Abstract：
:The treatment of visual pathway gliomas is controversial. The many retrospective studies reporting outcome data for patients with chiasmatic/hypothalamic gliomas are difficult to interpret for several reasons. First the natural history of these tumors is erratic with some reports suggesting that most visual pathway gliomas are hamartomas and follow an indolent course, and others reporting 10-year survival rates of close to 60%. Second, earlier studies did not clearly indicate which patients had neurofibromatosis type 1 (NF1) and recent evidence suggests that the natural history of optic gliomas is more favorable in patients with NF1. Third the methods and accuracy of diagnosis have changed dramatically and patients diagnosed before and after the advent of CT/MR imaging have often been included in the same series. While surgical resection is usually not a viable option for definitive treatment of these tumors, recent studies have shown favorable results after subtotal resection in selected patients. The efficacy of radiotherapy has not been unequivocally demonstrated and treatment-related morbidity has become a major concern, in particular, adverse effects on cognition and growth. Chemotherapy has been advanced as an viable alternative to avoid or delay the adverse affects of RT, but the long-term outcome benefits and adverse effects of treatment are just being defined. Despite the limitations of currently available information, sufficient data are now available to rational management quotelines for the majority of children with chiasmatic/hypothalamic gliomas.
journal_name
J Neurooncoljournal_title
Journal of neuro-oncologyauthors
Garvey M,Packer RJdoi
10.1007/BF00250197subject
Has Abstractpub_date
1996-05-01 00:00:00pages
167-83issue
2-3eissn
0167-594Xissn
1573-7373journal_volume
28pub_type
杂志文章,评审abstract：:We report a case of high risk medulloblastoma with leptomeningeal intracranial and spinal metastasis in a 10-year-old girl treated successfully with conventional prolonged chemotherapy without radiotherapy. This is a particular case of medulloblastoma that at onset did not receive standard therapy for medulloblastoma ...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1023/a:1006365511379
更新日期：1999-01-01 00:00:00
abstract：:Signal transducers and activators of transcription 3 (STAT3) are activated by various cytokines and oncogenes; however, the activity and pathogenesis of STAT3 in diffuse large B cell lymphoma of the central nervous system have not been thoroughly elucidated. We investigated the phosphorylation levels of STAT3 in 40 sp...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-015-1843-9
更新日期：2015-09-01 00:00:00
abstract：:Stereotactic radiosurgery is a frequently performed procedure for patients with benign intracranial tumors. Benign tumors are good candidates for radiosurgery because they are generally non-invasive, are well visualized by magnetic resonance imaging, and their slow rate of proliferation makes conventional radiation do...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章,评审
doi：10.1007/s11060-009-9831-6
更新日期：2009-05-01 00:00:00
abstract：:There is general agreement that most chemotherapy agents achieve only relatively low concentrations in the normal central nervous system, that the blood-brain barrier is variably disrupted in malignant brain tumors, and that the concentration of chemotherapy drugs in the brain adjacent to tumor is intermediate between...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章,评审
doi：10.1007/BF01052723
更新日期：1994-01-01 00:00:00
abstract：:Tripartite motif (TRIM) proteins are involved in tumorigenesis. Here, we examined the expression, biological function, and clinical significance of tripartite motif containing 28 (TRIM28) in glioma, a locally aggressive brain tumor. First, TRIM28 expression was significantly higher in glioma (n = 138) than in non-glio...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-015-1897-8
更新日期：2016-01-01 00:00:00
abstract：:We report the case of a 64 year old male patient with a history of ischemic heart disease who underwent surgery for an abdominal mass. The histological diagnosis was highly malignant non-Hodgkin's lymphoma. After surgery the patient was admitted to our Department and received 6 courses of chemotherapy according to the...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1023/a:1006180909837
更新日期：1999-03-01 00:00:00
abstract：:To date, no histopathological vascular investigation focusing on peritumoral brain zone (PBZ) has been reported for glioblastoma. We analyzed 10 newly diagnosed cases of glioblastomas. For these PBZs, histopathological investigation was performed by hematoxylin-eosin (H&E) staining and immunohistochemistry was analyze...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-017-2648-9
更新日期：2018-01-01 00:00:00
abstract：PURPOSE:Children with recurrent medulloblastoma have a poor prognosis. Re-irradiation is an option for some patients, but has not been well-studied in the era of molecular characterization for pediatric medulloblastoma. METHODS:This was a retrospective cohort study of 14 children age 18 years and younger at initial di...
