当前位置： SCI文献检索 > JOURNAL OF NEURO-ONCOLOGY期刊下所有文献 > The cell growth inhibitory transcription factor C/EBPdelta is expressed in human meningiomas in association with low histological grade and proliferation index.

The cell growth inhibitory transcription factor C/EBPdelta is expressed in human meningiomas in association with low histological grade and proliferation index.

Abstract：

:CCAAT/enhancer binding protein (C/EBP) delta is a transcription factor which has been demonstrated to mediate the growth arrest of mammary and prostate cancer cell lines. It is induced by several stimuli including inflammatory cytokines. In this study, C/EBPdelta immunohistochemical expression was assessed in 49 meningiomas of different histotype and grade and correlated with a variety of clinico-pathological data and with the overall and recurrence-free survival of the patients. Positive staining was observed in the nuclei of neoplastic cells in 22 out of the 49 cases analyzed. C/EBPdelta expression was significantly associated with a low histological grade and proliferation index, reflected by low Ki-67 labeling index (LI) and mitotic activity, and with the presence of intra-tumoral inflammatory infiltrate and the absence of necrosis. In addition, the absence of C/EBPdelta was significantly correlated with a shorter disease-free interval. Our findings suggest that C/EBPdelta expression may prevent the development of recurrences by inhibition of neoplastic growth in meningiomas. If further studies confirm its induction by inflammatory mediators, this might be exploited in novel therapies to prevent recurrences in meningiomas.

journal_name

J Neurooncol

journal_title

Journal of neuro-oncology

authors

Barresi V,Vitarelli E,Cerasoli S,Barresi G

doi

10.1007/s11060-009-0024-0

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

233-40

issue

2

eissn

0167-594X

issn

1573-7373

journal_volume

97

pub_type

杂志文章

相关文献

JOURNAL OF NEURO-ONCOLOGY文献大全
  • Epilepsy in cerebral glioma: timing of appearance and histological correlations.

    abstract：PURPOSE:A prospective study of patients with glioma was carried out. Special attention was paid to the first seizure, to the histology, and to the efficacy and prophylactic role of antiepileptic drugs (AEDs). Prognostic factors were analyzed. METHODS:Between February 1st 2004 and April 1st 2006 patients who underwent ...

    journal_title：Journal of neuro-oncology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s11060-009-9796-5

    authors： Rosati A,Tomassini A,Pollo B,Ambrosi C,Schwarz A,Padovani A,Bonetti B

    更新日期：2009-07-01 00:00:00

  • Evaluation of matrix metalloproteinase type IV-collagenases in serum of patients with tumors of the central nervous system.

    abstract：:The basement membrane collagen IV-degrading matrix metalloproteinases -2 and -9 (MMPs) are most often linked to the malignant phenotype of tumor cells by playing a critical role in invasion, metastasis, angiogenesis, and vasculogenesis. We verified the activity of these two MMPs in the sera of patients affected by bra...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-016-2297-4

    authors： Ricci S,Guadagno E,Bruzzese D,Del Basso De Caro M,Peca C,Sgulò FG,Maiuri F,Di Carlo A

    更新日期：2017-01-01 00:00:00

  • A prospective blinded study of the predictive value of an extreme drug resistance assay in patients receiving CPT-11 for recurrent glioma.

    abstract：:This adjunct to a prospective phase II blinded study of 48 patients with recurrent malignant glioma evaluated the predictive reliability of an extreme drug resistance (EDR) to identify clinical resistance to irinotecan (CPT-11), using fresh tumor biopsies obtained from recurrent patients immediately prior to their fir...

    journal_title：Journal of neuro-oncology

    pub_type： 临床试验,杂志文章

    doi：10.1023/b:neon.0000014549.77646.f6

    authors： Parker RJ,Fruehauf JP,Mehta R,Filka E,Cloughesy T

    更新日期：2004-02-01 00:00:00

  • Prediction value of unmeasurable MR enhancement at early stage after gross-total resection on the survival state of patients with high-grade glioma.

