当前位置： SCI文献检索 > JOURNAL OF NEURO-ONCOLOGY期刊下所有文献 > Diffusion abnormalities of the corpus callosum in patients receiving bevacizumab for malignant brain tumors: suspected treatment toxicity.

Diffusion abnormalities of the corpus callosum in patients receiving bevacizumab for malignant brain tumors: suspected treatment toxicity.

Abstract：

:Bevacizumab has been reported to cause diffusion restriction in the tumor bed of patients with malignant gliomas. This study evaluated prolonged diffusion restriction, in the corpus callosum (CC), of patients with malignant brain tumors treated with bevacizumab. We retrospectively reviewed our database of patients treated with bevacizumab for malignant brain tumors looking for those with restricted diffusion in the CC. CC ADC ratio measurements were obtained prior to and following treatment. Correlation was made with biopsy (n = 3) and MR perfusion (n = 7) and PET (n = 4). The temporal evolution of these changes relative to therapy was examined with mixed effects regression analysis. Nine patients (eight malignant gliomas, one malignant meningioma) out of 146 patients were found to have developed areas of diffusion restriction in the CC. These areas tended to enlarge and coalesce over serial MRIs and persisted for up to 22 months. Hypoperfusion was demonstrated in MR perfusion in 7/7. PET was hypometabolic in all 4. Biopsy of the CC showed no tumor in 3/3. ADC ratio measurements indicated a significant overall effect of time (F(16,60) = 11.2; p < 0.0001), consistent with persistent diffusion restriction over the measured time periods. Bevacizumab causes prolonged diffusion restriction in the CC. The negative MR perfusion, FDG PET and histopathology suggest this is a toxicity of bevacizumab and not active tumor. Awareness of these changes can assist in patient care.

journal_name

J Neurooncol

journal_title

Journal of neuro-oncology

authors

Futterer SF,Nemeth AJ,Grimm SA,Ragin AB,Chandler JP,Muro K,Marymont MH,Raizer JJ

doi

10.1007/s11060-014-1409-2

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

147-53

issue

1

eissn

0167-594X

issn

1573-7373

journal_volume

118

pub_type

杂志文章

相关文献

JOURNAL OF NEURO-ONCOLOGY文献大全
  • Stereotactic radiosurgery for small brain metastases and implications regarding management with systemic therapy alone.

    abstract：:While stereotactic radiosurgery (SRS) has been shown effective in the management of brain metastases, small brain metastases (≤10 mm) can pose unique challenges. Our aim was to investigate the efficacy of SRS in the treatment of small brain metastases, as well as elucidate clinically relevant factors impacting local f...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-017-2519-4

    authors： Trifiletti DM,Hill C,Cohen-Inbar O,Xu Z,Sheehan JP

    更新日期：2017-09-01 00:00:00

  • Definition and diagnostic implications of gemistocytic astrocytomas: a pathological perspective.

    abstract：:Gemistocytic astrocytoma still continues to be enigmatic; both in terms of definition and prognostic implications. The major issue of contention has been the clinical relevance of this pathological entity. The currently accepted definition of gemistocytic astrocytoma requires 20% or more gemistocytes, and considers th...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,评审

    doi：10.1007/s11060-005-4897-2

    authors： Tihan T,Vohra P,Berger MS,Keles GE

    更新日期：2006-01-01 00:00:00

  • Risk of neoplastic meningitis following surgical resection of cerebellar metastases.

    abstract：BACKGROUND:Based on limited literature, an at risk group of patients for development of neoplastic meningitis (NM) are those with resected cerebellar parenchymal metastases. OBJECTIVE:Characterize the incidence of NM in patients with cerebellar metastases treated with either surgical resection or radiotherapy. PATIEN...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-008-9594-5

    authors： Chamberlain MC

    更新日期：2008-08-01 00:00:00

  • Combined intracavitary thermotherapy with iron oxide nanoparticles and radiotherapy as local treatment modality in recurrent glioblastoma patients.

