Central nervous system atypical teratoid tumor/rhabdoid tumor: response to intensive therapy and review of the literature.

abstract：:To determine the impact of delay between surgery and radiotherapy on overall survival (OS) in temozolomide treatmented patients with the incorporation of O6-methylguanine-DNA methyltransferase (MGMT). From 2000 to 2012, 345 consecutive glioblastoma patients were treated with surgery, radiotherapy, and temozolomide at ...

journal_title：Journal of neuro-oncology

authors： Spratt DE,Folkert M,Zumsteg ZS,Chan TA,Beal K,Gutin PH,Pentsova E,Yamada Y

更新日期：2014-01-01 00:00:00

abstract：:We aimed to assess the efficacy of stereotactic irradiation for patients with recurrent high-grade glioma (HGG) and identify predictive factors of progression-free survival (PFS) and overall survival (OS) following reirradiation. We identified 32 patients with recurrent brain HGG who had been treated with either singl...

journal_title：Journal of neuro-oncology

authors： Attal J,Chaltiel L,Lubrano V,Sol JC,Lanaspeze C,Vieillevigne L,Latorzeff I,Cohen-Jonathan Moyal E

更新日期：2018-01-01 00:00:00

abstract：:Proneural and mesenchymal are two subtypes of glioblastoma identified by gene expression profiling. In this study, the primary aim was to detect markers to develop a clinically applicable method for distinguishing proneural and mesenchymal glioblastoma. The secondary aims were to investigate the temporospatial dynamic...

journal_title：Journal of neuro-oncology

authors： Murata H,Yoshimoto K,Hatae R,Akagi Y,Mizoguchi M,Hata N,Kuga D,Nakamizo A,Amano T,Sayama T,Iihara K

更新日期：2015-10-01 00:00:00

abstract：:The diagnosis of brain metastases is associated with a poor prognosis reflecting uncontrolled primary disease that has spread to the relative sanctuary of the central nervous system. 20 % of brain metastases occur in the posterior fossa and are associated with significant morbidity. The risk of acute hydrocephalus and...

journal_title：Journal of neuro-oncology

authors： Sunderland GJ,Jenkinson MD,Zakaria R

更新日期：2016-12-01 00:00:00

abstract：:Human melanoma proteoglycan (HMP), a melanoma-associated antigen, is expressed in both human melanomas and gliomas. We used HMP-specific monoclonal antibody (mAb) VT68.2 to investigate whether murine GL261 cerebral gliomas express the HMP homologue AN2 and to determine whether AN2 could be targeted for selective deliv...

journal_title：Journal of neuro-oncology

authors： Paul AK,Ciesielski MJ,Sajjad M,Wang X,Ferrone S,Abdel-Nabi H,Fenstermaker RA

更新日期：2009-08-01 00:00:00

abstract：:Twenty patients suspected of meningeal carcinomatosis (MC) secondary to small cell carcinoma of the lung were evaluated by myelography and by cytologic examination of cerebrospinal fluid (CSF). In 4 patients both investigations demonstrated MC. Four had positive cytology but a negative myelogram. Five patients had a p...

journal_title：Journal of neuro-oncology

authors： Pedersen AG,Paulson OB,Gyldensted C

更新日期：1985-01-01 00:00:00

abstract：:Stereotactic radiosurgery is a frequently performed procedure for patients with benign intracranial tumors. Benign tumors are good candidates for radiosurgery because they are generally non-invasive, are well visualized by magnetic resonance imaging, and their slow rate of proliferation makes conventional radiation do...

journal_title：Journal of neuro-oncology

authors： Pollock BE

更新日期：2009-05-01 00:00:00

abstract：:Twenty-eight patients with malignant brain tumors (16 with primary brain tumors and 12 with brain metastases) progressing after cranial irradiation with or without chemotherapy received varying doses of intracarotid VP-16. Courses of therapy were repeated every 4 weeks along with computerized axial tomography scan and...

journal_title：Journal of neuro-oncology

authors： Feun LG,Lee YY,Yung WK,Savaraj N,Wallace S

更新日期：1987-01-01 00:00:00

abstract：:When surgery and radiation are no longer treatment options, salvage systemic therapy has been used for recurrent meningiomas with little compelling evidence to suggest effectiveness. Patients with surgery and radiation refractory recurrent meningiomas were treated with the oral multifunctional tyrosine kinase inhibito...

journal_title：Journal of neuro-oncology

authors： Raizer JJ,Grimm SA,Rademaker A,Chandler JP,Muro K,Helenowski I,Rice L,McCarthy K,Johnston SK,Mrugala MM,Chamberlain M

更新日期：2014-03-01 00:00:00

abstract：:TERT promoter (TERTp) mutation is the most common mutation in glioblastomas. It creates a putative binding site for Ets/TCF transcription factors, enhancing telomerase expression and activity, whereas the rs2853669 variant disrupts another Ets/TCF binding. We explore here the interaction between these two alterations,...

