Anguidine potentiates cis-platinum in human brain tumor cells.

abstract：:Angiogenesis, the formation of blood vessels from a pre-existing vasculature, is a process whereby capillary sprouts are formed in response to externally supplied chemical stimuli. The sprouts then grow and develop, driven initially by endothelial cell migration, and organize themselves into a branched, connected netw...

journal_title：Journal of neuro-oncology

authors： Chaplain MA

更新日期：2000-10-01 00:00:00

abstract：:Future success using chemotherapy against human gliomas may result from exploiting unique molecular vulnerabilities of these tumors. Chemotherapy frequently results in DNA damage. When such damage is sensed by the cell, programmed cell death, or apoptosis, may be initiated. However, chemotherapy-induced DNA damage may...

journal_title：Journal of neuro-oncology

authors： Weaver KD,Yeyeodu S,Cusack JC Jr,Baldwin AS Jr,Ewend MG

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVE AND IMPORTANCE:Epithelioid hemangioendothelioma (EHE) is a rare vascular tumor that presents histological features and biological behavior of low-grade malignancy. The authors report a case of malignant intracranial EHE, in which surgical excisions and additional immuno-chemotherapy were ineffective. Emphasis...

journal_title：Journal of neuro-oncology

authors： Endo T,Su CC,Numagami Y,Shirane R

更新日期：2004-05-01 00:00:00

abstract：:There is general agreement that most chemotherapy agents achieve only relatively low concentrations in the normal central nervous system, that the blood-brain barrier is variably disrupted in malignant brain tumors, and that the concentration of chemotherapy drugs in the brain adjacent to tumor is intermediate between...

journal_title：Journal of neuro-oncology

authors： Stewart DJ

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Anaplastic lymphoma kinase (ALK) is expressed in ~ 60% of glioblastomas and conveys tumorigenic functions. Therefore, ALK inhibitory strategies with alectinib are conceivable for patients with glioblastoma. The aims of this preclinical study were to investigate efficacy as well as to understand and potential...

journal_title：Journal of neuro-oncology

authors： Berberich A,Schmitt LM,Pusch S,Hielscher T,Rübmann P,Hucke N,Latzer P,Heßling B,Lemke D,Kessler T,Platten M,Wick W

更新日期：2020-01-01 00:00:00

abstract：:Malignant primary spinal cord gliomas (PSCGs) are rare, and the optimal treatment for these lesions remains controversial. We report herein treatment outcomes of six malignant PSCGs managed with temozolomide (TMZ)-based multidisciplinary treatment. TMZ was administered concomitantly with fractionated radiotherapy for ...

journal_title：Journal of neuro-oncology

authors： Kim WH,Yoon SH,Kim CY,Kim KJ,Lee MM,Choe G,Kim IA,Kim JH,Kim YJ,Kim HJ

更新日期：2011-01-01 00:00:00

abstract：PURPOSE:Glioblastoma (GBM) is characterized by extensive clonal diversity suggesting the presence of tumor cells with varying degrees of treatment sensitivity. Radiotherapy is an integral part of glioblastoma treatment. Whether GBMs are comprised of spatially distinct cellular populations with uniform or varying degree...

journal_title：Journal of neuro-oncology

authors： McAbee JH,Degorre-Kerbaul C,Valdez K,Wendler A,Shankavaram UT,Watts C,Camphausen K,Tofilon PJ

更新日期：2020-09-01 00:00:00

abstract：:Adrenomedullin is a vasoactive peptide that is upregulated in higher-grade gliomas and promotes tumor cell proliferation. Since reduced activity of the anti-oncogene PTEN seems to also correlate with higher tumor grade, this suggests an inverse association between PTEN activity and adrenomedullin expression. PC12 pheo...

journal_title：Journal of neuro-oncology

authors： Betchen SA,Musatov S,Roberts J,Pena J,Kaplitt MG

更新日期：2006-09-01 00:00:00

abstract：:Embryonal tumors of the central nervous system (CNS) share histological features and were therefore initially grouped as primitive neuroectodermal tumors (PNET) and treated similarly. We sought to determine the relapse patterns of specific embryonal CNS tumors. We conducted a historical cohort study of children diagno...

journal_title：Journal of neuro-oncology

authors： Perreault S,Lober RM,Carret AS,Zhang G,Hershon L,Décarie JC,Yeom K,Vogel H,Fisher PG,Partap S

更新日期：2013-11-01 00:00:00

abstract：:New genetic models provide better biological mimics of human tumors. The new models can give deeper insight into tumorigenesis and provide better targets for testing therapies. To use the new models most successfully, it is useful to keep in mind limitations that are harder to overcome by genetic manipulation. These i...

journal_title：Journal of neuro-oncology

authors： Lampson LA

更新日期：2001-07-01 00:00:00

abstract：:Since the introduction of CT and MRI as diagnostic aids, it has been possible to obtain direct images of neoplastic meningiosis. After more than ten years experience, the combination of MRI with the administration of a paramagnetic contrast medium is now accepted as the method of choice for the sensitive detection of ...

