Pretreatment dynamic contrast-enhanced MRI biomarkers correlate with progression-free survival in primary central nervous system lymphoma.

abstract：:A phase II trial of Homoharringtonine (HHT) was performed in 15 patients with recurrent or progressive malignant glioma. The drug was administered at a initial dose of 4 mg/m2/day by continuous 5 day intravenous infusion (3 mg/m2/day x 5 days for heavily pretreated patients). Courses were repeated every 3-4 weeks upon...

journal_title：Journal of neuro-oncology

authors： Feun LG,Savaraj N,Landy H,Levin H,Lampidis T

更新日期：1990-10-01 00:00:00

abstract：:A better understanding of the relationship between glioblastomas molecular subtypes and radio-chemotherapy is needed for the development of individualized strategies. In this study, we aimed to assess whether non-homologous end-joining (NHEJ) protein expression is associated and could predict responses to treatment of...

journal_title：Journal of neuro-oncology

authors： Pinel B,Duchesne M,Godet J,Milin S,Berger A,Wager M,Karayan-Tapon L

更新日期：2017-04-01 00:00:00

abstract：:Pediatric glial tumors differ from adult gliomas in several ways that are of major therapeutic importance. First, the value of extensive tumor resection, which is controversial for malignant intrinsic brain tumors in adults, has been confirmed for a variety of childhood brain tumors, such as supratentorial high-grade ...

journal_title：Journal of neuro-oncology

authors： Pollack IF

更新日期：1999-05-01 00:00:00

abstract：PURPOSE:We evaluated the outcomes after stereotactic radiosurgery (SRS) for patients who developed new or progressive brain disease regardless of whether they had no prior radiation, PCI, or WBRT. METHODS:We retrospectively identified 90 SCLC patients who had SRS between 1991 and 2018. Thirty-one patients had no evide...

journal_title：Journal of neuro-oncology

authors： Faramand A,Niranjan A,Kano H,Flickinger J,Lunsford LD

更新日期：2019-08-01 00:00:00

abstract：:Intravascular lymphomatosis (IL) is a rare entity only recently included in lymphoma classification, whose main feature is the exclusive or predominant growth of neoplastic cells within blood vessels. The vast majority of the patients affected by IL belong to the 7th or 8th decade of life and present with skin rash or...

journal_title：Journal of neuro-oncology

authors： Massimino M,Giardini R,Cefalo G,Simonetti F,Pollo B,Giombini S,Tesoro-Tess JD,Ponzoni M,Patriarca C

更新日期：2001-01-01 00:00:00

abstract：:Surgical resection is not the standard of care for primary central nervous system lymphoma (PCNSL), as historical studies have demonstrated unfavorable complication rates and limited benefits. Some recent studies suggest that resection may provide a therapeutic benefit, yet the safety of these procedures has not been ...

journal_title：Journal of neuro-oncology

authors： Cloney MB,Sonabend AM,Yun J,Yang J,Iwamoto F,Singh S,Bhagat G,Canoll P,Zanazzi G,Bruce JN,Sisti M,Sheth S,Connolly ES,McKhann G

更新日期：2017-03-01 00:00:00

abstract：:Pediatric brain gliomas are not always amenable for complete surgical excision, therefore adjuvant treatment for a large tumor mass is often required. As tumor volume shrinkage may not be a reliable method for assessing response to treatment, information about the tumor growth potential is desirable for an adequate fo...

journal_title：Journal of neuro-oncology

authors： Lazareff JA,Gupta RK,Alger J

更新日期：1999-02-01 00:00:00

abstract：:Central nervous system (brain or leptomeningeal) metastases (BLm) are considered rare in castration-resistant prostate cancer (CRPC) patients. Now that docetaxel has become the reference drug for first-line treatment of CRPC, patients whose disease is not controlled by hormonal manipulations may live much longer than ...

journal_title：Journal of neuro-oncology

authors： Caffo O,Gernone A,Ortega C,Sava T,Cartenì G,Facchini G,Re GL,Amadio P,Bortolus R,Pagliarulo V,Prati V,Veccia A,Galligioni E

更新日期：2012-03-01 00:00:00

abstract：:Steroids are beneficial in neurological illness, but have many serious side effects. Having observed several patients with severe steroid psychoses, which greatly prolonged their hospitalizations, the authors sought to improve understanding of this entity. A literature review was conducted. The incidence of severe psy...

journal_title：Journal of neuro-oncology

authors： Ross DA,Cetas JS

更新日期：2012-09-01 00:00:00

abstract：:Improvements in imaging are increasing the detection of multiple lesions in the setting of glioblastoma. Occasionally distant non-enhancing lesions may be identified which have the appearances of a multicentric low-grade glioma. We aimed to determine the incidence, prognostic significance and diagnostic value of this ...

journal_title：Journal of neuro-oncology

authors： Lasocki A,Gaillard F,Tacey MA,Drummond KJ,Stuckey SL

更新日期：2016-09-01 00:00:00

abstract：:The Coronavirus pandemic has created unprecedented strain on medical resources at health care institutions around the world. At many institutions, this has resulted in efforts to prioritize cases with an attempt to balance the acuity of medical needs with available resources. Here, we provide a framework for instituti...

