Blood-brain barrier changes following intracerebral injection of human recombinant tumor necrosis factor-alpha in the rat.

abstract：PURPOSE:Preclinical studies have suggested promising activity for the combination of disulfiram and copper (DSF/Cu) against glioblastoma (GBM) including re-sensitization to temozolomide (TMZ). A previous phase I study demonstrated the safety of combining DSF/Cu with adjuvant TMZ for newly diagnosed GBM. This phase II s...

journal_title：Journal of neuro-oncology

authors： Huang J,Chaudhary R,Cohen AL,Fink K,Goldlust S,Boockvar J,Chinnaiyan P,Wan L,Marcus S,Campian JL

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:We sought to evaluate the effectiveness of definitive or adjuvant external-beam proton therapy on local control and survival in patients with skull-base chondrosarcoma. METHODS:We reviewed the medical records of 43 patients with a median age of 49 years (range, 23-80 years) treated with double-scattered 3D ...

journal_title：Journal of neuro-oncology

authors： Holtzman AL,Rotondo RL,Rutenberg MS,Indelicato DJ,Mercado CE,Rao D,Tavanaiepour D,Morris CG,Louis D,Flampouri S,Mendenhall WM

更新日期：2019-05-01 00:00:00

abstract：:The value of perfusion and diffusion-weighted MRI in differentiating histological subtypes according to the 2007 WHO glioma classification scheme (i.e. astrocytoma vs. oligodendroglioma) and genetic subtypes according to the 2016 WHO reclassification (e.g. 1p/19q co-deletion and IDH1 mutation status) in WHO grade II a...

journal_title：Journal of neuro-oncology

authors： Leu K,Ott GA,Lai A,Nghiemphu PL,Pope WB,Yong WH,Liau LM,Cloughesy TF,Ellingson BM

更新日期：2017-08-01 00:00:00

abstract：:The antiproliferative effect of IFNalpha was tested on the human glioblastoma cell lines, U-373MG and T98G. IFNalpha significantly inhibited the growth of both cell lines, but was more effective in retarding the growth of U-373MG cells. Flow cytometry analysis indicated that synchronized IFNalpha-treated U-373MG cells...

journal_title：Journal of neuro-oncology

authors： Tanabe T,Kominsky SL,Subramaniam PS,Johnson HM,Torres BA

更新日期：2000-07-01 00:00:00

abstract：:Bevacizumab, an anti-angiogenic agent, is FDA-approved for use in patients with recurrent glioblastoma multiforme (rGBM). The radiologic evaluation of tumor response to bevacizumab is complex and there is no validated method of monitoring tumor vascularity during therapy. We evaluated perfusion-weighted MR imaging (PW...

journal_title：Journal of neuro-oncology

authors： Bennett IE,Field KM,Hovens CM,Moffat BA,Rosenthal MA,Drummond K,Kaye AH,Morokoff AP

更新日期：2017-01-01 00:00:00

abstract：:To assess the clinical outcome and late side effect profile of pencil beam scanning proton therapy (PT) delivered to children with intracranial ependymoma. Between July-2004 and March-2013, 50 patients with intracranial ependymoma (n = 46, grade 3) received involved-field PT at Paul Scherrer Institute (PSI). Median ag...

journal_title：Journal of neuro-oncology

authors： Ares C,Albertini F,Frei-Welte M,Bolsi A,Grotzer MA,Goitein G,Weber DC

更新日期：2016-05-01 00:00:00

abstract：:Neural stem cells (NSC) have unique differentiation-, proliferation-, and motility properties. To investigate whether they secrete factors that interfere with the proliferation of glioma cells, we grew glioma cells in conditioned medium (CM) obtained from cultures of neurospheres including neural stem / progenitor cel...

journal_title：Journal of neuro-oncology

authors： Suzuki T,Izumoto S,Wada K,Fujimoto Y,Maruno M,Yamasaki M,Kanemura Y,Shimazaki T,Okano H,Yoshimine T