journal_title：Journal of neuro-oncology

authors： Schumacher M,Orszagh M

更新日期：1998-06-01 00:00:00

abstract：:Glucocorticoids, such as betamethasone, are often used to prevent possible acute reactions during radiation therapy of intracranial tumors (for example gliomas). The effect of the glucocorticoids is probably due to vascular changes decreasing the development of edemas. The radiosensitivity of two studied cell-lines of...

journal_title：Journal of neuro-oncology

authors： Benediktsson G,Blomquist E,Carlsson J

更新日期：1990-02-01 00:00:00

abstract：PURPOSE:The highly vascular malignant brain tumor glioblastoma (GBM) appears to be an ideal target for anti-angiogenic therapy; however, clinical trials to date suggest the VEGF antibody bevacizumab affects only progression-free survival. Here we analyze a group of patients with GBM who received bevacizumab treatment a...

journal_title：Journal of neuro-oncology

authors： Hovinga KE,McCrea HJ,Brennan C,Huse J,Zheng J,Esquenazi Y,Panageas KS,Tabar V

更新日期：2019-04-01 00:00:00

abstract：:The mainstays of primary treatment of ependymoma are aggressive surgery followed by radiotherapy. Although spreading occasionally occurs in the cerebrospinal pathways, chemotherapy is still not established and no ultimate drug has so far been found. Estramustine-phosphate (EMP), with a demonstrated effect on astrocyto...

journal_title：Journal of neuro-oncology

authors： Bergenheim AT,Hartman M,Bergh J,Ridderheim PA,Henriksson R

更新日期：1994-01-01 00:00:00

abstract：:Previous study revealed that higher expression of transforming growth factor beta induced (TGFBI) is correlated to poorer cancer-specific survival and higher proportion of tumor necrosis and Fuhrman grades III and IV in clear cell renal cell carcinomas. However, the relationships between TGFBI expression and malignant...

journal_title：Journal of neuro-oncology

authors： Pan YB,Zhang CH,Wang SQ,Ai PH,Chen K,Zhu L,Sun ZL,Feng DF

更新日期：2018-04-01 00:00:00

abstract：INTRODUCTION:This study evaluated an association between whole brain volume loss and neurocognitive decline following prophylactic cranial irradiation (PCI) for limited-stage small-cell lung cancer (SCLC). METHODS:This was a secondary analysis of a prospective clinical trial that accrued patients at a single instituti...

journal_title：Journal of neuro-oncology

authors： Gui C,Chintalapati N,Hales RK,Voong KR,Sair HI,Grimm J,Duhon M,Kleinberg LR,Vannorsdall TD,Redmond KJ

更新日期：2019-09-01 00:00:00

abstract：:Nineteen patients with nervous system metastasis of hepatocellular carcinoma (HCC) were evaluated retrospectively. Nervous system metastasis was frequently initial presentation of HCC (seven out of 19 patients). Seven patients had metastases of the brain, of whom four had a stroke-like presentation. CT or MRI in these...

journal_title：Journal of neuro-oncology

authors： Kim M,Na DL,Park SH,Jeon BS,Roh JK

更新日期：1998-01-01 00:00:00

abstract：:The treatment of childhood low grade glioma (LGG), if not amenable to complete resection, quite often is a relevant clinical challenge. LGG in many instances are indeed slow growing tumors, which, if not controlled, can cause severe morbidity and ultimately jeopardize life. Most of the time children bearing an unresec...

journal_title：Journal of neuro-oncology

authors： Perilongo G

更新日期：2005-12-01 00:00:00

abstract：:High expression of ERBB2 has been reported in medulloblastoma and ependymoma; EGFR is amplified and over-expressed in brainstem glioma suggesting these proteins as potential therapeutic targets. We conducted a molecular biology (MB) and phase II study to estimate inhibition of tumor ERBB signaling and sustained respon...

journal_title：Journal of neuro-oncology

authors： Fouladi M,Stewart CF,Blaney SM,Onar-Thomas A,Schaiquevich P,Packer RJ,Goldman S,Geyer JR,Gajjar A,Kun LE,Boyett JM,Gilbertson RJ

更新日期：2013-09-01 00:00:00

abstract：:Mutations in the gene encoding isocitrate dehydrogenase 1 (IDH1) have been identified in approximately 70-80 % of astrocytomas and oligodendrogliomas of WHO grades II and III, and in secondary glioblastomas. In addition, a low incidence of IDH2 mutations has been detected in these tumors, and the occurence of IDH1 and...

journal_title：Journal of neuro-oncology

authors： Ahmadi R,Stockhammer F,Becker N,Hohlen K,Misch M,Christians A,Dictus C,Herold-Mende C,Capper D,Unterberg A,von Deimling A,Wick W,Hartmann C

更新日期：2012-08-01 00:00:00

abstract：:Diffuse intrinsic pontine glioma (DIPG), a rare, often fatal childhood brain tumor, remains a major therapeutic challenge. In 2012, investigators, funded by the DIPG Collaborative (a philanthropic partnership among 29 private foundations), launched the International DIPG Registry (IDIPGR) to advance understanding of D...

