miR-335 promotes cell proliferation by directly targeting Rb1 in meningiomas.

abstract：:Approximately half of surgically-treated patients with low-grade-glioma (LGG) suffer recurrence or metastasis. Currently there is no effective drug treatment. While the selective COX-2 inhibitor celecoxib showed anti-neoplastic activity against several malignant tumors, its effects against LGG remain to be elucidated....

journal_title：Journal of neuro-oncology

authors： Sato A,Mizobuchi Y,Nakajima K,Shono K,Fujihara T,Kageji T,Kitazato K,Matsuzaki K,Mure H,Kuwayama K,Sumi A,Saya H,Sampetrean O,Nagahirao S

更新日期：2017-04-01 00:00:00

abstract：:To investigate late toxicity among patients with newly-diagnosed brain metastases undergoing stereotactic radiosurgery (SRS) with concurrent systemic therapies with or without whole-brain radiation therapy (WBRT). Patients with newly-diagnosed brain metastasis who underwent SRS at a single tertiary-care institution fr...

journal_title：Journal of neuro-oncology

authors： Kim JM,Miller JA,Kotecha R,Xiao R,Juloori A,Ward MC,Ahluwalia MS,Mohammadi AM,Peereboom DM,Murphy ES,Suh JH,Barnett GH,Vogelbaum MA,Angelov L,Stevens GH,Chao ST

更新日期：2017-06-01 00:00:00

abstract：:Future success using chemotherapy against human gliomas may result from exploiting unique molecular vulnerabilities of these tumors. Chemotherapy frequently results in DNA damage. When such damage is sensed by the cell, programmed cell death, or apoptosis, may be initiated. However, chemotherapy-induced DNA damage may...

journal_title：Journal of neuro-oncology

authors： Weaver KD,Yeyeodu S,Cusack JC Jr,Baldwin AS Jr,Ewend MG

更新日期：2003-02-01 00:00:00

abstract：:This study concerns the use of the MTT [3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H tetrazolium bromide] colorimetric assay to evaluate the chemosensitivity of the C6 rat glioma cell line to a panel of twelve chemotherapeutic agents. In a previous study of in vitro chemosensitivity of human glioma cell lines, the pre...

journal_title：Journal of neuro-oncology

authors： Hand CM,Vender JR,Black P

更新日期：1998-01-01 00:00:00

abstract：:Chordomas constitute about 1% of intracranial tumors. They are generally extradural destroying the bone. Intradural chordomas are very rare. We present one such case of a clival intradural chordoma who presented with a left trigeminal nerve sensory neuropathy. The lesion was totally excised uneventfully via a retromas...

journal_title：Journal of neuro-oncology

authors： Bhat DI,Yasha M,Rojin A,Sampath S,Shankar SK

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:To compare chemotherapy treatment monitoring in astrocytoma by 201thallium single photon emission computed tomography (SPECT) and photon magnetic resonance spectroscopy (1H-MRS) with magnetic resonance imaging (MRI), and to evaluate the influence of morphological tumor changes on cerebral 201thallium uptake and...

journal_title：Journal of neuro-oncology

authors： Kallén K,Burtscher IM,Holtås S,Ryding E,Rosén I

更新日期：2000-01-01 00:00:00

abstract：:Bevacizumab has been reported to cause diffusion restriction in the tumor bed of patients with malignant gliomas. This study evaluated prolonged diffusion restriction, in the corpus callosum (CC), of patients with malignant brain tumors treated with bevacizumab. We retrospectively reviewed our database of patients tre...

journal_title：Journal of neuro-oncology

authors： Futterer SF,Nemeth AJ,Grimm SA,Ragin AB,Chandler JP,Muro K,Marymont MH,Raizer JJ

