibition of the platelet-derived growth factor receptor (PDGFR) blocks the survival and migration of medulloblastoma cells. Identification of in vitro PDGFR-targeting pharmacologic agents that are suitable for preclinical testing in medulloblastoma models in vivo will be critical for effici...

journal_title：Journal of neuro-oncology

authors： Abouantoun TJ,Castellino RC,MacDonald TJ

更新日期：2011-01-01 00:00:00

abstract：:Membrane-type MMPs (MT-MMPs) constitute a growing subclass of recently identified matrix metalloproteinases (MMPs). In addition to the highly conserved MMP functional domains, the MT-MMPs have additional insertion sequences (IS) that confer unique functional roles. While most of the MMPs are secreted, the MT-MMPs are ...

journal_title：Journal of neuro-oncology

authors： Fillmore HL,VanMeter TE,Broaddus WC

更新日期：2001-06-01 00:00:00

abstract：:The records of thirty-four patients with meningeal carcinomatosis treated at our hospital between 1984 and 1990 were reviewed. The sources, histologies, metastatic lesions outside the central nervous system, the history of the treatment of primary lesions and intraparenchymal of metastatic brain tumors and the period ...

journal_title：Journal of neuro-oncology

authors： Nakagawa H,Murasawa A,Kubo S,Nakajima S,Nakajima Y,Izumoto S,Hayakawa T

更新日期：1992-05-01 00:00:00

abstract：:Glioblastomas are malignant brain tumors with poor prognosis. Lately, data from clinical studies assessing the role of co-medications in different cancer types suggested reduced mortality and potential anti-tumor activity for statins, angiotensin-I converting enzyme inhibitors (ACEI) and angiotensin II receptor blocke...

journal_title：Journal of neuro-oncology

authors： Happold C,Gorlia T,Nabors LB,Erridge SC,Reardon DA,Hicking C,Picard M,Stupp R,Weller M,EORTC Brain Tumor Group and on behalf of the CENTRIC and CORE Clinical Trial Groups.

更新日期：2018-05-01 00:00:00

abstract：:Patients with metastatic well-differentiated thyroid cancer have a generally favorable long-term outcome although multi-organ involvement is a known marker of poor prognosis. Brain metastases are rare, occurring in less than 1% of patients with thyroid cancer. Few patients have been managed with stereotactic radiosurg...

journal_title：Journal of neuro-oncology

authors： Bernad DM,Sperduto PW,Souhami L,Jensen AW,Roberge D

更新日期：2010-06-01 00:00:00

abstract：:Thirty-one patients with metastatic brain tumors that either failed to respond or recurred after conventional therapy were treated by intra-arterial infusion of 100 mg/m2 of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) into either a carotid or vertebral artery. Five patients (three with lung cancer, one with breast can...

journal_title：Journal of neuro-oncology

authors： Cascino TL,Byrne TN,Deck MD,Posner JB

更新日期：1983-01-01 00:00:00