Abstract：
:Proteasome activity is essential during cAMP-induced terminal differentiation of a murine neuroblastoma cell line (NBP2). However, the mechanisms through which proteasome affects NBP2 differentiation have not been characterized. We hypothesized that proteasome is required to implement the differentiation-mediated effects on cell cycle, and its partial inhibition during differentiation may have adverse consequences. Here we show that partial inhibition of proteasome during cAMP-induced differentiation of NBP2 cells causes apoptosis. Whereas differentiation induced growth arrest at G1 phase, partial proteasome inhibition during differentiation resulted in the accumulation of cells at G2M phase. Cell cycle data correlated with the level of cyclin-dependent kinase inhibitors p21WAF and p27Kip1, and cyclin A. While the level of p21 and p27 increased, the level of cyclin A decreased upon differentiation. In contrast, cells treated with proteasome inhibitor in the presence of cAMP-inducing agents showed increased levels of p21 and cyclin A early in the course of differentiation. However, the level of p21 and p27, but not cyclin A, decreased later during concomitant differentiation and partial proteasome inhibition when cells were undergoing apoptosis. Our data suggest that differentiation-mediated growth arrest is dependent on the temporal activity of cell cycle proteins. Partial inhibition of proteasome interferes with differentiation events partly by stabilizing cell cycle proteins and this triggers apoptosis. Thus, differentiating drugs combined with partial proteasome inhibition may impart higher therapeutic efficacy than differentiating agents alone for the treatment of neuroblastoma tumors.
journal_name
J Neurooncoljournal_title
Journal of neuro-oncologyauthors
Nahreini P,Andreatta C,Hanson A,Prasad KNdoi
10.1023/a:1023713008809subject
Has Abstractpub_date
2003-05-01 00:00:00pages
15-23issue
1eissn
0167-594Xissn
1573-7373journal_volume
63pub_type
杂志文章abstract：PURPOSE:Most recent literature has confirmed the efficacy of single-session radiosurgery (sRS) in the treatment of intracranial meningioma. Unfortunately, sRS is not always applicable due to large tumor volume and the proximity of the tumor to critical structures. When sRS is not recommended, multi-session radiosurgery...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章,多中心研究
doi：10.1007/s11060-019-03196-x
更新日期：2019-07-01 00:00:00
abstract：:This case study describes the long-term course of behavioral alterations and MRI findings in a patient with a combined limbic and cerebellar paraneoplastic syndrome, which was associated with a squamous lung carcinoma. Clinical equivalents were cerebellar ataxia, as well as severe anterograde memory loss, frontal exec...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1023/b:neon.0000013488.52742.b4
更新日期：2004-01-01 00:00:00
abstract：INTRODUCTION:While hypofractionated stereotactic radiotherapy (HFSRT) is being increasingly used for treating brain metastases, clinical data concerning the incidence and risk factors of its main side-effect, namely radiation necrosis (RN), remain limited. In this context, we assessed risk factors of RN in a single cen...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-020-03628-z
更新日期：2020-09-01 00:00:00
abstract：:Malignant gliomas are the main brain tumors notoriously resistant to currently available therapies, since they fail to undergo apoptosis upon anticancer treatment. Recent progress on enhanced studies of ion channels involved in glioma cells shed new light on the investigation of glioma cell growth and proliferation. H...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-004-4205-6
更新日期：2005-05-01 00:00:00
abstract：PURPOSE:White matter changes (WMCs) can develop following systemic chemotherapy in patients with primary central nervous system lymphomas (PCNSLs), but the frequency and extent of these changes is not well characterized. This single center retrospective semi-quantitative study was performed to determine the rate, timin...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-019-03279-9
更新日期：2019-12-01 00:00:00
abstract：:To evaluate whether vigorous treatment is beneficial for patients with meningeal gliomatosis (MG) we reviewed the case records of 20 consecutive patients treated for a symptomatic MG in our center. All received systemic or intrathecal chemotherapy and six received additional cranial or spinal radiotherapy. Six patient...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1023/a:1006399804896
更新日期：1999-09-01 00:00:00
abstract：:Neurological complications may occur in the course of Waldenström's macroglobulinemia (Wm). These complications affect both the central and peripheral nervous system. Pathogenesis is debated and several mechanisms have been suggested. Direct malignant lymphoid infiltration (MLI) is very rare and has only been reported...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1023/a:1023393532546
