当前位置： SCI文献检索 > JOURNAL OF NEURO-ONCOLOGY期刊下所有文献 > Long-term survivors of glioblastoma multiforme: clinical and molecular characteristics.

Long-term survivors of glioblastoma multiforme: clinical and molecular characteristics.

Abstract：

:Long term survival is rare in patients with glioblastoma multiforme (GBM). To determine if the tumors of patients with long survivals constitute a subgroup of patients with identifiable molecular genetic characteristics, we studied the p53 gene and Epidermal Growth Factor Receptor (EGF-R) expression in long-term survivors of GBM. A review of the Tumor Registry of Memorial Hospital for Cancer and Allied Diseases documented that 521 patients were treated for GBM between 1954 and 1987 and that 12 patients had seven-year or longer survivals. Six additional long-term survivors were identified from other institutions. After pathological re-examination, the diagnosis of 8 of these 18 (44%) tumors was changed to other histologic tumor types. Using immunohistochemical analysis, 4 of 10 confirmed malignant gliomas had over-expression of p53. Polymerase chain reaction/single-strand conformational polymorphism (PCR/SSCP) analysis and sequence analysis of these 4 tumors showed no p53 mutations in exons 5-8, the region where most mutations have been reported in human malignancies. Immunohistochemical analysis for EGF-R was performed on the tumors of the 10 long-term survivors. EGF-R over-expression was identified in 4 (40%), which is consistent with previous reported studies for GBM in general. These findings suggest that there is a subset of GBM defined by the accumulation of wild-type p53 and that the over-expression of EGF-R does not preclude long-term survival. The seven-year survival rate for confirmed GBM in patients from the Memorial Hospital Tumor Registry was at least 1%.

journal_name

J Neurooncol

journal_title

Journal of neuro-oncology

authors

Morita M,Rosenblum MK,Bilsky MH,Fraser RA,Rosenfeld MR

doi

10.1007/BF00165483

subject

Has Abstract

pub_date

1996-03-01 00:00:00

pages

259-66

issue

3

eissn

0167-594X

issn

1573-7373

journal_volume

27

pub_type

杂志文章

相关文献

JOURNAL OF NEURO-ONCOLOGY文献大全
  • Monotherapy with methotrexate for primary central nervous lymphoma has single agent activity in the absence of radiotherapy: a single institution cohort.

    abstract：:We have retrospectively reviewed toxicities and response of a cohort of primary central nervous system lymphoma (PCNSL) patients treated with high dose parenteral methotrexate (MTX) monotherapy without whole brain radiation. From The Massachusetts General Hospital (MGH) Cancer Registry, active since 1946, we selected ...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-009-0090-3

    authors： Cobert J,Hochberg E,Woldenberg N,Hochberg F

    更新日期：2010-07-01 00:00:00

  • Favorable long-term outcome of low-grade oligodendrogliomas irrespective of 1p/19q status when treated without radiotherapy.

    abstract：:Despite the accumulating evidences of high chemosensitivity especially in anaplastic oligodendrogliomas with loss of chromosomes 1p and 19q, the optimal management strategy for low-grade tumors using the 1p/19q information remains controversial. We have treated all low-grade oligodendrogliomas by a chemotherapy-preced...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-010-0340-4

    authors： Iwadate Y,Matsutani T,Hasegawa Y,Shinozaki N,Higuchi Y,Saeki N

    更新日期：2011-05-01 00:00:00

  • Occupational exposure to metals and risk of meningioma: a multinational case-control study.

    abstract：:The aim of the study was to examine associations between occupational exposure to metals and meningioma risk in the international INTEROCC study. INTEROCC is a seven-country population-based case-control study including 1906 adult meningioma cases and 5565 population controls. Incident cases were recruited between 200...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-016-2244-4

    authors： Sadetzki S,Chetrit A,Turner MC,van Tongeren M,Benke G,Figuerola J,Fleming S,Hours M,Kincl L,Krewski D,McLean D,Parent ME,Richardson L,Schlehofer B,Schlaefer K,Blettner M,Schüz J,Siemiatycki J,Cardis E

    更新日期：2016-12-01 00:00:00

  • Incidence of initial spinal metastasis in glioblastoma patients and the importance of spinal screening using MRI.

