Cognitive impairment in primary brain tumors outpatients: a prospective cross-sectional survey.

abstract：PURPOSE:Postoperative stereotactic radiosurgery (SRS) has been shown to establish local control in patients with resected brain metastases, yet its efficacy may be limited, particularly for resected lesions with large post-operative resection cavities. We describe the efficacy of postoperative fractionated stereotactic...

journal_title：Journal of neuro-oncology

authors： Traylor JI,Habib A,Patel R,Muir M,Gadot R,Briere T,Yeboa DN,Li J,Rao G

更新日期：2019-09-01 00:00:00

abstract：:We have expressed the tumor suppressor p16 under the control of a tetracycline-sensitive promoter in two human glioblastoma cell lines which do not contain endogenous p16. Ectopic p16 expression led to a stable but reversible G1 phase cell cycle arrest, reduced the growth of both cell lines in cell culture, and almost...

journal_title：Journal of neuro-oncology

authors： Simon M,Simon C,Köster G,Hans VH,Schramm J

更新日期：2002-10-01 00:00:00

abstract：INTRODUCTION:The field of neurosurgery has witnessed a dramatic increase in the use of stereotactic radiosurgery (SRS) as a modality to treat various cranial and spinal pathologies. However, studies have consistently demonstrated disparities in SRS training. Accordingly, the present study represents a cross-sectional a...

journal_title：Journal of neuro-oncology

authors： Samuel N,Trifiletti DM,Quinones-Hinojosa A,Lunsford LD,Sheehan J

更新日期：2021-01-04 00:00:00

abstract：:The time to tumor progression (TTP), time to death (TTD) and complications were studied prospectively in a cohort of patients treated by surgery and adjuvant radio- and intensified PCV chemotherapy for astrocytomas (AIII), oligodendrogliomas (OIII) and oligoastrocytomas (OAIII) WHO grade III. The treatment was carried...

journal_title：Journal of neuro-oncology

authors： Kristof RA,Neuloh G,Hans V,Deckert M,Urbach H,Schlegel U,Simon M,Schramm J

更新日期：2002-09-01 00:00:00

abstract：:To cast light on the mechanisms of drug-resistance, experimental brain tumors were immunohistochemically evaluated for expression of glutathione S-transferase (GST)-alpha, mu, pi, p-glycoprotein and apoptosis-related factors, such as bcl-2 and p53, as well as by the terminal deoxynucleotidyl transferase-mediated dUTP-...

journal_title：Journal of neuro-oncology

authors： Yabuno T,Konishi N,Nakamura M,Tsuzuki T,Tsunoda S,Sakaki T,Hiasa Y

更新日期：1998-01-01 00:00:00

abstract：:Disparities in American health care based on socially-defined patient characteristics such as race, ethnicity, and socioeconomic position are well-documented. We review differences and disparities in incidence, pathobiology, processes and outcomes of care, and survival based on social factors for brain tumors of all h...

journal_title：Journal of neuro-oncology

authors： Curry WT Jr,Barker FG 2nd

更新日期：2009-05-01 00:00:00

abstract：:We report the case of a 72-year-old woman with primary CNS lymphoma of the mid-brain and pons who had a complete response to oral temozolomide chemotherapy. She initially presented in early 2001 with several weeks of progressive memory loss and unresponsiveness. Because of her age and impaired renal function, she was ...

journal_title：Journal of neuro-oncology

authors： Lerro KA,Lacy J

更新日期：2002-09-01 00:00:00

abstract：:NF1, NF2, and Schwannomatosis are incurable tumor suppressor syndromes associated with poor quality of life. The aim of this study was to determine the feasibility, acceptability, and preliminary efficacy of an NF adapted, 8-week group mind body skills based intervention, the relaxation response resiliency program (3R...

journal_title：Journal of neuro-oncology

authors： Vranceanu AM,Merker VL,Plotkin SR,Park ER

更新日期：2014-10-01 00:00:00

abstract：:The aim of this work was to determine the accuracy and precision of stereotactic localization and treatment delivery using a helical tomotherapy based stereotactic radiosurgery (SRS) system. A tomotherapy specific radiosurgery workflow was designed that exploits the system's on board megavotage CT (MVCT) imaging syste...

journal_title：Journal of neuro-oncology

authors： Soisson ET,Hardcastle N,Tomé WA

更新日期：2010-06-01 00:00:00

abstract：:While the 5-year overall survival is better in pediatric than in adult patients diagnosed with glioblastoma (GBM), outcomes in children remain very poor. Understanding the mechanisms of tumorigenesis and tumor propagation can identify therapeutic targets to improve these outcomes. Human cytomegalovirus (CMV) proteins ...

journal_title：Journal of neuro-oncology

authors： Wakefield A,Pignata A,Ghazi A,Ashoori A,Hegde M,Landi D,Gray T,Scheurer ME,Chintagumpala M,Adesina A,Gottschalk S,Hicks J,Powell SZ,Ahmed N

