Abstract：
BACKGROUND:Paclitaxel-induced peripheral neuropathy (PN) may be severe and dose-limiting at initial doses > or = 275 mg/M2, but its neurotoxicity at doses < or = 250 mg/M2 has been incompletely characterized. The purposes of this study were to characterize and quantify paclitaxel-induced PN and to determine the utility of quantitative sensory testing (QST). METHODS:We prospectively examined clinically and by QST 37 women with metastatic breast cancer, treated with paclitaxel (200-250 mg/m2) (average number of cycles = 7.3 over an average of 20.1 weeks). QST included thermal threshold (TT) and vibration threshold (VT). RESULTS:Paresthesias appeared in 31 (84%) patients after an average of 1.7 cycles and an average cumulative dose of 371.5 mg/M2. Symptoms occurred after the first or second dose in 26 (84%) patients and then stabilized in 10 (32%), improved in 13 (42%) despite continued treatment, resolved completely in 6 (19%), and were progressive in 2 (7%). Paclitaxel was discontinued in only 1 (3%) patient because of neurotoxicity and no patient required dose reduction because of PN. Thirty-six (97%) developed signs of PN. The most sensitive QST was great toe VT but QST did not predict or identify subclinical PN in any patient. Neurologic syndromes other than PN developed in 12 (32%) patients, and 7 were due to metastatic cancer. CONCLUSIONS:1) Paclitaxel-induced PN is mostly sensory, and begins after the first or second dose. At these doses the neuropathy is mild, and rarely dose-limiting. 2) QST quantified the neuropathy but was less sensitive than the clinical examination. 3) Knowledge of the features of paclitaxel's PN allows it to be differentiated from other neurologic syndromes which may signal tumor progression.
journal_name
J Neurooncoljournal_title
Journal of neuro-oncologyauthors
Forsyth PA,Balmaceda C,Peterson K,Seidman AD,Brasher P,DeAngelis LMdoi
10.1023/a:1005805907311subject
Has Abstractpub_date
1997-10-01 00:00:00pages
47-53issue
1eissn
0167-594Xissn
1573-7373journal_volume
35pub_type
临床试验,杂志文章abstract：:Glioblastoma multiforme (GBM) represents a class of malignant gliomas which rapidly proliferate, invade and destroy surrounding brain tissues. This study examined micro-RNA (miRNA) speciation and miRNA effects on gene expression in six ATCC glioma and GBM cell lines and in 14 glioma and GBM samples obtained from human...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-008-9688-0
更新日期：2009-01-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
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更新日期：2008-04-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-014-1427-0
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章,评审
doi：10.1007/BF01328953
更新日期：1994-01-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章,评审
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更新日期：2001-09-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-009-9949-6
更新日期：2010-01-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
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更新日期：2019-01-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-014-1584-1
更新日期：2014-12-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
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更新日期：2016-12-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 临床试验,杂志文章
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更新日期：2000-01-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
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更新日期：2000-01-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-010-0274-x
更新日期：2011-02-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/BF02571303
更新日期：1987-01-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
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更新日期：2003-05-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-009-0090-3
更新日期：2010-07-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-015-1967-y
更新日期：2016-01-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1023/a:1006353322307
更新日期：1999-01-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1023/a:1005815503950
更新日期：1998-10-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-015-1905-z
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
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更新日期：2018-01-01 00:00:00
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journal_title：Journal of neuro-oncology
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更新日期：2005-05-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/BF01052627
更新日期：1995-12-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
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更新日期：2014-10-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章,meta分析,评审
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更新日期：2014-06-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章,评审
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更新日期：2014-09-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章,评审
doi：10.1007/BF00165526
更新日期：1991-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2018-04-01 00:00:00