    abstract：PURPOSE:Intracranial glioblastomas with simultaneous spinal lesions prior to chemoradiation therapy or craniotomy, defined as initial spinal metastasis, are not well understood. Herein, we investigated intracranial glioblastoma and demonstrated the importance of spinal screening using gadolinium enhanced spinal magneti...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-018-03036-4

    authors： Shibahara I,Saito R,Osada Y,Kanamori M,Sonoda Y,Kumabe T,Mugikura S,Watanabe M,Tominaga T

    更新日期：2019-01-01 00:00:00

  • The incidence and significance of multicentric noncontrast-enhancing lesions distant from a histologically-proven glioblastoma.

    abstract：:Improvements in imaging are increasing the detection of multiple lesions in the setting of glioblastoma. Occasionally distant non-enhancing lesions may be identified which have the appearances of a multicentric low-grade glioma. We aimed to determine the incidence, prognostic significance and diagnostic value of this ...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s11060-016-2193-y

    authors： Lasocki A,Gaillard F,Tacey MA,Drummond KJ,Stuckey SL

    更新日期：2016-09-01 00:00:00

  • Chemotherapy-induced peripheral neuropathies in hematological malignancies.

    abstract：:Recent developments in the treatment of hematological malignancies, especially with the advent of proteasome inhibitors and immunomodulatory drugs in plasma cell dyscrasias, call for an increased collaboration between hematologists and neurologists. This collaboration involves differentiating chemotherapy-induced peri...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,评审

    doi：10.1007/s11060-014-1632-x

    authors： Jongen JL,Broijl A,Sonneveld P

    更新日期：2015-01-01 00:00:00

  • Radical surgery after chemotherapy: a new therapeutic strategy to envision in grade II glioma.

    abstract：:While surgery is proned in low-grade glioma (LGG), the invasion of functional areas frequently prevents a complete resection. We report the first case of a patient operated on for a left frontal LGG, diagnosed because of seizures, with partial resection due to an invasion of the controlateral hemisphere. Chemotherapy ...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-006-9168-3

    authors： Duffau H,Taillandier L,Capelle L

    更新日期：2006-11-01 00:00:00

  • 5-Fluorocytosine-mediated apoptosis and DNA damage in glioma cells engineered to express cytosine deaminase and their enhancement with interferon.

    abstract：:To explore the antitumor mechanism of bacterial cytosine deaminase plus 5-fluorocytosine (CD/5-FCyt) in combination with interferons (IFNs), glioma cells were transduced with recombinant retroviruses expressing CD. The transduced glioma cells become sensitive to the nontoxic prodrug 5-FCyt. Apoptosis, DNA damage, byst...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1023/a:1005883128175

    authors： Wang ZH,Samuels S,Gama Sosa MA,Kolodny EH

    更新日期：1998-02-01 00:00:00

  • Quality assurance of an image guided intracranial stereotactic positioning system for radiosurgery treatment with helical tomotherapy.

    abstract：:The aim of this work was to determine the accuracy and precision of stereotactic localization and treatment delivery using a helical tomotherapy based stereotactic radiosurgery (SRS) system. A tomotherapy specific radiosurgery workflow was designed that exploits the system's on board megavotage CT (MVCT) imaging syste...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-010-0227-4

    authors： Soisson ET,Hardcastle N,Tomé WA

    更新日期：2010-06-01 00:00:00

  • Re-irradiation for children with recurrent medulloblastoma in Toronto, Canada: a 20-year experience.

    abstract：PURPOSE:Children with recurrent medulloblastoma have a poor prognosis. Re-irradiation is an option for some patients, but has not been well-studied in the era of molecular characterization for pediatric medulloblastoma. METHODS:This was a retrospective cohort study of 14 children age 18 years and younger at initial di...

    journal_title：Journal of neuro-oncology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s11060-019-03272-2

    authors： Tsang DS,Sarhan N,Ramaswamy V,Nobre L,Yee R,Taylor MD,Hawkins C,Bartels U,Huang A,Tabori U,Hodgson DC,Bouffet E,Laperriere N

    更新日期：2019-10-01 00:00:00

  • Reproductive factors and risk of primary brain tumors in women.