    abstract：PROPOSE:To explore the value of unmeasurable enhancement pattern of residual cavity in predicting survival at early stage after gross-total resection in high-grade glioma (HGG) patients. METHODS:This retrospective study enrolled consecutive 51 HGG patients with unmeasurable enhancement who underwent gross-total resect...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-018-2961-y

    authors： Quan G,Zheng Y,Chen J,Hua B,Ji X,Zhang K,Gao D,Lei J,Yuan T

    更新日期：2018-11-01 00:00:00

  • Is CMV a target in pediatric glioblastoma? Expression of CMV proteins, pp65 and IE1-72 and CMV nucleic acids in a cohort of pediatric glioblastoma patients.

    abstract：:While the 5-year overall survival is better in pediatric than in adult patients diagnosed with glioblastoma (GBM), outcomes in children remain very poor. Understanding the mechanisms of tumorigenesis and tumor propagation can identify therapeutic targets to improve these outcomes. Human cytomegalovirus (CMV) proteins ...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-015-1905-z

    authors： Wakefield A,Pignata A,Ghazi A,Ashoori A,Hegde M,Landi D,Gray T,Scheurer ME,Chintagumpala M,Adesina A,Gottschalk S,Hicks J,Powell SZ,Ahmed N

    更新日期：2015-11-01 00:00:00

  • How parents cope with their child's diagnosis and treatment of an embryonal tumor: results of a prospective and longitudinal study.

    abstract：:The current study reports longitudinal coping responses among parents of children diagnosed with an embryonal brain tumor. Patients (n = 219) were enrolled on a treatment protocol for a pediatric embryonal brain tumor. Their parents (n = 251) completed the Coping Response Inventory at time of their child's diagnosis a...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s11060-011-0574-9

    authors： Palmer SL,Lesh S,Wallace D,Bonner MJ,Swain M,Chapieski L,Janzen L,Mabbott D,Knight S,Boyle R,Armstrong CL,Gajjar A

    更新日期：2011-11-01 00:00:00

  • Waiting times before initiation of radiotherapy might not affect outcomes for patients with glioblastoma: a French retrospective analysis of patients treated in the era of concomitant temozolomide and radiotherapy.

    abstract：:Purpose of this study was to determine the effect of waiting time for radiotherapy on overall survival of patients with glioblastoma treated in the EORTC-NCIC trial at 18 centers in France. A total of 400 adult patients with glioblastoma who were treated between January 1, 2006 and December 31, 2006 were included. The...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-012-0883-7

    authors： Noel G,Huchet A,Feuvret L,Maire JP,Verrelle P,Le Rhun E,Aumont M,Thillays F,Sunyach MP,Henzen C,Missohou F,de Crevoisier R,Bondiau PY,Collin P,Durando X,Truc G,Kerr C,Bernier V,Clavier JB,Atlani D,D'Hombres A,Vi

    更新日期：2012-08-01 00:00:00

  • Expression of TrkA, TrkB and TrkC in human neuroblastomas.

    abstract：:There is considerable interest in the role of the TRK family of neurotrophin receptors in regulating the survival, growth and differentiation of normal and neoplastic nerve cells. Indeed, there is increasing evidence that TRK genes play an important role in the biology and clinical behavior of neuroblastomas, tumors o...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1023/a:1005729329526

    authors： Brodeur GM,Nakagawara A,Yamashiro DJ,Ikegaki N,Liu XG,Azar CG,Lee CP,Evans AE

    更新日期：1997-01-01 00:00:00

  • Effect of intracarotid infusion of etoposide with angiotensin II-induced hypertension on the blood-brain barrier and the brain tissue.

    abstract：:This study investigated the effects of the intracarotid infusion of etoposide in combination with angiotensin II (AT II)-induced hypertension on the blood-brain barrier (BBB) and brain tissue in rats. Eighty rats were divided into five groups: Group 1, intravenous infusion of AT II to increase arterial blood pressure;...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/BF00172760

    authors： Ogasawara H,Kiya K,Kurisu K,Hotta T,Mikami T,Sugiyama K,Nakahara T,Uozumi T

    更新日期：1992-06-01 00:00:00

  • A systematic review and meta-analysis of outcomes in pediatric, recurrent ependymoma.

