Radiation therapy for incompletely resected supratentorial low-grade glioma in adults.

abstract：:The value of perfusion and diffusion-weighted MRI in differentiating histological subtypes according to the 2007 WHO glioma classification scheme (i.e. astrocytoma vs. oligodendroglioma) and genetic subtypes according to the 2016 WHO reclassification (e.g. 1p/19q co-deletion and IDH1 mutation status) in WHO grade II a...

journal_title：Journal of neuro-oncology

authors： Leu K,Ott GA,Lai A,Nghiemphu PL,Pope WB,Yong WH,Liau LM,Cloughesy TF,Ellingson BM

更新日期：2017-08-01 00:00:00

abstract：:Medulloblastomas are the most common malignant brain tumors in childhood. Emerging evidence suggests that medulloblastoma comprises at least four distinct diseases (WNT, SHH, Group 3 and 4) with different biology, clinical presentation, and outcome, with especially poor prognosis in Group 3. The tight connection of bi...

journal_title：Journal of neuro-oncology

authors： Milde T,Lodrini M,Savelyeva L,Korshunov A,Kool M,Brueckner LM,Antunes AS,Oehme I,Pekrun A,Pfister SM,Kulozik AE,Witt O,Deubzer HE

更新日期：2012-12-01 00:00:00

abstract：PURPOSE:Glioblastoma (GBM) is the most aggressive adult brain cancer, with a 15 month median survivorship attributed to the existence of treatment-refractory brain tumor initiating cells (BTICs). In order to better understand the mechanisms regulating the tumorigenic properties of this population, we studied the role o...

journal_title：Journal of neuro-oncology

authors： Vora P,Seyfrid M,Venugopal C,Qazi MA,Salim S,Isserlin R,Subapanditha M,O'Farrell E,Mahendram S,Singh M,Bakhshinyan D,Chokshi C,McFarlane N,Dvorkin-Gheva A,Brown KR,Murty N,Moffat J,Bader GD,Singh SK

更新日期：2019-07-01 00:00:00

abstract：:Ceramide is a physiologic regulator of growth and differentiation in mammalian cells. In this study, the relationship between ceramide and FLICE inhibitory protein (FLIP) in the induction of apoptosis in glioblastoma cell lines was investigated. We found that LN215 cells were slightly more sensitive to Fas-mediated ap...

journal_title：Journal of neuro-oncology

authors： Yoon G,Kim KO,Lee J,Kwon D,Shin JS,Kim SJ,Choi IH

更新日期：2002-11-01 00:00:00

abstract：:We report a 13-month-old boy with diencephalic syndrome (DS) due to an optico-hypothalamic juvenile pilocytic astrocytoma (JPA). Massive neuroaxis dissemination was identified at diagnosis. He received 6 courses of combined conventional-dose chemotherapy consisting of carboplatin (CBDCA), etoposide (VP-16), and cyclop...

journal_title：Journal of neuro-oncology

authors： Kageji T,Nagahiro S,Horiguchi H,Watanabe T,Suzuya H,Okamoto Y,Kuroda Y

更新日期：2003-05-01 00:00:00

abstract：:The high incidence of gliomas in Li-Fraumeni families and the high frequency of somatic p53 mutations in sporadic glial tumors have raised the possibility that germline p53 mutations could play an important role in familial aggregation of gliomas. In the present study, 18 families with two or more gliomas were screene...

journal_title：Journal of neuro-oncology

authors： Paunu N,Syrjäkoski K,Sankila R,Simola KO,Helén P,Niemelä M,Matikainen M,Isola J,Haapasalo H

更新日期：2001-12-01 00:00:00

abstract：:Convection-enhanced delivery (CED) of highly stable PEGylated liposomes encapsulating chemotherapeutic drugs has previously been effective against malignant glioma xenografts. We have developed a novel, convectable non-PEGylated liposomal formulation that can be used to encapsulate both the topoisomerase I inhibitor t...

