Biodistribution of copper carboranyltetraphenylporphyrins in rodents bearing an isogeneic or human neoplasm.

abstract：BACKGROUND:In most patients with recurrent glioma chemotherapy is the only remaining treatment option. In general results of chemotherapy in these patients are poor, and trials on new regimens are indicated. Because relatively good results have been achieved with combinations of platin compounds and etoposide, we inves...

journal_title：Journal of neuro-oncology

authors： van den Bent MJ,Pronk L,Sillevis Smitt PA,Vecht CJ,Eskens FA,Verweij J

更新日期：1999-08-01 00:00:00

abstract：:We describe the case of a young man presenting with an extra-nodal, intramedullary non-Hodgkin's lymphoma of the cervical spinal cord. This is a very uncommon presentation of this neoplasm. The patient was treated with craniospinal radiotherapy, with survival for two and a half years before death from recurrent diseas...

journal_title：Journal of neuro-oncology

authors： McDonald AC,Nicoll JA,Rampling R

更新日期：1995-01-01 00:00:00

abstract：:Fibroblast growth factor-2 (FGF-2) is involved as an autocrine growth factor in the autonomous proliferation of glioma cells. To develop a new strategy for treating patients with glioma, we studied the effect on human glioma cells of a 16-mer oligopeptide with conformational similarity to the putative receptor-binding...

journal_title：Journal of neuro-oncology

authors： Kono K,Ueba T,Takahashi JA,Murai N,Hashimoto N,Myoumoto A,Itoh N,Fukumoto M

更新日期：2003-06-01 00:00:00

abstract：:Antiangiogenic therapies for malignant gliomas often result in transient response, and recurrent disease is characterized by adoption of invasive and hypoxic phenotype. The notch signaling pathway is activated in gliomas, and augments cell migration and hypoxic response. Here we report a clinical study of the combinat...

journal_title：Journal of neuro-oncology

authors： Pan E,Supko JG,Kaley TJ,Butowski NA,Cloughesy T,Jung J,Desideri S,Grossman S,Ye X,Park DM

更新日期：2016-12-01 00:00:00

abstract：:The optimal postoperative management of pediatric intracranial ependymomas is controversial. We analyzed clinical prognostic factors for their influence on outcome in such children. Our retrospective series included 15 with supratentorial and 28 with infratentorial tumors. Twenty ependymomas were grade II, and 23 were...

journal_title：Journal of neuro-oncology

authors： Jaing TH,Wang HS,Tsay PK,Tseng CK,Jung SM,Lin KL,Lui TN

更新日期：2004-07-01 00:00:00

abstract：:This study investigated the effects of the intracarotid infusion of etoposide in combination with angiotensin II (AT II)-induced hypertension on the blood-brain barrier (BBB) and brain tissue in rats. Eighty rats were divided into five groups: Group 1, intravenous infusion of AT II to increase arterial blood pressure;...

journal_title：Journal of neuro-oncology

authors： Ogasawara H,Kiya K,Kurisu K,Hotta T,Mikami T,Sugiyama K,Nakahara T,Uozumi T

更新日期：1992-06-01 00:00:00

abstract：INTRODUCTION:Low-grade glioma (LGG) represent the most common pediatric central nervous system tumor. When total surgical resection is not feasible, chemotherapy is first-line therapy in children. Multiple pediatric LGG chemotherapy regimens have been investigated with variable 2-year event free survival (EFS) rates of...

journal_title：Journal of neuro-oncology

authors： Nellan A,Wright E,Campbell K,Davies KD,Donson AM,Amani V,Judd A,Hemenway MS,Raybin J,Foreman NK,Rush S,Dorris K

更新日期：2020-07-01 00:00:00

abstract：:This study aims to evaluate the cost-effectiveness of surgical resection (S) and Cesium-131 (Cs-131) [S + Cs-131] intraoperative brachytherapy versus S and stereotactic radiosurgery (SRS) [S + SRS] for the treatment of brain metastases. Treatment records as well as hospital and outpatient charts of 49 patients with br...

journal_title：Journal of neuro-oncology

authors： Wernicke AG,Yondorf MZ,Parashar B,Nori D,Clifford Chao KS,Boockvar JA,Pannullo S,Stieg P,Schwartz TH

更新日期：2016-03-01 00:00:00

abstract：:Neurocytomas gained importance since 1995, which is reflected by the increasing number of reports on this entity. This study was performed to determine the best available treatment for typical and atypical neurocytomas (MIB-1 labeling index >3%, atypical histology) in various age groups ( 18 years). The...

journal_title：Journal of neuro-oncology

authors： Rades D,Schild SE

更新日期：2006-05-01 00:00:00

abstract：:Ependymoma is the third most common brain tumor in children, but there is a paucity of large studies with more than 10 years of follow-up examining the long-term survival and recurrence patterns of this disease. We conducted a retrospective chart review of 103 pediatric patients with WHO Grades II/III intracranial epe...

journal_title：Journal of neuro-oncology

authors： Marinoff AE,Ma C,Guo D,Snuderl M,Wright KD,Manley PE,Al-Sayegh H,Sinai CE,Ullrich NJ,Marcus K,Haas-Kogan D,Goumnerova L,London WB,Kieran MW,Chi SN,Fangusaro J,Bandopadhayay P