    abstract：PURPOSE:The purpose of this study was to determine outcomes in recurrent pediatric ependymoma. METHODS:We performed a systematic review of PubMed, Embase, Web of Science and the Cochrane Library for studies reporting on survival outcomes for pediatric patients with recurrent ependymoma. We then performed a meta-analys...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,meta分析

    doi：10.1007/s11060-019-03255-3

    authors： Byer L,Kline CN,Coleman C,Allen IE,Whitaker E,Mueller S

    更新日期：2019-09-01 00:00:00

  • PTEN inhibits adrenomedullin expression and function in brain tumor cells.

    abstract：:Adrenomedullin is a vasoactive peptide that is upregulated in higher-grade gliomas and promotes tumor cell proliferation. Since reduced activity of the anti-oncogene PTEN seems to also correlate with higher tumor grade, this suggests an inverse association between PTEN activity and adrenomedullin expression. PC12 pheo...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-005-9035-7

    authors： Betchen SA,Musatov S,Roberts J,Pena J,Kaplitt MG

    更新日期：2006-09-01 00:00:00

  • Randomized prospective trial of fractionated stereotactic radiosurgery with chemotherapy versus chemotherapy alone for bevacizumab-resistant high-grade glioma.

    abstract：PURPOSE:Outcomes for patients with recurrent high-grade glioma (HGG) progressing on bevacizumab (BEV) are dismal. Fractionated stereotactic radiosurgery (FSRS) has been shown to be feasible and safe when delivered in this setting, but prospective evidence is lacking. This single-institution randomized trial compared FS...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-020-03526-4

    authors： Bergman D,Modh A,Schultz L,Snyder J,Mikkelsen T,Shah M,Ryu S,Siddiqui MS,Walbert T

    更新日期：2020-06-01 00:00:00

  • Neural differentiation arrest in embryonal carcinoma cells with forced expression of EWS-FLI1.

    abstract：:Ewing's sarcoma/primitive neuroectodermal tumor (EWS/PNET) has a characteristic chimeric oncogene EWS-FLI1, which results from chromosomal translocation t (11; 22), that is believed to initiate tumorigenesis of EWS/PNET. However, the specific details of EWS/PNET oncogenesis and exact role of EWS-FLI1 remain largely un...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-008-9646-x

    authors： Yang Y,Zhang L,Wei Y,Wang H,Fukuma M,Xu H,Xiong W,Zheng J

    更新日期：2008-11-01 00:00:00

  • Blocking COX-2 induces apoptosis and inhibits cell proliferation via the Akt/survivin- and Akt/ID3 pathway in low-grade-glioma.

    abstract：:Approximately half of surgically-treated patients with low-grade-glioma (LGG) suffer recurrence or metastasis. Currently there is no effective drug treatment. While the selective COX-2 inhibitor celecoxib showed anti-neoplastic activity against several malignant tumors, its effects against LGG remain to be elucidated....

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-017-2380-5

    authors： Sato A,Mizobuchi Y,Nakajima K,Shono K,Fujihara T,Kageji T,Kitazato K,Matsuzaki K,Mure H,Kuwayama K,Sumi A,Saya H,Sampetrean O,Nagahirao S

    更新日期：2017-04-01 00:00:00

  • Stereotactic radiosurgical treatment of brain metastasis of primary tumors that rarely metastasize to the central nervous system.

    abstract：:We evaluated the local control of gamma knife stereotactic radiosurgery (GKSRS) in the treatment of cerebral metastases from primary tumors that rarely metastasize to the central nervous system (CNS). There is little published data on this subject with very few series on specific primary tumors. We present our experie...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-012-0916-2

    authors： Menendez JY,Bauer DF,Shannon CN,Fiveash J,Markert JM

    更新日期：2012-09-01 00:00:00

  • Temozolomide for malignant primary spinal cord glioma: an experience of six cases and a literature review.

    abstract：:Malignant primary spinal cord gliomas (PSCGs) are rare, and the optimal treatment for these lesions remains controversial. We report herein treatment outcomes of six malignant PSCGs managed with temozolomide (TMZ)-based multidisciplinary treatment. TMZ was administered concomitantly with fractionated radiotherapy for ...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,评审

    doi：10.1007/s11060-010-0249-y

    authors： Kim WH,Yoon SH,Kim CY,Kim KJ,Lee MM,Choe G,Kim IA,Kim JH,Kim YJ,Kim HJ

    更新日期：2011-01-01 00:00:00

  • Salvage chemotherapy with CPT-11 for recurrent glioblastoma multiforme.

