Scorpion venom induces glioma cell apoptosis in vivo and inhibits glioma tumor growth in vitro.

abstract：:We report a 5 year-old boy with primary anaplastic pleomorphic xanthoastrocytoma (PXA) with whole neuroaxis dissemination at diagnosis who experienced the sudden onset of generalized convulsion. Head- and spinal magnetic resonance imaging (MRI) showed widespread gadolinium (Gd)-enhanced lesions extending to the bilate...

journal_title：Journal of neuro-oncology

authors： Okazaki T,Kageji T,Matsuzaki K,Horiguchi H,Hirose T,Watanabe H,Ohnishi T,Nagahiro S

更新日期：2009-09-01 00:00:00

abstract：:Mutations in the gene encoding isocitrate dehydrogenase 1 (IDH1) have been identified in approximately 70-80 % of astrocytomas and oligodendrogliomas of WHO grades II and III, and in secondary glioblastomas. In addition, a low incidence of IDH2 mutations has been detected in these tumors, and the occurence of IDH1 and...

journal_title：Journal of neuro-oncology

authors： Ahmadi R,Stockhammer F,Becker N,Hohlen K,Misch M,Christians A,Dictus C,Herold-Mende C,Capper D,Unterberg A,von Deimling A,Wick W,Hartmann C

更新日期：2012-08-01 00:00:00

abstract：:Radiation therapy (RT) for brain tumors is associated with neurocognitive toxicity which may be a result of damage to neural progenitor cells (NPCs). We present a novel technique to limit the radiation dose to NPC without compromising tumor coverage. A study was performed in mice to examine the rationale and another w...

journal_title：Journal of neuro-oncology

authors： Redmond KJ,Achanta P,Grossman SA,Armour M,Reyes J,Kleinberg L,Tryggestad E,Quinones-Hinojosa A,Ford EC

更新日期：2011-09-01 00:00:00

abstract：:Increasing interest has developed in the use of the photodynamic agent, Hematoporphyrin derivative (HpD) for photoradiation therapy (PRT) as adjunctive therapy of malignant glial tumors of the brain. HpD, injected systemically, is preferentially taken up and retained by neoplastic tissue. Early studies of such uptake ...

journal_title：Journal of neuro-oncology

authors： Little FM,Gomer CJ,Hyman S,Apuzzo ML

更新日期：1984-01-01 00:00:00

abstract：PURPOSE:A major challenge to developing new therapies for patients with malignant brain tumors is that relatively few small molecule anticancer drugs penetrate the blood-brain barrier (BBB) well enough to provide therapeutically effective concentrations in brain tissue before drug exposure in non-CNS tissues results in...

journal_title：Journal of neuro-oncology

authors： Ciesielski MJ,Bu Y,Munich SA,Teegarden P,Smolinski MP,Clements JL,Lau JYN,Hangauer DG,Fenstermaker RA

更新日期：2018-12-01 00:00:00

abstract：:Transient cerebral hypoperfusion (TCH) has empirically been used to assist intraarterial (IA) drug delivery to brain tumors. Transient (<3 min) reduction of cerebral blood flow (CBF) occurs during many neuro- and cardiovascular interventions and has recently been used to better target IA drugs to brain tumors. In the ...

journal_title：Journal of neuro-oncology

authors： Joshi S,Singh-Moon RP,Wang M,Chaudhuri DB,Holcomb M,Straubinger NL,Bruce JN,Bigio IJ,Straubinger RM

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVE AND IMPORTANCE:Central neurocytoma is recognized as a indolent intraventricular tumor arising from the ependyma around the foramen of Monro and anterior part of the lateral ventricles, and well demarcated from the brain parenchyma. Surgical removal can be curative without postoperative therapy. However, malig...

