当前位置： SCI文献检索 > JOURNAL OF NEURO-ONCOLOGY期刊下所有文献 > Diagnosis and treatment of patients with meningeal carcinomatosis.

Diagnosis and treatment of patients with meningeal carcinomatosis.

Abstract：

:The records of thirty-four patients with meningeal carcinomatosis treated at our hospital between 1984 and 1990 were reviewed. The sources, histologies, metastatic lesions outside the central nervous system, the history of the treatment of primary lesions and intraparenchymal of metastatic brain tumors and the period from the diagnosis of primary lesions and the treatment of intraparenchymal metastatic brain tumors to the diagnosis of meningeal carcinomatosis were investigated. Meningeal carcinomatosis was diagnosed and by neurological signs, CSF cytology, CT scan and MRI. Each patient was given a 5 mg single dose of methotrexate (MTX) alone or combined with 20 mg cytosine arabinoside (Ara-C) administered by intrathecal injection via an Ommaya reservoir and standard lumbar puncture with or without radiotherapy. Following intrathecal chemotherapy 22 of 29 patients showed symptomatic improvement of meningeal irritation and in 10 of 29 patients with cranial nerve impairment amelioration of symptoms was also observed. Moreover, CSF cytology became negative in 10 of 29 patients after a full course of intrathecal chemotherapy. Neurotoxicity Leukoencephalopathy, a neurotoxic effect of intrathecal chemotherapy was not observed in any of the patients. From these results, MTX in small doses is recommended for intrathecal chemotherapy of meningeal carcinomatosis to prevent neurotoxicity.

journal_name

J Neurooncol

journal_title

Journal of neuro-oncology

authors

Nakagawa H,Murasawa A,Kubo S,Nakajima S,Nakajima Y,Izumoto S,Hayakawa T

doi

10.1007/BF00172949

subject

Has Abstract

pub_date

1992-05-01 00:00:00

pages

81-9

issue

1

eissn

0167-594X

issn

1573-7373

journal_volume

13

pub_type

杂志文章

相关文献

JOURNAL OF NEURO-ONCOLOGY文献大全
  • Intracerebral infusion of the bispecific targeted toxin DTATEGF in a mouse xenograft model of a human metastatic non-small cell lung cancer.

    abstract：:The aim of this study is to investigate the anti-cancer effect of the bispecific diphtheria toxin (DT) based immunotoxin DTATEGF, which targets both the epidermal growth factor (EGF) receptor (EGFR) and the urokinase-type plasminogen activator (uPA) receptor (uPAR) in vitro and in vivo when delivered by convection-enh...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-012-0904-6

    authors： Huang J,Li YM,Massague J,Sicheneder A,Vallera DA,Hall WA

    更新日期：2012-09-01 00:00:00

  • Clinical outcome of an alternative fotemustine schedule in elderly patients with recurrent glioblastoma: a mono-institutional retrospective study.

    abstract：:The optimal treatment of recurrent glioblastoma (GBM) in elderly patients is unclear. Fotemustine (FTM) is a third-generation nitrosourea showing efficacy in gliomas and it has been used with different schedules in adult patients. We performed, for the first time anywhere, a mono-institutional retrospective study to a...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-016-2136-7

    authors： Lombardi G,Bellu L,Pambuku A,Della Puppa A,Fiduccia P,Farina M,D'Avella D,Zagonel V

    更新日期：2016-07-01 00:00:00

  • Prognostic value of proliferation index and expression of the RNA component of human telomerase (hTR) in papillary meningiomas.

    abstract：:Papillary meningioma is a rare subtype of meningioma that often behaves aggressively. In order to characterize factors that may influence this behavior, we chose to compare MIB-1 labeling index (LI) and telomerase RNA localization (hTR) in papillary meningiomas, meningiomas, and atypical meningiomas. LI is now often u...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1023/a:1006353322307

    authors： Rushing EJ,Colvin SM,Gazdar A,Miura N,White CL 3rd,Coimbra C,Burns DK

    更新日期：1999-01-01 00:00:00

  • Location of subventricular zone recurrence and its radiation dose predicts survival in patients with glioblastoma.