journal_title：Journal of neuro-oncology

authors： Nencha U,Rahimian A,Giry M,Sechi A,Mokhtari K,Polivka M,Schmitt Y,Di Stefano AL,Alentorn A,Labussière M,Sanson M

更新日期：2016-02-01 00:00:00

abstract：:New genetic models provide better biological mimics of human tumors. The new models can give deeper insight into tumorigenesis and provide better targets for testing therapies. To use the new models most successfully, it is useful to keep in mind limitations that are harder to overcome by genetic manipulation. These i...

journal_title：Journal of neuro-oncology

authors： Lampson LA

更新日期：2001-07-01 00:00:00

abstract：:Primary brain tumors cumulatively represent the most common solid tumors of childhood and are the leading cause of cancer related death in this age group. Traditionally, molecular findings and histological analyses from biopsies of resected tumor tissue have been used for diagnosis and classification of these diseases...

journal_title：Journal of neuro-oncology

authors： Samuel N,Remke M,Rutka JT,Raught B,Malkin D

更新日期：2014-06-01 00:00:00

abstract：:Central neurocytoma was originally described as a rare benign neuronal tumor. However, progression and local recurrences after surgery are well recognized. Stereotactic radiosurgery is another option for treatment of CN. In order to evaluate the efficacy of SRS, we performed a quantitative systematic review of the ava...

journal_title：Journal of neuro-oncology

authors： Park HK,Steven D C

更新日期：2012-05-01 00:00:00

abstract：:Low grade tumors are associated with a high risk of seizures. Prolonged use of antiepileptic drugs (AEDs) is associated with morbidity. Determining which patients can safely discontinue AEDs perioperatively is difficult. We examined patients with low grade supratentorial brain tumors to determine characteristics of pa...

journal_title：Journal of neuro-oncology

authors： Das RR,Artsy E,Hurwitz S,Wen PY,Black P,Golby A,Dworetzky B,Lee JW

更新日期：2012-05-01 00:00:00

abstract：:To test the hypothesis on prolonged survival in glioblastoma cases with increased subventricular zone (SVZ) radiation dose. Sixty glioblastoma cases were previously treated with adjuvant radiotherapy and Temozolamide. Ipsilateral, contralateral and bilateral SVZs were contoured and their doses were retrospectively eva...

journal_title：Journal of neuro-oncology

authors： Elicin O,Inac E,Uzel EK,Karacam S,Uzel OE

更新日期：2014-06-01 00:00:00

abstract：:Increasing evidence suggests that an inflammatory microenvironment promotes invasion by glioblastoma (GBM) cells. Together with p38 mitogen-activated protein kinase (MAPK) activation being regarded as promoting inflammation, we hypothesized that elevated inflammatory cytokine secretion and p38 MAPK activity contribute...

journal_title：Journal of neuro-oncology

authors： Yeung YT,Bryce NS,Adams S,Braidy N,Konayagi M,McDonald KL,Teo C,Guillemin GJ,Grewal T,Munoz L

更新日期：2012-08-01 00:00:00

abstract：:We have expressed the tumor suppressor p16 under the control of a tetracycline-sensitive promoter in two human glioblastoma cell lines which do not contain endogenous p16. Ectopic p16 expression led to a stable but reversible G1 phase cell cycle arrest, reduced the growth of both cell lines in cell culture, and almost...

journal_title：Journal of neuro-oncology

authors： Simon M,Simon C,Köster G,Hans VH,Schramm J

更新日期：2002-10-01 00:00:00

abstract：:After the second recurrence of spinal seeding in hemangioblastoma not associated to von-Hippel-Lindau disease, we treated an adult female patient with thalidomide 200 mg orally/day at night for longer than 1 year. The patient reported subjective relief of symptoms after 1 month. Magnetic resonance imaging (MRI) contro...

journal_title：Journal of neuro-oncology

authors： Piribauer M,Czech T,Dieckmann K,Birner P,Hainfellner JA,Prayer D,Fazeny-Dörner B,Weinländer G,Marosi C

更新日期：2004-02-01 00:00:00

abstract：:The time to tumor progression (TTP), time to death (TTD) and complications were studied prospectively in a cohort of patients treated by surgery and adjuvant radio- and intensified PCV chemotherapy for astrocytomas (AIII), oligodendrogliomas (OIII) and oligoastrocytomas (OAIII) WHO grade III. The treatment was carried...

journal_title：Journal of neuro-oncology

authors： Kristof RA,Neuloh G,Hans V,Deckert M,Urbach H,Schlegel U,Simon M,Schramm J

更新日期：2002-09-01 00:00:00

abstract：:Embryonal tumors of the central nervous system (CNS) share histological features and were therefore initially grouped as primitive neuroectodermal tumors (PNET) and treated similarly. We sought to determine the relapse patterns of specific embryonal CNS tumors. We conducted a historical cohort study of children diagno...