更新日期：2014-05-01 00:00:00

abstract：PURPOSE:Prediction of clinical outcomes in patients with primary central nervous system lymphoma (PCNSL) is important for optimization of treatment planning. Quantitative imaging biomarkers for PCNSL have not yet been established. This study evaluated the prognostic value of pretreatment dynamic contrast-enhanced MRI a...

journal_title：Journal of neuro-oncology

authors： Hatzoglou V,Oh JH,Buck O,Lin X,Lee M,Shukla-Dave A,Young RJ,Peck KK,Vachha B,Holodny AI,Grommes C

更新日期：2018-11-01 00:00:00

abstract：:Treatment of recurrent primary CNS lymphoma (PCNSL) though not standardized most often utilizes whole brain radiotherapy, re-challenge with high-dose methotrexate, or administration of an alkylating chemotherapy. High-dose cytarabine (HD-araC) has been advocated as an active agent in PCNSL but limited information exis...

journal_title：Journal of neuro-oncology

authors： Chamberlain MC

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Paclitaxel-induced peripheral neuropathy (PN) may be severe and dose-limiting at initial doses > or = 275 mg/M2, but its neurotoxicity at doses < or = 250 mg/M2 has been incompletely characterized. The purposes of this study were to characterize and quantify paclitaxel-induced PN and to determine the utility...

journal_title：Journal of neuro-oncology

authors： Forsyth PA,Balmaceda C,Peterson K,Seidman AD,Brasher P,DeAngelis LM

更新日期：1997-10-01 00:00:00

abstract：:The aim of this work was to determine the accuracy and precision of stereotactic localization and treatment delivery using a helical tomotherapy based stereotactic radiosurgery (SRS) system. A tomotherapy specific radiosurgery workflow was designed that exploits the system's on board megavotage CT (MVCT) imaging syste...

journal_title：Journal of neuro-oncology

authors： Soisson ET,Hardcastle N,Tomé WA

更新日期：2010-06-01 00:00:00

abstract：:Ionizing radiation plays a major role in the treatment of brain tumors, but side-effects may restrict the efficacy of therapy. In the present study, our goals were to establish whether the administration of L-alpha-glycerylphosphorylcholine (GPC) can moderate or prevent any of the irradiation-induced functional and mo...

journal_title：Journal of neuro-oncology

authors： Plangár I,Szabó ER,Tőkés T,Mán I,Brinyiczki K,Fekete G,Németh I,Ghyczy M,Boros M,Hideghéty K

更新日期：2014-09-01 00:00:00

abstract：:Previous studies have shown an inverse association between allergies and glioma risk; however, results for associations between single nucleotide polymorphisms (SNPs) of allergy-related genes and glioma risk have been inconsistent and restricted to a small number of SNPs. The objective of this study was to examine the...

journal_title：Journal of neuro-oncology

authors： Backes DM,Siddiq A,Cox DG,Calboli FC,Gaziano JM,Ma J,Stampfer M,Hunter DJ,Camargo CA,Michaud DS

更新日期：2013-06-01 00:00:00

abstract：:Type 2 diabetes mellitus (DM) and obesity are known risk factors for poor outcomes in patients with systemic malignancies but are not well-studied in the brain tumor population. In this study we asked if type 2 DM and elevated body mass index (BMI) are independent risk factors for poor prognosis in patients with high-...

journal_title：Journal of neuro-oncology

authors： Chambless LB,Parker SL,Hassam-Malani L,McGirt MJ,Thompson RC

更新日期：2012-01-01 00:00:00

abstract：:Although 1p19q codeleted gliomas are the most favorable molecular subgroup of lower-grade gliomas, there are cases with early recurrence or short survival. The objective of this study was to elucidate molecular-genetic and clinicopathological prognostic factors in patients with gliomas showing total 1p19q loss. The st...