更新日期：2015-11-01 00:00:00

abstract：:Intracranial metastatic prostate carcinoma is rare. We sought to determine the clinical outcomes after Gamma Knife stereotactic radiosurgery (GKSRS) for patients with intracranial prostate carcinoma metastases. We studied data from 10 patients who underwent radiosurgery for 15 intracranial metastases (9 dural-based an...

journal_title：Journal of neuro-oncology

authors： Flannery T,Kano H,Niranjan A,Monaco EA 3rd,Flickinger JC,Lunsford LD,Kondziolka D

更新日期：2010-02-01 00:00:00

abstract：:Intramedullary spinal cord metastases of solid neoplasms are associated with poor long-term survival. As the characteristics of secondary intramedullary spinal cord non-Hodgkin's lymphoma (NHL) are not well understood, we sought to describe its clinical features and outcome. We retrospectively reviewed the Mayo Clinic...

journal_title：Journal of neuro-oncology

authors： Flanagan EP,O'Neill BP,Habermann TM,Porter AB,Keegan BM

更新日期：2012-05-01 00:00:00

abstract：:Serious dermatologic adverse events such as erythema multiforme (EM) and Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) have been reported in patients receiving antiepileptic drugs (AEDs) and cranial radiotherapy (RT). Given the frequency of AED-associated rashes and the infrequency of serious dermatolo...

journal_title：Journal of neuro-oncology

authors： Bishop AJ,Chang M,Lacouture ME,Barker CA

更新日期：2014-08-01 00:00:00

abstract：:To study the clinical characteristics, treatment approach and outcome of pleomorphic xanthoastrocytoma (PXA), patients were identified using the National Cancer Intitute's Surveillance, Epidemiology, and End Results (SEER) database. A total of 214 patients were identified with PXA using the November 2010 submission. P...

journal_title：Journal of neuro-oncology

authors： Perkins SM,Mitra N,Fei W,Shinohara ET

更新日期：2012-10-01 00:00:00

abstract：:Gemistocytic astrocytoma still continues to be enigmatic; both in terms of definition and prognostic implications. The major issue of contention has been the clinical relevance of this pathological entity. The currently accepted definition of gemistocytic astrocytoma requires 20% or more gemistocytes, and considers th...

journal_title：Journal of neuro-oncology

authors： Tihan T,Vohra P,Berger MS,Keles GE

更新日期：2006-01-01 00:00:00

abstract：:Although stereotactic radiosurgery (SRS) is an effective treatment option for patients with brain tumors, its increased use has raised concern for increased incidence of radiation necrosis (RN). No established standard or guidelines exists regarding non-invasive techniques to diagnose or treat RN. This study was condu...

journal_title：Journal of neuro-oncology

authors： Stockham AL,Ahluwalia M,Reddy CA,Suh JH,Kumar A,Vogelbaum MA,Barnett GH,Murphy ES,Chao ST

更新日期：2013-12-01 00:00:00

abstract：:Two patients with metastasis from lung carcinoma of the midbrain are presented. The computerized tomographic (CT) findings mimicked a primary pineal tumor, but autopsy confirmed a metastatic nodule in the midbrain in both cases. The rational approach to posterior third ventricular tumors seen on CT in adulthood is dis...

journal_title：Journal of neuro-oncology

authors： Tomita T,Wetzel N

更新日期：1984-01-01 00:00:00

abstract：:Anguidine pretreatment was previously shown to potentiate cis-platinum in Chinese hamster ovary cells by 100-fold, probably by enhancing cellular cis-platinum uptake. Since both cis-platinum and anguidine have been reported to have clinical efficacy in human brain tumors, the present study was initiated to investigate...

journal_title：Journal of neuro-oncology

authors： Hromas RA,Yung WK

更新日期：1986-01-01 00:00:00

abstract：:The aim of this study is to investigate the anti-cancer effect of the bispecific diphtheria toxin (DT) based immunotoxin DTATEGF, which targets both the epidermal growth factor (EGF) receptor (EGFR) and the urokinase-type plasminogen activator (uPA) receptor (uPAR) in vitro and in vivo when delivered by convection-enh...

journal_title：Journal of neuro-oncology

authors： Huang J,Li YM,Massague J,Sicheneder A,Vallera DA,Hall WA

更新日期：2012-09-01 00:00:00

abstract：:O(6)-methylguanine-DNA-methyltransferase (MGMT) is mainly regulated by cytosine-guanine island promoter methylation that is believed to occur only in neoplastic tissue. The present study was undertaken to investigate whether methylation occurs also in non-neoplastic brains by collecting 45 non-neoplastic brains from a...

journal_title：Journal of neuro-oncology

authors： Hsu CY,Ho HL,Chang-Chien YC,Chang YW,Ho DM

更新日期：2015-02-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) are important modulators of various cellular and molecular events, including cancer-associated pathways. The Anti-differentiation ncRNA (ANCR) is a key regulator of keratinocyte differentiation, where its expression is necessary to maintain epidermal progenitor's cells. Herein, we invest...

