Identifying the needs of brain tumor patients and their caregivers.


:The purpose of this study is to identify the needs of brain tumor patients and their caregivers to provide improved health services to these populations. Two different questionnaires were designed for patients and caregivers. Both questionnaires contained questions pertaining to three realms: disease symptoms/treatment, health care provider, daily living/finances. The caregivers' questionnaires contained an additional domain on emotional needs. Each question was evaluated for the degree of importance and satisfaction. Exploratory analyses determined whether baseline characteristics affect responder importance or satisfaction. Also, areas of high agreement/disagreement in satisfaction between the participating patient-caregiver pairs were identified. Questions for which >50% of the patients and caregivers thought were "very important" but >30% were dissatisfied include: understanding the cause of brain tumors, dealing with patients' lower energy, identifying healthful foods and activities for patients, telephone access to health care providers, information on medical insurance coverage, and support from their employer. In the emotional realm, caregivers identified 9 out of 10 items as important but need further improvement. Areas of high disagreement in satisfaction between participating patient-caregiver pairs include: getting help with household chores (P value = 0.006) and finding time for personal needs (P value < 0.001). This study provides insights into areas to improve services for brain tumor patients and their caregivers. The caregivers' highest amount of burden is placed on their emotional needs, emphasizing the importance of providing appropriate medical and psychosocial support for caregivers to cope with emotional difficulties they face during the patients' treatment process.


J Neurooncol


Parvataneni R,Polley MY,Freeman T,Lamborn K,Prados M,Butowski N,Liu R,Clarke J,Page M,Rabbitt J,Fedoroff A,Clow E,Hsieh E,Kivett V,Deboer R,Chang S




Has Abstract


2011-09-01 00:00:00












  • Central nervous system metastases from castration-resistant prostate cancer in the docetaxel era.

    abstract::Central nervous system (brain or leptomeningeal) metastases (BLm) are considered rare in castration-resistant prostate cancer (CRPC) patients. Now that docetaxel has become the reference drug for first-line treatment of CRPC, patients whose disease is not controlled by hormonal manipulations may live much longer than ...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Caffo O,Gernone A,Ortega C,Sava T,Cartenì G,Facchini G,Re GL,Amadio P,Bortolus R,Pagliarulo V,Prati V,Veccia A,Galligioni E

    更新日期:2012-03-01 00:00:00

  • Increased sensitivity of glioma cells to 5-fluorocytosine following photo-chemical internalization enhanced nonviral transfection of the cytosine deaminase suicide gene.

    abstract::Despite advances in surgery, chemotherapy and radiotherapy, the outcomes of patients with GBM have not significantly improved. Tumor recurrence in the resection margins occurs in more than 80% of cases indicating aggressive treatment modalities, such as gene therapy are warranted. We have examined photochemical intern...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Wang F,Zamora G,Sun CH,Trinidad A,Chun C,Kwon YJ,Berg K,Madsen SJ,Hirschberg H

    更新日期:2014-05-01 00:00:00

  • Evolution of a gene therapy clinical trial. From bench to bedside and back.

    abstract::Developing and conducting gene therapy clinical trials poses unique challenges which must be addressed to satisfy regulatory requirements and, most importantly, to protect human subjects. Experimental products used for gene transfer studies, such as viral vectors, are often complex and cannot be sterilized or complete...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章,评审


    authors: Aguilar LK,Aguilar-Cordova E

    更新日期:2003-12-01 00:00:00

  • Health-related quality of life, cognitive screening, and functional status in a randomized phase III trial (EF-14) of tumor treating fields with temozolomide compared to temozolomide alone in newly diagnosed glioblastoma.

    abstract::We characterized health-related quality of life (HRQoL), cognitive, and functional status in newly diagnosed glioblastoma (GBM) patients receiving Tumor treating fields (TTFields) with temozolomide (TMZ) versus TMZ alone in a planned interim analysis of a randomized phase III trial [NCT00916409], which showed signific...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章,随机对照试验


    authors: Zhu JJ,Demireva P,Kanner AA,Pannullo S,Mehdorn M,Avgeropoulos N,Salmaggi A,Silvani A,Goldlust S,David C,Benouaich-Amiel A,Zvi Ram on behalf of the EF-14 Trial Investigators.

