Folate receptors as potential therapeutic targets in choroid plexus tumors of SV40 transgenic mice.

abstract：:Intracranial melanotic schwannomas (IMSch) are extremely rare nerve sheath tumors with features of Schwann cells that produce melanin. After a thorough review of the available literature since 1967, we report not only the 20th case of IMSch but a comprehensive modern-era analysis of radiographic and histological key-p...

journal_title：Journal of neuro-oncology

authors： Mahato D,Vivas-Buitrago T,Gassie K,Jentoft M,Tavanaiepour D,Quiñones-Hinojosa A

更新日期：2018-01-01 00:00:00

abstract：:Extracranial metastases from glioblastoma (GBM) are uncommon with an estimated incidence of less than 2%. We report two cases of metastatic GBM seen within an 8-week period followed by a literature review. We attempted to identify common factors or a causative mechanism. Factors that predominated among the reviewed ca...

journal_title：Journal of neuro-oncology

authors： Kalokhe G,Grimm SA,Chandler JP,Helenowski I,Rademaker A,Raizer JJ

更新日期：2012-03-01 00:00:00

abstract：PURPOSE:Preclinical studies have suggested promising activity for the combination of disulfiram and copper (DSF/Cu) against glioblastoma (GBM) including re-sensitization to temozolomide (TMZ). A previous phase I study demonstrated the safety of combining DSF/Cu with adjuvant TMZ for newly diagnosed GBM. This phase II s...

journal_title：Journal of neuro-oncology

authors： Huang J,Chaudhary R,Cohen AL,Fink K,Goldlust S,Boockvar J,Chinnaiyan P,Wan L,Marcus S,Campian JL

更新日期：2019-05-01 00:00:00

abstract：:Extra-axial cerebellopontine angle (CPA) tumors account for approximately 10% of all brain neoplasms in adults. Vestibular schwannomas are the most common, followed by meningiomas. Gliomas in the CPA are rare and quite often are the exophytic extension of primary brain stem or cerebellar tumors. We describe a pilocyti...

journal_title：Journal of neuro-oncology

authors： Francesco F,Maurizio I,Stefano C,Marina S,Ugo S,Massimo S

更新日期：2010-04-01 00:00:00

abstract：:An extremely rare case of primary intracranial myxoma mimicking an intraaxial parenchymal tumour is reported. A 25 year old male presented with complaints of headache and right sided hemiparesis. A gross total resection of the tumour was achieved. Histology confirmed that the tumour was a myxoma. Investigations did no...

journal_title：Journal of neuro-oncology

authors： Menon RK,Goel A,Shah A,Goel N,Rajashekharan P

更新日期：2008-06-01 00:00:00

abstract：:Choroid plexus carcinoma (CPC) arising in the infant poses several treatment dilemmas. The tumor is often not totally resectable at presentation given its large size and tendency to invade adjacent brain. Because of its predisposition to regrow and metastasize, some form of postoperative cytotoxic therapy is required....

journal_title：Journal of neuro-oncology

authors： Allen J,Wisoff J,Helson L,Pearce J,Arenson E

更新日期：1992-01-01 00:00:00

abstract：:Improvements in imaging are increasing the detection of multiple lesions in the setting of glioblastoma. Occasionally distant non-enhancing lesions may be identified which have the appearances of a multicentric low-grade glioma. We aimed to determine the incidence, prognostic significance and diagnostic value of this ...

journal_title：Journal of neuro-oncology

authors： Lasocki A,Gaillard F,Tacey MA,Drummond KJ,Stuckey SL

更新日期：2016-09-01 00:00:00

abstract：:Twenty patients suspected of meningeal carcinomatosis (MC) secondary to small cell carcinoma of the lung were evaluated by myelography and by cytologic examination of cerebrospinal fluid (CSF). In 4 patients both investigations demonstrated MC. Four had positive cytology but a negative myelogram. Five patients had a p...

journal_title：Journal of neuro-oncology

authors： Pedersen AG,Paulson OB,Gyldensted C

更新日期：1985-01-01 00:00:00

abstract：INTRODUCTION:Informal family caregivers (FCG) are an integral and crucial human component in the cancer care continuum. However, research and interventions to help alleviate documented anxiety and burden on this group is lacking. To address the absence of effective interventions, we developed the electronic Support Net...

journal_title：Journal of neuro-oncology

authors： Reblin M,Ketcher D,Forsyth P,Mendivil E,Kane L,Pok J,Meyer M,Wu YP,Agutter J

更新日期：2018-09-01 00:00:00

abstract：PURPOSE:Current medulloblastoma therapy, surgery, radiation, and chemotherapy, is unacceptably toxic. However, 13-cis retinoic acid (RA) and SAHA, a histone deacetylase inhibitor, have each been shown to induce apoptosis in medulloblastoma cultures and mouse models. Both drugs cross the blood brain barrier, have been g...

