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Establishment of interleukin 2 dependent cytotoxic T lymphocyte cell line specific for autologous brain tumor and its intracranial administration for therapy of the tumor.

Abstract：

:Autologous brain tumor specific CTLs were induced from the patient's PBL by a mixed lymphocyte-tumor culture, and were maintained for more than 2 months in a medium containing exogenous IL-2. The autologous T cell line containing specific CTL was administered into the tumor-bed for the treatment of malignant glioma. In 2 cases out of 5, tumors regressed more than 50% in diameter. One of these patients is still alive now with full of his social activities, and it is 104 weeks after the initiation of the immunotherapy. Autologous T cell lines were safely administered in all cases without any complications nor toxicities.

journal_name

J Neurooncol

journal_title

Journal of neuro-oncology

authors

Kitahara T,Watanabe O,Yamaura A,Makino H,Watanabe T,Suzuki G,Okumura K

doi

10.1007/BF00195603

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

329-36

issue

4

eissn

0167-594X

issn

1573-7373

journal_volume

4

pub_type

杂志文章

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