    abstract：BACKGROUND:There is an increasing interest in local tumor ablative treatment modalities that induce immunogenic cell death and the generation of antitumor immune responses. METHODS:We report six recurrent glioblastoma patients who were treated with intracavitary thermotherapy after coating the resection cavity wall wi...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-018-03005-x

    authors： Grauer O,Jaber M,Hess K,Weckesser M,Schwindt W,Maring S,Wölfer J,Stummer W

    更新日期：2019-01-01 00:00:00

  • A new schedule of fotemustine in temozolomide-pretreated patients with relapsing glioblastoma.

    abstract：:In the present study we investigated the feasibility and effectiveness of a new biweekly schedule of fotemustine (FTM) in patients with recurrent glioblastoma, after at least one previous treatment. The primary endpoint was progression-free survival at 6 months; secondary objectives were clinical response, overall sur...

    journal_title：Journal of neuro-oncology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s11060-010-0329-z

    authors： Addeo R,Caraglia M,De Santi MS,Montella L,Abbruzzese A,Parlato C,Vincenzi B,Carraturo M,Faiola V,Genovese M,Cennamo G,Del Prete S

    更新日期：2011-05-01 00:00:00

  • Chondroid chordoma versus low-grade chondrosarcoma of the base of the skull: can immunohistochemistry resolve the controversy?

    abstract：:The classification of cartilaginous tumors of the skull base, including chondroid chordoma and chondrosarcoma remains the subject of controversy. Critical review of the literature and our own experience of chordomas and cartilaginous tumors of the skull base led to the following conclusions: 1) Chondrosarcoma of the s...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,评审

    doi：10.1007/BF01328954

    authors： Ishida T,Dorfman HD

    更新日期：1994-01-01 00:00:00

  • MR-spectroscopic imaging of glial tumors in the spotlight of the 2016 WHO classification.

    abstract：BACKGROUND:The purpose of this study is to map spatial metabolite differences across three molecular subgroups of glial tumors, defined by the IDH1/2 mutation and 1p19q-co-deletion, using magnetic resonance spectroscopy. This work reports a new MR spectroscopy based classification algorithm by applying a radiomics anal...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-018-2881-x

    authors： Diamandis E,Gabriel CPS,Würtemberger U,Guggenberger K,Urbach H,Staszewski O,Lassmann S,Schnell O,Grauvogel J,Mader I,Heiland DH

    更新日期：2018-09-01 00:00:00

  • High-dose cytarabine salvage therapy for recurrent primary CNS lymphoma.

    abstract：:Treatment of recurrent primary CNS lymphoma (PCNSL) though not standardized most often utilizes whole brain radiotherapy, re-challenge with high-dose methotrexate, or administration of an alkylating chemotherapy. High-dose cytarabine (HD-araC) has been advocated as an active agent in PCNSL but limited information exis...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-015-1994-8

    authors： Chamberlain MC

    更新日期：2016-02-01 00:00:00

  • Potentiation of chemotherapeutic agents following antagonism of nuclear factor kappa B in human gliomas.

    abstract：:Future success using chemotherapy against human gliomas may result from exploiting unique molecular vulnerabilities of these tumors. Chemotherapy frequently results in DNA damage. When such damage is sensed by the cell, programmed cell death, or apoptosis, may be initiated. However, chemotherapy-induced DNA damage may...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1023/a:1022554824129

    authors： Weaver KD,Yeyeodu S,Cusack JC Jr,Baldwin AS Jr,Ewend MG

    更新日期：2003-02-01 00:00:00

  • Hypophyseal non-Hodgkin's lymphoma presenting with diabetes insipidus: a case report.

    abstract：:We report the case of a 64 year old male patient with a history of ischemic heart disease who underwent surgery for an abdominal mass. The histological diagnosis was highly malignant non-Hodgkin's lymphoma. After surgery the patient was admitted to our Department and received 6 courses of chemotherapy according to the...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1023/a:1006180909837

    authors： Merlo EM,Maiolo A,Brocchieri A,Tua A,Grignani G

    更新日期：1999-03-01 00:00:00

  • Rethinking childhood ependymoma: a retrospective, multi-center analysis reveals poor long-term overall survival.