journal_title：Journal of neuro-oncology

authors： Malakootian M,Mirzadeh Azad F,Fouani Y,Taheri Bajgan E,Saberi H,Mowla SJ

更新日期：2018-06-01 00:00:00

abstract：:Pituitary tumors were experimentally induced in female Wistar rats by repeated injections of estradiol dipropionate. The hypothalamus and pituitary tumors were studied simultaneously by fluorescence histochemistry and immunohistochemistry. The pituitary gland became larger with a concomitant increase of serum prolacti...

journal_title：Journal of neuro-oncology

authors： Fujimoto M,Yoshino E,Hirakawa K,Chihara K,Ibata Y

更新日期：1987-01-01 00:00:00

abstract：:Optimal treatment of recurrent glioblastoma multiforme (rGBM) in elderly and/or frail patients remains virtually unexplored, the best supportive care (BSC) only is routinely administered due to the fatal prognosis. We evaluated the impact of different treatment methods on post-progression survival (PPS) and overall su...

journal_title：Journal of neuro-oncology

authors： Socha J,Kepka L,Ghosh S,Roa W,Kumar N,Sinaika V,Matiello J,Lomidze D,de Castro DG,Hentati D,Fidarova E

更新日期：2016-02-01 00:00:00

abstract：:In the treatment of malignant glioma, chemotherapy plays a critical role as do surgical resection and irradiation. Cepharanthine (CEP), a biscoclaurine-derived alkaloid, reportedly potentiates the effects of antitumor agents and induces apoptosis in some cancer cells. Here, we examined the effects of CEP, alone and in...

journal_title：Journal of neuro-oncology

authors： Kono K,Takahashi JA,Ueba T,Mori H,Hashimoto N,Fukumoto M

更新日期：2002-01-01 00:00:00

abstract：:Primary brain tumor patients experience high levels of distress. The purpose of this cross-sectional, retrospective study is to evaluate the level and different sources of psychosocial distress and how these pertain to health-related quality of life (HRQoL). The Primary and Recurrent Glioma registry at Duke's The Pres...

journal_title：Journal of neuro-oncology

authors： Randazzo DM,McSherry F,Herndon JE 2nd,Affronti ML,Lipp ES,Flahiff C,Miller E,Woodring S,Freeman M,Healy P,Minchew J,Boulton S,Desjardins A,Vlahovic G,Friedman HS,Keir S,Peters KB

更新日期：2017-09-01 00:00:00

abstract：:This paper presents a study of the effects of scanning parameters variability when assessing glioma sizes on MRI. A database of lesions of various shapes and sizes, segmented on 3D-SPGR MRI images, was acquired on 65 patients with low-grade glioma. Simulations of large slice thickness and patient's head rotation were ...

journal_title：Journal of neuro-oncology

authors： Schmitt P,Mandonnet E,Perdreau A,Angelini ED

更新日期：2013-04-01 00:00:00

abstract：:Glioblastoma is the most common and most aggressive primary brain tumor. Despite maximum treatment, patients only have a median survival time of 15 months, because of the tumor's resistance to current therapeutic approaches. Thus far, methylation of the O (6)-methylguanine-DNA methyltransferase (MGMT) promoter has bee...

journal_title：Journal of neuro-oncology

authors： Bleeker FE,Molenaar RJ,Leenstra S

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:There is an increasing interest in local tumor ablative treatment modalities that induce immunogenic cell death and the generation of antitumor immune responses. METHODS:We report six recurrent glioblastoma patients who were treated with intracavitary thermotherapy after coating the resection cavity wall wi...

journal_title：Journal of neuro-oncology

authors： Grauer O,Jaber M,Hess K,Weckesser M,Schwindt W,Maring S,Wölfer J,Stummer W

更新日期：2019-01-01 00:00:00

abstract：INTRODUCTION:Intracranial meningiomas rarely present with multiple lesions. To the best of our knowledge, current literature regarding meningiomatosis (MM) is mostly comprised of small case series and individual reports. Hence, survival outcome data are limited. The Objective of this study is to explore the influence o...

journal_title：Journal of neuro-oncology

authors： Ramos-Fresnedo A,Domingo RA,Vivas-Buitrago T,Lundy L,Trifiletti DM,Jentoft ME,Desai AB,Quiñones-Hinojosa A

更新日期：2020-09-01 00:00:00

abstract：:Magnetic resonance imaging (MRI) or computerized tomography (CT) is routinely performed after resection of brain metastases (BrM), regardless of whether there are specific clinical concerns about residual tumor or potential complications. Routine imaging studies contribute a significant amount to the cost of medical c...

journal_title：Journal of neuro-oncology

authors： Benveniste RJ,Ferraro N,Tsimpas A

更新日期：2014-06-01 00:00:00