journal_title：Journal of neuro-oncology

authors： Hayashi S,Kitamura Y,Hirose Y,Yoshida K,Sasaki H

更新日期：2017-03-01 00:00:00

abstract：:Anaplastic oligodendroglioma (AO) is an uncommon intracranial tumor and prognosis is poor. In this study, we assessed the factors affecting the prognosis of AO patients. Seventy AO patients were recruited from 2001 to 2006 in Shanghai Huashan Hospital of Fudan University; all were treated surgically. Kaplan-Meier surv...

journal_title：Journal of neuro-oncology

authors： Yang LS,Huang FP,Zheng K,Zhang HS,Zhou X,Bao XH,Zheng JJ,Chang C,Zhou LF

更新日期：2010-10-01 00:00:00

abstract：PURPOSE:Current medulloblastoma therapy, surgery, radiation, and chemotherapy, is unacceptably toxic. However, 13-cis retinoic acid (RA) and SAHA, a histone deacetylase inhibitor, have each been shown to induce apoptosis in medulloblastoma cultures and mouse models. Both drugs cross the blood brain barrier, have been g...

journal_title：Journal of neuro-oncology

authors： Spiller SE,Ditzler SH,Pullar BJ,Olson JM

更新日期：2008-04-01 00:00:00

abstract：:Developing and conducting gene therapy clinical trials poses unique challenges which must be addressed to satisfy regulatory requirements and, most importantly, to protect human subjects. Experimental products used for gene transfer studies, such as viral vectors, are often complex and cannot be sterilized or complete...

journal_title：Journal of neuro-oncology

authors： Aguilar LK,Aguilar-Cordova E

更新日期：2003-12-01 00:00:00

abstract：:Central nervous system (brain or leptomeningeal) metastases (BLm) are considered rare in castration-resistant prostate cancer (CRPC) patients. Now that docetaxel has become the reference drug for first-line treatment of CRPC, patients whose disease is not controlled by hormonal manipulations may live much longer than ...

journal_title：Journal of neuro-oncology

authors： Caffo O,Gernone A,Ortega C,Sava T,Cartenì G,Facchini G,Re GL,Amadio P,Bortolus R,Pagliarulo V,Prati V,Veccia A,Galligioni E

更新日期：2012-03-01 00:00:00

abstract：:Long term survival is rare in patients with glioblastoma multiforme (GBM). To determine if the tumors of patients with long survivals constitute a subgroup of patients with identifiable molecular genetic characteristics, we studied the p53 gene and Epidermal Growth Factor Receptor (EGF-R) expression in long-term survi...

journal_title：Journal of neuro-oncology

authors： Morita M,Rosenblum MK,Bilsky MH,Fraser RA,Rosenfeld MR

更新日期：1996-03-01 00:00:00

abstract：PURPOSE:Postoperative stereotactic radiosurgery (SRS) has been shown to establish local control in patients with resected brain metastases, yet its efficacy may be limited, particularly for resected lesions with large post-operative resection cavities. We describe the efficacy of postoperative fractionated stereotactic...

journal_title：Journal of neuro-oncology

authors： Traylor JI,Habib A,Patel R,Muir M,Gadot R,Briere T,Yeboa DN,Li J,Rao G

更新日期：2019-09-01 00:00:00

abstract：INTRODUCTION:Carmustine (BCNU)-impregnated biodegradable polymer wafers have been shown to prolong survival in patients with recurrent malignant glioma. Interferon alfa-2b (IFNalpha(2b)) has demonstrated antitumor activity against a number of cancers, but its use in glioma has been limited. The use of these agents in c...

journal_title：Journal of neuro-oncology

authors： Olson JJ,McKenzie E,Skurski-Martin M,Zhang Z,Brat D,Phuphanich S

更新日期：2008-12-01 00:00:00

abstract：:Extensive surgical resection of centrally localized, newly diagnosed glioblastoma can lead to opening ventricles and therefore carries a potential risk of spreading tumor cells into the cebrospinal fluid. However, whether ventricle opening consequently implies a greater frequency of distant tumor recurrence after radi...