更新日期：2005-09-01 00:00:00

abstract：:In the following study, we present our experience in the treatment of PCNSL patients using a multi-step schedule combining chemotherapy and deferred radiotherapy. Patients were treated with two modified M-BACOD cycles and then differently according to radiological response For PR, SD and PD patients, chemotherapy was ...

journal_title：Journal of neuro-oncology

authors： Silvani A,Salmaggi A,Eoli M,Lamperti E,Broggi G,Marras CE,Fariselli L,Milanesi I,Fiumani A,Gaviani P,Erbetta A,Giovagnoli AR,Pollo B,Botturi A,Boiardi A

更新日期：2007-05-01 00:00:00

abstract：PURPOSE:Elongation of telomeres is necessary for tumor cell immortalization and senescence escape; neoplastic cells use to alternative pathways to elongate telomeres: telomerase reactivation or a telomerase-independent mechanism termed alternative lengthening of telomeres (ALT). Telomerase and ALT pathway has been expl...

journal_title：Journal of neuro-oncology

authors： Minasi S,Baldi C,Pietsch T,Donofrio V,Pollo B,Antonelli M,Massimino M,Giangaspero F,Buttarelli FR

更新日期：2019-05-01 00:00:00

abstract：:Immune mediated demyelinating disease (IMDD) after allogeneic hemopoietic stem cell transplant (HSCT) is rare and its etiology unclear. In this retrospective study, we identified patients who underwent HSCT between January 1992 and December 2010 and had IMDD post transplant. A total of 1,484 patients received HSCT and...

journal_title：Journal of neuro-oncology

authors： Delios AM,Rosenblum M,Jakubowski AA,DeAngelis LM

更新日期：2012-11-01 00:00:00

abstract：:We used double-label quantitative autoradiography to measure blood flow (with 131I-iodoantipyrine) and blood-to-tissue transport of 14C-alpha aminoisobutyric acid, AIB) in thirteen 9L gliosarcomas transplanted intracerebrally into Fischer-344 rats. Microscopically, the typical pattern of 9L tumor growth was observed: ...

journal_title：Journal of neuro-oncology

authors： Fross RD,Warnke PC,Groothuis DR

更新日期：1991-12-01 00:00:00

abstract：:Anaplastic ganglioglioma (AGG) are rare central nervous system tumours. Patient and treatment factors associated with outcome are poorly defined and limited to small retrospective case series and single case reports. Using the Surveillance, Epidemiology, and End Results (SEER) cancer registry, we investigated potentia...

journal_title：Journal of neuro-oncology

authors： Selvanathan SK,Hammouche S,Salminen HJ,Jenkinson MD

更新日期：2011-12-01 00:00:00

abstract：INTRODUCTION:It is useful to know the molecular subtype of lower-grade gliomas (LGG) when deciding on a treatment strategy. This study aims to diagnose this preoperatively. METHODS:A deep learning model was developed to predict the 3-group molecular subtype using multimodal data including magnetic resonance imaging (M...

journal_title：Journal of neuro-oncology

authors： Matsui Y,Maruyama T,Nitta M,Saito T,Tsuzuki S,Tamura M,Kusuda K,Fukuya Y,Asano H,Kawamata T,Masamune K,Muragaki Y

更新日期：2020-01-01 00:00:00

abstract：:Mutations in the gene encoding isocitrate dehydrogenase 1 (IDH1) have been identified in approximately 70-80 % of astrocytomas and oligodendrogliomas of WHO grades II and III, and in secondary glioblastomas. In addition, a low incidence of IDH2 mutations has been detected in these tumors, and the occurence of IDH1 and...

journal_title：Journal of neuro-oncology

authors： Ahmadi R,Stockhammer F,Becker N,Hohlen K,Misch M,Christians A,Dictus C,Herold-Mende C,Capper D,Unterberg A,von Deimling A,Wick W,Hartmann C

更新日期：2012-08-01 00:00:00

abstract：:We describe a 61-year-old man with a multiple neurologic complication of Merkel cell carcinoma, a rare skin cancer. An enhancing brain mass, and cytologically proven leptomeningeal disease produced a succession of symptoms including seizures, bilateral radiculopathies, myoclonus, a cauda equina syndrome and altered me...