    abstract：:Ependymoma is the third most common brain tumor in children, but there is a paucity of large studies with more than 10 years of follow-up examining the long-term survival and recurrence patterns of this disease. We conducted a retrospective chart review of 103 pediatric patients with WHO Grades II/III intracranial epe...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s11060-017-2568-8

    authors： Marinoff AE,Ma C,Guo D,Snuderl M,Wright KD,Manley PE,Al-Sayegh H,Sinai CE,Ullrich NJ,Marcus K,Haas-Kogan D,Goumnerova L,London WB,Kieran MW,Chi SN,Fangusaro J,Bandopadhayay P

    更新日期：2017-10-01 00:00:00

  • Gamma knife surgery for 1-10 brain metastases without prophylactic whole-brain radiation therapy: analysis of cases meeting the Japanese prospective multi-institute study (JLGK0901) inclusion criteria.

    abstract：:We evaluated the results of stereotactic radiosurgery (SRS) alone using gamma knife (GK) for selected patients with 1-10 brain metastases without prophylactic whole-brain radiation therapy (WBRT) among JLGK0901-eligible cases. Seven hundred seventy-eight consecutive cases meeting the following JLGK0901 study inclusion...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s11060-010-0169-x

    authors： Serizawa T,Hirai T,Nagano O,Higuchi Y,Matsuda S,Ono J,Saeki N

    更新日期：2010-06-01 00:00:00

  • Signal transduction molecules in gliomas of all grades.

    abstract：PURPOSE:To interrogate grade II, III, and IV gliomas and characterize the critical effectors within the PI3-kinase pathway upstream and downstream of mTOR. Experimental design Tissues from 87 patients who were treated at UCSF between 1990 and 2004 were analyzed. Twenty-eight grade II, 17 grade III glioma, 26 grade IV g...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-008-9683-5

    authors： Ermoian RP,Kaprealian T,Lamborn KR,Yang X,Jelluma N,Arvold ND,Zeidman R,Berger MS,Stokoe D,Haas-Kogan DA

    更新日期：2009-01-01 00:00:00

  • Efficacy of '8-drugs-in-one-day' combination in treatment of recurrent GBM patients.

    abstract：:Thirty-five adult recurrent GBM patients, divided randomly in two groups of 19 and 16 cases, had been treated with two regimens of chemotherapy: a) 'eight-drugs-in-one-day'; b) procarbazine + CCNU + vincristine (PCV) respectively. Chemotherapy was planned at the tumour relapse and delivered as long as tolerated withou...

    journal_title：Journal of neuro-oncology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF00172666

    authors： Boiardi A,Silvani A,Milanesi I,Broggi G,Fariselli L

    更新日期：1992-02-01 00:00:00

  • The biology and pathology of selected skull base tumors.

    abstract：:This paper describes the pathobiology of some of the more common skull base tumors. In addition to clinicopathologic features, emphasis is placed upon methods of diagnosis utilizing immunoperoxidase stains and molecular markers that may or may not impact upon prognosis. ...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,评审

    doi：10.1007/BF01053041

    authors： Barnes L,Kapadia SB

    更新日期：1994-01-01 00:00:00

  • Expression of HMP/AN2, a melanoma associated antigen, in murine cerebral gliomas: potential for radioimmunotargeting.

    abstract：:Human melanoma proteoglycan (HMP), a melanoma-associated antigen, is expressed in both human melanomas and gliomas. We used HMP-specific monoclonal antibody (mAb) VT68.2 to investigate whether murine GL261 cerebral gliomas express the HMP homologue AN2 and to determine whether AN2 could be targeted for selective deliv...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-009-9798-3

    authors： Paul AK,Ciesielski MJ,Sajjad M,Wang X,Ferrone S,Abdel-Nabi H,Fenstermaker RA

    更新日期：2009-08-01 00:00:00

  • PTEN inhibits adrenomedullin expression and function in brain tumor cells.