更新日期：2017-10-01 00:00:00

abstract：:Ionizing radiation plays a major role in the treatment of brain tumors, but side-effects may restrict the efficacy of therapy. In the present study, our goals were to establish whether the administration of L-alpha-glycerylphosphorylcholine (GPC) can moderate or prevent any of the irradiation-induced functional and mo...

journal_title：Journal of neuro-oncology

authors： Plangár I,Szabó ER,Tőkés T,Mán I,Brinyiczki K,Fekete G,Németh I,Ghyczy M,Boros M,Hideghéty K

更新日期：2014-09-01 00:00:00

abstract：:After the second recurrence of spinal seeding in hemangioblastoma not associated to von-Hippel-Lindau disease, we treated an adult female patient with thalidomide 200 mg orally/day at night for longer than 1 year. The patient reported subjective relief of symptoms after 1 month. Magnetic resonance imaging (MRI) contro...

journal_title：Journal of neuro-oncology

authors： Piribauer M,Czech T,Dieckmann K,Birner P,Hainfellner JA,Prayer D,Fazeny-Dörner B,Weinländer G,Marosi C

更新日期：2004-02-01 00:00:00

abstract：:Intracranial pseudolymphoma is a rare tumor of the central nervous system. A 35-year-old woman presented with a frontal subcutaneous tumor. Magnetic resonance imaging revealed a left frontal meningeal tumor involving subcutaneous tissue without bone involvement. The mass was completely removed and the histological asp...

journal_title：Journal of neuro-oncology

authors： Donnet A,Horschowski N,Dufour H,Figarella-Branger D,Bryon PA,Berger F,Harle JR,Grisoli F

更新日期：2000-04-01 00:00:00

abstract：:We report on the long-term results of a phase II study of pre-irradiation temozolomide followed by concurrent temozolomide and radiotherapy (RT) in patients with newly diagnosed anaplastic oligodendroglioma (AO) and mixed anaplastic oligoastrocytoma. Pre-RT temozolomide was given for up to 6 cycles. RT with concurrent...

journal_title：Journal of neuro-oncology

authors： Vogelbaum MA,Hu C,Peereboom DM,Macdonald DR,Giannini C,Suh JH,Jenkins RB,Laack NN,Brachman DG,Shrieve DC,Souhami L,Mehta MP

更新日期：2015-09-01 00:00:00

abstract：:Visual field defect is a major indication for surgery of pituitary adenoma, but visual outcome after surgery is difficult to predict. We developed a nomogram that predicts postoperative restoration of visual field defects in patients with pituitary adenoma. This study was a retrospective cohort investigation of patien...

journal_title：Journal of neuro-oncology

authors： Lee J,Kim SW,Kim DW,Shin JY,Choi M,Oh MC,Kim SM,Kim EH,Kim SH,Byeon SH

更新日期：2016-10-01 00:00:00

abstract：SUBJECT:To date there is no established tumor marker for the clinical follow-up of glioblastoma, WHO grade IV, (GBM) which constitutes the most frequent and malignant primary brain tumor. However, since there is promising data that the serum glial fibrillary acidic protein (sGFAP) may serve as a biomarker for glial bra...

journal_title：Journal of neuro-oncology

authors： Baumgarten P,Quick-Weller J,Gessler F,Wagner M,Tichy J,Forster MT,Foerch C,Seifert V,Mittelbronn M,Senft C

更新日期：2018-09-01 00:00:00

abstract：:Various histological types of tumors arise in the pineal region. The most common tumors are pineal parenchymal tumors and germ cell tumors. Pineal parenchymal tumors are divided into pineocytoma, pineal parenchymal tumor with intermediate differentiation and pineoblastoma. Pineocytomas are well-differentiated tumors a...

journal_title：Journal of neuro-oncology

authors： Hirato J,Nakazato Y

更新日期：2001-09-01 00:00:00

abstract：:New genetic models provide better biological mimics of human tumors. The new models can give deeper insight into tumorigenesis and provide better targets for testing therapies. To use the new models most successfully, it is useful to keep in mind limitations that are harder to overcome by genetic manipulation. These i...

journal_title：Journal of neuro-oncology

authors： Lampson LA

更新日期：2001-07-01 00:00:00

abstract：:We used double-label quantitative autoradiography to measure blood flow (with 131I-iodoantipyrine) and blood-to-tissue transport of 14C-alpha aminoisobutyric acid, AIB) in thirteen 9L gliosarcomas transplanted intracerebrally into Fischer-344 rats. Microscopically, the typical pattern of 9L tumor growth was observed: ...

journal_title：Journal of neuro-oncology

authors： Fross RD,Warnke PC,Groothuis DR

更新日期：1991-12-01 00:00:00

abstract：:Patients with metastatic disease are living longer and may be confronted with locally or regionally recurrent brain metastases (BM) after prior stereotactic radiosurgery (SRS) or fractionated stereotactic radiotherapy (FSRT). This study analyzes outcomes in patients without prior whole brain radiotherapy (WBRT) who we...