journal_title：Journal of neuro-oncology

authors： Snodgrass SM,Landy H,Markoe AM,Feun L

更新日期：1994-01-01 00:00:00

abstract：:Gliomatosis cerebri (GC) are extensively infiltrative glial tumors classified as astrocytic tumors in the current World Health Organization (WHO) classification scheme. In investigating the tumorigenesis of GC, we reviewed 28 cases of GC immunohistochemically and carried out array-based comparative genomic hybridizati...

journal_title：Journal of neuro-oncology

authors： Min HS,Kim B,Park SH

更新日期：2008-12-01 00:00:00

abstract：:Fibroblast growth factor-2 (FGF-2) is involved as an autocrine growth factor in the autonomous proliferation of glioma cells. To develop a new strategy for treating patients with glioma, we studied the effect on human glioma cells of a 16-mer oligopeptide with conformational similarity to the putative receptor-binding...

journal_title：Journal of neuro-oncology

authors： Kono K,Ueba T,Takahashi JA,Murai N,Hashimoto N,Myoumoto A,Itoh N,Fukumoto M

更新日期：2003-06-01 00:00:00

abstract：:The endothelins (ETs) are a family of three peptides named ET-1, ET-2 and ET-3 that have been initially isolated as potent vasoactive peptides; ETs are synthesized as precursor proteins (preproETs) and are activated by proteolytic cleavage. ETs exert their biological effects through the activation of two receptors sub...

journal_title：Journal of neuro-oncology

authors： Paolillo M,Barbieri A,Zanassi P,Schinelli S

更新日期：2006-08-01 00:00:00

abstract：:Twenty patients suspected of meningeal carcinomatosis (MC) secondary to small cell carcinoma of the lung were evaluated by myelography and by cytologic examination of cerebrospinal fluid (CSF). In 4 patients both investigations demonstrated MC. Four had positive cytology but a negative myelogram. Five patients had a p...

journal_title：Journal of neuro-oncology

authors： Pedersen AG,Paulson OB,Gyldensted C

更新日期：1985-01-01 00:00:00

abstract：:The Hedgehog (Hh) signaling pathway has been implicated in the most common childhood brain tumor, medulloblastoma (MB). Given the toxicity of post-surgical treatments for MB, continued need exists for new, targeted therapies. Based upon our finding that Neuropilin (Nrp) transmembrane proteins are required for Hh signa...

journal_title：Journal of neuro-oncology

authors： Hayden Gephart MG,Su YS,Bandara S,Tsai FC,Hong J,Conley N,Rayburn H,Milenkovic L,Meyer T,Scott MP

更新日期：2013-11-01 00:00:00

abstract：:To increase awareness about lymphomatosis cerebri by describing a patient with a unique presentation Case report a 58 year old woman presented with progressive lower extremity weakness, postural hypotension, and 90 pound weight loss over 3 months a brain magnetic resonance image revealed multiple non-enhancing foci of...

journal_title：Journal of neuro-oncology

authors： Keswani A,Bigio E,Grimm S

更新日期：2012-09-01 00:00:00

abstract：:Glioblastomas (GBM) may originate de novo (primary), or following transformation from a lower grade glioma (secondary), and it has been postulated that these tumors may have different biological behaviors. We performed a correlative analysis involving 204 patients with glioma treated prospectively on NCCTG clinical tr...

journal_title：Journal of neuro-oncology

authors： Jaeckle KA,Decker PA,Ballman KV,Flynn PJ,Giannini C,Scheithauer BW,Jenkins RB,Buckner JC

更新日期：2011-08-01 00:00:00

abstract：:Although 1p19q codeleted gliomas are the most favorable molecular subgroup of lower-grade gliomas, there are cases with early recurrence or short survival. The objective of this study was to elucidate molecular-genetic and clinicopathological prognostic factors in patients with gliomas showing total 1p19q loss. The st...