journal_title：Journal of neuro-oncology
pub_type： 临床试验,杂志文章
doi：10.1007/s11060-019-03272-2
更新日期：2019-10-01 00:00:00
abstract：:The aim of this work is to evaluate patterns of failure in patients with recurrent meningioma after stereotactic radiotherapy. Of 411 patients with intracranial meningioma treated with radiotherapy at our institution, 22 patients with local tumor progression diagnosed by magnetic resonance imaging (MRI) after radiothe...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-009-0084-1
更新日期：2010-07-01 00:00:00
abstract：:Malignancy involving the skull base remains a formidable management challenge. Advances and refinements in diagnostic imaging, instrumentation, microvascular reconstruction, and an improved overall appreciation of the anatomy of the skullbase have extended the boundaries of tumor resectability and in some cases, obvia...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章,评审
doi：10.1023/b:neon.0000041882.41369.9b
更新日期：2004-08-01 00:00:00
abstract：:The stable isotope 10B has a peculiarly marked avidity to capture slow neutrons whereupon it disintegrates into a lithium and a helium atom. These give up the 2.4 MeV of disintegration energy which they share within 5 and 9 microns of the 10B atom respectively. This means that the cell closest to the 10B atom bears th...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章,评审
doi：10.1023/a:1005752827194
更新日期：1997-05-01 00:00:00
abstract：:Identification of patients suffering from elevated psychosocial distress, the sources of the distress, and the necessary treatment of the distress can be rather difficult within the neurosurgical setting (e.g., lack of time, cognitive or aphasic disorders of the patients). The distress thermometer (DT) is a single-ite...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-010-0501-5
更新日期：2011-08-01 00:00:00
abstract：:A list of active investigative brain tumor protocols in North America is presented. The fact that there are 138 protocols (and certainly some have been missed) indicates the diversity and intensity of research into this difficult problem. The geographic diversity of institutions involved in brain tumor clinical trials...
journal_title：Journal of neuro-oncology
pub_type：
doi：10.1007/BF01049979
更新日期：1993-09-01 00:00:00
abstract：:We retrospectively evaluated the relationship between the response of lung lesions and distant progression-free survival (DPFS) after radiosurgery in patients with brain metastases. A total of 47 consecutive patients were treated with radiosurgery for brain metastases. Distant progression was defined as a new enhancin...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-011-0653-y
更新日期：2012-01-01 00:00:00
abstract：:The anti-Hu syndrome is the most common paraneoplastic neurologic syndrome but the exact mechanism of immune mediated neuronal injury remains unknown. Anti-Hu antibodies do not appear to play a pivotal role in the pathogenesis of the disease. To assess cell-mediated immunity, we selected 51 peptides from the Hu-D sequ...
journal_title：Journal of neuro-oncology
pub_type： 临床试验,杂志文章
doi：10.1007/s11060-004-1723-1
更新日期：2005-02-01 00:00:00
abstract：PURPOSE:Post-operative radiation therapy for brain metastases (BM) has become standard treatment. Concerns regarding the deleterious cognitive effects of Whole Brain Radiation Therapy spurred a trend to use focal therapies such as stereotactic radiosurgery (SRS). The purpose of this study was to prospectively evaluate ...