    abstract：:Glioblastomas are aggressive brain tumors that frequently recur in the subventricular zone (SVZ) despite maximal treatment. The purpose of this study was to evaluate imaging patterns of subventricular progression and impact of recurrent subventricular tumor involvement and radiation dose to patient outcome. Retrospect...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-018-2822-8

    authors： Weinberg BD,Boreta L,Braunstein S,Cha S

    更新日期：2018-07-01 00:00:00

  • Mathematical modelling of angiogenesis.

    abstract：:Angiogenesis, the formation of blood vessels from a pre-existing vasculature, is a process whereby capillary sprouts are formed in response to externally supplied chemical stimuli. The sprouts then grow and develop, driven initially by endothelial cell migration, and organize themselves into a branched, connected netw...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,评审

    doi：10.1023/a:1006446020377

    authors： Chaplain MA

    更新日期：2000-10-01 00:00:00

  • Brain stem gliomas in childhood. Rational approach and treatment.

    abstract：:Thirty-six infants and children with brain stem glioma diagnosed between 1967 and 1980 were reviewed. Posterior fossa craniotomy was performed in 25, with biopsy or partial resection in 18, cyst aspiration in 2, and exploration alone in 5. The 19 surgical specimens obtained revealed neoplastic cells in 15 but only gli...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/BF00177896

    authors： Tomita T,McLone DG,Naidich TP

    更新日期：1984-01-01 00:00:00

  • Tissue uptake of BSH in patients with glioblastoma in the EORTC 11961 phase I BNCT trial.

    abstract：PURPOSE:The uptake of the boron compound Na2B12H10-SH (BSH) in tumor and normal tissues was investigated in the frame of the EORTC phase I trial 'Postoperative treatment of glioblastoma with BNCT at the Petten Irradiation Facility' (protocol 11961). METHODS AND MATERIALS:The boron concentration in blood, tumor, normal...

    journal_title：Journal of neuro-oncology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1007/BF02699941

    authors： Hideghéty K,Sauerwein W,Wittig A,Götz C,Paquis P,Grochulla F,Haselsberger K,Wolbers J,Moss R,Huiskamp R,Fankhauser H,de Vries M,Gabel D

    更新日期：2003-03-01 00:00:00

  • The impact of concurrent temozolomide with adjuvant radiation and IDH mutation status among patients with anaplastic astrocytoma.

    abstract：:This study assesses the controversial role of temozolomide (TMZ) concurrent with adjuvant radiation (RT) in patients with anaplastic astrocytoma (AA). The impact of isocitrate dehydrogenase (IDH) status on therapy and outcomes is also examined. All adult patients diagnosed with AA from 2001 to 2011 and treated with st...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-014-1520-4

    authors： Kizilbash SH,Giannini C,Voss JS,Decker PA,Jenkins RB,Hardie J,Laack NN,Parney IF,Uhm JH,Buckner JC

    更新日期：2014-10-01 00:00:00

  • Favorable long-term outcome of low-grade oligodendrogliomas irrespective of 1p/19q status when treated without radiotherapy.

    abstract：:Despite the accumulating evidences of high chemosensitivity especially in anaplastic oligodendrogliomas with loss of chromosomes 1p and 19q, the optimal management strategy for low-grade tumors using the 1p/19q information remains controversial. We have treated all low-grade oligodendrogliomas by a chemotherapy-preced...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-010-0340-4

    authors： Iwadate Y,Matsutani T,Hasegawa Y,Shinozaki N,Higuchi Y,Saeki N

    更新日期：2011-05-01 00:00:00

  • A myxoid chondrosarcoma associated with an anti-Hu-positive paraneoplastic encephalomyelitis.

    abstract：:Extraskeletal myxoid chondrosarcoma is a rare tumor with less than 100 cases reported in the literature. The prevalence of anti-Hu positive myxoid chondrosarcoma-associated paraneoplastic subacute cerebellar degeneration is exceedingly rare. We present a report of a patient with confirmed myxoid chondrosarcoma-associa...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-010-0216-7

    authors： Hoosien M,Vredenburgh J,Lanfranco J,Ochoa R,Robinson P,Martinez R,Singer C,Silva O