更新日期：2003-05-01 00:00:00
abstract：:The utility of current response criteria has not been established in anaplastic astrocytoma (AA). We retrospectively reviewed MR images for 20 patients with AA and compared RANO-based approaches to clinician impression described as follow: (1) standard RANO-based criteria met by growth of or development of new enhanci...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-014-1703-z
更新日期：2015-03-01 00:00:00
abstract：:Aberrant activation of Akt is a common finding in adult malignant gliomas, resulting in most cases from mutations or deletions involving PTEN, which allows constitutive Akt phosphorylation. In contrast, we have previously reported that pediatric malignant gliomas, which are morphologically similar to lesions arising i...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-010-0297-3
更新日期：2010-09-01 00:00:00
abstract：:Thermal stability signatures of complex molecule interaction in biological fluids can be measured using a new approach called differential scanning calorimetry (DSC). The thermal stability of plasma proteome has been described previously as a method of producing a disease-specific "signature," termed thermogram, in se...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-011-0630-5
更新日期：2011-12-01 00:00:00
abstract：:A high affinity folate receptor is expressed in some human cancers, including choroid plexus tumors and ependymomas, and has been suggested as a target for therapeutics. In this report, the expression of folate receptors in an SV40 large T antigen transgenic mouse (SV11) was investigated. SV11 mice develop choroid ple...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1023/a:1005713115147
更新日期：1997-04-01 00:00:00
abstract：PURPOSE:A prospective study of patients with glioma was carried out. Special attention was paid to the first seizure, to the histology, and to the efficacy and prophylactic role of antiepileptic drugs (AEDs). Prognostic factors were analyzed. METHODS:Between February 1st 2004 and April 1st 2006 patients who underwent ...
journal_title：Journal of neuro-oncology
pub_type： 临床试验,杂志文章
doi：10.1007/s11060-009-9796-5
更新日期：2009-07-01 00:00:00
abstract：:Glioblastoma Multiforme frequently metastasises from their original location by for example infiltration along white matter tracts [1]. GBM metastasis outside the central nervous system is distinctly rare though there are previous reports of spread to various organs [2-5]. We add an unusual case of a patient with aggr...
journal_title：Journal of neuro-oncology
pub_type： 信件
doi：10.1007/s11060-005-1480-9
更新日期：2005-09-01 00:00:00
abstract：:The aim of the present study was to investigate the localization and distribution of the putative brain tumour stem cell marker CD133 in formalin fixed paraffin embedded astrocytomas. A retrospective analysis of 114 grade II, III and IV astrocytomas was undertaken. The immunohistochemical expression of CD133 in paraff...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-008-9648-8
更新日期：2008-11-01 00:00:00
abstract：:Malignant gliomas (MG) are very aggressive tumors. In an effort to improve the outcome, the patients receive multi-modal therapies such as surgery, radiation and chemotherapy (temozolomide followed in many cases by bevacizumab). The survivors are affected by multiple learning and memory deficits. Greater deterioration...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-016-2188-8
更新日期：2016-09-01 00:00:00
abstract：BACKGROUND:Tumor treating fields (TTFields) are anti-mitotic, non-invasive loco-regional cancer therapy comprising low intensity, intermediate frequency alternating electric fields. TTFields plus Temozolomide (TTFields/TMZ) extended survival versus TMZ alone in newly diagnosed glioblastoma (GBM) patients in the EF-14 t...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s11060-019-03361-2
更新日期：2020-02-01 00:00:00
abstract：:Immune mediated demyelinating disease (IMDD) after allogeneic hemopoietic stem cell transplant (HSCT) is rare and its etiology unclear. In this retrospective study, we identified patients who underwent HSCT between January 1992 and December 2010 and had IMDD post transplant. A total of 1,484 patients received HSCT and...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-012-0962-9
更新日期：2012-11-01 00:00:00
abstract：:Brain tumors and anti-cancer treatments can cause a wide range of cognitive deficits that in turn, being a major cause of disability, significantly affect patients' independence and quality of life. To evaluate the neurocognitive status of a non selected population of brain tumors outpatients, investigating the correl...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-013-1076-8
更新日期：2013-05-01 00:00:00