    更新日期:2017-12-01 00:00:00

  • MR-spectroscopic imaging of glial tumors in the spotlight of the 2016 WHO classification.

    abstract:BACKGROUND:The purpose of this study is to map spatial metabolite differences across three molecular subgroups of glial tumors, defined by the IDH1/2 mutation and 1p19q-co-deletion, using magnetic resonance spectroscopy. This work reports a new MR spectroscopy based classification algorithm by applying a radiomics anal...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Diamandis E,Gabriel CPS,Würtemberger U,Guggenberger K,Urbach H,Staszewski O,Lassmann S,Schnell O,Grauvogel J,Mader I,Heiland DH

    更新日期:2018-09-01 00:00:00

  • The role of imaging for the management of newly diagnosed glioblastoma in adults: a systematic review and evidence-based clinical practice guideline update.

    abstract:TARGET POPULATION:These recommendations apply to adults with a newly diagnosed lesion with a suspected or histopathologically proven glioblastoma (GBM). QUESTION:What are the optimal imaging techniques to be used in the management of a suspected glioblastoma (GBM), specifically: which imaging sequences are critical fo...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章,评审


    authors: Lundy P,Domino J,Ryken T,Fouke S,McCracken DJ,Ormond DR,Olson JJ

    更新日期:2020-11-01 00:00:00

  • Drug resistance and apoptosis in ENU-induced rat brain tumors treated with anti-cancer drugs.

    abstract::To cast light on the mechanisms of drug-resistance, experimental brain tumors were immunohistochemically evaluated for expression of glutathione S-transferase (GST)-alpha, mu, pi, p-glycoprotein and apoptosis-related factors, such as bcl-2 and p53, as well as by the terminal deoxynucleotidyl transferase-mediated dUTP-...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Yabuno T,Konishi N,Nakamura M,Tsuzuki T,Tsunoda S,Sakaki T,Hiasa Y

    更新日期:1998-01-01 00:00:00

  • Accelerator-based epithermal neutron sources for boron neutron capture therapy of brain tumors.

    abstract::This paper reviews the development of low-energy light ion accelerator-based neutron sources (ABNSs) for the treatment of brain tumors through an intact scalp and skull using boron neutron capture therapy (BNCT). A major advantage of an ABNS for BNCT over reactor-based neutron sources is the potential for siting withi...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章,评审


    authors: Blue TE,Yanch JC

    更新日期:2003-03-01 00:00:00

  • Prognostic value of proliferation index and expression of the RNA component of human telomerase (hTR) in papillary meningiomas.

    abstract::Papillary meningioma is a rare subtype of meningioma that often behaves aggressively. In order to characterize factors that may influence this behavior, we chose to compare MIB-1 labeling index (LI) and telomerase RNA localization (hTR) in papillary meningiomas, meningiomas, and atypical meningiomas. LI is now often u...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Rushing EJ,Colvin SM,Gazdar A,Miura N,White CL 3rd,Coimbra C,Burns DK

    更新日期:1999-01-01 00:00:00

  • Aneurysmal bone cysts of the spine: treatment options and considerations.

    abstract::Aneurysmal bone cysts (ABCs) are benign bone lesions with annual incidences ranging from 1.4 to 3.2 cases per million people. Approximately, 10-30% of ABCs are found in the spine. Such lesions are traditionally treated with curettage or other intralesional techniques. Because ABCs can be locally aggressive, intralesio...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章,多中心研究


    authors: Boriani S,Lo SF,Puvanesarajah V,Fisher CG,Varga PP,Rhines LD,Germscheid NM,Luzzati A,Chou D,Reynolds JJ,Williams RP,Zadnik P,Groves M,Sciubba DM,Bettegowda C,Gokaslan ZL,AOSpine Knowledge Forum Tumor.

    更新日期:2014-10-01 00:00:00

  • Neurological dysfunction associated with postoperative cerebellar mutism.

    abstract:BACKGROUND AND OBJECTIVES:The postoperative cerebellar mutism syndrome (CMS) is an unique acute postoperative complication characterized by transient decrease in speech output (often mutism), apathy, irritability as well as global cerebellar dysfunction. As much as 25% of patients undergoing a resection of a cerebellar...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Siffert J,Poussaint TY,Goumnerova LC,Scott RM,LaValley B,Tarbell NJ,Pomeroy SL

    更新日期:2000-05-01 00:00:00

  • Stripe-like increase of rCBV beyond the visible border of glioblastomas: site of tumor infiltration growing after neurosurgery.

    abstract::We observed a stripe-like pattern of regional cerebral blood volume (rCBV) increase in a defined region adjacent to the contrast enhancement (CE) on MRI of glioblastomas (GBM) that we defined as the "striate sign" (SS). We hypothesized that the SS marks infiltration of GBM outside the CE volume transforming into futur...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Blasel S,Franz K,Ackermann H,Weidauer S,Zanella F,Hattingen E

    更新日期:2011-07-01 00:00:00

  • EpCAM-based assays for epithelial tumor cell detection in cerebrospinal fluid.

    abstract::The diagnosis of leptomeningeal metastases (LM) of solid tumors is complicated due to low sensitivities of both magnetic resonance imaging (MRI) and cytology. MRI has a sensitivity of 76% for the diagnosis of LM and cerebrospinal fluid (CSF) cytology has a sensitivity of 44-67% at first lumbar puncture which increases...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章,评审


    authors: van Bussel MTJ,Pluim D,Bol M,Beijnen JH,Schellens JHM,Brandsma D

    更新日期:2018-03-01 00:00:00

  • Single fraction spine stereotactic ablative body radiotherapy with volumetric modulated arc therapy.