journal_title：Journal of neuro-oncology

authors： Spiller SE,Ditzler SH,Pullar BJ,Olson JM

更新日期：2008-04-01 00:00:00

abstract：:BCNU is increasingly used in low ethanol (ETOH) concentrations, 5% dextrose-water (D5W), or normal saline (NS) solutions, especially for intra-arterial and prolonged (e.g., 3 day) intravenous (IV) infusions. Little work, however, has been done to evaluate BCNU decomposition rates in concentrations, diluents, and tempe...

journal_title：Journal of neuro-oncology

authors： Tepe P,Hassenbusch SJ,Benoit R,Anderson JH

更新日期：1991-04-01 00:00:00

abstract：:A better understanding of the relationship between glioblastomas molecular subtypes and radio-chemotherapy is needed for the development of individualized strategies. In this study, we aimed to assess whether non-homologous end-joining (NHEJ) protein expression is associated and could predict responses to treatment of...

journal_title：Journal of neuro-oncology

authors： Pinel B,Duchesne M,Godet J,Milin S,Berger A,Wager M,Karayan-Tapon L

更新日期：2017-04-01 00:00:00

abstract：:TERT promoter (TERTp) mutation is the most common mutation in glioblastomas. It creates a putative binding site for Ets/TCF transcription factors, enhancing telomerase expression and activity, whereas the rs2853669 variant disrupts another Ets/TCF binding. We explore here the interaction between these two alterations,...

journal_title：Journal of neuro-oncology

authors： Nencha U,Rahimian A,Giry M,Sechi A,Mokhtari K,Polivka M,Schmitt Y,Di Stefano AL,Alentorn A,Labussière M,Sanson M

更新日期：2016-02-01 00:00:00

abstract：:The outcome of children less than 3 years of age with medulloblastoma has been poor in comparison to older children. The cure rates were below 30%, and the quality of life for cured children was frequently reduced by a complex syndrome of long-term sequelae including intellectual retardation and growth hormone deficie...

journal_title：Journal of neuro-oncology

authors： Schmandt S,Kühl J

更新日期：1998-06-01 00:00:00

abstract：:The classification of cartilaginous tumors of the skull base, including chondroid chordoma and chondrosarcoma remains the subject of controversy. Critical review of the literature and our own experience of chordomas and cartilaginous tumors of the skull base led to the following conclusions: 1) Chondrosarcoma of the s...

journal_title：Journal of neuro-oncology

authors： Ishida T,Dorfman HD

更新日期：1994-01-01 00:00:00

abstract：:One hundred-twenty seven human brain tumors were examined by an immunoperoxidase technique for the expression of collagen Type IV, a major constituent of basement membrane. The parenchymal components were negative for the marker protein in all tumors except for neurilemmomas which were positively stained. In every cas...

journal_title：Journal of neuro-oncology

authors： Ogawa K,Oguchi M,Nakashima Y,Yamabe H

更新日期：1989-11-01 00:00:00

abstract：:Von Hippel-Lindau Disease, a multisystem familial cancer syndrome, is inherited as an autosomal-dominant trait. Common manifestations of the disease are retinal, cerebellar and medullary hemangioblastomas; renal cysts and carcinomas; pancreatic cysts; pheochromocytoma; and papilllary cystadenoma of the epididym. We re...

journal_title：Journal of neuro-oncology

authors： Ertas G,Altundag MB,Ucer AR,Cankal F,Altundag K

更新日期：2005-07-01 00:00:00

abstract：:We describe two patients with fatal vascular malformations of the thalamus whom we thought had gliomas. They had progressive neurological impairment with subacute onset as adults. Computed tomography showed lesions of increased density with slight post-contrast enhancement; cerebral angiography was normal. Without bio...

journal_title：Journal of neuro-oncology

authors： Norcross K,Ciric IS,Mikhael MA,Vick NA

更新日期：1985-01-01 00:00:00

abstract：:Hospital readmissions are a major contributor to increased health care costs and are associated with worse patient outcomes after neurosurgery. We used the newly released Nationwide Readmissions Database (NRD) to describe the association between patient, hospital and payer factors with 30- and 90-day readmission follo...

journal_title：Journal of neuro-oncology

authors： Donoho DA,Wen T,Babadjouni RM,Schwartzman W,Buchanan IA,Cen SY,Zada G,Mack WJ,Attenello FJ

更新日期：2018-01-01 00:00:00

abstract：:Central nervous system atypical teratoid/rhabdoid tumor (ATT/RT) of infancy and childhood is a unique histologic entity with an extremely aggressive natural history. Standard therapy for infant and childhood medulloblastoma, for which this entity is often mistaken, has been ineffective; most children survive less than...

journal_title：Journal of neuro-oncology

authors： Hilden JM,Watterson J,Longee DC,Moertel CL,Dunn ME,Kurtzberg J,Scheithauer BW

更新日期：1998-12-01 00:00:00

abstract：:Platelet-derived growth factor receptor (PDGFR) signaling plays an important role in the biology of malignant gliomas. To investigate mechanisms modulating PDGFR signaling in gliomagenesis, we employed a Drosophila glioma model and genetic screen to identify genes interacting with Pvr, the fly homolog of PDGFRs. Glial...