journal_title：Journal of neuro-oncology

authors： Ramakrishna R,Zadeh G,Sheehan JP,Aghi MK

更新日期：2020-05-01 00:00:00

abstract：:A high affinity folate receptor is expressed in some human cancers, including choroid plexus tumors and ependymomas, and has been suggested as a target for therapeutics. In this report, the expression of folate receptors in an SV40 large T antigen transgenic mouse (SV11) was investigated. SV11 mice develop choroid ple...

journal_title：Journal of neuro-oncology

authors： Patrick TA,Kranz DM,van Dyke TA,Roy EJ

更新日期：1997-04-01 00:00:00

abstract：INTRODUCTION:There has been a resurgence of interest in brachytherapy as a treatment for glioblastoma, with several currently ongoing clinical trials. To provide a foundation for the analysis of these trials, we analyze the Surveillance, Epidemiology, and End Results (SEER) database to determine whether receipt of brac...

journal_title：Journal of neuro-oncology

authors： Bartek J Jr,Alattar AA,Dhawan S,Ma J,Koga T,Nakaji P,Dusenbery KE,Chen CC

更新日期：2019-10-01 00:00:00

abstract：:Alkaline phosphatase (ALPase) and Mg2+-activated ATPase (Mg2+-ATPase) activities were demonstrated in human brain tumors by light and electron microscopy. Four cases of glioma, i.e., two cases of astrocytoma, grade II, and two cases of glioblastoma, were used as materials. At the light microscopic level, Mg2+-ATPase a...

journal_title：Journal of neuro-oncology

authors： Maeda T,Nishiyama F,Ogashiwa M,Takeuchi K,Hirano H

更新日期：1985-01-01 00:00:00

abstract：:Autologous brain tumor specific CTLs were induced from the patient's PBL by a mixed lymphocyte-tumor culture, and were maintained for more than 2 months in a medium containing exogenous IL-2. The autologous T cell line containing specific CTL was administered into the tumor-bed for the treatment of malignant glioma. I...

journal_title：Journal of neuro-oncology

authors： Kitahara T,Watanabe O,Yamaura A,Makino H,Watanabe T,Suzuki G,Okumura K

更新日期：1987-01-01 00:00:00

abstract：:Pituitary tumors were experimentally induced in female Wistar rats by repeated injections of estradiol dipropionate. The hypothalamus and pituitary tumors were studied simultaneously by fluorescence histochemistry and immunohistochemistry. The pituitary gland became larger with a concomitant increase of serum prolacti...

journal_title：Journal of neuro-oncology

authors： Fujimoto M,Yoshino E,Hirakawa K,Chihara K,Ibata Y

更新日期：1987-01-01 00:00:00

abstract：:Several molecular markers have been proposed as predictors of outcome in patients with high grade gliomas. We report a retrospective multicenter study of 97 consecutive adult patients with anaplastic astrocytoma (AA) treated with radiation therapy (RT) plus concomitant and adjuvant temozolomide (TMZ) between October 2...

journal_title：Journal of neuro-oncology

authors： Minniti G,Scaringi C,Arcella A,Lanzetta G,Di Stefano D,Scarpino S,Bozzao A,Pace A,Villani V,Salvati M,Esposito V,Giangaspero F,Enrici RM

更新日期：2014-06-01 00:00:00

abstract：:Membrane-type MMPs (MT-MMPs) constitute a growing subclass of recently identified matrix metalloproteinases (MMPs). In addition to the highly conserved MMP functional domains, the MT-MMPs have additional insertion sequences (IS) that confer unique functional roles. While most of the MMPs are secreted, the MT-MMPs are ...

journal_title：Journal of neuro-oncology

authors： Fillmore HL,VanMeter TE,Broaddus WC

更新日期：2001-06-01 00:00:00

abstract：:Anaplastic mixed gliomas are rare tumors that occur mostly in the cerebral hemispheres. They have a distinctive histological appearance characterized by the presence of two or more glial cellular constituents. The incidence of malignant mixed glioma of the brainstem and posterior fossa is extremely low. The authors re...

journal_title：Journal of neuro-oncology

authors： Lee TT,Galarza M,Petito CK,Heros RC

更新日期：1998-04-01 00:00:00

abstract：:A rat glioma model was employed to estimate the Ca2+ kinetics in the tumor arteriolar smooth muscle cells. Electron microcytochemistry revealed that the density of intracellular Ca2+ deposits in the intra-tumor arteriolar smooth muscle cells was significantly greater, with slightly higher membrane Ca(2+)-adenosine tri...

journal_title：Journal of neuro-oncology

authors： Zenke K,Nakagawa K,Kumon Y,Ohta S,Hatakeyama T,Sakaki S

更新日期：1996-10-01 00:00:00

abstract：:Antisense bcl-2 therapy combined with chemotherapy has been proved to be effective in various tumors. However, the role played by antisense bcl-2 therapy alone is not clear. In this study, we compared the apoptosis and the protein profiles of antisense bcl-2 transfected human neuroblastoma SK-N-MC cells to the control...

