"Comet tail sign": A pitfall of post-gadolinium magnetic resonance imaging findings for metastatic brain tumors.

abstract：:We aimed to assess the efficacy of stereotactic irradiation for patients with recurrent high-grade glioma (HGG) and identify predictive factors of progression-free survival (PFS) and overall survival (OS) following reirradiation. We identified 32 patients with recurrent brain HGG who had been treated with either singl...

journal_title：Journal of neuro-oncology

authors： Attal J,Chaltiel L,Lubrano V,Sol JC,Lanaspeze C,Vieillevigne L,Latorzeff I,Cohen-Jonathan Moyal E

更新日期：2018-01-01 00:00:00

abstract：:Using the novel tissue microarray technique, we studied immunohistochemical expression of cell cycle regulators p53, p21, pRb in 42 grade II oligodendrogliomas, 16 grade III anaplastic oligodendrogliomas, 10 primary and 4 recidive grade II oligoastrocytomas, 10 grade III oligoastrocytomas and 2 other grade II mixed gl...

journal_title：Journal of neuro-oncology

authors： Miettinen HE,Paunu N,Rantala I,Kalimo H,Paljärvi L,Helin H,Haapasalo H

更新日期：2001-10-01 00:00:00

abstract：INTRODUCTION:Pediatric spinal tumors are unique pathologies treated by pediatric neurosurgeons. Special attention is required for the preservation of neural function and bony alignment. We reported our experience in the management of these challenging lesions. METHODS:A total of 75 pediatric patients with spinal tumor...

journal_title：Journal of neuro-oncology

authors： Chou SC,Kuo MF,Lai DM,Chen CM,Xiao F,Tsuang FY,Yang SH

更新日期：2020-02-01 00:00:00

abstract：:The Notch signal regulates both cell viability and apoptosis, and maintains stemness of various cancers including glioblastoma (GBM). Although Notch signal inhibition may be an effective strategy in treating GBM initiating cells (GICs), its applicability to the different subtypes of GBM remains unclear. Here, we analy...

journal_title：Journal of neuro-oncology

authors： Tanaka S,Nakada M,Yamada D,Nakano I,Todo T,Ino Y,Hoshii T,Tadokoro Y,Ohta K,Ali MA,Hayashi Y,Hamada J,Hirao A

更新日期：2015-01-01 00:00:00

abstract：:In earlier studies, we demonstrated that intratumoral infusions of alloreactive cytotoxic T lymphocytes (aCTL), sensitized to the major histocompatibility complex (MHC) antigens of the host, effectively retarded the intracranial growth of Fischer 9L gliosarcoma. We further demonstrated that continuous in vitro exposur...

journal_title：Journal of neuro-oncology

authors： Paul DB,Read SB,Kulprathipanja NV,Gomez GG,Kleinschmidt-DeMasters BK,Schiltz PM,Kruse CA

更新日期：2003-08-01 00:00:00

abstract：OBJECT:Prophylactic cranial irradiation (PCI) is commonly offered to patients with limited stage primary small cell lung cancer following a complete response. METHODS:We present the unique case of a 76-year-old woman treated with PCI with a dose of 30 Gy in 15 fractions, at 200 cGy per fraction who developed progressi...

journal_title：Journal of neuro-oncology

authors： D'Ambrosio DJ,Cohen RB,Glass J,Konski A,Buyyounouski MK,Feigenberg SJ

更新日期：2007-10-01 00:00:00

abstract：:The effect of methionine enkephalin on the growth of human brain tumor cells was investigated. The results show that this endogenous opioid has dual effects on tumor cell growth. This peptide exerted an inhibitory effect in SK-N-MC human neuroblastoma cell line; in contrast, in U-373 MG human astrocytoma cell line, th...

journal_title：Journal of neuro-oncology

authors： Lee YS,Wurster RD

更新日期：1994-01-01 00:00:00

abstract：:Medulloblastoma is a rare malignancy in adults, accounting for approximately 1% of all primary brain tumors. Extraneural metastases have been reported in 10-30% of cases and most commonly involve bone; rarely lymph nodes, visceral organs and bone marrow may be involved with disease. We report here our experience with ...

journal_title：Journal of neuro-oncology

authors： Wendland MM,Shrieve DC,Watson GA,Chin SS,Blumenthal DT

更新日期：2006-06-01 00:00:00

abstract：:Two patients with metastasis from lung carcinoma of the midbrain are presented. The computerized tomographic (CT) findings mimicked a primary pineal tumor, but autopsy confirmed a metastatic nodule in the midbrain in both cases. The rational approach to posterior third ventricular tumors seen on CT in adulthood is dis...

journal_title：Journal of neuro-oncology

authors： Tomita T,Wetzel N

更新日期：1984-01-01 00:00:00

abstract：OBJECT:Although atypical teratoid/rhabdoid tumor (AT/RT) is known to generate through inactivation of the hSNF5/INI1 gene on chromosome 22q, the downstream molecular mechanism remains unclear. We histologically and molecularly reviewed our pediatric brain tumors for unrecognized AT/RTs and evaluated the role of cyclin ...