journal_title：Journal of neuro-oncology

authors： Hayashi S,Kitamura Y,Hirose Y,Yoshida K,Sasaki H

更新日期：2017-03-01 00:00:00

abstract：:Embryonal tumors of the central nervous system (CNS) share histological features and were therefore initially grouped as primitive neuroectodermal tumors (PNET) and treated similarly. We sought to determine the relapse patterns of specific embryonal CNS tumors. We conducted a historical cohort study of children diagno...

journal_title：Journal of neuro-oncology

authors： Perreault S,Lober RM,Carret AS,Zhang G,Hershon L,Décarie JC,Yeom K,Vogel H,Fisher PG,Partap S

更新日期：2013-11-01 00:00:00

abstract：:ATP-binding cassette transporters (ABC transporters) regulate traffic of multiple compounds, including chemotherapeutic agents, through biological membranes. They are expressed by multiple cell types and have been implicated in the drug resistance of some cancer cells. Despite significant research in ABC transporters ...

journal_title：Journal of neuro-oncology

authors： Dréan A,Rosenberg S,Lejeune FX,Goli L,Nadaradjane AA,Guehennec J,Schmitt C,Verreault M,Bielle F,Mokhtari K,Sanson M,Carpentier A,Delattre JY,Idbaih A

更新日期：2018-07-01 00:00:00

abstract：:Steady improvements in imaging modalities have enabled a new realm of capabilities in the identification and assessment of meningiomas. The cross-sectional imaging modalities, MRI and CT, have improved in resolution and fidelity. These modalites now provide not only improved structural information but also insights in...

journal_title：Journal of neuro-oncology

authors： Saloner D,Uzelac A,Hetts S,Martin A,Dillon W

更新日期：2010-09-01 00:00:00

abstract：PURPOSE:Intracranial glioblastomas with simultaneous spinal lesions prior to chemoradiation therapy or craniotomy, defined as initial spinal metastasis, are not well understood. Herein, we investigated intracranial glioblastoma and demonstrated the importance of spinal screening using gadolinium enhanced spinal magneti...

journal_title：Journal of neuro-oncology

authors： Shibahara I,Saito R,Osada Y,Kanamori M,Sonoda Y,Kumabe T,Mugikura S,Watanabe M,Tominaga T

更新日期：2019-01-01 00:00:00

abstract：:Glioblastoma cells secrete transforming growth factor-beta (TGF-beta), which has a variety of immunosuppressive properties. We investigated the effect of irradiation TGF-beta secretion by malignant glioma cells. Three malignant glioma cell lines (T98G, A172, KG-1-C) were cultured and irradiated using 10 and 50 Gy Lina...

journal_title：Journal of neuro-oncology

authors： Satoh E,Naganuma H,Sasaki A,Nagasaka M,Ogata H,Nukui H

更新日期：1997-07-01 00:00:00

abstract：PURPOSE:Although the survival of most melanoma patients diagnosed with leptomeningeal disease (LMD) is short, some patients can have better outcomes and prolonged survival. A large retrospective cohort of patients was analyzed to identify features associated with survival with LMD from melanoma. METHODS:Clinical chara...

journal_title：Journal of neuro-oncology

authors： Ferguson SD,Bindal S,Bassett RL Jr,Haydu LE,McCutcheon IE,Heimberger AB,Li J,O'Brien BJ,Guha-Thakurta N,Tetzlaff MT,Tawbi H,Davies MA,Glitza IC

更新日期：2019-05-01 00:00:00

abstract：:We observed a stripe-like pattern of regional cerebral blood volume (rCBV) increase in a defined region adjacent to the contrast enhancement (CE) on MRI of glioblastomas (GBM) that we defined as the "striate sign" (SS). We hypothesized that the SS marks infiltration of GBM outside the CE volume transforming into futur...

journal_title：Journal of neuro-oncology

authors： Blasel S,Franz K,Ackermann H,Weidauer S,Zanella F,Hattingen E

更新日期：2011-07-01 00:00:00