journal_title：Journal of neuro-oncology

authors： Grahn AY,Bankiewicz KS,Dugich-Djordjevic M,Bringas JR,Hadaczek P,Johnson GA,Eastman S,Luz M

更新日期：2009-11-01 00:00:00

abstract：PURPOSE:Preclinical studies have suggested promising activity for the combination of disulfiram and copper (DSF/Cu) against glioblastoma (GBM) including re-sensitization to temozolomide (TMZ). A previous phase I study demonstrated the safety of combining DSF/Cu with adjuvant TMZ for newly diagnosed GBM. This phase II s...

journal_title：Journal of neuro-oncology

authors： Huang J,Chaudhary R,Cohen AL,Fink K,Goldlust S,Boockvar J,Chinnaiyan P,Wan L,Marcus S,Campian JL

更新日期：2019-05-01 00:00:00

abstract：:Assessing central nervous system (CNS) involvement in patients with lymphoma or carcinoma is important in determining therapy and prognosis. Progranulin (PGRN) is a secreted glycosylated protein with roles in cancer growth and survival; it is highly expressed in aggressive cancer cell lines and specimens from many can...

journal_title：Journal of neuro-oncology

authors： Kimura A,Takemura M,Serrero G,Yoshikura N,Hayashi Y,Saito K,Inuzuka T

更新日期：2018-05-01 00:00:00

abstract：:The activation of autocrine loops involving proto-oncogene related receptor tyrosine kinases has led to the analysis of a large number of growth factor systems in human glioma specimens and cell lines. The ErbB-2 system, also called HER-2 or neu, is analogous to the epidermal growth factor receptor system (EGF-R, ErbB...

journal_title：Journal of neuro-oncology

authors： Westphal M,Meima L,Szonyi E,Lofgren J,Meissner H,Hamel W,Nikolics K,Sliwkowski MX

更新日期：1997-12-01 00:00:00

abstract：:Supratentorial primitive neuroectodermal tumors (sPNET) occurring in adults are rare. Only 56 such cases have been previously reported. This report documents a 56-year-old male who presented with the chief complaint of right facial palsy. Magnetic resonance imaging (MRI) revealed left frontal and bilateral periventric...

journal_title：Journal of neuro-oncology

authors： Ohba S,Yoshida K,Hirose Y,Ikeda E,Kawase T

更新日期：2008-01-01 00:00:00

abstract：:Ionizing radiation plays a major role in the treatment of brain tumors, but side-effects may restrict the efficacy of therapy. In the present study, our goals were to establish whether the administration of L-alpha-glycerylphosphorylcholine (GPC) can moderate or prevent any of the irradiation-induced functional and mo...

journal_title：Journal of neuro-oncology

authors： Plangár I,Szabó ER,Tőkés T,Mán I,Brinyiczki K,Fekete G,Németh I,Ghyczy M,Boros M,Hideghéty K

更新日期：2014-09-01 00:00:00

abstract：:An anti-epithelial membrane antigen monoclonal (Clone E29) was used as part of a panel of antisera in the investigation of primary CNS and metastatic tumours. In contrast to others, definite and often strongly positive cross-reactivity has been demonstrated on glial cells. The material consisted of fourteen astrocytom...

journal_title：Journal of neuro-oncology

authors： Hitchcock E,Morris CS

更新日期：1987-01-01 00:00:00

abstract：:Choroid plexus papillomas (CPPs) are generally regarded as benign tumours, with a favourable long-term prognosis. Complete resection should result in cure. We present a case of diffuse craniospinal seeding from an apparently completely resected fourth ventricular primary tumour. A 51-year-old male is discussed, who pr...

journal_title：Journal of neuro-oncology

authors： McEvoy AW,Galloway M,Revesz T,Kitchen ND

更新日期：2002-02-01 00:00:00

abstract：:Twenty-nine patients received the cytotoxic radiosensitizing agent lonidamine before, during, and after cranial irradiation for brain metastases. One patient was ineligible (meningioma). In 28 eligible patients, median survival was 29 weeks (range, 2 to > 220 weeks). Nine patients (32%) survived > 1 year and 3 (11%) s...