    abstract：:Gender-specific incidence patterns and the presence of hormonal receptors on tumor cells suggest that sex hormones may play a role in the onset of primary brain tumors. However, epidemiological studies on the relation of hormonal risk factors to the risk of brain tumors have been inconsistent. We examined the role of ...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-014-1427-0

    authors： Anic GM,Madden MH,Nabors LB,Olson JJ,LaRocca RV,Thompson ZJ,Pamnani SJ,Forsyth PA,Thompson RC,Egan KM

    更新日期：2014-06-01 00:00:00

  • Binding and distribution of Na2B12H11SH on cellular and subcellular level in tumor tissue of glioma patients in boron neutron capture therapy.

    abstract：:To determine binding and distribution of Na2B12H11SH (BSH) in glioma tissue in case of boron neutron capture therapy, an antibody to this compound was produced and used in immunohistochemical investigations. It is possible to trace BSH in immunohistochemistry, because BSH is firmly bound to the glioma tissue. The anti...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1023/a:1005789802603

    authors： Otersen B,Haritz D,Grochulla F,Bergmann M,Sierralta W,Gabel D

    更新日期：1997-05-01 00:00:00

  • Functioning oncocytic adenoma of the pituitary.

    abstract：:A case of a functioning invasive pituitary oncocytoma in a 50-year-old man is reported. The serum prolactin was increased and immunocytochemical staining was positive for prolactin. In addition to numerous mitochondria within the neoplastic cells, structurally abnormal mitochondria with crystalline inclusions were als...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/BF00165379

    authors： Chowdhury C,Roy S,Gupta N,Kochupillai N,Banerji AK

    更新日期：1986-01-01 00:00:00

  • Pilot study of estramustine added to radiosurgery and radiotherapy for treatment of high grade glioma.

    abstract：:Patients with high grade glioma generally have poor prognoses. Addition of radiosensitizing agents might improve the response to irradiation. The chemotherapeutic agent estramustine sensitizes experimental gliomas to radiation. Gliomas express estramustine binding proteins, and cytotoxic concentrations of estramustine...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1023/b:neon.0000021825.41221.b5

    authors： Landy H,Markoe A,Potter P,Lasalle G,Marini A,Savaraj N,Reis I,Heros D,Wangpaichitr M,Feun L

    更新日期：2004-03-01 00:00:00

  • Incidence, survival, pathology, and genetics of adult Latino Americans with glioblastoma.

    abstract：:Latino Americans are a rapidly growing ethnic group in the United States but studies of glioblastoma in this population are limited. We have evaluated characteristics of 21,184 glioblastoma patients from the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute. This SEER data fro...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s11060-017-2377-0

    authors： Shabihkhani M,Telesca D,Movassaghi M,Naeini YB,Naeini KM,Hojat SA,Gupta D,Lucey GM,Ontiveros M,Wang MW,Hanna LS,Sanchez DE,Mareninov S,Khanlou N,Vinters HV,Bergsneider M,Nghiemphu PL,Lai A,Liau LM,Cloughesy TF,Yon

    更新日期：2017-04-01 00:00:00

  • Waiting times before initiation of radiotherapy might not affect outcomes for patients with glioblastoma: a French retrospective analysis of patients treated in the era of concomitant temozolomide and radiotherapy.

    abstract：:Purpose of this study was to determine the effect of waiting time for radiotherapy on overall survival of patients with glioblastoma treated in the EORTC-NCIC trial at 18 centers in France. A total of 400 adult patients with glioblastoma who were treated between January 1, 2006 and December 31, 2006 were included. The...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-012-0883-7

    authors： Noel G,Huchet A,Feuvret L,Maire JP,Verrelle P,Le Rhun E,Aumont M,Thillays F,Sunyach MP,Henzen C,Missohou F,de Crevoisier R,Bondiau PY,Collin P,Durando X,Truc G,Kerr C,Bernier V,Clavier JB,Atlani D,D'Hombres A,Vi

    更新日期：2012-08-01 00:00:00

  • Rethinking childhood ependymoma: a retrospective, multi-center analysis reveals poor long-term overall survival.

    abstract：:Ependymoma is the third most common brain tumor in children, but there is a paucity of large studies with more than 10 years of follow-up examining the long-term survival and recurrence patterns of this disease. We conducted a retrospective chart review of 103 pediatric patients with WHO Grades II/III intracranial epe...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s11060-017-2568-8

    authors： Marinoff AE,Ma C,Guo D,Snuderl M,Wright KD,Manley PE,Al-Sayegh H,Sinai CE,Ullrich NJ,Marcus K,Haas-Kogan D,Goumnerova L,London WB,Kieran MW,Chi SN,Fangusaro J,Bandopadhayay P