    abstract：BACKGROUND:A prospective Phase II study of CPT-11 in adult patients with recurrent supratentorial glioblastoma multiforme (GBM). METHODS:Forty patients (25 men, 15 women) ages 32-71 years (median 59), with recurrent GBM were treated. All patients had previously been treated with surgery and involved field radiotherapy...

    journal_title：Journal of neuro-oncology

    pub_type： 临床试验,杂志文章

    doi：10.1023/a:1014532202188

    authors： Chamberlain MC

    更新日期：2002-01-01 00:00:00

  • Outcome and prognostic features in anaplastic ganglioglioma: analysis of cases from the SEER database.

    abstract：:Anaplastic ganglioglioma (AGG) are rare central nervous system tumours. Patient and treatment factors associated with outcome are poorly defined and limited to small retrospective case series and single case reports. Using the Surveillance, Epidemiology, and End Results (SEER) cancer registry, we investigated potentia...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-011-0615-4

    authors： Selvanathan SK,Hammouche S,Salminen HJ,Jenkinson MD

    更新日期：2011-12-01 00:00:00

  • Time from stereotactic radiosurgery to immunotherapy in patients with melanoma brain metastases and impact on outcome.

    abstract：BACKGROUND:The role of immunotherapy for metastatic melanoma has expanded over the past decade triggering questions regarding the combination and timing of immunotherapy and radiation for brain metastases. We used the National Cancer Database (NCDB) to see if the time from radiation to immunotherapy in patients with me...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-020-03663-w

    authors： Wegner RE,Abel S,D'Amico RS,Mehta GU,Sheehan J

    更新日期：2021-01-11 00:00:00

  • Prospective study of paclitaxel-induced peripheral neuropathy with quantitative sensory testing.

    abstract：BACKGROUND:Paclitaxel-induced peripheral neuropathy (PN) may be severe and dose-limiting at initial doses > or = 275 mg/M2, but its neurotoxicity at doses < or = 250 mg/M2 has been incompletely characterized. The purposes of this study were to characterize and quantify paclitaxel-induced PN and to determine the utility...

    journal_title：Journal of neuro-oncology

    pub_type： 临床试验,杂志文章

    doi：10.1023/a:1005805907311

    authors： Forsyth PA,Balmaceda C,Peterson K,Seidman AD,Brasher P,DeAngelis LM

    更新日期：1997-10-01 00:00:00

  • Radio-induced gliomas: 20-year experience and critical review of the pathology.

    abstract：:The authors report their personal experience with a surgical series of 16 cases of cerebral radiation-induced gliomas, defining diagnostic criteria and surgical and clinical characteristics. There were ten males and six females, with a median age of 45.9 years. Irradiation had initially been given for acute lymphoblas...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-008-9565-x

    authors： Salvati M,D'Elia A,Melone GA,Brogna C,Frati A,Raco A,Delfini R

    更新日期：2008-09-01 00:00:00

  • Particular features of cell-mediated immunity in patients with anaplastic gliomas. A comparison with kidney and bladder cancer patients.

    abstract：:The authors studied 24 patients affected by anaplastic gliomas in regard to the killer (Antibody-Dependent Cellular Cytotoxicity) and natural killer (Spontaneous Lymphocyte-Mediated Cytotoxicity) immunological functions, by counting the Cr51 release in Change liver and K 562 cell cultures, respectively. These paramete...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/BF00165716

    authors： Servadei F,Parente R,Bucci M,Beltrandi E,Tognetti F,Gaist G

    更新日期：1983-01-01 00:00:00

  • Response of preclinical medulloblastoma models to combination therapy with 13-cis retinoic acid and suberoylanilide hydroxamic acid (SAHA).

    abstract：PURPOSE:Current medulloblastoma therapy, surgery, radiation, and chemotherapy, is unacceptably toxic. However, 13-cis retinoic acid (RA) and SAHA, a histone deacetylase inhibitor, have each been shown to induce apoptosis in medulloblastoma cultures and mouse models. Both drugs cross the blood brain barrier, have been g...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-007-9505-1

    authors： Spiller SE,Ditzler SH,Pullar BJ,Olson JM

    更新日期：2008-04-01 00:00:00

  • Factor analysis of the immunophenotypes of astrocytomas and malignant gliomas: correlations with tumor grade and patient survival.

