Fractionated stereotactic radiotherapy to the post-operative cavity for radioresistant and radiosensitive brain metastases.

abstract：BACKGROUND:Recent studies suggest a relatively high prevalence of autoimmune disorders (AD) among primary CNS lymphoma (PCNSL) patients, however, the literature is limited to case reports. To gain a better understanding of AD-PCNSL we reviewed and analyzed all cases described in the literature. METHODS:We searched the...

journal_title：Journal of neuro-oncology

authors： Kaulen LD,Karschnia P,Dietrich J,Baehring JM

更新日期：2020-08-01 00:00:00

abstract：:Central neurocytomas are uncommon intraventricular neoplasms whose optimal management remains controversial due to their rarity. We assessed outcomes for a historical cohort of neurocytoma patients and evaluated effects of tumor atypia, size, resection extent, and adjuvant radiotherapy. Progression-free survival (PFS)...

journal_title：Journal of neuro-oncology

authors： Imber BS,Braunstein SE,Wu FY,Nabavizadeh N,Boehling N,Weinberg VK,Tihan T,Barnes M,Mueller S,Butowski NA,Clarke JL,Chang SM,McDermott MM,Prados MD,Berger MS,Haas-Kogan DA

更新日期：2016-01-01 00:00:00

abstract：:Malignant glioma (MG), the most common primary brain tumor in adults, is extremely aggressive and uniformly fatal. Several treatment strategies have shown significant preclinical promise in murine models of glioma; however, none have produced meaningful clinical responses in human patients. We hypothesize that introdu...

journal_title：Journal of neuro-oncology

authors： Filley A,Henriquez M,Bhowmik T,Tewari BN,Rao X,Wan J,Miller MA,Liu Y,Bentley RT,Dey M

更新日期：2018-05-01 00:00:00

abstract：PURPOSE:This study explored the superiority of temozolomide (TMZ) + interferonβ (IFNβ) to standard TMZ as treatment for newly diagnosed glioblastoma (GBM) via randomized phase II screening design. EXPERIMENTAL DESIGN:Eligibility criteria included histologically proven GBM, with 50% of the tumor located in supratentori...

journal_title：Journal of neuro-oncology

authors： Wakabayashi T,Natsume A,Mizusawa J,Katayama H,Fukuda H,Sumi M,Nishikawa R,Narita Y,Muragaki Y,Maruyama T,Ito T,Beppu T,Nakamura H,Kayama T,Sato S,Nagane M,Mishima K,Nakasu Y,Kurisu K,Yamasaki F,Sugiyama K,Onishi

更新日期：2018-07-01 00:00:00

abstract：:During glioma resection, 5-aminolevulinic acid (5-ALA) and fluorescein sodium (Fl-Na) are used for photodynamic tumor visualization. The objective of this study was to evaluate the pathological findings of the boundary zone between the tumor and adjacent normal brain in glioblastoma patients undergoing simultaneous do...

journal_title：Journal of neuro-oncology

authors： Yano H,Nakayama N,Ohe N,Miwa K,Shinoda J,Iwama T

更新日期：2017-06-01 00:00:00

abstract：PURPOSE:To analyze patterns of failure according to treatment modalities and evaluate the adequacy of an institution's current volume of postoperative radiotherapy (PORT) for World Health Organization (WHO) grade II or III meningiomas. PATIENTS AND METHODS:Data of 98 patients treated by either surgery and PORT (PORT g...

journal_title：Journal of neuro-oncology

authors： Lee JJB,Lee J,Yoon HI,Kim SH,Cho J,Lee KS,Chang JH,Suh CO

更新日期：2019-09-01 00:00:00

abstract：:Accumulating evidence has supported the role of microRNAs in the initiation and development of malignant tumors. MicroRNA-211 (miR-211), which was reported to involve in diverse physiological activities in several cancers, was investigated for its expression in human glioma and adjacent normal brain tissues, as well a...