    更新日期：2017-10-01 00:00:00

  • Central and peripheral nervous system immune mediated demyelinating disease after allogeneic hemopoietic stem cell transplantation for hematologic disease.

    abstract：:Immune mediated demyelinating disease (IMDD) after allogeneic hemopoietic stem cell transplant (HSCT) is rare and its etiology unclear. In this retrospective study, we identified patients who underwent HSCT between January 1992 and December 2010 and had IMDD post transplant. A total of 1,484 patients received HSCT and...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-012-0962-9

    authors： Delios AM,Rosenblum M,Jakubowski AA,DeAngelis LM

    更新日期：2012-11-01 00:00:00

  • Histopathological vascular investigation of the peritumoral brain zone of glioblastomas.

    abstract：:To date, no histopathological vascular investigation focusing on peritumoral brain zone (PBZ) has been reported for glioblastoma. We analyzed 10 newly diagnosed cases of glioblastomas. For these PBZs, histopathological investigation was performed by hematoxylin-eosin (H&E) staining and immunohistochemistry was analyze...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-017-2648-9

    authors： Tamura R,Ohara K,Sasaki H,Morimoto Y,Yoshida K,Toda M

    更新日期：2018-01-01 00:00:00

  • Cytotoxic human peripheral blood-derived γδT cells kill glioblastoma cell lines: implications for cell-based immunotherapy for patients with glioblastoma.

    abstract：:Glioblastoma (GBM) is a highly aggressive brain tumor for which novel therapeutic approaches, such as immunotherapy, are urgently needed. Zoledronate (ZOL), an inhibitor of osteoclastic activity, is known to stimulate peripheral blood-derived γδT cells and sensitize tumors to γδT cell-mediated killing. To investigate ...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-013-1258-4

    authors： Nakazawa T,Nakamura M,Park YS,Motoyama Y,Hironaka Y,Nishimura F,Nakagawa I,Yamada S,Matsuda R,Tamura K,Sugimoto T,Takeshima Y,Marutani A,Tsujimura T,Ouji N,Ouji Y,Yoshikawa M,Nakase H

    更新日期：2014-01-01 00:00:00

  • Clinical and dosimetric study of radiotherapy for glioblastoma: three-dimensional conformal radiotherapy versus intensity-modulated radiotherapy.

    abstract：BACKGROUND AND PURPOSE:We aimed to compare three-dimensional conformal radiotherapy (3D-CRT) with intensity-modulated radiotherapy (IMRT) for the treatment of glioblastoma. MATERIALS AND METHODS:Retrospective study of 220 patients with glioblastoma, treated with 3D-CRT or IMRT, with or without surgery. Dosimetric para...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-017-2735-y

    authors： Thibouw D,Truc G,Bertaut A,Chevalier C,Aubignac L,Mirjolet C

    更新日期：2018-04-01 00:00:00

  • Shortened ex vivo manufacturing time of EGFRvIII-specific chimeric antigen receptor (CAR) T cells reduces immune exhaustion and enhances antiglioma therapeutic function.

    abstract：BACKGROUND:Non-viral manufacturing of CAR T cells via the Sleeping Beauty transposon is cost effective and reduces the risk of insertional mutagenesis from viral transduction. However, the current gold standard methodology requires ex vivo numerical expansion of these cells on artificial antigen-presenting cells (AaPCs...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-019-03311-y

    authors： Caruso HG,Tanaka R,Liang J,Ling X,Sabbagh A,Henry VK,Collier TL,Heimberger AB

    更新日期：2019-12-01 00:00:00

  • Intracerebral infusion of the bispecific targeted toxin DTATEGF in a mouse xenograft model of a human metastatic non-small cell lung cancer.

    abstract：:The aim of this study is to investigate the anti-cancer effect of the bispecific diphtheria toxin (DT) based immunotoxin DTATEGF, which targets both the epidermal growth factor (EGF) receptor (EGFR) and the urokinase-type plasminogen activator (uPA) receptor (uPAR) in vitro and in vivo when delivered by convection-enh...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-012-0904-6

    authors： Huang J,Li YM,Massague J,Sicheneder A,Vallera DA,Hall WA

    更新日期：2012-09-01 00:00:00

  • Metastatic medulloblastoma in 10-year-old girl treated successfully with chemotherapy without radiotherapy.

