Long-term survival in primary CNS lymphoma treated by high-dose methotrexate monochemotherapy: role of STAT6 activation as prognostic determinant.

abstract：:Magnetic resonance imaging (MRI) or computerized tomography (CT) is routinely performed after resection of brain metastases (BrM), regardless of whether there are specific clinical concerns about residual tumor or potential complications. Routine imaging studies contribute a significant amount to the cost of medical c...

journal_title：Journal of neuro-oncology

authors： Benveniste RJ,Ferraro N,Tsimpas A

更新日期：2014-06-01 00:00:00

abstract：:Ependymomas (EPN) show site specific genetic alterations and a recent DNA methylation profiling study identified nine molecular subgroups. C11orf95-RELA and YAP1 fusions characterise the RELA and YAP1 molecular subgroups, respectively, of supratentorial (ST)-EPNs. Current guidelines recommend molecular subgrouping ove...

journal_title：Journal of neuro-oncology

authors： Malgulwar PB,Nambirajan A,Pathak P,Faruq M,Rajeshwari M,Singh M,Suri V,Sarkar C,Sharma MC

更新日期：2018-05-01 00:00:00

abstract：:The effectiveness of temozolomide (TMZ) dosing schemes and the "rechallenge" of recurrent glioblastoma (GBM) with TMZ are controversial. We therefore compared the efficacy of different TMZ dosing schemes against GBM cancer stem cell (CSC) lines in vitro. In O(6)-methyl-guanidine-methyl-transferase (MGMT)-negative CSC ...

journal_title：Journal of neuro-oncology

authors： Beier D,Schriefer B,Brawanski K,Hau P,Weis J,Schulz JB,Beier CP

更新日期：2012-08-01 00:00:00

abstract：:We have expressed the tumor suppressor p16 under the control of a tetracycline-sensitive promoter in two human glioblastoma cell lines which do not contain endogenous p16. Ectopic p16 expression led to a stable but reversible G1 phase cell cycle arrest, reduced the growth of both cell lines in cell culture, and almost...

journal_title：Journal of neuro-oncology

authors： Simon M,Simon C,Köster G,Hans VH,Schramm J

更新日期：2002-10-01 00:00:00

abstract：:A highly enhanced cap attached to the surface of metastatic tumors in the brain parenchyma is occasionally encountered on magnetic resonance (MR) images. This atypical enhanced cap tends to occur in severe peritumoral edema and may produce the characteristic bulge of a metastatic mass lesion termed the "comet tail sig...

journal_title：Journal of neuro-oncology

authors： Mitsuya K,Nakasu Y,Narita Y,Nakasu S,Ohno M,Miyakita Y,Abe M,Ito I,Hayashi N,Endo M

更新日期：2016-05-01 00:00:00

abstract：INTRODUCTION:Carmustine (BCNU)-impregnated biodegradable polymer wafers have been shown to prolong survival in patients with recurrent malignant glioma. Interferon alfa-2b (IFNalpha(2b)) has demonstrated antitumor activity against a number of cancers, but its use in glioma has been limited. The use of these agents in c...

journal_title：Journal of neuro-oncology

authors： Olson JJ,McKenzie E,Skurski-Martin M,Zhang Z,Brat D,Phuphanich S

更新日期：2008-12-01 00:00:00

abstract：PURPOSE:Glioblastoma (GBM) is characterized by extensive clonal diversity suggesting the presence of tumor cells with varying degrees of treatment sensitivity. Radiotherapy is an integral part of glioblastoma treatment. Whether GBMs are comprised of spatially distinct cellular populations with uniform or varying degree...

journal_title：Journal of neuro-oncology

authors： McAbee JH,Degorre-Kerbaul C,Valdez K,Wendler A,Shankavaram UT,Watts C,Camphausen K,Tofilon PJ

更新日期：2020-09-01 00:00:00

abstract：:High grade astrocytomas remain incurable even though these tumors often appear localized on modern imaging studies, rarely metastasize to systemic sites, and can be aggressively treated with surgery and radiation therapy. Recent data suggest that the dissemination of astrocytoma cells along white matter tracts to dist...

journal_title：Journal of neuro-oncology

authors： Geer CP,Grossman SA

更新日期：1997-05-01 00:00:00

abstract：:Thirty-one patients with metastatic brain tumors that either failed to respond or recurred after conventional therapy were treated by intra-arterial infusion of 100 mg/m2 of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) into either a carotid or vertebral artery. Five patients (three with lung cancer, one with breast can...

journal_title：Journal of neuro-oncology

authors： Cascino TL,Byrne TN,Deck MD,Posner JB

更新日期：1983-01-01 00:00:00

abstract：:Glioblastoma Multiforme frequently metastasises from their original location by for example infiltration along white matter tracts [1]. GBM metastasis outside the central nervous system is distinctly rare though there are previous reports of spread to various organs [2-5]. We add an unusual case of a patient with aggr...