    更新日期：2011-01-01 00:00:00

  • The role of imaging for the management of newly diagnosed glioblastoma in adults: a systematic review and evidence-based clinical practice guideline update.

    abstract：TARGET POPULATION:These recommendations apply to adults with a newly diagnosed lesion with a suspected or histopathologically proven glioblastoma (GBM). QUESTION:What are the optimal imaging techniques to be used in the management of a suspected glioblastoma (GBM), specifically: which imaging sequences are critical fo...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,评审

    doi：10.1007/s11060-020-03597-3

    authors： Lundy P,Domino J,Ryken T,Fouke S,McCracken DJ,Ormond DR,Olson JJ

    更新日期：2020-11-01 00:00:00

  • Salvage chemotherapy with CPT-11 for recurrent glioblastoma multiforme.

    abstract：BACKGROUND:A prospective Phase II study of CPT-11 in adult patients with recurrent supratentorial glioblastoma multiforme (GBM). METHODS:Forty patients (25 men, 15 women) ages 32-71 years (median 59), with recurrent GBM were treated. All patients had previously been treated with surgery and involved field radiotherapy...

    journal_title：Journal of neuro-oncology

    pub_type： 临床试验,杂志文章

    doi：10.1023/a:1014532202188

    authors： Chamberlain MC

    更新日期：2002-01-01 00:00:00

  • Reproductive factors and risk of primary brain tumors in women.

    abstract：:Gender-specific incidence patterns and the presence of hormonal receptors on tumor cells suggest that sex hormones may play a role in the onset of primary brain tumors. However, epidemiological studies on the relation of hormonal risk factors to the risk of brain tumors have been inconsistent. We examined the role of ...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-014-1427-0

    authors： Anic GM,Madden MH,Nabors LB,Olson JJ,LaRocca RV,Thompson ZJ,Pamnani SJ,Forsyth PA,Thompson RC,Egan KM

    更新日期：2014-06-01 00:00:00

  • MiR-519a functions as a tumor suppressor in glioma by targeting the oncogenic STAT3 pathway.

    abstract：:Glioblastoma (GBM) is among the most aggressive primary brain tumors, with a median survival rate of 12-15 months. MicroRNAs have been implicated in GBM development as oncogenes or tumor suppressors. In this study, we demonstrated that miR-519a expression was frequently downregulated in GBM specimens and cell lines, a...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-016-2095-z

    authors： Hong L,Ya-Wei L,Hai W,Qiang Z,Jun-Jie L,Huang A,Song-Tao Q,Yun-Tao L

    更新日期：2016-05-01 00:00:00

  • Histologic evidence of a radiosensitizing effect of Taxol in patients with astrocytomas.

    abstract：:The new anticancer agent Taxol appears to potentiate the effects of radiation on brain tumor cell lines in vitro and was recently evaluated by our group as a radiosensitizer in a phase I study for primary brain tumors. In that study, we administered Taxol as a three-hour IV infusion repeated every week for six weeks a...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1023/a:1005710710418

    authors： Wehbe T,Glantz M,Choy H,Glantz L,Cortez S,Akerley W 3rd,Mills P,Cole B

    更新日期：1998-09-01 00:00:00

  • miR-331-3p regulates expression of neuropilin-2 in glioblastoma.

    abstract：:Aberrant expression of microRNAs (miRNAs), a class of small non-coding regulatory RNAs, has been implicated in the development and progression of high-grade gliomas. However, the precise mechanistic role of many miRNAs in this disease remains unclear. Here, we investigate the functional role of miR-331-3p in glioblast...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-013-1271-7

    authors： Epis MR,Giles KM,Candy PA,Webster RJ,Leedman PJ

    更新日期：2014-01-01 00:00:00

  • Inhibition of the glioblastoma cell cycle by type I IFNs occurs at both the G1 and S phases and correlates with the upregulation of p21(WAF1/CIP1).