    abstract：:We report a case of high risk medulloblastoma with leptomeningeal intracranial and spinal metastasis in a 10-year-old girl treated successfully with conventional prolonged chemotherapy without radiotherapy. This is a particular case of medulloblastoma that at onset did not receive standard therapy for medulloblastoma ...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1023/a:1006365511379

    authors： Schiavetti A,Varrasso G,Maurizi P,Trasimeni G,Carapella C,Castello MA

    更新日期：1999-01-01 00:00:00

  • Changes in PlGF and MET-HGF expressions in paired initial and recurrent glioblastoma.

    abstract：:Angiogenesis is one of the key features of glioblastoma (GB). However, the use of anti-angiogenic therapies directed against vascular endothelial growth factor (VEGF) is limited by primary or acquired resistance. MET/HGF and PlGF signaling are involved in potential alternative escape mechanisms to VEGF pathway. Our ob...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-016-2251-5

    authors： Tabouret E,Denicolai E,Delfino C,Graillon T,Boucard C,Nanni I,Padovani L,Figarella-Branger D,Chinot O

    更新日期：2016-12-01 00:00:00

  • A phase II trial of PTK787/ZK 222584 in recurrent or progressive radiation and surgery refractory meningiomas.

    abstract：:When surgery and radiation are no longer treatment options, salvage systemic therapy has been used for recurrent meningiomas with little compelling evidence to suggest effectiveness. Patients with surgery and radiation refractory recurrent meningiomas were treated with the oral multifunctional tyrosine kinase inhibito...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-014-1358-9

    authors： Raizer JJ,Grimm SA,Rademaker A,Chandler JP,Muro K,Helenowski I,Rice L,McCarthy K,Johnston SK,Mrugala MM,Chamberlain M

    更新日期：2014-03-01 00:00:00

  • Outcome of treatment of recurrent glioblastoma multiforme in elderly and/or frail patients.

    abstract：:Optimal treatment of recurrent glioblastoma multiforme (rGBM) in elderly and/or frail patients remains virtually unexplored, the best supportive care (BSC) only is routinely administered due to the fatal prognosis. We evaluated the impact of different treatment methods on post-progression survival (PPS) and overall su...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s11060-015-1987-7

    authors： Socha J,Kepka L,Ghosh S,Roa W,Kumar N,Sinaika V,Matiello J,Lomidze D,de Castro DG,Hentati D,Fidarova E

    更新日期：2016-02-01 00:00:00

  • Prospective evaluation of serum glial fibrillary acidic protein (GFAP) as a diagnostic marker for glioblastoma.

    abstract：:Glioblastoma (GBM) is the most common malignant primary brain tumor. Although clinical presentation and brain imaging might be suggestive, histopathological evaluation by means of a brain biopsy is routinely performed to establish the diagnosis. A serum marker indicative of GBM may simplify the diagnostic work-up of p...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-015-1978-8

    authors： Tichy J,Spechtmeyer S,Mittelbronn M,Hattingen E,Rieger J,Senft C,Foerch C

    更新日期：2016-01-01 00:00:00

  • Induction of apoptosis in glioma cells by molecules released from activated macrophages.

    abstract：:Macrophages play an important role in the regulation of malignant tumors. Although glioma contains abundance of macrophages, their role in apoptosis of glioma is not known. We stimulated macrophages with lipopolysaccharide and culture supernatants of activated macrophages were collected to treat glioma cells. The resu...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1023/a:1015763916020

    authors： Chen GG,Chu YS,Chak EC,Leung BC,Poon WS

    更新日期：2002-05-01 00:00:00

  • Stereotactic radiosurgical treatment of brain metastasis of primary tumors that rarely metastasize to the central nervous system.

    abstract：:We evaluated the local control of gamma knife stereotactic radiosurgery (GKSRS) in the treatment of cerebral metastases from primary tumors that rarely metastasize to the central nervous system (CNS). There is little published data on this subject with very few series on specific primary tumors. We present our experie...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-012-0916-2

    authors： Menendez JY,Bauer DF,Shannon CN,Fiveash J,Markert JM

    更新日期：2012-09-01 00:00:00