journal_title：Journal of neuro-oncology

authors： Ogungbo BI,Perry RH,Bozzino J,Mahadeva D

更新日期：2005-09-01 00:00:00

abstract：:Approximately half of surgically-treated patients with low-grade-glioma (LGG) suffer recurrence or metastasis. Currently there is no effective drug treatment. While the selective COX-2 inhibitor celecoxib showed anti-neoplastic activity against several malignant tumors, its effects against LGG remain to be elucidated....

journal_title：Journal of neuro-oncology

authors： Sato A,Mizobuchi Y,Nakajima K,Shono K,Fujihara T,Kageji T,Kitazato K,Matsuzaki K,Mure H,Kuwayama K,Sumi A,Saya H,Sampetrean O,Nagahirao S

更新日期：2017-04-01 00:00:00

abstract：:Membrane-type MMPs (MT-MMPs) constitute a growing subclass of recently identified matrix metalloproteinases (MMPs). In addition to the highly conserved MMP functional domains, the MT-MMPs have additional insertion sequences (IS) that confer unique functional roles. While most of the MMPs are secreted, the MT-MMPs are ...

journal_title：Journal of neuro-oncology

authors： Fillmore HL,VanMeter TE,Broaddus WC

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:A retrospective comparison evaluating survival in two well-matched cohorts of patients with cytologically positive neoplastic meningitis (NM) presenting with or without encephalopathy. METHODS:Two cohorts were studied: 20 with and 20 without of NM-related encephalopathy defined as a confusional syndrome. Co...

journal_title：Journal of neuro-oncology

authors： Chamberlain MC,Tsao-Wei D,Groshen S

更新日期：2005-04-01 00:00:00

abstract：:The authors studied 24 patients affected by anaplastic gliomas in regard to the killer (Antibody-Dependent Cellular Cytotoxicity) and natural killer (Spontaneous Lymphocyte-Mediated Cytotoxicity) immunological functions, by counting the Cr51 release in Change liver and K 562 cell cultures, respectively. These paramete...

journal_title：Journal of neuro-oncology

authors： Servadei F,Parente R,Bucci M,Beltrandi E,Tognetti F,Gaist G

更新日期：1983-01-01 00:00:00

abstract：:Anaplastic oligodendroglioma (AO) is an uncommon intracranial tumor and prognosis is poor. In this study, we assessed the factors affecting the prognosis of AO patients. Seventy AO patients were recruited from 2001 to 2006 in Shanghai Huashan Hospital of Fudan University; all were treated surgically. Kaplan-Meier surv...

journal_title：Journal of neuro-oncology

authors： Yang LS,Huang FP,Zheng K,Zhang HS,Zhou X,Bao XH,Zheng JJ,Chang C,Zhou LF

更新日期：2010-10-01 00:00:00

abstract：:Five quantitative histologic factors, differing linear combinations of 26 reliably recognized histologic features, account for much of the histologic variance in 1068 children with infratentorial neuroglial tumors in the Childhood Brain Tumor Consortium (CBTC) database. In this study, we used the scores on the Spongy,...

journal_title：Journal of neuro-oncology

authors： Gilles FH,Sobel EL,Leviton A,Tavaré CJ

更新日期：1998-08-01 00:00:00

abstract：PURPOSE:Intracranial glioblastomas with simultaneous spinal lesions prior to chemoradiation therapy or craniotomy, defined as initial spinal metastasis, are not well understood. Herein, we investigated intracranial glioblastoma and demonstrated the importance of spinal screening using gadolinium enhanced spinal magneti...

journal_title：Journal of neuro-oncology

authors： Shibahara I,Saito R,Osada Y,Kanamori M,Sonoda Y,Kumabe T,Mugikura S,Watanabe M,Tominaga T

更新日期：2019-01-01 00:00:00

abstract：:Steroids are beneficial in neurological illness, but have many serious side effects. Having observed several patients with severe steroid psychoses, which greatly prolonged their hospitalizations, the authors sought to improve understanding of this entity. A literature review was conducted. The incidence of severe psy...

journal_title：Journal of neuro-oncology

authors： Ross DA,Cetas JS

更新日期：2012-09-01 00:00:00

abstract：:The labeling index (LI) of 216 cases of human brain tumors was determined by the immunohistochemical technique with monoclonal antibody to bromodeoxyuridine (BrdU). The proliferative potential of 110 cases was estimated using the intra-operative intravenous infusion of BrdU at a dose of 200 mg/sq m. In another 106 cas...

journal_title：Journal of neuro-oncology

authors： Kharbanda K,Dinda AK,Sarkar C,Karak AK,Dhir R,Mathur M,Roy S

更新日期：1995-01-01 00:00:00

abstract：:Twenty-nine patients received the cytotoxic radiosensitizing agent lonidamine before, during, and after cranial irradiation for brain metastases. One patient was ineligible (meningioma). In 28 eligible patients, median survival was 29 weeks (range, 2 to > 220 weeks). Nine patients (32%) survived > 1 year and 3 (11%) s...