journal_title：Journal of neuro-oncology

authors： Baugh J,Bartels U,Leach J,Jones B,Chaney B,Warren KE,Kirkendall J,Doughman R,Hawkins C,Miles L,Fuller C,Hassall T,Bouffet E,Lane A,Hargrave D,Grill J,Hoffman LM,Jones C,Towbin A,Savage SA,Monje M,Li XN,Ziegler

更新日期：2017-04-01 00:00:00

abstract：:Bevacizumab is effective for the treatment of non-small cell lung cancer (NSCLC). Ongoing trials are exploring the safety of bevacizumab in patients with inactive, previously treated brain metastases. However, bevacizumab safety and efficacy in the treatment of active brain metastases is unknown. Bevacizumab received ...

journal_title：Journal of neuro-oncology

authors： De Braganca KC,Janjigian YY,Azzoli CG,Kris MG,Pietanza MC,Nolan CP,Omuro AM,Holodny AI,Lassman AB

更新日期：2010-12-01 00:00:00

abstract：:Peripheral neuropathies occur in 5% of patients with Non-Hodgkin Lymphoma and represent the effects of therapy, direct compression or nerve infiltration by tumor, or paraneoplastic effects. Multifocal motor neuropathy with conduction block (MMNCB) is a rare demyelinating disorder of unknown etiology characterized by p...

journal_title：Journal of neuro-oncology

authors： Stern BV,Baehring JM,Kleopa KA,Hochberg FH

更新日期：2006-05-01 00:00:00

abstract：:Twenty-eight patients with malignant brain tumors (16 with primary brain tumors and 12 with brain metastases) progressing after cranial irradiation with or without chemotherapy received varying doses of intracarotid VP-16. Courses of therapy were repeated every 4 weeks along with computerized axial tomography scan and...

journal_title：Journal of neuro-oncology

authors： Feun LG,Lee YY,Yung WK,Savaraj N,Wallace S

更新日期：1987-01-01 00:00:00

abstract：:The basic mechanism of cell death induced by 5-aminolevulinic acid (5-ALA)-mediated photodynamic therapy (PDT) (ALA-PDT) in glioma cells has not been fully elucidated. In this study, the details of the cell death mechanism induced by ALA-PDT were investigated in three human glioma cell lines (U251MG, U87MG, and U118MG...

journal_title：Journal of neuro-oncology

authors： Inoue H,Kajimoto Y,Shibata MA,Miyoshi N,Ogawa N,Miyatake S,Otsuki Y,Kuroiwa T

更新日期：2007-07-01 00:00:00

abstract：:As the outcome for pediatric central nervous system (CNS) malignancies improves, data regarding long term effects and risk of early mortality are needed. Using the Surveillance, Epidemiology, and End Results database, we evaluated the causes of mortality in 5-year survivors of a CNS tumor diagnosed prior to the age of...

journal_title：Journal of neuro-oncology

authors： Perkins SM,Fei W,Mitra N,Shinohara ET

更新日期：2013-10-01 00:00:00

abstract：:Elevated neutrophil-lymphocyte ratio (NLR) may predict worse outcomes in cancer, including glioblastoma (GBM). This study assessed whether change in NLR during focal radiotherapy and concomitant temozolomide (RT-TMZ) provides further prognostic information. This was a retrospective review of patients treated with RT-T...

journal_title：Journal of neuro-oncology

authors： Mason M,Maurice C,McNamara MG,Tieu MT,Lwin Z,Millar BA,Menard C,Laperriere N,Milosevic M,Atenafu EG,Mason W,Chung C

更新日期：2017-05-01 00:00:00

abstract：:Primary malignant brain and other central nervous system tumors (BT) are a rare cancer that causes morbidity and mortality disproportionate to their incidence. This study presents the most up-to-date mortality data for malignant BT in the United States (US) by histology groupings, age, race, and sex. Mortality rates f...

journal_title：Journal of neuro-oncology

authors： Gittleman H,Kromer C,Ostrom QT,Blanda R,Russell J,Kruchko C,Barnholtz-Sloan JS

更新日期：2017-06-01 00:00:00

abstract：:The aim of the present study is to evaluate the impact of extent of resection at initial and repeat craniotomy on overall survival of patients with recurrent glioblastoma. The authors retrospectively reviewed the records of all adults patients who underwent repeat resection of recurrent glioblastoma following radiatio...

journal_title：Journal of neuro-oncology

authors： Perrini P,Gambacciani C,Weiss A,Pasqualetti F,Delishaj D,Paiar F,Morganti R,Vannozzi R,Lutzemberger L

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Our primary objective was to report the current neuroimaging classification systems of spatial patterns of progression in glioblastoma. In addition, we aimed to report the terminology used to describe 'progression' and to assess the compliance with the Response Assessment in Neuro-Oncology (RANO) Criteria. ...

journal_title：Journal of neuro-oncology

authors： Piper RJ,Senthil KK,Yan JL,Price SJ

更新日期：2018-08-01 00:00:00