journal_title：Journal of neuro-oncology

authors： Stewart DJ,Eapen L,Girard A,Verma S,Genest P,Evans WK

更新日期：1993-01-01 00:00:00

abstract：:Injection of dendritic cells (DC) pulsed with tumor antigens is a novel treatment strategy against malignancies, and aims to elicit anti-tumoral cell-mediated immune responses. We studied the in vitro proliferative responses and cytokine production in T cell cultures after 2 stimulations with autologous DC loaded with...

journal_title：Journal of neuro-oncology

authors： De Vleeschouwer S,Spencer Lopes I,Ceuppens JL,Van Gool SW

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:A retrospective comparison evaluating survival in two well-matched cohorts of patients with cytologically positive neoplastic meningitis (NM) presenting with or without encephalopathy. METHODS:Two cohorts were studied: 20 with and 20 without of NM-related encephalopathy defined as a confusional syndrome. Co...

journal_title：Journal of neuro-oncology

authors： Chamberlain MC,Tsao-Wei D,Groshen S

更新日期：2005-04-01 00:00:00

abstract：:Medulloblastoma with melanotic differentiation, a rare variant of medulloblastoma, often carries a poor prognosis. We present such a case of a 4 year male with this rare, aggressive tumor. Additionally, we have reviewed the literature and report on the features important in the pathologic and radiologic diagnosis in t...

journal_title：Journal of neuro-oncology

authors： Phillips CL,Miles L,Jones BV,Sutton M,Crone K,Fouladi M

更新日期：2011-07-01 00:00:00

abstract：:We report a case of a 2 year-old boy who initially presented with macrocephaly and severe global developmental delay. Imaging revealed a large left temporo-parietal mass that was lobulated, calcified, focally enhancing and partially cystic. A second surgery was required for tumor recurrence approximately one year late...

journal_title：Journal of neuro-oncology

authors： Dunham C,Sugo E,Tobias V,Wills E,Perry A

更新日期：2007-08-01 00:00:00

abstract：PURPOSE:Children with recurrent medulloblastoma have a poor prognosis. Re-irradiation is an option for some patients, but has not been well-studied in the era of molecular characterization for pediatric medulloblastoma. METHODS:This was a retrospective cohort study of 14 children age 18 years and younger at initial di...

journal_title：Journal of neuro-oncology

authors： Tsang DS,Sarhan N,Ramaswamy V,Nobre L,Yee R,Taylor MD,Hawkins C,Bartels U,Huang A,Tabori U,Hodgson DC,Bouffet E,Laperriere N

更新日期：2019-10-01 00:00:00

abstract：:Optimal treatment of anaplastic oligodendroglial tumors (AOT) in elderly patients is debatable. We report a retrospective study of 44 consecutive patients aged 70 years or older [median age: 74 years; median Karnofsky performance status (KPS): 70] treated with up-front chemotherapy using temozolomide (TMZ) at conventi...

journal_title：Journal of neuro-oncology

authors： Ducray F,del Rio MS,Carpentier C,Psimaras D,Idbaih A,Dehais C,Kaloshi G,Mokhtari K,Taillibert S,Laigle-Donadey F,Omuro A,Sanson M,Delattre JY,Hoang-Xuan K

更新日期：2011-02-01 00:00:00

abstract：:Antiangiogenic therapies for malignant gliomas often result in transient response, and recurrent disease is characterized by adoption of invasive and hypoxic phenotype. The notch signaling pathway is activated in gliomas, and augments cell migration and hypoxic response. Here we report a clinical study of the combinat...

journal_title：Journal of neuro-oncology

authors： Pan E,Supko JG,Kaley TJ,Butowski NA,Cloughesy T,Jung J,Desideri S,Grossman S,Ye X,Park DM

更新日期：2016-12-01 00:00:00

abstract：:Global and gene-specific changes to the epigenome are hallmarks of most tumours including those of pituitary origin, and this fact might offer important clues about diagnostic and therapeutic applications. We performed global DNA methylation screening with 6 invasive and 6 noninvasive nonfunctioning pituitary adenomas...