    abstract::This study investigated a single institution's experience with volumetric modulated arc therapy (VMAT) directed stereotactic ablative body radiotherapy (SABR) for vertebral metastases. From 2010 to 2014, 95 lesions of spinal metastases in 73 patients were treated with SABR using VMAT. Clinical local control, pain leve...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Gestaut MM,Thawani N,Kim S,Gutti VR,Jhavar S,Deb N,Morrow A,Ward RA,Huang JH,Patel M

    更新日期:2017-05-01 00:00:00

  • Choroid plexus carcinoma--responses to chemotherapy alone in newly diagnosed young children.

    abstract::Choroid plexus carcinoma (CPC) arising in the infant poses several treatment dilemmas. The tumor is often not totally resectable at presentation given its large size and tendency to invade adjacent brain. Because of its predisposition to regrow and metastasize, some form of postoperative cytotoxic therapy is required....

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Allen J,Wisoff J,Helson L,Pearce J,Arenson E

    更新日期:1992-01-01 00:00:00

  • Regional disparities in hospitalization charges for patients undergoing craniotomy for tumor resection in New York State: correlation with outcomes.

    abstract::There is increasing regulatory pressure for cost containment in neuro-oncology, and rationalization of the observed regional disparities. We investigated the presence of such disparities in New York State and examined the impact of risk adjustment on the magnitude of this variation. We performed a cohort study involvi...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Missios S,Bekelis K

    更新日期:2016-06-01 00:00:00

  • Interstitial fluid flow along white matter tracts: a potentially important mechanism for the dissemination of primary brain tumors.

    abstract::High grade astrocytomas remain incurable even though these tumors often appear localized on modern imaging studies, rarely metastasize to systemic sites, and can be aggressively treated with surgery and radiation therapy. Recent data suggest that the dissemination of astrocytoma cells along white matter tracts to dist...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Geer CP,Grossman SA

    更新日期:1997-05-01 00:00:00

  • Late radiation necrosis of the brain: case report.

    abstract::We report a case of radiation necrosis occurring 47 years after resection and radiotherapy for a juvenile pilocystic cerebellar astrocytoma, the longest yet reported. The patient presented with progressive lower cranial nerve dysfunction, and eventually died from cardiopulmonary arrest secondary to aspiration. The pre...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章,评审


    authors: Babu R,Huang PP,Epstein F,Budzilovich GN

    更新日期:1993-07-01 00:00:00

  • Re-irradiation for children with recurrent medulloblastoma in Toronto, Canada: a 20-year experience.

    abstract:PURPOSE:Children with recurrent medulloblastoma have a poor prognosis. Re-irradiation is an option for some patients, but has not been well-studied in the era of molecular characterization for pediatric medulloblastoma. METHODS:This was a retrospective cohort study of 14 children age 18 years and younger at initial di...

    journal_title:Journal of neuro-oncology

    pub_type: 临床试验,杂志文章


    authors: Tsang DS,Sarhan N,Ramaswamy V,Nobre L,Yee R,Taylor MD,Hawkins C,Bartels U,Huang A,Tabori U,Hodgson DC,Bouffet E,Laperriere N

    更新日期:2019-10-01 00:00:00

  • Upregulation of LRIG1 suppresses malignant glioma cell growth by attenuating EGFR activity.

    abstract::Activated epidermal growth factor receptor (EGFR) has emerged as an important therapeutic target for a variety of solid tumors, particularly malignant gliomas. A recently discovered transmembrane glycoprotein, LRIG1, antagonizes the activity of epidermal growth factor receptor family receptor tyrosine kinases and acts...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Ye F,Gao Q,Xu T,Zeng L,Ou Y,Mao F,Wang H,He Y,Wang B,Yang Z,Guo D,Lei T

    更新日期:2009-09-01 00:00:00

  • Tumorigenesis and prognostic role of hepatoma-derived growth factor in human gliomas.

    abstract::Hepatoma-derived growth factor (HDGF) is a neurotrophic factor found in mouse spinal cord and hippocampal neurons. In various malignant tumors, the role of HDGF in tumor progression and its use as a diagnostic biomarker or therapeutic target have been extensively explored. However, the prognostic function and mitogeni...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Hsu SS,Chen CH,Liu GS,Tai MH,Wang JS,Wu JC,Kung ML,Chan EC,Liu LF

    更新日期:2012-03-01 00:00:00

  • Impact of tumor location and pathological discordance on survival of children with midline high-grade gliomas treated on Children's Cancer Group high-grade glioma study CCG-945.