journal_title：Journal of neuro-oncology

authors： Ogawa Y,Sugawara T,Seki H,Sakuma T

更新日期：2006-09-01 00:00:00

abstract：:Glioblastoma multiforme is the most frequent and aggressive primary brain tumor. A strong rationale to identify innovative approaches to treat these tumors is required since treatment failures result in local recurrences and median survivals range from 9 to 12 months. Glioma cells are reported to have less mitochondri...

journal_title：Journal of neuro-oncology

authors： Huang Z,Jiang J,Belikova NA,Stoyanovsky DA,Kagan VE,Mintz AH

更新日期：2010-10-01 00:00:00

abstract：:To study the clinical characteristics, treatment approach and outcome of pleomorphic xanthoastrocytoma (PXA), patients were identified using the National Cancer Intitute's Surveillance, Epidemiology, and End Results (SEER) database. A total of 214 patients were identified with PXA using the November 2010 submission. P...

journal_title：Journal of neuro-oncology

authors： Perkins SM,Mitra N,Fei W,Shinohara ET

更新日期：2012-10-01 00:00:00

abstract：:We report a 13-month-old boy with diencephalic syndrome (DS) due to an optico-hypothalamic juvenile pilocytic astrocytoma (JPA). Massive neuroaxis dissemination was identified at diagnosis. He received 6 courses of combined conventional-dose chemotherapy consisting of carboplatin (CBDCA), etoposide (VP-16), and cyclop...

journal_title：Journal of neuro-oncology

authors： Kageji T,Nagahiro S,Horiguchi H,Watanabe T,Suzuya H,Okamoto Y,Kuroda Y

更新日期：2003-05-01 00:00:00

abstract：:Glioblastomas are aggressive brain tumors that frequently recur in the subventricular zone (SVZ) despite maximal treatment. The purpose of this study was to evaluate imaging patterns of subventricular progression and impact of recurrent subventricular tumor involvement and radiation dose to patient outcome. Retrospect...

journal_title：Journal of neuro-oncology

authors： Weinberg BD,Boreta L,Braunstein S,Cha S

更新日期：2018-07-01 00:00:00

abstract：:Brain metastasis often has a poor prognosis in patients with advanced non-small cell lung cancer (NSCLC). Therefore, it is urgent to identify factors associated with lung cancer brain metastasis. Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) also known as noncoding nuclear-enriched abundant transcrip...

journal_title：Journal of neuro-oncology

authors： Shen L,Chen L,Wang Y,Jiang X,Xia H,Zhuang Z

更新日期：2015-01-01 00:00:00

abstract：:Intraspinal location of central PNET (cPNET) is very rare. We present a case, critically review all publications of primary intraspinal cPNET occurrence and discuss tendencies in clinical presentation. In several previous attempts to summarise, authors often confused cPNET with peripheral PNET (pPNET). cPNET and pPNET...

journal_title：Journal of neuro-oncology

authors： Kampman WA,Kros JM,De Jong TH,Lequin MH

更新日期：2006-03-01 00:00:00

abstract：:High-dose (1-3.5 g/m2) methotrexate (MTX) followed by whole-brain radiation therapy (WBRT) has consistently improved length of survival in primary central nervous system lymphoma (PCNSL), but the prognosis remains dismal. To optimize and enhance the dose intensity of MTX, we applied MTX at 8 g/m2 to 20 patients with P...

journal_title：Journal of neuro-oncology

authors： Watanabe T,Katayama Y,Yoshino A,Komine C,Yokoyama T,Fukushima T

更新日期：2003-05-01 00:00:00

abstract：:Anaplastic ganglioglioma (AGG) are rare central nervous system tumours. Patient and treatment factors associated with outcome are poorly defined and limited to small retrospective case series and single case reports. Using the Surveillance, Epidemiology, and End Results (SEER) cancer registry, we investigated potentia...