journal_title：Journal of neuro-oncology

authors： Li Y,Lu Z,Chen F,Guan J,Hu L,Xu Y,Chen J

更新日期：2005-03-01 00:00:00

abstract：:Death ligand-mediated apoptosis is a promising strategy of gene therapy for human malignant glioma. We here report that the infection of human malignant glioma cell lines with an adenoviral vector encoding full length human Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand (Ad-Apo2L/TRAIL) results in...

journal_title：Journal of neuro-oncology

authors： Naumann U,Waltereit R,Schulz JB,Weller M

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Oligodendroglial tumors are rare and chemosensitive diseases; but the overall results with current chemotherapy regimens cannot be considered satisfactory and other active treatments are necessary. We decided to determine the efficacy and toxicity profile of the carboplatin and etoposide (CE) regimen in this...

journal_title：Journal of neuro-oncology

authors： Scopece L,Franceschi E,Cavallo G,Paioli A,Paioli G,Conforti R,Palmerini E,Berzioli C,Spagnolli F,Esposti RD,Crinò L

更新日期：2006-09-01 00:00:00

abstract：:Neural cell adhesion molecule (NCAM) is a cell surface glycoprotein whose expression may be important in metastatic or local growth of neoplasms. Expression of NCAM in human pituitary adenomas was assessed on snap-frozen and Bouin's and/or formalin-fixed, paraffin-embedded archival tissue using a sensitive alkaline ph...

journal_title：Journal of neuro-oncology

authors： Kleinschmidt-DeMasters BK,Conway DR,Franklin WA,Lillehei KO,Kruse CA

更新日期：1995-01-01 00:00:00

abstract：:The neural cell adhesion molecule (NCAM) is involved in the intercellular junctions of neurons and glial cells. We investigated its relevance as a biomarker in gliomas which main characteristic is their high invasiveness. We studied by Western blot the pattern of serum NCAM bands in patients with gliomas (n = 34), wit...

journal_title：Journal of neuro-oncology

authors： Todaro L,Christiansen S,Varela M,Campodónico P,Pallotta MG,Lastiri J,Sacerdote de Lustig E,Bal de Kier Joffé E,Puricelli L

更新日期：2007-06-01 00:00:00

abstract：:In this retrospective, IRB-exempt study, we analyzed data from 68 patients diagnosed with glioblastoma (GBM) in two institutions and investigated the relationship between tumor shape, quantified using algorithmic analysis of magnetic resonance images, and survival. Each patient's Fluid Attenuated Inversion Recovery (F...

journal_title：Journal of neuro-oncology

authors： Czarnek N,Clark K,Peters KB,Mazurowski MA

更新日期：2017-03-01 00:00:00

abstract：:Lonidamine (LND) has been shown to inhibit tumor aerobic glycolysis. Its effect was evaluated on several human astrocytomas at different degrees of malignancy; a correlation was found between LDN effect on lactate production and tumor malignancy: in grade I and II astrocytomas LND stimulates lactate production, while ...

journal_title：Journal of neuro-oncology

authors： Paggi MG,Carapella CM,Fanciulli M,Del Carlo C,Giorno S,Zupi G,Silvestrini B,Caputo A,Floridi A

更新日期：1988-11-01 00:00:00

abstract：:Gliomatosis cerebri is a rare diffusely infiltrating primary neoplastic glial process of the brain. Our objective is to review clinical presentation, management, and outcome in a large single institution series of gliomatosis cerebri patients. 54 consecutive gliomatosis cerebri cases presenting to Mayo Clinic Rocheste...

journal_title：Journal of neuro-oncology

authors： Chen S,Tanaka S,Giannini C,Morris J,Yan ES,Buckner J,Lachance DH,Parney IF

更新日期：2013-04-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) and its receptors (VEGFR) are central components in the development and progression of glioblastoma. To investigate if genetic variation in VEGF and VEGFR2 is associated with glioblastoma prognosis, we examined blood samples from 154 glioblastoma cases collected in Sweden and ...

journal_title：Journal of neuro-oncology

authors： Sjöström S,Wibom C,Andersson U,Brännström T,Broholm H,Johansen C,Collatz-Laier H,Liu Y,Bondy M,Henriksson R,Melin B

更新日期：2011-09-01 00:00:00

abstract：:Anti-PD-1/PD-L1 therapies have demonstrated activity in patients with advanced stage non-small cell lung cancer (NSCLC). However, little is known about the safety and feasibility of patients receiving anti-PD-1/PD-L1 therapy and stereotactic radiation for the treatment of brain metastases. Data were analyzed retrospec...

journal_title：Journal of neuro-oncology

authors： Ahmed KA,Kim S,Arrington J,Naghavi AO,Dilling TJ,Creelan BC,Antonia SJ,Caudell JJ,Harrison LB,Sahebjam S,Gray JE,Etame AB,Johnstone PA,Yu M,Perez BA

更新日期：2017-06-01 00:00:00