abstract：:To assess the clinical outcome and late side effect profile of pencil beam scanning proton therapy (PT) delivered to children with intracranial ependymoma. Between July-2004 and March-2013, 50 patients with intracranial ependymoma (n = 46, grade 3) received involved-field PT at Paul Scherrer Institute (PSI). Median ag...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-016-2090-4
更新日期：2016-05-01 00:00:00
abstract：:CCAAT/enhancer binding protein (C/EBP) delta is a transcription factor which has been demonstrated to mediate the growth arrest of mammary and prostate cancer cell lines. It is induced by several stimuli including inflammatory cytokines. In this study, C/EBPdelta immunohistochemical expression was assessed in 49 menin...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-009-0024-0
更新日期：2010-04-01 00:00:00
abstract：INTRODUCTION:Clinical trials directed at mechanistic target of rapamycin (mTOR) inhibition have yielded disappointing results in glioblastoma (GBM). A major mechanism of resistance involves the activation of a salvage pathway stimulating internal ribosome entry site (IRES)-mediated protein synthesis. PRMT5 activity has...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-019-03274-0
更新日期：2019-10-01 00:00:00
abstract：UNLABELLED:The pupose of this study is to assess the long-term outcome and toxicity of fractionated stereotactic radiation therapy (FSRT) and stereotactic radiosurgery (SRS) for 100 vestibular schwannomas treated at a single institution. From 1993 to 2007, 104 patients underwent were treated with radiation therapy for ...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-013-1282-4
更新日期：2014-01-01 00:00:00
abstract：PURPOSE:A major challenge to developing new therapies for patients with malignant brain tumors is that relatively few small molecule anticancer drugs penetrate the blood-brain barrier (BBB) well enough to provide therapeutically effective concentrations in brain tissue before drug exposure in non-CNS tissues results in...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-018-2992-4
更新日期：2018-12-01 00:00:00
abstract：:Primary germinomas in the spinal cord are very rare with only 15 cases published previously. In this case a 22-year-old woman with urinary incontinence, lumbago, and bilateral leg pain and weakness was found to have a solid tumor in the conus medullaris between the L1 and L2 vertebral bodies. Serum HCG was elevated wi...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-005-3092-9
更新日期：2006-01-01 00:00:00
abstract：:Cranial radiation can impact the cerebral vasculature in many ways, with a wide range of clinical manifestations. The incidence of these late effects including cerebrovascular accidents (CVAs), lacunar lesions, vascular occlusive disease including moyamoya syndrome, vascular malformations, and hemorrhage is not well k...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章,评审
doi：10.1007/s11060-015-1732-2
更新日期：2015-05-01 00:00:00
abstract：:Although bevacizumab has not proven effective in adults with newly diagnosed high-grade gliomas (HGG), feasibility in newly diagnosed children with diffuse intrinsic pontine gliomas (DIPG) or HGG has not been reported in a prospective study. In a safety and feasibility study, children and young adults with newly diagn...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-015-2008-6
更新日期：2016-03-01 00:00:00
abstract：:A case of multiple brain metastases from breast carcinoma treated with tamoxifen is described. She remained in remission for 58 months and is still alive after 82+ months of hormone therapy. The case indicates that hormonal treatment may be very effective in the management of brain metastases from breast carcinoma. ...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/BF00146879
更新日期：1991-04-01 00:00:00
abstract：:Visual field defect is a major indication for surgery of pituitary adenoma, but visual outcome after surgery is difficult to predict. We developed a nomogram that predicts postoperative restoration of visual field defects in patients with pituitary adenoma. This study was a retrospective cohort investigation of patien...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-016-2227-5
更新日期：2016-10-01 00:00:00
abstract：PURPOSE:Current medulloblastoma therapy, surgery, radiation, and chemotherapy, is unacceptably toxic. However, 13-cis retinoic acid (RA) and SAHA, a histone deacetylase inhibitor, have each been shown to induce apoptosis in medulloblastoma cultures and mouse models. Both drugs cross the blood brain barrier, have been g...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-007-9505-1
更新日期：2008-04-01 00:00:00
abstract：:Targeting tumor angiogenesis is a potential therapeutic strategy for glioblastoma because of its high vascularization. Tivozanib is an oral pan-VEGF receptor tyrosine kinase inhibitor that hits a central pathway in glioblastoma angiogenesis. We conducted a phase II study to test the effectiveness of tivozanib in patie...
journal_title：Journal of neuro-oncology
pub_type： 杂志文章
doi：10.1007/s11060-016-2332-5
更新日期：2017-02-01 00:00:00