    abstract::Children with high-grade glioma (HGG) have a poor prognosis compared to those with low-grade glioma (LGG). Adjuvant chemotherapy may be beneficial, but its optimal use remains undetermined. Histology and extent of resection are important prognostic factors. We tested the hypothesis that patients with midline HGG treat...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章,随机对照试验


    authors: Eisenstat DD,Pollack IF,Demers A,Sapp MV,Lambert P,Weisfeld-Adams JD,Burger PC,Gilles F,Davis RL,Packer R,Boyett JM,Finlay JL

    更新日期:2015-02-01 00:00:00

  • Patterns of failures after surgical resection in olfactory neuroblastoma.

    abstract:INTRODUCTION:Patterns of failure in patients with olfactory neuroblastoma (ONB) according to two surgical approaches, craniofacial resection (CFR) and endoscopic surgery (ENDO), have yet to be analyzed. METHODS:We retrospectively reviewed 28 patients with surgically treated ONB between January 1995 and October 2017. F...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Kim N,Lee CG,Kim EH,Kim CH,Keum KC,Lee KS,Chang JH,Suh CO

    更新日期:2019-01-01 00:00:00

  • Anti-differentiation non-coding RNA, ANCR, is differentially expressed in different types of brain tumors.

    abstract::Long non-coding RNAs (lncRNAs) are important modulators of various cellular and molecular events, including cancer-associated pathways. The Anti-differentiation ncRNA (ANCR) is a key regulator of keratinocyte differentiation, where its expression is necessary to maintain epidermal progenitor's cells. Herein, we invest...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Malakootian M,Mirzadeh Azad F,Fouani Y,Taheri Bajgan E,Saberi H,Mowla SJ

    更新日期:2018-06-01 00:00:00

  • Effects of hypoxia on drug resistance phenotype and genotype in human glioma cell lines.

    abstract::Recurrent gliomas are most often treated by chemotherapy. However, these tumors typically acquire resistance to most drugs administered, and patients will usually die of recurrent tumor. Factors which may play a role include overexpression of putative multidrug resistance genes, such as the multidrug resistance gene 1...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Liang BC

    更新日期:1996-08-01 00:00:00

  • Radiation therapy and the management of intramedullary spinal cord tumors.

    abstract::The use of radiation therapy in the management of intramedullary spinal cord tumors remains controversial. Several studies indicate that the use of postoperative radiation therapy modestly improves both local control and survival in spinal cord ependymomas and astrocytomas. Modern treatment planning and imaging allow ...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章,评审


    authors: Isaacson SR

    更新日期:2000-05-01 00:00:00

  • Multisession gamma knife surgery for large brain metastases.

    abstract::This study aimed to explore the safety and efficacy of multisession gamma knife surgery (GKS) for large brain metastases with a volume of 10 cm3 or larger. Fifty-six patients who had 65 brain metastases with a volume of at least 10 cm3 were treated with multisession GKS. Three-session GKS at a prescription dose of 10 ...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Hasegawa T,Kato T,Yamamoto T,Iizuka H,Nishikawa T,Ito H,Kato N

    更新日期:2017-02-01 00:00:00

  • Radiation therapy for incompletely resected supratentorial low-grade glioma in adults.

    abstract::In this review on current concepts in radiation therapy in the treatment of incompletely resected supratentorial low-grade glioma, a number of important issues are discussed. They include indication for radiation therapy, timing (early vs delayed), dose response issue, impact of modern neuroimaging, 'optimal' treatmen...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章,评审


    authors: Jeremic B,Bamberg M

    更新日期:2001-11-01 00:00:00

  • Subependymoma revisited: clinicopathological evaluation of 83 cases.

    abstract:OBJECT:Subependymomas are rare ependymal neoplasms. To date, a large clinicopathologic study of these benign neoplasms treated with modern neurosurgical techniques has not been reported. METHODS:Eighty-three cases of subependymoma were retrieved from the files of the Armed Forces Institute of Pathology. Clinicopatholo...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Rushing EJ,Cooper PB,Quezado M,Begnami M,Crespo A,Smirniotopoulos JG,Ecklund J,Olsen C,Santi M

    更新日期:2007-12-01 00:00:00

  • Adeno-associated viral vector gene transfer into leptomeningeal xenografts.

    abstract::Leptomeningeal carcinomatosis is a painful and debilitating complication of cancer. Indwelling reservoirs provide continuous assess to the subarachnoid space, making leptomeningeal cancer potentially amenable to gene therapy. Adeno-associated virus (AAV) is a defective virus not associated with any human disease. We u...

    journal_title:Journal of neuro-oncology

    pub_type: 杂志文章


    authors: Rosenfeld MR,Bergman I,Schramm L,Griffin JA,Kaplitt MG,Meneses PI

    更新日期:1997-09-01 00:00:00