journal_title：Journal of neuro-oncology

authors： Fujisawa H,Misaki K,Takabatake Y,Hasegawa M,Yamashita J

更新日期：2005-06-01 00:00:00

abstract：:Glioblastoma (GBM) is the most common and deadly form of primary brain tumor with a median survival of eleven months, despite use of extensive chemotherapy, radiotherapy and surgery. We have previously shown that nuclear factor-kappa B (NF-κB) is aberrantly expressed in GBM tumors and primary cell lines derived from t...

journal_title：Journal of neuro-oncology

authors： Raychaudhuri B,Vogelbaum MA

更新日期：2011-01-01 00:00:00

abstract：:Malignancy involving the skull base remains a formidable management challenge. Advances and refinements in diagnostic imaging, instrumentation, microvascular reconstruction, and an improved overall appreciation of the anatomy of the skullbase have extended the boundaries of tumor resectability and in some cases, obvia...

journal_title：Journal of neuro-oncology

authors： DeMonte F

更新日期：2004-08-01 00:00:00

abstract：:Neuron-specific enolase (NSE) is one of the iso-forms of enolase, a glycolytic enzyme found in the neuroendocrine system. NSE is one of the most widely used tumor markers in small-cell lung carcinoma (SCLC). To assess the value of NSE in discriminating between the sites of metastases in SCLC-patients with and without ...

journal_title：Journal of neuro-oncology

authors： van de Pol M,Twijnstra A,ten Velde GP,Menheere PP

更新日期：1994-01-01 00:00:00

abstract：:We report a single-center experience of 16 immunocompetent patients diagnosed with primary central nervous system lymphoma and treated with monochemotherapy with high-dose methotrexate (MTX) and deferred radiotherapy. MTX was given at a dose of 8.0 g/m2 for induction and at a dose of 3.5-8.0 g/m2 for maintenance. Ther...

journal_title：Journal of neuro-oncology

authors： Yang SH,Lee KS,Kim IS,Hong JT,Sung JH,Son BC,Lee SW,Hong YK

更新日期：2009-03-01 00:00:00

abstract：:Despite total macroscopic resection of meningiomas relapses do occur in these tumours, possibly because of microscopic clusters of neoplastic cells left in the dura mater or in the arachnoid membrane. The invasiveness of the neoplastic cells of human meningiomas has been related to expression of matrix-metalloproteina...

journal_title：Journal of neuro-oncology

authors： Barresi V,Vitarelli E,Tuccari G,Barresi G

更新日期：2011-04-01 00:00:00

abstract：:Central neurocytomas are uncommon intraventricular neoplasms whose optimal management remains controversial due to their rarity. We assessed outcomes for a historical cohort of neurocytoma patients and evaluated effects of tumor atypia, size, resection extent, and adjuvant radiotherapy. Progression-free survival (PFS)...

journal_title：Journal of neuro-oncology

authors： Imber BS,Braunstein SE,Wu FY,Nabavizadeh N,Boehling N,Weinberg VK,Tihan T,Barnes M,Mueller S,Butowski NA,Clarke JL,Chang SM,McDermott MM,Prados MD,Berger MS,Haas-Kogan DA

更新日期：2016-01-01 00:00:00

abstract：:Meningiomas may display benign (Grade I), atypical (Grade II) and anaplastic (Grade III) histopathological findings. The cytogenetic studies strongly suggest that secondary changes (moreover loss of chromosome 22) appear to be associated with more atypical features and with greater clinical aggressivity. We studied 60...

journal_title：Journal of neuro-oncology

authors： Cerdá-Nicolás M,López-Gineś C,Pérez-Bacete M,Barcia-Salorio JL,Llombart-Bosch A

更新日期：2000-04-01 00:00:00

abstract：:This study investigated the effects of the intracarotid infusion of etoposide in combination with angiotensin II (AT II)-induced hypertension on the blood-brain barrier (BBB) and brain tissue in rats. Eighty rats were divided into five groups: Group 1, intravenous infusion of AT II to increase arterial blood pressure;...

journal_title：Journal of neuro-oncology

authors： Ogasawara H,Kiya K,Kurisu K,Hotta T,Mikami T,Sugiyama K,Nakahara T,Uozumi T

更新日期：1992-06-01 00:00:00

abstract：:Injection of dendritic cells (DC) pulsed with tumor antigens is a novel treatment strategy against malignancies, and aims to elicit anti-tumoral cell-mediated immune responses. We studied the in vitro proliferative responses and cytokine production in T cell cultures after 2 stimulations with autologous DC loaded with...

journal_title：Journal of neuro-oncology

authors： De Vleeschouwer S,Spencer Lopes I,Ceuppens JL,Van Gool SW

更新日期：2007-09-01 00:00:00

abstract：:Comparison between myelography (MY) and magnetic resonance imaging (MRI) was carried out in 36 patients with clinical suspicion of spinal cord or root compression due to metastatic disease in the spinal canal. In 3 patients metastatic lesions were visualized on MY but not on MRI, while there were no cases with a negat...

journal_title：Journal of neuro-oncology

authors： Helweg-Larsen S,Wagner A,Kjaer L,Johnsen A,Boesen J,Palner T,Sørensen PS

