Growth factor (M-CSF) and antigenic properties of macrophages in meningioma.

Abstract:

:In meningiomas, transformed meningeal cells can share morphological aspects (in hemangiopericytic meningioma) and antigenic properties (i.e.: HLA-DR antigens expression) with elements of the monocyte/macrophage lineage. In this report, we describe a case of a highly vascular meningioma where numerous tumor cells, studied with immunohistochemical methods, present phenotypic properties of macrophages. Moreover, the cerebrospinal fluid (CF) analysis disclosed, using a biological assay, a high level of a growth factor for monocytic elements, the Macrophages Colony Stimulating Factor (M-CSF). Our findings may confirm that transitional aspects between different mesenchymal cells could be present in meningiomas.

journal_name

J Neurooncol

authors

Giometto B,Bozza F,Gallo P,Pagni S,Argentiero V,Ferla S,Mingrino S,Tavolato B

doi

10.1007/BF00172943

subject

Has Abstract

pub_date

1992-05-01 00:00:00

pages

25-33

issue

1

eissn

0167-594X

issn

1573-7373

journal_volume

13

pub_type

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