Abstract：
:Various histological types of tumors arise in the pineal region. The most common tumors are pineal parenchymal tumors and germ cell tumors. Pineal parenchymal tumors are divided into pineocytoma, pineal parenchymal tumor with intermediate differentiation and pineoblastoma. Pineocytomas are well-differentiated tumors and retain the morphological and immunohistochemical features of pineal parenchymal cells. Lobular architectures and pineocytomatous rosettes are also typical features. In contrast, pineoblastomas are embryonal tumors resembling primitive neuroectodermal tumors (PNET). However, pineoblastomas are distinct from PNET in other sites due to their exhibiting photosensory differentiation including Flexner-Wintersteiner rosettes and fleurettes. Although pineal cysts are tumor-like lesions, and not true neoplasms, they are occasionally difficult to distinguish from pineocytoma and astrocytoma. From the therapeutic aspect, a precise differential diagnosis is critical. The pineal region is the most common site of the brain in which germ cell tumors occur. Germinoma, teratoma, embryonal carcinoma, yolk sac tumor and choriocarcinoma are encountered, and the latter three types of tumors usually constitute elements of mixed germ cell tumors. The morphological and immunohistochemical features of intracranial germ cell tumors are very similar to those of gonadal germ cell tumors, although there are some differences in germinoma. Pineal germinoma may exhibit carcinomatous differentiation. Other types of tumors are occasionally observed, including fibrillary and pilocytic astrocytoma, glioblastoma, ependymoma, melanoma, meningioma and so on. Metastatic pineal tumors are also rare. The most common site of origin for pineal metastasis is the lung.
journal_name
J Neurooncoljournal_title
Journal of neuro-oncologyauthors
Hirato J,Nakazato Ydoi
10.1023/a:1012721723387subject
Has Abstractpub_date
2001-09-01 00:00:00pages
239-49issue
3eissn
0167-594Xissn
1573-7373journal_volume
54pub_type
杂志文章,评审abstract：:Accumulating evidence has supported the role of microRNAs in the initiation and development of malignant tumors. MicroRNA-211 (miR-211), which was reported to involve in diverse physiological activities in several cancers, was investigated for its expression in human glioma and adjacent normal brain tissues, as well a...
journal_title：Journal of neuro-oncology
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journal_title：Journal of neuro-oncology
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doi：10.1007/s11060-015-1897-8
更新日期：2016-01-01 00:00:00
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journal_title：Journal of neuro-oncology
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doi：10.1007/s11060-016-2136-7
更新日期：2016-07-01 00:00:00
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journal_title：Journal of neuro-oncology
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doi：10.1007/BF00163713
更新日期：1988-11-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章,评审
doi：10.1023/a:1006470523052
更新日期：2000-05-01 00:00:00
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journal_title：Journal of neuro-oncology
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doi：10.1007/s11060-007-9507-z
更新日期：2008-04-01 00:00:00
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更新日期：2013-04-01 00:00:00
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journal_title：Journal of neuro-oncology
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更新日期：2014-12-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章,多中心研究
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更新日期：2017-04-01 00:00:00
abstract：:Stereotactic radiosurgery is a frequently performed procedure for patients with benign intracranial tumors. Benign tumors are good candidates for radiosurgery because they are generally non-invasive, are well visualized by magnetic resonance imaging, and their slow rate of proliferation makes conventional radiation do...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章,评审
doi：10.1007/s11060-009-9831-6
更新日期：2009-05-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章,meta分析
doi：10.1007/s11060-013-1294-0
更新日期：2014-01-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-012-0904-6
更新日期：2012-09-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-016-2227-5
更新日期：2016-10-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-010-0476-2
更新日期：2011-08-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-020-03400-3
更新日期：2020-02-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章,评审
doi：10.1007/s11060-016-2198-6
更新日期：2016-11-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/BF00172603
更新日期：1992-11-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章,评审
doi：10.1007/s11060-012-0811-x
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
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更新日期：2012-05-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/BF01052898
更新日期：1994-01-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-010-0200-2
更新日期：2010-12-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1023/a:1005878402133
更新日期：1998-01-01 00:00:00
abstract：:A 44 year-old man with subcutaneous meningioma and rare combination of spinal lesions, consisting of dermal sinus and lipoma of the filum terminale. The literature concerning the subcutaneous meningioma is reviewed and the embryogenesis of these lesions is discussed. ...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1023/a:1005981110128
更新日期：1998-05-01 00:00:00
abstract：:The cerebrospinal fluid (CSF) pharmacokinetics of cytosine arabinoside (Ara-C) was determined in 8 patients with metastatic cancer in the central nervous system. High dose (3 gm/M2) one-hour intravenous infusions of Ara-C were given with serial CSF sampling obtained from indwelling Ommaya reservoirs. CSF was analyzed ...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/BF02228887
更新日期：1985-01-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-012-0937-x
更新日期：2012-10-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-017-2415-y
更新日期：2017-06-01 00:00:00
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journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-015-1959-y
更新日期：2016-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2010-06-01 00:00:00
