Metastatic glioblastoma: case presentations and a review of the literature.

abstract：:Glioblastoma Multiforme frequently metastasises from their original location by for example infiltration along white matter tracts [1]. GBM metastasis outside the central nervous system is distinctly rare though there are previous reports of spread to various organs [2-5]. We add an unusual case of a patient with aggr...

journal_title：Journal of neuro-oncology

authors： Ogungbo BI,Perry RH,Bozzino J,Mahadeva D

更新日期：2005-09-01 00:00:00

abstract：:Leptomeningeal carcinomatosis is a painful and debilitating complication of cancer. Indwelling reservoirs provide continuous assess to the subarachnoid space, making leptomeningeal cancer potentially amenable to gene therapy. Adeno-associated virus (AAV) is a defective virus not associated with any human disease. We u...

journal_title：Journal of neuro-oncology

authors： Rosenfeld MR,Bergman I,Schramm L,Griffin JA,Kaplitt MG,Meneses PI

更新日期：1997-09-01 00:00:00

abstract：INTRODUCTION:Malignant gliomas have a dismal prognosis and significant efforts are being made to develop more effective treatments. Sonodynamic therapy (SDT) is an emerging modality for cancer treatment which combines ultrasound with sonosensitizers to produce a localized cytotoxic effect. The aim of this study is to d...

journal_title：Journal of neuro-oncology

authors： Prada F,Sheybani N,Franzini A,Moore D,Cordeiro D,Sheehan J,Timbie K,Xu Z

更新日期：2020-07-01 00:00:00

abstract：:Topotecan was studied as a 72 h infusion given every 3 weeks. Treatment began at a dose of 1.0 mg/m2/day and was increased to 1.25 mg/m2/day after the first 6 patients tolerated this higher dose without excessive toxicities. Eighty-eight evaluable children were accrued in 6 strata. There were no complete nor partial r...

journal_title：Journal of neuro-oncology

authors： Kadota RP,Stewart CF,Horn M,Kuttesch JF Jr,Burger PC,Kepner JL,Kun LE,Friedman HS,Heideman RL

更新日期：1999-05-01 00:00:00

abstract：:Choroid plexus carcinoma (CPC) arising in the infant poses several treatment dilemmas. The tumor is often not totally resectable at presentation given its large size and tendency to invade adjacent brain. Because of its predisposition to regrow and metastasize, some form of postoperative cytotoxic therapy is required....

journal_title：Journal of neuro-oncology

authors： Allen J,Wisoff J,Helson L,Pearce J,Arenson E

更新日期：1992-01-01 00:00:00

abstract：:Human recombinant tumor necrosis factor-alpha (rTNF-alpha) was administered to normal Fischer 344 rats by stereotaxic intracerebral (IC) injection. Animals receiving a single injection of either 6 x 10(4) U rTNF-alpha or an equivalent volume of excipient (vehicle) in their right parietal lobe. In order to demonstrate ...

journal_title：Journal of neuro-oncology

authors： Wright JL,Merchant RE

更新日期：1994-01-01 00:00:00

abstract：:Despite total macroscopic resection of meningiomas relapses do occur in these tumours, possibly because of microscopic clusters of neoplastic cells left in the dura mater or in the arachnoid membrane. The invasiveness of the neoplastic cells of human meningiomas has been related to expression of matrix-metalloproteina...

journal_title：Journal of neuro-oncology

authors： Barresi V,Vitarelli E,Tuccari G,Barresi G

更新日期：2011-04-01 00:00:00

abstract：PURPOSE:Feasibility, antitumor activity and toxicity of accelerated hyperfractionated radiation therapy (Acc Hfx RT) and concurrent carboplatin/etoposide (CBDCA/VP 16) chemotherapy were investigated in patients with malignant glioma. MATERIAL AND METHODS:Seventy-nine patients with either glioblastoma multiforme (GBM) ...

journal_title：Journal of neuro-oncology

authors： Jeremic B,Shibamoto Y,Grujicic D,Stojanovic M,Milicic B,Nikolic N,Dagovic A,Aleksandrovic J

更新日期：2001-01-01 00:00:00

abstract：:Neurological complications may occur in the course of Waldenström's macroglobulinemia (Wm). These complications affect both the central and peripheral nervous system. Pathogenesis is debated and several mechanisms have been suggested. Direct malignant lymphoid infiltration (MLI) is very rare and has only been reported...

journal_title：Journal of neuro-oncology

authors： Massengo S,Riffaud L,Morandi X,Bernard M,Verin M

更新日期：2003-05-01 00:00:00

abstract：:We present a computer aided diagnostic workflow focusing on two diagnostic branch points in neuropathology (intraoperative consultation and p53 status in tumor biopsy specimens) by means of texture analysis via discrete wavelet frames decomposition. For intraoperative consultation, our methodology is capable of classi...