journal_title：Journal of neuro-oncology

authors： Jeibmann A,Halama K,Witte HT,Kim SN,Eikmeier K,Koos B,Klämbt C,Paulus W

更新日期：2015-09-01 00:00:00

abstract：:Differentiating oligodendroglioma from extraventricular neurocytoma by conventional light microscopy alone can present a diagnostic challenge. We report pathologic findings of an unusual spinal cord tumor from a 33-year-old male patient which showed hybrid features of oligodendroglioma and extraventricular neurocytoma...

journal_title：Journal of neuro-oncology

authors： Makuria AT,Henderson FC,Rushing EJ,Hartmann DP,Azumi N,Ozdemirli M

更新日期：2007-04-01 00:00:00

abstract：INTRODUCTION:A previous study confirmed that a novel splicing variant of large vascular endothelial growth factor (L-VEGF) termed L-VEGF144, a nucleolus protein, is found in glioblastoma cells and specimens, but the actual biological function and clinical significance of L-VEGF144 remain unclear. METHODS:In this study...

journal_title：Journal of neuro-oncology

authors： Cheng WY,Shen CC,Chiao MT,Liang YJ,Mao TF,Liu BS,Chen JP

更新日期：2018-10-01 00:00:00

abstract：:Glioblastomas are malignant brain tumors with poor prognosis. Lately, data from clinical studies assessing the role of co-medications in different cancer types suggested reduced mortality and potential anti-tumor activity for statins, angiotensin-I converting enzyme inhibitors (ACEI) and angiotensin II receptor blocke...

journal_title：Journal of neuro-oncology

authors： Happold C,Gorlia T,Nabors LB,Erridge SC,Reardon DA,Hicking C,Picard M,Stupp R,Weller M,EORTC Brain Tumor Group and on behalf of the CENTRIC and CORE Clinical Trial Groups.

更新日期：2018-05-01 00:00:00

abstract：:Neuroblastoma (NB) is a tumor of pediatric age that is associated with high mortality in metastatic stages, although stage IVS patients undergo frequent spontaneous regression. Since apoptosis has been proposed as a possible cause of remission among cancer patients, we tested this hypothesis among both localized and m...

journal_title：Journal of neuro-oncology

authors： Tonini GP,Mazzocco K,di Vinci A,Geido E,de Bernardi B,Giaretti W

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:We sought to evaluate the effectiveness of definitive or adjuvant external-beam proton therapy on local control and survival in patients with skull-base chondrosarcoma. METHODS:We reviewed the medical records of 43 patients with a median age of 49 years (range, 23-80 years) treated with double-scattered 3D ...

journal_title：Journal of neuro-oncology

authors： Holtzman AL,Rotondo RL,Rutenberg MS,Indelicato DJ,Mercado CE,Rao D,Tavanaiepour D,Morris CG,Louis D,Flampouri S,Mendenhall WM

更新日期：2019-05-01 00:00:00

abstract：:To assess the clinical outcome and late side effect profile of pencil beam scanning proton therapy (PT) delivered to children with intracranial ependymoma. Between July-2004 and March-2013, 50 patients with intracranial ependymoma (n = 46, grade 3) received involved-field PT at Paul Scherrer Institute (PSI). Median ag...

journal_title：Journal of neuro-oncology

authors： Ares C,Albertini F,Frei-Welte M,Bolsi A,Grotzer MA,Goitein G,Weber DC

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVE AND IMPORTANCE:Epithelioid hemangioendothelioma (EHE) is a rare vascular tumor that presents histological features and biological behavior of low-grade malignancy. The authors report a case of malignant intracranial EHE, in which surgical excisions and additional immuno-chemotherapy were ineffective. Emphasis...

journal_title：Journal of neuro-oncology

authors： Endo T,Su CC,Numagami Y,Shirane R

更新日期：2004-05-01 00:00:00

abstract：:In the following study, we present our experience in the treatment of PCNSL patients using a multi-step schedule combining chemotherapy and deferred radiotherapy. Patients were treated with two modified M-BACOD cycles and then differently according to radiological response For PR, SD and PD patients, chemotherapy was ...

journal_title：Journal of neuro-oncology

authors： Silvani A,Salmaggi A,Eoli M,Lamperti E,Broggi G,Marras CE,Fariselli L,Milanesi I,Fiumani A,Gaviani P,Erbetta A,Giovagnoli AR,Pollo B,Botturi A,Boiardi A

更新日期：2007-05-01 00:00:00

abstract：:The main problem in the treatment of malignant astrocytomas is their invasive behaviour. Successful resection of the main tumour mass cannot prevent recurrence due to single cells invading the surrounding brain parenchyma at the time of diagnosis. The classical combination therapy, PCV (Procarbazine, CCNU and Vincrist...

journal_title：Journal of neuro-oncology

authors： Kinsella P,Clynes M,Amberger-Murphy V

更新日期：2011-01-01 00:00:00