journal_title：Journal of neuro-oncology

authors： Zhang J,Lv J,Zhang F,Che H,Liao Q,Huang W,Li S,Li Y

更新日期：2017-07-01 00:00:00

abstract：:As the outcome for pediatric central nervous system (CNS) malignancies improves, data regarding long term effects and risk of early mortality are needed. Using the Surveillance, Epidemiology, and End Results database, we evaluated the causes of mortality in 5-year survivors of a CNS tumor diagnosed prior to the age of...

journal_title：Journal of neuro-oncology

authors： Perkins SM,Fei W,Mitra N,Shinohara ET

更新日期：2013-10-01 00:00:00

abstract：:High expression of ERBB2 has been reported in medulloblastoma and ependymoma; EGFR is amplified and over-expressed in brainstem glioma suggesting these proteins as potential therapeutic targets. We conducted a molecular biology (MB) and phase II study to estimate inhibition of tumor ERBB signaling and sustained respon...

journal_title：Journal of neuro-oncology

authors： Fouladi M,Stewart CF,Blaney SM,Onar-Thomas A,Schaiquevich P,Packer RJ,Goldman S,Geyer JR,Gajjar A,Kun LE,Boyett JM,Gilbertson RJ

更新日期：2013-09-01 00:00:00

abstract：:Rapid first pass uptake of drugs is necessary to increase tissue deposition after intraarterial (IA) injection. Here we tested whether brain tissue deposition of a nanoparticulate liposomal carrier could be enhanced by coordinated manipulation of liposome surface charge and physiological parameters, such as IA injecti...

journal_title：Journal of neuro-oncology

authors： Joshi S,Singh-Moon R,Wang M,Chaudhuri DB,Ellis JA,Bruce JN,Bigio IJ,Straubinger RM

更新日期：2014-12-01 00:00:00

abstract：:We have established a new xenogeneic animal model of leptomeningeal metastasis (LM) by intracisternal inoculation of human CEM T-cell lymphoma into nude rats, and used it to evaluate the anti-lymphoma efficacy of an anti-CD7 ricin A chain immunotoxin (DA7). In vitro incubation with 2 microg/ml DA7 for 72 h inhibited C...

journal_title：Journal of neuro-oncology

authors： Herrlinger U,Schmidberger H,Buchholz R,Wehrmann M,Vallera DA,Schabet M

更新日期：1998-10-01 00:00:00

abstract：INTRODUCTION:Central nervous system hemangioblastoma is a benign tumor associated with or without von Hippel-Lindau (VHL) disease which is an autosomal dominant hereditary disease that results from a germline mutation in the VHL gene. A main axis of signaling pathways in central nervous system hemangioblastoma is VHL-H...

journal_title：Journal of neuro-oncology

authors： Kanno H,Yoshizumi T,Shinonaga M,Kubo A,Murata H,Yao M

更新日期：2020-05-01 00:00:00

abstract：:A greater understanding of brain metastases is imperative for developing novel therapeutic strategies. Our previous study showed that insulin-like growth factor (IGF) signaling pathway was activated in brain-tropic cancer cells. In this study, we investigated the clinical relevance of activated (phosphorylated) IGF-1 ...

journal_title：Journal of neuro-oncology

authors： Wu PF,Huang WC,Yang JC,Lu YS,Shih JY,Wu SG,Lin CH,Cheng AL

更新日期：2013-10-01 00:00:00

abstract：:Primary germinomas in the spinal cord are very rare with only 15 cases published previously. In this case a 22-year-old woman with urinary incontinence, lumbago, and bilateral leg pain and weakness was found to have a solid tumor in the conus medullaris between the L1 and L2 vertebral bodies. Serum HCG was elevated wi...

journal_title：Journal of neuro-oncology

authors： Takahashi M,Koyama H,Matsubara T,Murata H,Miura K,Nagano A

更新日期：2006-01-01 00:00:00

abstract：:We report a case of radiation necrosis occurring 47 years after resection and radiotherapy for a juvenile pilocystic cerebellar astrocytoma, the longest yet reported. The patient presented with progressive lower cranial nerve dysfunction, and eventually died from cardiopulmonary arrest secondary to aspiration. The pre...