journal_title：Journal of neuro-oncology

authors： Fauzi MFA,Gokozan HN,Elder B,Puduvalli VK,Pierson CR,Otero JJ,Gurcan MN

更新日期：2015-09-01 00:00:00

abstract：:Epigenetic silencing of the O(6)-methylguanine-DNA-methyltransferase (MGMT) gene by promoter methylation is correlated with improved progression-free survival (PFS) and overall survival (OS) in adult patients with newly diagnosed glioblastoma multiforme (GBM) who receive alkylating agents. The aim of this study is to ...

journal_title：Journal of neuro-oncology

authors： Minniti G,Salvati M,Arcella A,Buttarelli F,D'Elia A,Lanzetta G,Esposito V,Scarpino S,Maurizi Enrici R,Giangaspero F

更新日期：2011-04-01 00:00:00

abstract：:Little is known on the natural history, recurrence patterns, neurocognitive outcomes and prognostic factors associated with survival in long-term survivors (≥10 years) from brain metastasis (BM). In this study, the records of 1953 patients who underwent treatment for BM with a potential for ≥10 years of follow-up were...

journal_title：Journal of neuro-oncology

authors： Kotecha R,Vogel S,Suh JH,Barnett GH,Murphy ES,Reddy CA,Parsons M,Vogelbaum MA,Angelov L,Mohammadi AM,Stevens GHJ,Peereboom DM,Ahluwalia MS,Chao ST

更新日期：2016-09-01 00:00:00

abstract：PURPOSE:Most recent literature has confirmed the efficacy of single-session radiosurgery (sRS) in the treatment of intracranial meningioma. Unfortunately, sRS is not always applicable due to large tumor volume and the proximity of the tumor to critical structures. When sRS is not recommended, multi-session radiosurgery...

journal_title：Journal of neuro-oncology

authors： Marchetti M,Conti A,Beltramo G,Pinzi V,Pontoriero A,Tramacere I,Senger C,Pergolizzi S,Fariselli L

更新日期：2019-07-01 00:00:00

abstract：:This study assesses the controversial role of temozolomide (TMZ) concurrent with adjuvant radiation (RT) in patients with anaplastic astrocytoma (AA). The impact of isocitrate dehydrogenase (IDH) status on therapy and outcomes is also examined. All adult patients diagnosed with AA from 2001 to 2011 and treated with st...

journal_title：Journal of neuro-oncology

authors： Kizilbash SH,Giannini C,Voss JS,Decker PA,Jenkins RB,Hardie J,Laack NN,Parney IF,Uhm JH,Buckner JC

更新日期：2014-10-01 00:00:00

abstract：:Identification of patients suffering from elevated psychosocial distress, the sources of the distress, and the necessary treatment of the distress can be rather difficult within the neurosurgical setting (e.g., lack of time, cognitive or aphasic disorders of the patients). The distress thermometer (DT) is a single-ite...

journal_title：Journal of neuro-oncology

authors： Goebel S,Mehdorn HM

更新日期：2011-08-01 00:00:00

abstract：:Patients with neglect fail to report, respond to, or orient to stimuli presented on the opposite side of the brain lesion. Spatial neglect is a multi-componential syndrome and many of its symptoms and signs need specific testing to detect their different clinical manifestations. Given that neglect has a dramatic effec...

journal_title：Journal of neuro-oncology

authors： Emanuele B,Santini B,Talacchi A,Gerosa M,Savazzi S

更新日期：2012-06-01 00:00:00

abstract：:Purpose of this study was to determine the effect of waiting time for radiotherapy on overall survival of patients with glioblastoma treated in the EORTC-NCIC trial at 18 centers in France. A total of 400 adult patients with glioblastoma who were treated between January 1, 2006 and December 31, 2006 were included. The...

journal_title：Journal of neuro-oncology

authors： Noel G,Huchet A,Feuvret L,Maire JP,Verrelle P,Le Rhun E,Aumont M,Thillays F,Sunyach MP,Henzen C,Missohou F,de Crevoisier R,Bondiau PY,Collin P,Durando X,Truc G,Kerr C,Bernier V,Clavier JB,Atlani D,D'Hombres A,Vi

更新日期：2012-08-01 00:00:00

abstract：SUBJECT:To date there is no established tumor marker for the clinical follow-up of glioblastoma, WHO grade IV, (GBM) which constitutes the most frequent and malignant primary brain tumor. However, since there is promising data that the serum glial fibrillary acidic protein (sGFAP) may serve as a biomarker for glial bra...

journal_title：Journal of neuro-oncology

authors： Baumgarten P,Quick-Weller J,Gessler F,Wagner M,Tichy J,Forster MT,Foerch C,Seifert V,Mittelbronn M,Senft C

更新日期：2018-09-01 00:00:00

abstract：:Glioblastoma is the most common and most aggressive primary brain tumor. Despite maximum treatment, patients only have a median survival time of 15 months, because of the tumor's resistance to current therapeutic approaches. Thus far, methylation of the O (6)-methylguanine-DNA methyltransferase (MGMT) promoter has bee...