journal_title：Journal of neuro-oncology

authors： Stewart DJ,Eapen L,Girard A,Verma S,Genest P,Evans WK

更新日期：1993-01-01 00:00:00

abstract：:The antiproliferative effect of IFNalpha was tested on the human glioblastoma cell lines, U-373MG and T98G. IFNalpha significantly inhibited the growth of both cell lines, but was more effective in retarding the growth of U-373MG cells. Flow cytometry analysis indicated that synchronized IFNalpha-treated U-373MG cells...

journal_title：Journal of neuro-oncology

authors： Tanabe T,Kominsky SL,Subramaniam PS,Johnson HM,Torres BA

更新日期：2000-07-01 00:00:00

abstract：:This study investigated the effects of the intracarotid infusion of etoposide in combination with angiotensin II (AT II)-induced hypertension on the blood-brain barrier (BBB) and brain tissue in rats. Eighty rats were divided into five groups: Group 1, intravenous infusion of AT II to increase arterial blood pressure;...

journal_title：Journal of neuro-oncology

authors： Ogasawara H,Kiya K,Kurisu K,Hotta T,Mikami T,Sugiyama K,Nakahara T,Uozumi T

更新日期：1992-06-01 00:00:00

abstract：:While surgery is proned in low-grade glioma (LGG), the invasion of functional areas frequently prevents a complete resection. We report the first case of a patient operated on for a left frontal LGG, diagnosed because of seizures, with partial resection due to an invasion of the controlateral hemisphere. Chemotherapy ...

journal_title：Journal of neuro-oncology

authors： Duffau H,Taillandier L,Capelle L

更新日期：2006-11-01 00:00:00

abstract：:Central nervous system atypical teratoid/rhabdoid tumor (ATT/RT) of infancy and childhood is a unique histologic entity with an extremely aggressive natural history. Standard therapy for infant and childhood medulloblastoma, for which this entity is often mistaken, has been ineffective; most children survive less than...

journal_title：Journal of neuro-oncology

authors： Hilden JM,Watterson J,Longee DC,Moertel CL,Dunn ME,Kurtzberg J,Scheithauer BW

更新日期：1998-12-01 00:00:00

abstract：:Four cases of intracranial osteosarcoma are reported. In three cases the tumors were primary neoplasms arising from the sellar region, base of the occiput and the parieto-occipital area. One case represented osteosarcoma metastatic to the cerebellum, a site not previously described, from a primary tumor at the femur. ...

journal_title：Journal of neuro-oncology

authors： Ashkan K,Pollock J,D'Arrigo C,Kitchen ND

更新日期：1998-10-01 00:00:00

abstract：:Central neurocytoma was originally described as a rare benign neuronal tumor. However, progression and local recurrences after surgery are well recognized. Stereotactic radiosurgery is another option for treatment of CN. In order to evaluate the efficacy of SRS, we performed a quantitative systematic review of the ava...

journal_title：Journal of neuro-oncology

authors： Park HK,Steven D C

更新日期：2012-05-01 00:00:00

abstract：:Aberrant expression of microRNAs (miRNAs), a class of small non-coding regulatory RNAs, has been implicated in the development and progression of high-grade gliomas. However, the precise mechanistic role of many miRNAs in this disease remains unclear. Here, we investigate the functional role of miR-331-3p in glioblast...

journal_title：Journal of neuro-oncology

authors： Epis MR,Giles KM,Candy PA,Webster RJ,Leedman PJ

更新日期：2014-01-01 00:00:00

abstract：:Anti-PD-1/PD-L1 therapies have demonstrated activity in patients with advanced stage non-small cell lung cancer (NSCLC). However, little is known about the safety and feasibility of patients receiving anti-PD-1/PD-L1 therapy and stereotactic radiation for the treatment of brain metastases. Data were analyzed retrospec...

journal_title：Journal of neuro-oncology

authors： Ahmed KA,Kim S,Arrington J,Naghavi AO,Dilling TJ,Creelan BC,Antonia SJ,Caudell JJ,Harrison LB,Sahebjam S,Gray JE,Etame AB,Johnstone PA,Yu M,Perez BA

更新日期：2017-06-01 00:00:00

abstract：:Glioblastoma is a highly angiogenic tumor with a dismal prognosis. Continuous oral low-dose chemotherapy with methotrexate (MTX) and cyclophosphamide (CPM) has modest activity in heavily pretreated patients with breast cancer. We explored the efficacy of 100 mg CPM daily and 5 mg MTX twice weekly in relapsed glioblast...

journal_title：Journal of neuro-oncology

authors： Herrlinger U,Rieger J,Steinbach JP,Nägele T,Dichgans J,Weller M

更新日期：2005-02-01 00:00:00

abstract：:We prospectively addressed whether EGFR and KRAS mutations, EML4-ALK, ROS1 and RET rearrangements, or wild-type (WT), affects radiosurgery outcomes and overall survival (OS) in non-small cell lung cancer (NSCLC) patients with brain metastases (BM). Of 326 patients with BM treated in 2012-2014 with Gamma Knife radiosur...

journal_title：Journal of neuro-oncology

authors： Shin SM,Cooper BT,Chachoua A,Butler J,Donahue B,Silverman JS,Kondziolka D

更新日期：2016-02-01 00:00:00