    abstract：:Adrenomedullin is a vasoactive peptide that is upregulated in higher-grade gliomas and promotes tumor cell proliferation. Since reduced activity of the anti-oncogene PTEN seems to also correlate with higher tumor grade, this suggests an inverse association between PTEN activity and adrenomedullin expression. PC12 pheo...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-005-9035-7

    authors： Betchen SA,Musatov S,Roberts J,Pena J,Kaplitt MG

    更新日期：2006-09-01 00:00:00

  • Assessment of tumor angiogenesis as a prognostic factor of survival in patients with oligodendroglioma.

    abstract：:According to World Health Organization (WHO) and Daumas-Duport grading systems, progression of oligodendrogliomas (ODGs) to a higher grade (WHO grade III, grade B) is associated with increased angiogenesis. Based on multivariate assessment of molecular, pathological, and radiological parameters, we further assessed th...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-009-9961-x

    authors： Quon H,Hasbini A,Cougnard J,Djafari L,Lacroix C,Abdulkarim B

    更新日期：2010-01-01 00:00:00

  • EGFR amplification and classical subtype are associated with a poor response to bevacizumab in recurrent glioblastoma.

    abstract：PURPOSE:The highly vascular malignant brain tumor glioblastoma (GBM) appears to be an ideal target for anti-angiogenic therapy; however, clinical trials to date suggest the VEGF antibody bevacizumab affects only progression-free survival. Here we analyze a group of patients with GBM who received bevacizumab treatment a...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-019-03102-5

    authors： Hovinga KE,McCrea HJ,Brennan C,Huse J,Zheng J,Esquenazi Y,Panageas KS,Tabar V

    更新日期：2019-04-01 00:00:00

  • Outcomes of an electronic social network intervention with neuro-oncology patient family caregivers.

    abstract：INTRODUCTION:Informal family caregivers (FCG) are an integral and crucial human component in the cancer care continuum. However, research and interventions to help alleviate documented anxiety and burden on this group is lacking. To address the absence of effective interventions, we developed the electronic Support Net...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s11060-018-2909-2

    authors： Reblin M,Ketcher D,Forsyth P,Mendivil E,Kane L,Pok J,Meyer M,Wu YP,Agutter J

    更新日期：2018-09-01 00:00:00

  • Biomimetic brain tumor niche regulates glioblastoma cells towards a cancer stem cell phenotype.

    abstract：:Glioblastoma (GBM) is the most malignant primary brain tumor and contains tumorigenic cancer stem cells (CSCs), which support the progression of tumor growth. The selection of CSCs and facilitation of the brain tumor niches may assist the development of novel therapeutics for GBM. Herein, hydrogel materials composed o...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-018-2763-2

    authors： Liu YC,Lee IC,Chen PY

    更新日期：2018-05-01 00:00:00

  • CDKN2/p16 predicts survival in oligodendrogliomas: comparison with astrocytomas.

    abstract：:Cyclin-dependent kinase 4 inhibitor (CDKN2/p16) is a cell cycle regulatory protein that has been demonstrated to be inactivated by mutations, deletions or transcriptional silencing during pathogenesis of a variety of human malignancies. We studied the correlation of CDKN2/p16 expression with cell proliferation activit...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1023/a:1006185220369

    authors： Miettinen H,Kononen J,Sallinen P,Alho H,Helen P,Helin H,Kalimo H,Paljärvi L,Isola J,Haapasalo H

    更新日期：1999-02-01 00:00:00

  • Pencil beam scanning proton therapy for pediatric intracranial ependymoma.

    abstract：:To assess the clinical outcome and late side effect profile of pencil beam scanning proton therapy (PT) delivered to children with intracranial ependymoma. Between July-2004 and March-2013, 50 patients with intracranial ependymoma (n = 46, grade 3) received involved-field PT at Paul Scherrer Institute (PSI). Median ag...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-016-2090-4

    authors： Ares C,Albertini F,Frei-Welte M,Bolsi A,Grotzer MA,Goitein G,Weber DC

    更新日期：2016-05-01 00:00:00

  • Adeno-associated viral vector gene transfer into leptomeningeal xenografts.