更新日期：1992-07-01 00:00:00

abstract：:Neurological complications may occur in the course of Waldenström's macroglobulinemia (Wm). These complications affect both the central and peripheral nervous system. Pathogenesis is debated and several mechanisms have been suggested. Direct malignant lymphoid infiltration (MLI) is very rare and has only been reported...

journal_title：Journal of neuro-oncology

authors： Massengo S,Riffaud L,Morandi X,Bernard M,Verin M

更新日期：2003-05-01 00:00:00

abstract：:A better understanding of the relationship between glioblastomas molecular subtypes and radio-chemotherapy is needed for the development of individualized strategies. In this study, we aimed to assess whether non-homologous end-joining (NHEJ) protein expression is associated and could predict responses to treatment of...

journal_title：Journal of neuro-oncology

authors： Pinel B,Duchesne M,Godet J,Milin S,Berger A,Wager M,Karayan-Tapon L

更新日期：2017-04-01 00:00:00

abstract：:We conducted a phase II study to test methotrexate (5 g/m(2)), as a single agent prior to radiochemotherapy for pediatric high-grade glioma and diffuse intrinsic pontine glioma. Thirty patients (19 male, median age 10.8) were enrolled. Tumors were located as follows: cortex 10, pons 7, other 13. Tumor resection was cl...

journal_title：Journal of neuro-oncology

authors： Wolff JE,Kortmann RD,Wolff B,Pietsch T,Peters O,Schmid HJ,Rutkowski S,Warmuth-Metz M,Kramm C

更新日期：2011-05-01 00:00:00

abstract：:Four cases of intracranial osteosarcoma are reported. In three cases the tumors were primary neoplasms arising from the sellar region, base of the occiput and the parieto-occipital area. One case represented osteosarcoma metastatic to the cerebellum, a site not previously described, from a primary tumor at the femur. ...

journal_title：Journal of neuro-oncology

authors： Ashkan K,Pollock J,D'Arrigo C,Kitchen ND

更新日期：1998-10-01 00:00:00

abstract：:Two main varieties of recognition disorders are distinguished in neuropsychology: agnosias and semantic disorders. The term agnosias is generally used to denote recognition defects limited to a single perceptual modality (which is itself apparently intact), whereas the term semantic disorders is used to denote recogni...

journal_title：Journal of neuro-oncology

authors： Gainotti G

更新日期：2012-06-01 00:00:00

abstract：:Glioblastoma (GBM) is the most common malignant primary brain tumor. Although clinical presentation and brain imaging might be suggestive, histopathological evaluation by means of a brain biopsy is routinely performed to establish the diagnosis. A serum marker indicative of GBM may simplify the diagnostic work-up of p...

journal_title：Journal of neuro-oncology

authors： Tichy J,Spechtmeyer S,Mittelbronn M,Hattingen E,Rieger J,Senft C,Foerch C

更新日期：2016-01-01 00:00:00

abstract：:The Coronavirus pandemic has created unprecedented strain on medical resources at health care institutions around the world. At many institutions, this has resulted in efforts to prioritize cases with an attempt to balance the acuity of medical needs with available resources. Here, we provide a framework for instituti...

journal_title：Journal of neuro-oncology

authors： Ramakrishna R,Zadeh G,Sheehan JP,Aghi MK

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Macroautophagy/autophagy is considered to play key roles in tumor cell evasion of therapy and establishment of metastases in breast cancer. High expression of LC3, a residual autophagy marker, in primary breast tumors has been associated with metastatic disease and poor outcome. FIP200/Atg17, a multi-functio...

journal_title：Journal of neuro-oncology

authors： Hashemi-Sadraei N,Müller-Greven GM,Abdul-Karim FW,Ulasov I,Downs-Kelly E,Burgett ME,Lauko A,Qadan MA,Weil RJ,Ahluwalia MS,Du L,Prayson RA,Chao ST,Budd TG,Barnholtz-Sloan J,Nowacki AS,Keri RA,Gladson CL

更新日期：2018-11-01 00:00:00

abstract：:Tanshinone IIA is a derivative of phenanthrene-quinone isolated from Danshen, a widely used Chinese herbal medicine. It has antioxidant properties, cytotoxic activities against multiple human cancer cells, inducing apoptosis and differentiation of some human cancer cells. The purpose of this study is to confirm its an...

journal_title：Journal of neuro-oncology

authors： Wang J,Wang X,Jiang S,Yuan S,Lin P,Zhang J,Lu Y,Wang Q,Xiong Z,Wu Y,Ren J,Yang H

更新日期：2007-03-01 00:00:00

abstract：:Thrombin is known to play a role as regulator in tumor spreading and tumor growth. Proteinase-activated receptor 1 (PAR 1)-type thrombin receptors were identified in different cancer cells including human glioblastoma cells. Thus a function of PAR 1 in brain tumors may be suggested. In this study, the presence of PAR ...

journal_title：Journal of neuro-oncology

authors： Kaufmann R,Patt S,Kraft R,Zieger M,Henklein P,Neupert G,Nowak G

更新日期：1999-04-01 00:00:00