    abstract：:The antiproliferative effect of IFNalpha was tested on the human glioblastoma cell lines, U-373MG and T98G. IFNalpha significantly inhibited the growth of both cell lines, but was more effective in retarding the growth of U-373MG cells. Flow cytometry analysis indicated that synchronized IFNalpha-treated U-373MG cells...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1023/a:1006476408190

    authors： Tanabe T,Kominsky SL,Subramaniam PS,Johnson HM,Torres BA

    更新日期：2000-07-01 00:00:00

  • Stereotactic radiosurgery for central neurocytoma: a quantitative systematic review.

    abstract：:Central neurocytoma was originally described as a rare benign neuronal tumor. However, progression and local recurrences after surgery are well recognized. Stereotactic radiosurgery is another option for treatment of CN. In order to evaluate the efficacy of SRS, we performed a quantitative systematic review of the ava...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,评审

    doi：10.1007/s11060-012-0803-x

    authors： Park HK,Steven D C

    更新日期：2012-05-01 00:00:00

  • Effect of intracarotid infusion of etoposide with angiotensin II-induced hypertension on the blood-brain barrier and the brain tissue.

    abstract：:This study investigated the effects of the intracarotid infusion of etoposide in combination with angiotensin II (AT II)-induced hypertension on the blood-brain barrier (BBB) and brain tissue in rats. Eighty rats were divided into five groups: Group 1, intravenous infusion of AT II to increase arterial blood pressure;...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/BF00172760

    authors： Ogasawara H,Kiya K,Kurisu K,Hotta T,Mikami T,Sugiyama K,Nakahara T,Uozumi T

    更新日期：1992-06-01 00:00:00

  • Prospective evaluation of serum glial fibrillary acidic protein (GFAP) as a diagnostic marker for glioblastoma.

    abstract：:Glioblastoma (GBM) is the most common malignant primary brain tumor. Although clinical presentation and brain imaging might be suggestive, histopathological evaluation by means of a brain biopsy is routinely performed to establish the diagnosis. A serum marker indicative of GBM may simplify the diagnostic work-up of p...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-015-1978-8

    authors： Tichy J,Spechtmeyer S,Mittelbronn M,Hattingen E,Rieger J,Senft C,Foerch C

    更新日期：2016-01-01 00:00:00

  • 201Thallium SPECT and 1H-MRS compared with MRI in chemotherapy monitoring of high-grade malignant astrocytomas.

    abstract：PURPOSE:To compare chemotherapy treatment monitoring in astrocytoma by 201thallium single photon emission computed tomography (SPECT) and photon magnetic resonance spectroscopy (1H-MRS) with magnetic resonance imaging (MRI), and to evaluate the influence of morphological tumor changes on cerebral 201thallium uptake and...

    journal_title：Journal of neuro-oncology

    pub_type： 临床试验,杂志文章

    doi：10.1023/a:1006429329677

    authors： Kallén K,Burtscher IM,Holtås S,Ryding E,Rosén I

    更新日期：2000-01-01 00:00:00

  • Chemotherapy, hormonal therapy, and immunotherapy for recurrent meningiomas.

    abstract：:Meningioma is a common intracranial tumor, originating from the meninges of the skull or spinal canal. Most meningiomas are benign tumors, however atypical or anaplastic tumors can be found in 6% of cases. Patients with asymptomatic small benign meningiomas can be followed without therapy, but in symptomatic patients ...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,评审

    doi：10.1007/s11060-008-9734-y

    authors： Sioka C,Kyritsis AP

    更新日期：2009-03-01 00:00:00

  • IL-8 is a mediator of NF-κB induced invasion by gliomas.

    abstract：:Glioblastoma (GBM) is the most common and deadly form of primary brain tumor with a median survival of eleven months, despite use of extensive chemotherapy, radiotherapy and surgery. We have previously shown that nuclear factor-kappa B (NF-κB) is aberrantly expressed in GBM tumors and primary cell lines derived from t...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-010-0261-2

    authors： Raychaudhuri B,Vogelbaum MA

    更新日期：2011-01-01 00:00:00

  • Vertebral collapse with quadraparesis due to metastatic gliobla multiforme: case report and review of the literature.