journal_title：Journal of neuro-oncology

authors： Adeberg S,Diehl C,Jung CS,Rieken S,Combs SE,Unterberg A,Debus J

更新日期：2016-05-01 00:00:00

abstract：:Identification of cytotoxic T lymphocyte (CTL) epitopes from additional tumor antigens is essential for the development of specific immunotherapy of malignant tumors. Neuritin, a recently discovered antigen overexpressed in astrocytoma, is considered to be a promising target for biological therapy. In the present stud...

journal_title：Journal of neuro-oncology

authors： Yang Z,Zhao T,Liu Y,Gong Z,Cheng S,Yang Q

更新日期：2013-08-01 00:00:00

abstract：:To identify molecular therapeutic targets for glioma, we performed gene expression profiling by using a complementary DNA (cDNA) microarray method and identified the urokinase plasminogen activator receptor-associated protein (uPARAP/Endo180) as a gene expressed highly in glioma tissue compared with the normal brain t...

journal_title：Journal of neuro-oncology

authors： Takahashi S,Yamada-Okabe H,Hamada K,Ohta S,Kawase T,Yoshida K,Toda M

更新日期：2011-06-01 00:00:00

abstract：:Gliomatosis cerebri (GC) are extensively infiltrative glial tumors classified as astrocytic tumors in the current World Health Organization (WHO) classification scheme. In investigating the tumorigenesis of GC, we reviewed 28 cases of GC immunohistochemically and carried out array-based comparative genomic hybridizati...

journal_title：Journal of neuro-oncology

authors： Min HS,Kim B,Park SH

更新日期：2008-12-01 00:00:00

abstract：:The determination of optimal therapy for ependymoma (EP) in infants is ongoing. We describe the incidence, management and outcomes of Canadian infants with EP to discern potential future research questions. Of 579 cases registered in a national database of children <36 months of age diagnosed with a brain tumor from 1...

journal_title：Journal of neuro-oncology

authors： Purdy E,Johnston DL,Bartels U,Fryer C,Carret AS,Crooks B,Eisenstat DD,Lafay-Cousin L,Larouche V,Wilson B,Zelcer S,Silva M,Bouffet E,Keene D,Strother DR

更新日期：2014-04-01 00:00:00

abstract：:Medulloblastoma with melanotic differentiation, a rare variant of medulloblastoma, often carries a poor prognosis. We present such a case of a 4 year male with this rare, aggressive tumor. Additionally, we have reviewed the literature and report on the features important in the pathologic and radiologic diagnosis in t...

journal_title：Journal of neuro-oncology

authors： Phillips CL,Miles L,Jones BV,Sutton M,Crone K,Fouladi M

更新日期：2011-07-01 00:00:00

abstract：:The aim of this study was to assess the effectiveness of adding viral vector-mediated gene therapy with herpes simplex virus thymidine kinase (HSV-tk) to standard treatment, in comparison with standard treatment alone to treat patients with high-grade gliomas (HGGs). A literature search of the databases PubMed, Embase...

journal_title：Journal of neuro-oncology

authors： Zhao F,Tian J,An L,Yang K

更新日期：2014-06-01 00:00:00

abstract：:There are two errors and one omission in the original article. Author Gottardo's correct name is Nicholas G. Gottardo, author Hulleman's correct affiliation is no. 3 (VUMC, Amsterdam), and the Acknowledgements should include the following sentence: "We would like to thank Dr Angel Montero Carcaboso (Hospital Sant Joan...

journal_title：Journal of neuro-oncology

authors： Tsoli M,Shen H,Mayoh C,Franshaw L,Ehteda A,Upton D,Carvalho D,Vinci M,Meel MH,van Vuurden D,Plessier A,Castel D,Drissi R,Farrell M,Cryan J,Crimmins D,Caird J,Pears J,Francis S,Ludlow LEA,Carai A,Mastronuzzi A,

更新日期：2019-01-01 00:00:00