journal_title：Journal of neuro-oncology

authors： Bleeker FE,Molenaar RJ,Leenstra S

更新日期：2012-05-01 00:00:00

abstract：:Subcutaneous vaccination using granulocyte-macrophage colony-stimulating factor (GM-CSF)-transduced glioma cells substantially prolongs survival in the mouse GL261 glioma model. To potentiate the efficacy of GM-CSF-based vaccination, syngeneic C57BL/6 mice bearing pre-implanted intracerebral GL261 gliomas were vaccina...

journal_title：Journal of neuro-oncology

authors： Herrlinger U,Aulwurm S,Strik H,Weit S,Naumann U,Weller M

更新日期：2004-01-01 00:00:00

abstract：:To investigate local control and radiation-induced brain necrosis in patients with melanoma brain metastases who received complete resection plus fractionated stereotactic radiosurgery (fSRS, 3 × 9 Gy) or fSRS alone. Factors associated with the clinical outcomes and the development of brain necrosis have been assessed...

journal_title：Journal of neuro-oncology

authors： Minniti G,Paolini S,D'Andrea G,Lanzetta G,Cicone F,Confaloni V,Bozzao A,Esposito V,Osti M

更新日期：2017-05-01 00:00:00

abstract：:Two main varieties of recognition disorders are distinguished in neuropsychology: agnosias and semantic disorders. The term agnosias is generally used to denote recognition defects limited to a single perceptual modality (which is itself apparently intact), whereas the term semantic disorders is used to denote recogni...

journal_title：Journal of neuro-oncology

authors： Gainotti G

更新日期：2012-06-01 00:00:00

abstract：:Death ligand-mediated apoptosis is a promising strategy of gene therapy for human malignant glioma. We here report that the infection of human malignant glioma cell lines with an adenoviral vector encoding full length human Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand (Ad-Apo2L/TRAIL) results in...

journal_title：Journal of neuro-oncology

authors： Naumann U,Waltereit R,Schulz JB,Weller M

更新日期：2003-01-01 00:00:00

abstract：:Sacral chordoma is a vessel-rich and infiltrative tumor, but the fundamental knowledge of its biological behavior remains unknown. This study was designed to investigate the expression levels and contributions of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) in the angiogenesis and r...

journal_title：Journal of neuro-oncology

authors： Chen KW,Yang HL,Lu J,Wang GL,Ji YM,Wu GZ,Zhu LF,Liu JY,Chen XQ,Gu YP

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:A prospective Phase II study of CPT-11 in adult patients with recurrent supratentorial glioblastoma multiforme (GBM). METHODS:Forty patients (25 men, 15 women) ages 32-71 years (median 59), with recurrent GBM were treated. All patients had previously been treated with surgery and involved field radiotherapy...

journal_title：Journal of neuro-oncology

authors： Chamberlain MC

更新日期：2002-01-01 00:00:00

abstract：:Autologous brain tumor specific CTLs were induced from the patient's PBL by a mixed lymphocyte-tumor culture, and were maintained for more than 2 months in a medium containing exogenous IL-2. The autologous T cell line containing specific CTL was administered into the tumor-bed for the treatment of malignant glioma. I...

journal_title：Journal of neuro-oncology

authors： Kitahara T,Watanabe O,Yamaura A,Makino H,Watanabe T,Suzuki G,Okumura K

更新日期：1987-01-01 00:00:00

abstract：:This paper describes the pathobiology of some of the more common skull base tumors. In addition to clinicopathologic features, emphasis is placed upon methods of diagnosis utilizing immunoperoxidase stains and molecular markers that may or may not impact upon prognosis. ...

journal_title：Journal of neuro-oncology

authors： Barnes L,Kapadia SB

更新日期：1994-01-01 00:00:00

abstract：:Accumulating evidence has supported the role of microRNAs in the initiation and development of malignant tumors. MicroRNA-211 (miR-211), which was reported to involve in diverse physiological activities in several cancers, was investigated for its expression in human glioma and adjacent normal brain tissues, as well a...

journal_title：Journal of neuro-oncology

authors： Zhang J,Lv J,Zhang F,Che H,Liao Q,Huang W,Li S,Li Y

更新日期：2017-07-01 00:00:00

abstract：:Intramedullary spinal cord metastases of solid neoplasms are associated with poor long-term survival. As the characteristics of secondary intramedullary spinal cord non-Hodgkin's lymphoma (NHL) are not well understood, we sought to describe its clinical features and outcome. We retrospectively reviewed the Mayo Clinic...

journal_title：Journal of neuro-oncology

authors： Flanagan EP,O'Neill BP,Habermann TM,Porter AB,Keegan BM

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVES:To study the inhibitory effects of plasmid-based siRNA targeting human epidermal growth factor receptor (EGFR) on tumor proliferation and invasion of TJ905 glioblastoma cells. METHODS:Two siRNA expression constructs targeting human EGFR extracellular domain (516-536) and catalytic domain (2400-2420) were tr...

journal_title：Journal of neuro-oncology

authors： Kang CS,Pu PY,Li YH,Zhang ZY,Qiu MZ,Huang Q,Wang GX

更新日期：2005-09-01 00:00:00