    abstract：:A case is reported of a patient rendered quadraparetic following collapse of a cervical vertebra due to neoplastic invasion by metastatic glioblastoma multiforme. The case is discussed in light of a review of the world literature regarding the clinical incidence and significance of metastasis of glial tumors. It is re...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,评审

    doi：10.1007/BF01324700

    authors： Chesnut RM,Abitbol JJ,Chamberlain M,Marshall LF

    更新日期：1993-05-01 00:00:00

  • Advances in genetic and epigenetic analyses of gliomas: a neuropathological perspective.

    abstract：:Gliomas, the most common malignant primary brain tumors, are universally fatal once they progress from low-grade into high-grade neoplasms. In recent years, we have accumulated unprecedented data about the genetic and epigenetic abnormalities in gliomas; yet, our appreciation of how these deadly tumors arise is still ...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,评审

    doi：10.1007/s11060-014-1499-x

    authors： Tsankova NM,Canoll P

    更新日期：2014-09-01 00:00:00

  • Inhibition of glioma cell proliferation by neural stem cell factor.

    abstract：:Neural stem cells (NSC) have unique differentiation-, proliferation-, and motility properties. To investigate whether they secrete factors that interfere with the proliferation of glioma cells, we grew glioma cells in conditioned medium (CM) obtained from cultures of neurospheres including neural stem / progenitor cel...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-004-7118-5

    authors： Suzuki T,Izumoto S,Wada K,Fujimoto Y,Maruno M,Yamasaki M,Kanemura Y,Shimazaki T,Okano H,Yoshimine T

    更新日期：2005-09-01 00:00:00

  • Waiting times before initiation of radiotherapy might not affect outcomes for patients with glioblastoma: a French retrospective analysis of patients treated in the era of concomitant temozolomide and radiotherapy.

    abstract：:Purpose of this study was to determine the effect of waiting time for radiotherapy on overall survival of patients with glioblastoma treated in the EORTC-NCIC trial at 18 centers in France. A total of 400 adult patients with glioblastoma who were treated between January 1, 2006 and December 31, 2006 were included. The...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-012-0883-7

    authors： Noel G,Huchet A,Feuvret L,Maire JP,Verrelle P,Le Rhun E,Aumont M,Thillays F,Sunyach MP,Henzen C,Missohou F,de Crevoisier R,Bondiau PY,Collin P,Durando X,Truc G,Kerr C,Bernier V,Clavier JB,Atlani D,D'Hombres A,Vi

    更新日期：2012-08-01 00:00:00

  • Phenotypic and functional characterization of Glioblastoma cancer stem cells identified through 5-aminolevulinic acid-assisted surgery [corrected].

    abstract：:5-aminolevulinic acid (5-ALA) introduction in the surgical management of Glioblastoma (GBM) enables the intra-operatively identification of cancer cells in the mass by means of fluorescence. Here, we analyzed the phenotype of GBM cells isolated from distinct tumour areas determined by 5-ALA (tumour core, 5-ALA intense...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-013-1348-3

    authors： Rampazzo E,Della Puppa A,Frasson C,Battilana G,Bianco S,Scienza R,Basso G,Persano L

    更新日期：2014-02-01 00:00:00

  • Sensitivity of glioma and fetal brain cell lines to natural killer cytolysis in a monolayer assay.

    abstract：:We have developed an in vitro assay for Natural Killer (NK) cell cytolysis of and binding to substrate attached human glioma and fetal brain cells. The monolayer cells were labeled with [51Cr] and the effectors were directly sedimented onto these substrate attached target cells. Using this method we screened several g...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/BF00165099

    authors： Kazimer RM,Whisler RL,Stephens RE,Pearl DK,Yates AJ

    更新日期：1989-07-01 00:00:00

  • Downregulation of uPARAP mediates cytoskeletal rearrangements and decreases invasion and migration properties in glioma cells.

    abstract：:To identify molecular therapeutic targets for glioma, we performed gene expression profiling by using a complementary DNA (cDNA) microarray method and identified the urokinase plasminogen activator receptor-associated protein (uPARAP/Endo180) as a gene expressed highly in glioma tissue compared with the normal brain t...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-010-0398-z

    authors： Takahashi S,Yamada-Okabe H,Hamada K,Ohta S,Kawase T,Yoshida K,Toda M

    更新日期：2011-06-01 00:00:00