journal_title：Journal of neuro-oncology
pub_type： 临床试验,杂志文章
doi：10.1007/s11060-018-2954-x
更新日期：2018-11-01 00:00:00
abstract：:Children with recurrent high grade gliomas (HGG) have a dismal outcome with a median progression free survival (PFS) of 12 weeks. Adults with recurrent HGG treated with irinotecan and bevacizumab reportedly have a 63% response rate and a median PFS of 23 weeks. There is a paucity of corresponding published pediatric d...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-010-0444-x
更新日期：2011-07-01 00:00:00
abstract：:Cell differentiation agent-2 (CDA-2) is an extraction from healthy human urine consisting of primary organic acids and peptides, and it has been demonstrated to inhibit growth and induce differentiation in glioma and other cell lines. But the mechanism of CDA-2 remains unclear. In this study, we demonstrated that CDA-...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-012-0961-x
更新日期：2012-11-01 00:00:00
abstract：:The growth pattern of pilocytic astrocytoma (PAs) is unpredictable. Gene expression profiling has recently demonstrated an inverse relationship between myelin basic protein (MBP) expression and progression free survival (PFS) in PAs. We present here the pattern of expression of oligodendroglial differentiation markers...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-007-9455-7
更新日期：2008-01-01 00:00:00
abstract：:We studied the effect of intracarotid infusion of various calcium antagonists on regional CBF (rCBF) in the C6 rat glioma by a hydrogen clearance method. Nimodipine at doses of 0.1, 0.5 and 1 microgram/kg/min was found to produce tumor-specific increases in the rCBF (40.2 +/- 18.4%, p < 0.01, 67.8 +/- 32.6%, p < 0.001...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/BF00146078
更新日期：1996-01-01 00:00:00
abstract：PURPOSE:To report outcomes of salvage re-irradiation (re-RT) in recurrent/progressive medulloblastoma (MB). METHODS:Medical records of patients treated with curative-intent re-RT as multi-modality management for recurrent/progressive MB between 2008 and 2018 were analyzed retrospectively. RESULTS:A total of 28 patien...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-019-03225-9
更新日期：2019-09-01 00:00:00
abstract：:Radiation (RT) is critical to the treatment of high-grade gliomas (HGGs) but cures remain elusive. The BRAF mutation V600E is critical to the pathogenesis of 10-20% of pediatric gliomas, and a small proportion of adult HGGs. Here we aim to determine whether PLX4720, a specific BRAF V600E inhibitor, enhances the activi...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-015-1939-2
更新日期：2016-02-01 00:00:00
abstract：:We report a single-center experience of 16 immunocompetent patients diagnosed with primary central nervous system lymphoma and treated with monochemotherapy with high-dose methotrexate (MTX) and deferred radiotherapy. MTX was given at a dose of 8.0 g/m2 for induction and at a dose of 3.5-8.0 g/m2 for maintenance. Ther...
journal_title：Journal of neuro-oncology
pub_type： 临床试验,杂志文章
doi：10.1007/s11060-008-9736-9
更新日期：2009-03-01 00:00:00
abstract：:Combination of procarbazine, lomustine and vincristine (PCV) with radiation therapy (RT) has been associated with longer survival in patients with anaplastic oligodendroglioma (AO) and anaplastic oligoastrocytoma (AOA), especially in those with chromosome 1p/19q codeletion. We report a multicenter retrospective study ...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章,多中心研究
doi：10.1007/s11060-013-1288-y
更新日期：2014-01-01 00:00:00
abstract：:Intramedullary spinal cord metastases of solid neoplasms are associated with poor long-term survival. As the characteristics of secondary intramedullary spinal cord non-Hodgkin's lymphoma (NHL) are not well understood, we sought to describe its clinical features and outcome. We retrospectively reviewed the Mayo Clinic...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-011-0781-4
更新日期：2012-05-01 00:00:00
abstract：:Meningiomas, one of the most common benign brain tumors in humans, arise from arachnoid cells in the brain meninges. Our investigations have revealed that miR-335 is a typical microRNA overexpressed in meningiomas in humans. Characterization of the effects of miR-335 overexpression in meningiomas demonstrated that ele...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-012-0951-z
更新日期：2012-11-01 00:00:00
abstract：:Ceramide is a physiologic regulator of growth and differentiation in mammalian cells. In this study, the relationship between ceramide and FLICE inhibitory protein (FLIP) in the induction of apoptosis in glioblastoma cell lines was investigated. We found that LN215 cells were slightly more sensitive to Fas-mediated ap...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1023/a:1020604705831
更新日期：2002-11-01 00:00:00
abstract：:Despite advances in surgery, chemotherapy and radiotherapy, the outcomes of patients with GBM have not significantly improved. Tumor recurrence in the resection margins occurs in more than 80% of cases indicating aggressive treatment modalities, such as gene therapy are warranted. We have examined photochemical intern...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-014-1410-9
更新日期：2014-05-01 00:00:00
abstract：:The objective of this study was to investigate whether activity and protein expression of ornithine decarboxylase (ODC) the metabolism-rate limiting enzyme of the polyamine biosynthesis, which is involved in the regulation of cellular growth and differentiation, reflects the distinct histopathologic characteristics in...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1023/b:neon.0000013483.50955.2f
更新日期：2004-01-01 00:00:00
abstract：:'Benign' brain tumors are a heterogeneous group of primary neoplasms representing 40% of primary brain tumors. Amongst neuroepithelial tumors, astrocytic neoplasms predominate, followed by oligodendroglial and mixed glial and glial-neuronal neoplasms. Less common are tumors of the ependyma, choroid plexus and neuroepi...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章,评审
doi：10.1023/b:neon.0000041871.46785.53
更新日期：2004-08-01 00:00:00