journal_title：Journal of neuro-oncology

authors： Babu R,Huang PP,Epstein F,Budzilovich GN

更新日期：1993-07-01 00:00:00

abstract：:The basic mechanism of cell death induced by 5-aminolevulinic acid (5-ALA)-mediated photodynamic therapy (PDT) (ALA-PDT) in glioma cells has not been fully elucidated. In this study, the details of the cell death mechanism induced by ALA-PDT were investigated in three human glioma cell lines (U251MG, U87MG, and U118MG...

journal_title：Journal of neuro-oncology

authors： Inoue H,Kajimoto Y,Shibata MA,Miyoshi N,Ogawa N,Miyatake S,Otsuki Y,Kuroiwa T

更新日期：2007-07-01 00:00:00

abstract：:Mucus-secreting adenomas or acinar adenoma of the choroid plexus are very rare. We report the case of a 79-year-old male with a 3-year history of occipital headaches with vomiting, ataxia and cerebellar signs. He was first seen due to difficulty while walking. He was admitted to the hospital with significant tumor exp...

journal_title：Journal of neuro-oncology

authors： Rembao-Bojórquez D,Vega R,Bermúdez-Maldonado L,Gutiérrez R,Salinas C,Tena-Suck M

更新日期：2007-06-01 00:00:00

abstract：:We report results of a conservative treatment for brain metastases from malignant melanoma with a combination of irradiation and chemotherapy (fotemustine and/or DTIC). To date, 12 patients have been treated. There was a complete remission of the brain metastases in four patients. In two patients a partial remission w...

journal_title：Journal of neuro-oncology

authors： Ulrich J,Gademann G,Gollnick H

更新日期：1999-06-01 00:00:00

abstract：:The antiproliferative effect of IFNalpha was tested on the human glioblastoma cell lines, U-373MG and T98G. IFNalpha significantly inhibited the growth of both cell lines, but was more effective in retarding the growth of U-373MG cells. Flow cytometry analysis indicated that synchronized IFNalpha-treated U-373MG cells...

journal_title：Journal of neuro-oncology

authors： Tanabe T,Kominsky SL,Subramaniam PS,Johnson HM,Torres BA

更新日期：2000-07-01 00:00:00

abstract：INTRODUCTION:High hospital case volumes are associated with improved treatment outcomes for numerous diseases. We assessed the association between academic non-profit hospital case volume and survival of adult glioblastoma patients. METHODS:From the nationwide Finnish Cancer Registry, we identified all adult (≥ 18 yea...

journal_title：Journal of neuro-oncology

authors： Raj R,Seppä K,Luostarinen T,Malila N,Seppälä M,Pitkäniemi J,Korja M

更新日期：2020-04-01 00:00:00

abstract：:Latino Americans are a rapidly growing ethnic group in the United States but studies of glioblastoma in this population are limited. We have evaluated characteristics of 21,184 glioblastoma patients from the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute. This SEER data fro...

journal_title：Journal of neuro-oncology

authors： Shabihkhani M,Telesca D,Movassaghi M,Naeini YB,Naeini KM,Hojat SA,Gupta D,Lucey GM,Ontiveros M,Wang MW,Hanna LS,Sanchez DE,Mareninov S,Khanlou N,Vinters HV,Bergsneider M,Nghiemphu PL,Lai A,Liau LM,Cloughesy TF,Yon

更新日期：2017-04-01 00:00:00

abstract：:In meningiomas, transformed meningeal cells can share morphological aspects (in hemangiopericytic meningioma) and antigenic properties (i.e.: HLA-DR antigens expression) with elements of the monocyte/macrophage lineage. In this report, we describe a case of a highly vascular meningioma where numerous tumor cells, stud...

journal_title：Journal of neuro-oncology

authors： Giometto B,Bozza F,Gallo P,Pagni S,Argentiero V,Ferla S,Mingrino S,Tavolato B