journal_title：Journal of neuro-oncology

authors： Perreault S,Lober RM,Carret AS,Zhang G,Hershon L,Décarie JC,Yeom K,Vogel H,Fisher PG,Partap S

更新日期：2013-11-01 00:00:00

abstract：:Previous study revealed that higher expression of transforming growth factor beta induced (TGFBI) is correlated to poorer cancer-specific survival and higher proportion of tumor necrosis and Fuhrman grades III and IV in clear cell renal cell carcinomas. However, the relationships between TGFBI expression and malignant...

journal_title：Journal of neuro-oncology

authors： Pan YB,Zhang CH,Wang SQ,Ai PH,Chen K,Zhu L,Sun ZL,Feng DF

更新日期：2018-04-01 00:00:00

abstract：:Neurocytomas gained importance since 1995, which is reflected by the increasing number of reports on this entity. This study was performed to determine the best available treatment for typical and atypical neurocytomas (MIB-1 labeling index >3%, atypical histology) in various age groups ( 18 years). The...

journal_title：Journal of neuro-oncology

authors： Rades D,Schild SE

更新日期：2006-05-01 00:00:00

abstract：:Glioblastoma multiforme is a primary brain tumor associated with extensive invasion into surrounding brain tissue. Matrix metalloproteinases (MMPs) and urokinase plasminogen activation (uPA) system are shown to be involved in tumor invasion as they help in degradation of extracellular matrix (ECM) proteins and thus as...

journal_title：Journal of neuro-oncology

authors： Puli S,Lai JC,Bhushan A

更新日期：2006-09-01 00:00:00

abstract：:The frequency of the diagnosis of brain metastases has increased in recent years, probably due to an increased diagnostic sensitivity. Site predilection of brain lesions in oncological patients at the time of onset, may suggest mechanisms of brain-specific vulnerability to metastasis. The aim of the study is to determ...

journal_title：Journal of neuro-oncology

authors： Quattrocchi CC,Errante Y,Gaudino C,Mallio CA,Giona A,Santini D,Tonini G,Zobel BB

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Prior studies have highlighted infratentorial tumor location as a prognostic factor for solitary fibrous tumor (SFT) and hemangiopericytoma (HPC) of the central nervous system (CNS), and spinal location is considered a positive prognostic factor for other tumors of the CNS. While SFT/HPC of the CNS is known ...

journal_title：Journal of neuro-oncology

authors： Boyett D,Kinslow CJ,Bruce SS,Sonabend AM,Rae AI,McKhann GM,Sisti MB,Bruce JN,Cheng SK,Wang TJC

更新日期：2019-07-01 00:00:00

abstract：:Glucocorticoids, such as betamethasone, are often used to prevent possible acute reactions during radiation therapy of intracranial tumors (for example gliomas). The effect of the glucocorticoids is probably due to vascular changes decreasing the development of edemas. The radiosensitivity of two studied cell-lines of...

journal_title：Journal of neuro-oncology

authors： Benediktsson G,Blomquist E,Carlsson J

更新日期：1990-02-01 00:00:00

abstract：:Death ligand-mediated apoptosis is a promising strategy of gene therapy for human malignant glioma. We here report that the infection of human malignant glioma cell lines with an adenoviral vector encoding full length human Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand (Ad-Apo2L/TRAIL) results in...

journal_title：Journal of neuro-oncology

authors： Naumann U,Waltereit R,Schulz JB,Weller M

更新日期：2003-01-01 00:00:00

abstract：:Retaspimycin hydrochloride (IPI-504), an Hsp90 (heat shock protein 90) inhibitor, has shown activity in multiple preclinical cancer models, such as lung, breast and ovarian cancers. However, its biological effects in gliomas and normal brain derived cellular populations remain unknown. In this study, we profiled the e...

journal_title：Journal of neuro-oncology

authors： Di K,Keir ST,Alexandru-Abrams D,Gong X,Nguyen H,Friedman HS,Bota DA

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:Comparison of the influence of two different brain tumors (C6 and CNS1 glioma) on methotrexate (MTX) disposition in plasma, brain, and tumor tissue extracellular fluid (ECF). METHODS:Serial collection of plasma samples and brain ECF dialysates after i.v. bolus administration of MTX (50 mg kg(-1)) for 4 h. Quan...

journal_title：Journal of neuro-oncology

authors： Dukic SF,Kaltenbach ML,Heurtaux T,Hoizey G,Lallemand A,Vistelle R

更新日期：2004-03-01 00:00:00

abstract：:A rat glioma model was employed to estimate the Ca2+ kinetics in the tumor arteriolar smooth muscle cells. Electron microcytochemistry revealed that the density of intracellular Ca2+ deposits in the intra-tumor arteriolar smooth muscle cells was significantly greater, with slightly higher membrane Ca(2+)-adenosine tri...

journal_title：Journal of neuro-oncology

authors： Zenke K,Nakagawa K,Kumon Y,Ohta S,Hatakeyama T,Sakaki S

更新日期：1996-10-01 00:00:00