journal_title：Journal of neuro-oncology

authors： Kim DH,Schultheiss TE,Radany EH,Badie B,Pezner RD

更新日期：2013-10-01 00:00:00

abstract：:Meningiomas in identical twins are extremely rare. To our knowledge, only one previous report of meningiomas in identical twins has been published. We present identical twin sisters with meningiomas. The tumors were located at a similar, but not a common, position (the cerebellopontine angle) in both twins. Histologic...

journal_title：Journal of neuro-oncology

authors： Ohba S,Yoshida K,Hirose Y,Ikeda E,Kawase T

更新日期：2010-07-01 00:00:00

abstract：:Various subtypes of intracerebral hamartomas, associated with seizure disorders, have long been described. We describe a cerebral hamartoma placed in the left frontal lobe, associated with drug-resistant epilepsy, composed exclusively of mature oligodendroglial cells. The patient was a 27-year-old right-handed male pr...

journal_title：Journal of neuro-oncology

authors： Marucci G,Giulioni M,Martinoni M,Volpi L,Michelucci R

更新日期：2011-01-01 00:00:00

abstract：:Brain tumors and anti-cancer treatments can cause a wide range of cognitive deficits that in turn, being a major cause of disability, significantly affect patients' independence and quality of life. To evaluate the neurocognitive status of a non selected population of brain tumors outpatients, investigating the correl...

journal_title：Journal of neuro-oncology

authors： Zucchella C,Bartolo M,Di Lorenzo C,Villani V,Pace A

更新日期：2013-05-01 00:00:00

abstract：:Leptomeningeal spread of childhood primary central nervous system (CNS) neoplasms, also known as leptomeningeal disease (LMD), significantly affects prognosis and treatment. Lumbar cerebrospinal fluid (CSF) cytology and spinal magnetic resonance imaging (MRI) are considered critical for diagnosis of LMD. It has been s...

journal_title：Journal of neuro-oncology

authors： Pang J,Banerjee A,Tihan T

更新日期：2008-03-01 00:00:00

abstract：:The aim of this article is to evaluate and assess the impact of various factors on quality of life (QOL) in adult patients with primary brain tumors seen consecutively in routine neurooncology practice. Two hundred and fifty-seven adult patients, after undergoing surgical intervention and histologically proven primary...

journal_title：Journal of neuro-oncology

authors： Budrukkar A,Jalali R,Dutta D,Sarin R,Devlekar R,Parab S,Kakde A

更新日期：2009-12-01 00:00:00

abstract：:Magnetic resonance imaging (MRI) or computerized tomography (CT) is routinely performed after resection of brain metastases (BrM), regardless of whether there are specific clinical concerns about residual tumor or potential complications. Routine imaging studies contribute a significant amount to the cost of medical c...

journal_title：Journal of neuro-oncology

authors： Benveniste RJ,Ferraro N,Tsimpas A

更新日期：2014-06-01 00:00:00

abstract：:We present a case of de novo fibrosarcoma in a 43-year-old male, with MRI documented evolution from a 5 mm hyperintense area to 5 cm tumor mass in a 12-month period. The diagnosis of low-grade fibrosarcoma was established by three experienced neuropathologists. The patient underwent gross total resection with adjuvant...

journal_title：Journal of neuro-oncology

authors： Adeleye AO,Fellig Y,Umansky F,Shoshan Y

更新日期：2009-04-01 00:00:00

abstract：PURPOSE:Stereotactic radiosurgery is an established treatment option for sporadic meningiomas, though limited data exists for radiation-induced lesions. METHODS:Patients treated with cobalt-60 radiosurgery between October 2005 and December 2018 in an institutional registry were reviewed. Single fraction treatments wer...

journal_title：Journal of neuro-oncology

authors： Huo M,Laperriere N,van Prooijen M,Shultz D,Coolens C,Hodaie M,Cusimano M,Gentili F,Zadeh G,Payne D,Schwartz M,Tsang DS

更新日期：2020-06-01 00:00:00

abstract：:Thrombin is known to play a role as regulator in tumor spreading and tumor growth. Proteinase-activated receptor 1 (PAR 1)-type thrombin receptors were identified in different cancer cells including human glioblastoma cells. Thus a function of PAR 1 in brain tumors may be suggested. In this study, the presence of PAR ...

journal_title：Journal of neuro-oncology

authors： Kaufmann R,Patt S,Kraft R,Zieger M,Henklein P,Neupert G,Nowak G

更新日期：1999-04-01 00:00:00

abstract：:The basement membrane collagen IV-degrading matrix metalloproteinases -2 and -9 (MMPs) are most often linked to the malignant phenotype of tumor cells by playing a critical role in invasion, metastasis, angiogenesis, and vasculogenesis. We verified the activity of these two MMPs in the sera of patients affected by bra...

journal_title：Journal of neuro-oncology

authors： Ricci S,Guadagno E,Bruzzese D,Del Basso De Caro M,Peca C,Sgulò FG,Maiuri F,Di Carlo A

更新日期：2017-01-01 00:00:00