更新日期：1992-05-01 00:00:00

abstract：:We have retrospectively reviewed toxicities and response of a cohort of primary central nervous system lymphoma (PCNSL) patients treated with high dose parenteral methotrexate (MTX) monotherapy without whole brain radiation. From The Massachusetts General Hospital (MGH) Cancer Registry, active since 1946, we selected ...

journal_title：Journal of neuro-oncology

authors： Cobert J,Hochberg E,Woldenberg N,Hochberg F

更新日期：2010-07-01 00:00:00

abstract：:The labeling index (LI) of 216 cases of human brain tumors was determined by the immunohistochemical technique with monoclonal antibody to bromodeoxyuridine (BrdU). The proliferative potential of 110 cases was estimated using the intra-operative intravenous infusion of BrdU at a dose of 200 mg/sq m. In another 106 cas...

journal_title：Journal of neuro-oncology

authors： Kharbanda K,Dinda AK,Sarkar C,Karak AK,Dhir R,Mathur M,Roy S

更新日期：1995-01-01 00:00:00

abstract：:Combination of procarbazine, lomustine and vincristine (PCV) with radiation therapy (RT) has been associated with longer survival in patients with anaplastic oligodendroglioma (AO) and anaplastic oligoastrocytoma (AOA), especially in those with chromosome 1p/19q codeletion. We report a multicenter retrospective study ...

journal_title：Journal of neuro-oncology

authors： Minniti G,Arcella A,Scaringi C,Lanzetta G,Di Stefano D,Scarpino S,Pace A,Giangaspero F,Osti MF,Enrici RM

更新日期：2014-01-01 00:00:00

abstract：INTRODUCTION:Ollier Disease is a sporadic skeletal disorder with a predisposition to oncogenesis. It is estimated at around 1/100,000. We are presenting a young patient with Ollier Disease and high-grade astrocytoma. CASE REPORT:A 14-year-old, Caucasian male with Ollier Disease presented with a history of headaches, v...

journal_title：Journal of neuro-oncology

authors： Walid MS,Troup EC

更新日期：2008-08-01 00:00:00

abstract：:Since its description in 1982, central neurocytoma (CN) has been a relatively innocuous rare tumor of the central nervous system. Comprising of less than 0.5% of all intracranial tumors, most are reported to be slow growing, with low recurrence rates, and a favorable prognosis. Because of its rarity, its cellular biol...

journal_title：Journal of neuro-oncology

authors： Tran H,Medina-Flores R,Cerilli LA,Phelps J,Lee FC,Wong G,Turner P

更新日期：2010-11-01 00:00:00

abstract：:Meningioma is a common intracranial tumor, originating from the meninges of the skull or spinal canal. Most meningiomas are benign tumors, however atypical or anaplastic tumors can be found in 6% of cases. Patients with asymptomatic small benign meningiomas can be followed without therapy, but in symptomatic patients ...

journal_title：Journal of neuro-oncology

authors： Sioka C,Kyritsis AP

更新日期：2009-03-01 00:00:00

abstract：:Diffuse invasion of the brain by tumor cells is a hallmark of human glioblastomas and a major cause for the poor prognosis of these tumors. This phenomenon is only partially reproduced by rodent models of gliomas that display a very high rate of proliferation and limited cell migration. We have analyzed the developmen...

journal_title：Journal of neuro-oncology

authors： Guillamo JS,Lisovoski F,Christov C,Le Guérinel C,Defer GL,Peschanski M,Lefrançois T

更新日期：2001-05-01 00:00:00

abstract：:We report the case of a 58 year old woman with an epidermoid cyst of the right cerebello-pontine angle that was subtotally excised. She recurred 2 years later and received radiotherapy with resolution of symptoms and shrinkage of the cyst. The natural history of epidermoid cysts and the role of radiotherapy in their m...

journal_title：Journal of neuro-oncology

authors： Parikh S,Milosevic M,Wong CS,Laperriere N

更新日期：1995-01-01 00:00:00