    abstract：:Our previous investigations correlated the degree of cytogenetic and immunophenotypic heterogeneity of cultured normal glia, astrocytomas and malignant gliomas. The possible significance was suggested by the statistical correlation of individual antigens with diagnosis and patient survival. The present study has estab...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/BF02341157

    authors： Jennings MT,Asadourian LL,Jennings VD,Shapiro JR,Thaler HT

    更新日期：1990-12-01 00:00:00

  • Extraneural metastatic medulloblastoma in an adult.

    abstract：:Medulloblastoma is a rare malignancy in adults, accounting for approximately 1% of all primary brain tumors. Extraneural metastases have been reported in 10-30% of cases and most commonly involve bone; rarely lymph nodes, visceral organs and bone marrow may be involved with disease. We report here our experience with ...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-005-9087-8

    authors： Wendland MM,Shrieve DC,Watson GA,Chin SS,Blumenthal DT

    更新日期：2006-06-01 00:00:00

  • Central nervous system atypical teratoid tumor/rhabdoid tumor: response to intensive therapy and review of the literature.

    abstract：:Central nervous system atypical teratoid/rhabdoid tumor (ATT/RT) of infancy and childhood is a unique histologic entity with an extremely aggressive natural history. Standard therapy for infant and childhood medulloblastoma, for which this entity is often mistaken, has been ineffective; most children survive less than...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,评审

    doi：10.1023/a:1006125120866

    authors： Hilden JM,Watterson J,Longee DC,Moertel CL,Dunn ME,Kurtzberg J,Scheithauer BW

    更新日期：1998-12-01 00:00:00

  • Immunologic and gene expression profiles of spontaneous canine oligodendrogliomas.

    abstract：:Malignant glioma (MG), the most common primary brain tumor in adults, is extremely aggressive and uniformly fatal. Several treatment strategies have shown significant preclinical promise in murine models of glioma; however, none have produced meaningful clinical responses in human patients. We hypothesize that introdu...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-018-2753-4

    authors： Filley A,Henriquez M,Bhowmik T,Tewari BN,Rao X,Wan J,Miller MA,Liu Y,Bentley RT,Dey M

    更新日期：2018-05-01 00:00:00

  • Radiation therapy for incompletely resected supratentorial low-grade glioma in adults.

    abstract：:In this review on current concepts in radiation therapy in the treatment of incompletely resected supratentorial low-grade glioma, a number of important issues are discussed. They include indication for radiation therapy, timing (early vs delayed), dose response issue, impact of modern neuroimaging, 'optimal' treatmen...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,评审

    doi：10.1023/a:1013333905202

    authors： Jeremic B,Bamberg M

    更新日期：2001-11-01 00:00:00

  • Monotherapy with methotrexate for primary central nervous lymphoma has single agent activity in the absence of radiotherapy: a single institution cohort.

    abstract：:We have retrospectively reviewed toxicities and response of a cohort of primary central nervous system lymphoma (PCNSL) patients treated with high dose parenteral methotrexate (MTX) monotherapy without whole brain radiation. From The Massachusetts General Hospital (MGH) Cancer Registry, active since 1946, we selected ...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章

    doi：10.1007/s11060-009-0090-3

    authors： Cobert J,Hochberg E,Woldenberg N,Hochberg F

    更新日期：2010-07-01 00:00:00

  • The role of surgical resection in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline.

    abstract：QUESTION:Should patients with newly-diagnosed metastatic brain tumors undergo open surgical resection versus whole brain radiation therapy (WBRT) and/or other treatment modalities such as radiosurgery, and in what clinical settings? Target population These recommendations apply to adults with a newly diagnosed single b...

    journal_title：Journal of neuro-oncology

    pub_type： 杂志文章,评审

    doi：10.1007/s11060-009-0061-8

    authors： Kalkanis SN,Kondziolka D,Gaspar LE,Burri SH,Asher AL,Cobbs CS,Ammirati M,Robinson PD,Andrews DW,Loeffler JS,McDermott M,Mehta MP,Mikkelsen T,Olson JJ,Paleologos NA,Patchell RA,Ryken TC,Linskey ME

    更新日期：2010-01-01 00:00:00