journal_title：Journal of neuro-oncology

authors： Selvanathan SK,Hammouche S,Salminen HJ,Jenkinson MD

更新日期：2011-12-01 00:00:00

abstract：:A prospective study was performed in patients treated with cisplatin to evaluate the occurrence and degree of central, peripheral and autonomic neuropathy and to determine the most accurate method to study this neuropathy. Twelve patients were examined before, during and after treatment. Evaluation included neurologic...

journal_title：Journal of neuro-oncology

authors： Boogerd W,ten Bokkel Huinink WW,Dalesio O,Hoppenbrouwers WJ,van der Sande JJ

更新日期：1990-12-01 00:00:00

abstract：INTRODUCTION:Carmustine (BCNU)-impregnated biodegradable polymer wafers have been shown to prolong survival in patients with recurrent malignant glioma. Interferon alfa-2b (IFNalpha(2b)) has demonstrated antitumor activity against a number of cancers, but its use in glioma has been limited. The use of these agents in c...

journal_title：Journal of neuro-oncology

authors： Olson JJ,McKenzie E,Skurski-Martin M,Zhang Z,Brat D,Phuphanich S

更新日期：2008-12-01 00:00:00

abstract：:BCNU is increasingly used in low ethanol (ETOH) concentrations, 5% dextrose-water (D5W), or normal saline (NS) solutions, especially for intra-arterial and prolonged (e.g., 3 day) intravenous (IV) infusions. Little work, however, has been done to evaluate BCNU decomposition rates in concentrations, diluents, and tempe...

journal_title：Journal of neuro-oncology

authors： Tepe P,Hassenbusch SJ,Benoit R,Anderson JH

更新日期：1991-04-01 00:00:00

abstract：:Papillary meningioma is a rare subtype of meningioma that often behaves aggressively. In order to characterize factors that may influence this behavior, we chose to compare MIB-1 labeling index (LI) and telomerase RNA localization (hTR) in papillary meningiomas, meningiomas, and atypical meningiomas. LI is now often u...

journal_title：Journal of neuro-oncology

authors： Rushing EJ,Colvin SM,Gazdar A,Miura N,White CL 3rd,Coimbra C,Burns DK

更新日期：1999-01-01 00:00:00

abstract：:Malignant gliomas (MG) are very aggressive tumors. In an effort to improve the outcome, the patients receive multi-modal therapies such as surgery, radiation and chemotherapy (temozolomide followed in many cases by bevacizumab). The survivors are affected by multiple learning and memory deficits. Greater deterioration...

journal_title：Journal of neuro-oncology

authors： Nolen SC,Lee B,Shantharam S,Yu HJ,Su L,Billimek J,Bota DA

更新日期：2016-09-01 00:00:00

abstract：PURPOSE:Therapeutic intervention at glioblastoma (GBM) progression, as defined by current assessment criteria, is arguably too late as second-line therapies fail to extend survival. Still, most GBM trials target recurrent disease. We propose integration of a novel imaging biomarker to more confidently and promptly defi...

journal_title：Journal of neuro-oncology

authors： Gatson NTN,Bross SP,Odia Y,Mongelluzzo GJ,Hu Y,Lockard L,Manikowski JJ,Mahadevan A,Kazmi SAJ,Lacroix M,Conger AR,Vadakara J,Nayak L,Chi TL,Mehta MP,Puduvalli VK

更新日期：2020-07-01 00:00:00

abstract：:Mitochondrial dysfunction is putatively central to glioblastoma (GBM) pathophysiology but there has been no systematic analysis in GBM of the proteins which are integral to mitochondrial function. Alterations in proteins in mitochondrial enriched fractions from patients with GBM were defined with label-free liquid chr...

journal_title：Journal of neuro-oncology

authors： Deighton RF,Le Bihan T,Martin SF,Gerth AMJ,McCulloch M,Edgar JM,Kerr LE,Whittle IR,McCulloch J