    abstract：:Leptomeningeal carcinomatosis is a painful and debilitating complication of cancer. Indwelling reservoirs provide continuous assess to the subarachnoid space, making leptomeningeal cancer potentially amenable to gene therapy. Adeno-associated virus (AAV) is a defective virus not associated with any human disease. We u...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1023/a:1005702228721

    authors： Rosenfeld MR,Bergman I,Schramm L,Griffin JA,Kaplitt MG,Meneses PI

    更新日期：1997-09-01 00:00:00

  • The role of surgery in pediatric gliomas.

    abstract：:Pediatric glial tumors differ from adult gliomas in several ways that are of major therapeutic importance. First, the value of extensive tumor resection, which is controversial for malignant intrinsic brain tumors in adults, has been confirmed for a variety of childhood brain tumors, such as supratentorial high-grade ...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,评审

    doi：10.1023/a:1006107227856

    authors： Pollack IF

    更新日期：1999-05-01 00:00:00

  • Cerebellar anaplastic astrocytoma in a teenager with Ollier Disease.

    abstract：INTRODUCTION:Ollier Disease is a sporadic skeletal disorder with a predisposition to oncogenesis. It is estimated at around 1/100,000. We are presenting a young patient with Ollier Disease and high-grade astrocytoma. CASE REPORT:A 14-year-old, Caucasian male with Ollier Disease presented with a history of headaches, v...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-008-9583-8

    authors： Walid MS,Troup EC

    更新日期：2008-08-01 00:00:00

  • Improved 3-year survival rates for glioblastoma multiforme are associated with trends in treatment: analysis of the national cancer database from 2004 to 2013.

    abstract：PURPOSE:Glioblastoma multiforme (GBM) is a common and aggressive malignancy associated with poor prognosis. Characteristics and treatment of long-term survivors are of particular interest in efforts to improve outcomes. Therefore, the objective of this study was to examine trends and prognostic factors for 3-year survi...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-020-03469-w

    authors： Zreik J,Moinuddin FM,Yolcu YU,Alvi MA,Chaichana KL,Quinones-Hinojosa A,Bydon M

    更新日期：2020-05-01 00:00:00

  • Phosphorylated insulin-like growth factor-1 receptor (pIGF1R) is a poor prognostic factor in brain metastases from lung adenocarcinomas.

    abstract：:A greater understanding of brain metastases is imperative for developing novel therapeutic strategies. Our previous study showed that insulin-like growth factor (IGF) signaling pathway was activated in brain-tropic cancer cells. In this study, we investigated the clinical relevance of activated (phosphorylated) IGF-1 ...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-013-1194-3

    authors： Wu PF,Huang WC,Yang JC,Lu YS,Shih JY,Wu SG,Lin CH,Cheng AL

    更新日期：2013-10-01 00:00:00

  • Metabolic patterns in meningiomas.

    abstract：:The aim of this investigation was to define characteristic properties of cellular energy metabolism in meningiomas in vitro dependent on the histological subtype. We analysed marker enzymes of representative metabolic pathways localized in the mitochondria (respiratory chain, citric acid cycle, beta-oxidation of fatty...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1023/b:neon.0000003680.84840.52

    authors： Herting B,Meixensberger J,Roggendorf W,Reichmann H

    更新日期：2003-11-01 00:00:00

  • miR-335 promotes cell proliferation by directly targeting Rb1 in meningiomas.

    abstract：:Meningiomas, one of the most common benign brain tumors in humans, arise from arachnoid cells in the brain meninges. Our investigations have revealed that miR-335 is a typical microRNA overexpressed in meningiomas in humans. Characterization of the effects of miR-335 overexpression in meningiomas demonstrated that ele...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-012-0951-z

    authors： Shi L,Jiang D,Sun G,Wan Y,Zhang S,Zeng Y,Pan T,Wang Z

    更新日期：2012-11-01 00:00:00