journal_title：Journal of neuro-oncology

authors： Gu Y,Zhou X,Hu F,Yu Y,Xie T,Huang Y,Zhao X,Zhang X

更新日期：2016-08-01 00:00:00

abstract：:We studied the effect of intracarotid infusion of various calcium antagonists on regional CBF (rCBF) in the C6 rat glioma by a hydrogen clearance method. Nimodipine at doses of 0.1, 0.5 and 1 microgram/kg/min was found to produce tumor-specific increases in the rCBF (40.2 +/- 18.4%, p < 0.01, 67.8 +/- 32.6%, p < 0.001...

journal_title：Journal of neuro-oncology

authors： Matsukado K,Ikezaki K,Nomura T,Fukui M

更新日期：1996-01-01 00:00:00

abstract：:Cavernous sinus is an uncommon site of metastasis for the head and neck tumors, and especially for the tumors of parotid gland. The case reported here is the second reported case of parotid carcinoma metastatic to the cavernous sinus, proven by histopathology. Also it is the first reported parotid gland acinic cell ca...

journal_title：Journal of neuro-oncology

authors： Yildirim N,Oksüzoğlu B,Vural M,Han O,Zengin N

更新日期：2005-06-01 00:00:00

abstract：:To investigate local control and radiation-induced brain necrosis in patients with melanoma brain metastases who received complete resection plus fractionated stereotactic radiosurgery (fSRS, 3 × 9 Gy) or fSRS alone. Factors associated with the clinical outcomes and the development of brain necrosis have been assessed...

journal_title：Journal of neuro-oncology

authors： Minniti G,Paolini S,D'Andrea G,Lanzetta G,Cicone F,Confaloni V,Bozzao A,Esposito V,Osti M

更新日期：2017-05-01 00:00:00

abstract：:After chromosome 22 and NF2 inactivation, the loss of chromosome 1p is one of the most frequent abnormalities encountered in meningiomas. However the putative tumor suppressor gene located on 1p inactivated in meningiomas has still to be identified. We screened 68 meningiomas for LOH on chromosome 22 and 1. We found 3...

journal_title：Journal of neuro-oncology

authors： Leuraud P,Marie Y,Robin E,Huguet S,He J,Mokhtari K,Cornu P,Hoang-Xuan K,Sanson M

更新日期：2000-12-01 00:00:00

abstract：INTRODUCTION:Malignant gliomas have a dismal prognosis and significant efforts are being made to develop more effective treatments. Sonodynamic therapy (SDT) is an emerging modality for cancer treatment which combines ultrasound with sonosensitizers to produce a localized cytotoxic effect. The aim of this study is to d...

journal_title：Journal of neuro-oncology

authors： Prada F,Sheybani N,Franzini A,Moore D,Cordeiro D,Sheehan J,Timbie K,Xu Z

更新日期：2020-07-01 00:00:00

abstract：:Intracranial melanotic schwannomas (IMSch) are extremely rare nerve sheath tumors with features of Schwann cells that produce melanin. After a thorough review of the available literature since 1967, we report not only the 20th case of IMSch but a comprehensive modern-era analysis of radiographic and histological key-p...

journal_title：Journal of neuro-oncology

authors： Mahato D,Vivas-Buitrago T,Gassie K,Jentoft M,Tavanaiepour D,Quiñones-Hinojosa A

更新日期：2018-01-01 00:00:00

abstract：:To evaluate the safety and efficacy of hypofractionated radiotherapy (RT) with a standard temozolomide (TMZ) regimen for adults with newly diagnosed glioblastoma multiforme (GBM), twenty-six consecutive adults (range 39-79 years) who met our enrollment criteria received short courses of hypofractionated RT (45 Gy in 1...

journal_title：Journal of neuro-oncology

authors： Terasaki M,Eto T,Nakashima S,Okada Y,Ogo E,Sugita Y,Tokutomi T,Shigemori M

更新日期：2011-04-01 00:00:00