更新日期：2014-06-01 00:00:00

abstract：:The leucine-rich repeats and immunoglobulin-like domains (LRIG) protein family is comprised of three integral membrane proteins: LRIG1, LRIG2, and LRIG3. LRIG1 is a negative regulator of growth factor signaling. The expression and subcellular localization of LRIG proteins have prognostic implications in primary brain ...

journal_title：Journal of neuro-oncology

authors： Ghasimi S,Haapasalo H,Eray M,Korhonen K,Brännström T,Hedman H,Andersson U

更新日期：2012-07-01 00:00:00

abstract：:The EORTC trial which solidified the role of external beam radiotherapy (EBRT) plus temozolomide (TMZ) in the management of GBM excluded patients over age 70. Randomized studies of elderly patients showed that hypofractionated EBRT (HFRT) alone or TMZ alone was at least equivalent to conventionally fractionated EBRT (...

journal_title：Journal of neuro-oncology

authors： Glaser SM,Dohopolski MJ,Balasubramani GK,Flickinger JC,Beriwal S

更新日期：2017-08-01 00:00:00

abstract：:Glioblastoma Multiforme frequently metastasises from their original location by for example infiltration along white matter tracts [1]. GBM metastasis outside the central nervous system is distinctly rare though there are previous reports of spread to various organs [2-5]. We add an unusual case of a patient with aggr...

journal_title：Journal of neuro-oncology

authors： Ogungbo BI,Perry RH,Bozzino J,Mahadeva D

更新日期：2005-09-01 00:00:00

abstract：:This study aimed to explore the safety and efficacy of multisession gamma knife surgery (GKS) for large brain metastases with a volume of 10 cm3 or larger. Fifty-six patients who had 65 brain metastases with a volume of at least 10 cm3 were treated with multisession GKS. Three-session GKS at a prescription dose of 10 ...

journal_title：Journal of neuro-oncology

authors： Hasegawa T,Kato T,Yamamoto T,Iizuka H,Nishikawa T,Ito H,Kato N

更新日期：2017-02-01 00:00:00

abstract：OBJECT:Etoposide, a topoisomerase-II inhibitor promotes DNA damage and apoptosis of cancer cells. In this study, we have examined the ability of the histone deacetylase inhibitor, valproic acid (VPA) to modulate gene expression and sensitize glioblastoma cell lines to the cytotoxic effects of etoposide in vitro. METHO...

journal_title：Journal of neuro-oncology

authors： Das CM,Aguilera D,Vasquez H,Prasad P,Zhang M,Wolff JE,Gopalakrishnan V

更新日期：2007-11-01 00:00:00

abstract：:Stereotactic radiosurgery is a frequently performed procedure for patients with benign intracranial tumors. Benign tumors are good candidates for radiosurgery because they are generally non-invasive, are well visualized by magnetic resonance imaging, and their slow rate of proliferation makes conventional radiation do...

journal_title：Journal of neuro-oncology

authors： Pollock BE

更新日期：2009-05-01 00:00:00

abstract：:Data concerning treatment of secondary glioblastoma evolving from previously treated WHO II or III grade tumors are very scarce. The aim of this study was to evaluate the impact of surgical resection and adjuvant treatment on survival in patients with secondary glioblastoma. Thirty-nine patients with secondary gliobla...

journal_title：Journal of neuro-oncology

authors： Hamisch C,Ruge M,Kellermann S,Kohl AC,Duval I,Goldbrunner R,Grau SJ

更新日期：2017-06-01 00:00:00

abstract：:A thirty-year-old male with an intracranial malignant meningioma, first diagnosed 9 years ago, with three recurrences was admitted with a hypoglycemic shock. The blood glucose level was 17 mg/dl, requiring treatment with high doses of intravenous and oral dextrose for improvement. A large metastatic tumor in the liver...

journal_title：Journal of neuro-oncology

authors： Yoshida D,Sugisaki Y,Tamaki T,Saitoh N,Node Y,Shimura T,Teramoto A

更新日期：2000-03-01 00:00:00